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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNH5
Full Name:
Potassium voltage-gated channel subfamily H member 5
Alias:
Ether-a-go-go potassium channel 2;Voltage-gated potassium channel subunit Kv10.2
Type:
Mass (Da):
111907
Number AA:
988
UniProt ID:
Q8NCM2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
E
N
I
V
R
R
S
S
E
S
S
F
L
L
Site 2
S24
E
N
I
V
R
R
S
S
E
S
S
F
L
L
G
Site 3
S26
I
V
R
R
S
S
E
S
S
F
L
L
G
N
A
Site 4
S27
V
R
R
S
S
E
S
S
F
L
L
G
N
A
Q
Site 5
Y53
G
F
C
K
L
S
G
Y
H
R
A
D
V
M
Q
Site 6
S66
M
Q
K
S
S
T
C
S
F
M
Y
G
E
L
T
Site 7
T73
S
F
M
Y
G
E
L
T
D
K
K
T
I
E
K
Site 8
T77
G
E
L
T
D
K
K
T
I
E
K
V
R
Q
T
Site 9
T84
T
I
E
K
V
R
Q
T
F
D
N
Y
E
S
N
Site 10
Y88
V
R
Q
T
F
D
N
Y
E
S
N
C
F
E
V
Site 11
Y98
N
C
F
E
V
L
L
Y
K
K
N
R
T
P
V
Site 12
T103
L
L
Y
K
K
N
R
T
P
V
W
F
Y
M
Q
Site 13
S142
K
Q
P
I
E
D
D
S
T
K
G
W
T
K
F
Site 14
T143
Q
P
I
E
D
D
S
T
K
G
W
T
K
F
A
Site 15
T153
W
T
K
F
A
R
L
T
R
A
L
T
N
S
R
Site 16
T157
A
R
L
T
R
A
L
T
N
S
R
S
V
L
Q
Site 17
S159
L
T
R
A
L
T
N
S
R
S
V
L
Q
Q
L
Site 18
S161
R
A
L
T
N
S
R
S
V
L
Q
Q
L
T
P
Site 19
T167
R
S
V
L
Q
Q
L
T
P
M
N
K
T
E
V
Site 20
T172
Q
L
T
P
M
N
K
T
E
V
V
H
K
H
S
Site 21
Y195
G
S
D
I
L
P
Q
Y
K
Q
E
A
P
K
T
Site 22
T202
Y
K
Q
E
A
P
K
T
P
P
H
I
I
L
H
Site 23
S279
G
P
G
G
E
V
I
S
D
P
K
L
I
R
M
Site 24
S317
E
N
V
D
E
G
I
S
S
L
F
S
S
L
K
Site 25
Y341
V
A
R
K
L
D
H
Y
L
E
Y
G
A
A
V
Site 26
T398
Q
L
A
L
S
I
G
T
P
Y
R
Y
N
T
S
Site 27
Y402
S
I
G
T
P
Y
R
Y
N
T
S
A
G
I
W
Site 28
T404
G
T
P
Y
R
Y
N
T
S
A
G
I
W
E
G
Site 29
S414
G
I
W
E
G
G
P
S
K
D
S
L
Y
V
S
Site 30
S417
E
G
G
P
S
K
D
S
L
Y
V
S
S
L
Y
Site 31
Y419
G
P
S
K
D
S
L
Y
V
S
S
L
Y
F
T
Site 32
S421
S
K
D
S
L
Y
V
S
S
L
Y
F
T
M
T
Site 33
S422
K
D
S
L
Y
V
S
S
L
Y
F
T
M
T
S
Site 34
T442
F
G
N
I
A
P
T
T
D
V
E
K
M
F
S
Site 35
Y495
V
R
D
F
L
K
L
Y
Q
V
P
K
G
L
S
Site 36
S502
Y
Q
V
P
K
G
L
S
E
R
V
M
D
Y
I
Site 37
S526
I
D
T
E
K
V
L
S
I
C
P
K
D
M
R
Site 38
Y578
C
A
P
G
D
L
I
Y
H
A
G
E
S
V
D
Site 39
T665
N
S
F
S
R
N
L
T
L
T
C
N
L
R
K
Site 40
T667
F
S
R
N
L
T
L
T
C
N
L
R
K
R
I
Site 41
S680
R
I
I
F
R
K
I
S
D
V
K
K
E
E
E
Site 42
S699
Q
K
N
E
V
T
L
S
I
P
V
D
H
P
V
Site 43
S724
K
E
L
R
N
Q
G
S
T
Q
G
D
P
E
R
Site 44
S740
Q
L
Q
V
E
S
R
S
L
Q
N
G
T
S
I
Site 45
S746
R
S
L
Q
N
G
T
S
I
T
G
T
S
V
V
Site 46
Y767
P
I
Q
T
S
L
A
Y
V
K
T
S
E
S
L
Site 47
T770
T
S
L
A
Y
V
K
T
S
E
S
L
K
Q
N
Site 48
S799
Q
K
C
L
K
V
N
S
P
I
R
M
K
N
G
Site 49
T832
K
E
D
W
N
N
V
T
K
A
E
S
M
G
L
Site 50
S841
A
E
S
M
G
L
L
S
E
D
P
K
S
S
D
Site 51
S846
L
L
S
E
D
P
K
S
S
D
S
E
N
S
V
Site 52
S847
L
S
E
D
P
K
S
S
D
S
E
N
S
V
T
Site 53
S849
E
D
P
K
S
S
D
S
E
N
S
V
T
K
N
Site 54
S852
K
S
S
D
S
E
N
S
V
T
K
N
P
L
R
Site 55
T854
S
D
S
E
N
S
V
T
K
N
P
L
R
K
T
Site 56
T861
T
K
N
P
L
R
K
T
D
S
C
D
S
G
I
Site 57
S863
N
P
L
R
K
T
D
S
C
D
S
G
I
T
K
Site 58
S866
R
K
T
D
S
C
D
S
G
I
T
K
S
D
L
Site 59
S871
C
D
S
G
I
T
K
S
D
L
R
L
D
K
A
Site 60
S883
D
K
A
G
E
A
R
S
P
L
E
H
S
P
I
Site 61
S888
A
R
S
P
L
E
H
S
P
I
Q
A
D
A
K
Site 62
Y899
A
D
A
K
H
P
F
Y
P
I
P
E
Q
A
L
Site 63
S925
K
E
D
I
Q
L
L
S
C
R
M
T
A
L
E
Site 64
S946
L
K
I
L
S
E
K
S
V
P
Q
A
S
S
P
Site 65
S951
E
K
S
V
P
Q
A
S
S
P
K
S
Q
M
P
Site 66
S952
K
S
V
P
Q
A
S
S
P
K
S
Q
M
P
L
Site 67
S955
P
Q
A
S
S
P
K
S
Q
M
P
L
Q
V
P
Site 68
S972
I
P
C
Q
D
I
F
S
V
S
R
P
E
S
P
Site 69
S974
C
Q
D
I
F
S
V
S
R
P
E
S
P
E
S
Site 70
S978
F
S
V
S
R
P
E
S
P
E
S
D
K
D
E
Site 71
S981
S
R
P
E
S
P
E
S
D
K
D
E
I
H
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation