KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DYNC2H1
Full Name:
Cytoplasmic dynein 2 heavy chain 1
Alias:
Cytoplasmic dynein 2 heavy chain;Dynein cytoplasmic heavy chain 2;Dynein heavy chain 11;Dynein heavy chain isotype 1B
Type:
Mass (Da):
492575
Number AA:
4307
UniProt ID:
Q8NCM8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0035085
GO:0030286
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0007030
GO:0030030
GO:0007018
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
I
F
T
T
T
Q
N
Y
F
G
L
M
S
E
L
Site 2
S61
Q
R
S
D
A
G
I
S
F
S
N
T
I
E
F
Site 3
S63
S
D
A
G
I
S
F
S
N
T
I
E
F
G
D
Site 4
T65
A
G
I
S
F
S
N
T
I
E
F
G
D
T
K
Site 5
T71
N
T
I
E
F
G
D
T
K
D
K
V
L
V
F
Site 6
T87
K
L
R
P
E
V
I
T
D
E
N
L
H
D
N
Site 7
S106
S
M
L
E
S
P
I
S
S
L
Y
Q
A
V
R
Site 8
S107
M
L
E
S
P
I
S
S
L
Y
Q
A
V
R
Q
Site 9
Y109
E
S
P
I
S
S
L
Y
Q
A
V
R
Q
V
F
Site 10
S139
P
K
L
Q
N
L
L
S
E
L
E
A
G
L
G
Site 11
T154
I
V
L
R
R
S
D
T
N
L
T
K
L
K
F
Site 12
T166
L
K
F
K
E
D
D
T
R
G
I
L
T
P
S
Site 13
T171
D
D
T
R
G
I
L
T
P
S
D
E
F
Q
F
Site 14
S173
T
R
G
I
L
T
P
S
D
E
F
Q
F
W
I
Site 15
S191
H
R
G
N
K
Q
I
S
K
E
R
A
N
Y
F
Site 16
Y197
I
S
K
E
R
A
N
Y
F
K
E
L
F
E
T
Site 17
Y210
E
T
I
A
R
E
F
Y
N
L
D
S
L
S
L
Site 18
Y243
R
Q
T
E
H
D
H
Y
P
E
S
R
M
L
H
Site 19
Y277
L
N
L
W
E
D
P
Y
Y
L
V
K
E
S
L
Site 20
Y278
N
L
W
E
D
P
Y
Y
L
V
K
E
S
L
K
Site 21
Y319
H
P
W
K
N
E
K
Y
F
P
E
T
L
D
K
Site 22
T323
N
E
K
Y
F
P
E
T
L
D
K
L
G
K
R
Site 23
Y346
T
I
H
E
K
F
L
Y
F
L
P
A
S
E
E
Site 24
Y373
T
G
L
N
P
V
Q
Y
N
P
Y
T
E
P
L
Site 25
Y376
N
P
V
Q
Y
N
P
Y
T
E
P
L
W
K
A
Site 26
T377
P
V
Q
Y
N
P
Y
T
E
P
L
W
K
A
A
Site 27
S408
G
K
L
K
N
Y
I
S
E
I
Q
D
S
P
Q
Site 28
S413
Y
I
S
E
I
Q
D
S
P
Q
Q
L
L
Q
A
Site 29
T432
K
E
L
V
K
R
P
T
I
S
K
E
L
M
L
Site 30
S471
R
G
I
P
G
D
A
S
G
P
L
S
G
K
N
Site 31
S475
G
D
A
S
G
P
L
S
G
K
N
L
S
E
V
Site 32
S519
G
F
R
C
F
H
Q
S
A
K
D
L
L
D
Q
Site 33
Y530
L
L
D
Q
L
K
L
Y
E
Q
E
Q
F
D
D
Site 34
S539
Q
E
Q
F
D
D
W
S
R
D
I
Q
S
G
L
Site 35
S544
D
W
S
R
D
I
Q
S
G
L
S
D
S
R
S
Site 36
S547
R
D
I
Q
S
G
L
S
D
S
R
S
G
L
C
Site 37
S549
I
Q
S
G
L
S
D
S
R
S
G
L
C
I
E
Site 38
S551
S
G
L
S
D
S
R
S
G
L
C
I
E
A
S
Site 39
S566
S
R
I
M
E
L
D
S
N
D
G
L
L
K
V
Site 40
Y624
L
K
Q
V
A
H
F
Y
N
S
I
D
Q
Q
M
Site 41
S653
F
E
Q
I
I
K
N
S
K
A
G
S
G
G
K
Site 42
S657
I
K
N
S
K
A
G
S
G
G
K
S
Q
I
T
Site 43
S661
K
A
G
S
G
G
K
S
Q
I
T
W
D
N
P
Site 44
Y674
N
P
K
E
L
E
G
Y
I
Q
K
L
Q
N
A
Site 45
T687
N
A
A
E
R
L
A
T
E
N
R
K
L
R
K
Site 46
T697
R
K
L
R
K
W
H
T
T
F
C
E
K
V
V
Site 47
T731
E
L
R
T
G
L
A
T
V
E
A
Q
G
F
Q
Site 48
T780
P
E
I
N
I
D
L
T
Y
K
Q
G
R
L
Q
Site 49
Y781
E
I
N
I
D
L
T
Y
K
Q
G
R
L
Q
F
Site 50
Y799
F
E
E
I
R
A
K
Y
Y
R
E
M
K
R
F
Site 51
S826
A
G
D
E
S
I
F
S
I
M
I
D
R
N
A
Site 52
T838
R
N
A
S
G
F
L
T
I
F
S
K
A
E
D
Site 53
S851
E
D
L
F
R
R
L
S
A
V
L
H
Q
H
K
Site 54
S901
K
E
V
E
R
L
P
S
A
V
K
V
D
C
L
Site 55
T947
A
H
L
H
E
I
D
T
F
V
T
E
A
M
E
Site 56
Y973
I
G
D
A
N
L
Q
Y
S
K
L
Q
E
R
K
Site 57
T999
D
K
N
R
L
L
R
T
V
A
G
G
G
L
E
Site 58
S1009
G
G
G
L
E
T
I
S
N
L
K
A
K
W
D
Site 59
S1024
K
F
E
L
M
M
E
S
H
Q
L
M
I
K
D
Site 60
Y1048
K
S
R
L
Q
I
Y
Y
Q
E
L
E
K
F
K
Site 61
S1079
Q
H
N
T
L
D
K
S
A
K
L
I
K
E
K
Site 62
S1115
R
L
E
E
P
N
F
S
L
A
S
S
I
S
K
Site 63
S1119
P
N
F
S
L
A
S
S
I
S
K
D
I
E
S
Site 64
S1206
Y
V
R
G
E
H
L
S
P
D
H
W
L
D
L
Site 65
S1252
A
D
L
K
D
L
N
S
R
A
Q
G
E
V
T
Site 66
T1259
S
R
A
Q
G
E
V
T
I
R
E
A
L
R
E
Site 67
Y1281
A
V
F
T
L
I
D
Y
E
D
S
Q
S
R
T
Site 68
S1284
T
L
I
D
Y
E
D
S
Q
S
R
T
M
K
L
Site 69
S1286
I
D
Y
E
D
S
Q
S
R
T
M
K
L
I
K
Site 70
T1288
Y
E
D
S
Q
S
R
T
M
K
L
I
K
D
W
Site 71
S1311
D
N
R
C
L
L
Q
S
L
K
D
S
P
Y
Y
Site 72
S1315
L
L
Q
S
L
K
D
S
P
Y
Y
K
G
F
E
Site 73
Y1317
Q
S
L
K
D
S
P
Y
Y
K
G
F
E
D
K
Site 74
Y1318
S
L
K
D
S
P
Y
Y
K
G
F
E
D
K
V
Site 75
S1326
K
G
F
E
D
K
V
S
I
W
E
R
K
L
A
Site 76
Y1338
K
L
A
E
L
D
E
Y
L
Q
N
L
N
H
I
Site 77
Y1351
H
I
Q
R
K
W
V
Y
L
E
P
I
F
G
R
Site 78
S1377
R
V
D
E
D
F
R
S
I
M
T
D
I
K
K
Site 79
T1389
I
K
K
D
N
R
V
T
T
L
T
T
H
A
G
Site 80
T1390
K
K
D
N
R
V
T
T
L
T
T
H
A
G
I
Site 81
T1392
D
N
R
V
T
T
L
T
T
H
A
G
I
R
N
Site 82
T1403
G
I
R
N
S
L
L
T
I
L
D
Q
L
Q
R
Site 83
S1414
Q
L
Q
R
C
Q
K
S
L
N
E
F
L
E
E
Site 84
S1424
E
F
L
E
E
K
R
S
A
F
P
R
F
Y
F
Site 85
Y1430
R
S
A
F
P
R
F
Y
F
I
G
D
D
D
L
Site 86
S1448
L
G
Q
S
T
N
P
S
V
I
Q
S
H
L
K
Site 87
S1452
T
N
P
S
V
I
Q
S
H
L
K
K
L
F
A
Site 88
S1463
K
L
F
A
G
I
N
S
V
C
F
D
E
K
S
Site 89
T1474
D
E
K
S
K
H
I
T
A
M
K
S
L
E
G
Site 90
S1478
K
H
I
T
A
M
K
S
L
E
G
E
V
V
P
Site 91
S1493
F
K
N
K
V
P
L
S
N
N
V
E
T
W
L
Site 92
T1510
L
A
L
E
M
K
K
T
L
E
Q
L
L
K
E
Site 93
T1520
Q
L
L
K
E
C
V
T
T
G
R
S
S
Q
G
Site 94
T1521
L
L
K
E
C
V
T
T
G
R
S
S
Q
G
A
Site 95
S1525
C
V
T
T
G
R
S
S
Q
G
A
V
D
P
S
Site 96
T1579
E
Q
Y
T
N
I
D
T
S
S
E
D
P
G
N
Site 97
S1581
Y
T
N
I
D
T
S
S
E
D
P
G
N
T
E
Site 98
S1589
E
D
P
G
N
T
E
S
G
I
L
E
L
K
L
Site 99
Y1651
M
V
D
S
E
F
Q
Y
T
Y
E
Y
Q
G
N
Site 100
T1652
V
D
S
E
F
Q
Y
T
Y
E
Y
Q
G
N
A
Site 101
Y1653
D
S
E
F
Q
Y
T
Y
E
Y
Q
G
N
A
S
Site 102
Y1655
E
F
Q
Y
T
Y
E
Y
Q
G
N
A
S
K
L
Site 103
Y1664
G
N
A
S
K
L
V
Y
T
P
L
T
D
K
C
Site 104
T1665
N
A
S
K
L
V
Y
T
P
L
T
D
K
C
Y
Site 105
Y1688
M
G
L
G
G
N
P
Y
G
P
A
G
T
G
K
Site 106
T1696
G
P
A
G
T
G
K
T
E
S
V
K
A
L
G
Site 107
S1698
A
G
T
G
K
T
E
S
V
K
A
L
G
G
L
Site 108
S1723
D
E
G
I
D
V
K
S
M
G
R
I
F
V
G
Site 109
S1749
E
F
N
R
L
E
E
S
V
L
S
A
V
S
M
Site 110
T1770
D
A
L
K
N
H
R
T
V
C
E
L
L
G
K
Site 111
S1783
G
K
E
V
E
V
N
S
N
S
G
I
F
I
T
Site 112
S1785
E
V
E
V
N
S
N
S
G
I
F
I
T
M
N
Site 113
T1790
S
N
S
G
I
F
I
T
M
N
P
A
G
K
G
Site 114
S1818
L
F
R
P
V
A
M
S
H
P
D
N
E
L
I
Site 115
S1852
L
V
A
I
F
N
L
S
R
E
L
L
T
P
Q
Site 116
T1857
N
L
S
R
E
L
L
T
P
Q
Q
H
Y
D
W
Site 117
T1871
W
G
L
R
A
L
K
T
V
L
R
G
S
G
N
Site 118
S1876
L
K
T
V
L
R
G
S
G
N
L
L
R
Q
L
Site 119
S1886
L
L
R
Q
L
N
K
S
G
T
T
Q
N
A
N
Site 120
Y1936
I
E
L
K
E
V
E
Y
D
E
L
S
A
A
L
Site 121
S1940
E
V
E
Y
D
E
L
S
A
A
L
K
Q
V
F
Site 122
Y1952
Q
V
F
E
E
A
N
Y
E
I
I
P
N
Q
I
Site 123
Y1966
I
K
K
A
L
E
L
Y
E
Q
L
C
Q
R
M
Site 124
S1986
G
P
S
G
A
G
K
S
T
L
W
R
M
L
R
Site 125
T1987
P
S
G
A
G
K
S
T
L
W
R
M
L
R
A
Site 126
Y2006
T
G
K
V
V
K
Q
Y
T
M
N
P
K
A
M
Site 127
Y2016
N
P
K
A
M
P
R
Y
Q
L
L
G
H
I
D
Site 128
T2026
L
G
H
I
D
M
D
T
R
E
W
S
D
G
V
Site 129
S2030
D
M
D
T
R
E
W
S
D
G
V
L
T
N
S
Site 130
S2037
S
D
G
V
L
T
N
S
A
R
Q
V
V
R
E
Site 131
S2050
R
E
P
Q
D
V
S
S
W
I
I
C
D
G
D
Site 132
S2065
I
D
P
E
W
I
E
S
L
N
S
V
L
D
D
Site 133
S2068
E
W
I
E
S
L
N
S
V
L
D
D
N
R
L
Site 134
T2077
L
D
D
N
R
L
L
T
M
P
S
G
E
R
I
Site 135
S2080
N
R
L
L
T
M
P
S
G
E
R
I
Q
F
G
Site 136
S2103
T
H
D
L
S
C
A
S
P
A
T
I
S
R
M
Site 137
S2116
R
M
G
M
I
F
L
S
D
E
E
T
D
L
N
Site 138
T2120
I
F
L
S
D
E
E
T
D
L
N
S
L
I
K
Site 139
S2124
D
E
E
T
D
L
N
S
L
I
K
S
W
L
R
Site 140
S2128
D
L
N
S
L
I
K
S
W
L
R
N
Q
P
A
Site 141
Y2148
L
E
N
W
I
G
D
Y
F
E
K
A
L
Q
W
Site 142
S2204
G
G
N
L
N
M
K
S
R
L
E
F
T
K
E
Site 143
S2219
V
F
H
W
A
R
E
S
P
P
D
F
H
K
P
Site 144
T2229
D
F
H
K
P
M
D
T
Y
Y
D
S
T
R
G
Site 145
Y2230
F
H
K
P
M
D
T
Y
Y
D
S
T
R
G
R
Site 146
Y2231
H
K
P
M
D
T
Y
Y
D
S
T
R
G
R
L
Site 147
S2233
P
M
D
T
Y
Y
D
S
T
R
G
R
L
A
T
Site 148
T2240
S
T
R
G
R
L
A
T
Y
V
L
K
K
P
E
Site 149
Y2241
T
R
G
R
L
A
T
Y
V
L
K
K
P
E
D
Site 150
T2250
L
K
K
P
E
D
L
T
A
D
D
F
S
N
G
Site 151
T2259
D
D
F
S
N
G
L
T
L
P
V
I
Q
T
P
Site 152
Y2274
D
M
Q
R
G
L
D
Y
F
K
P
W
L
S
S
Site 153
S2280
D
Y
F
K
P
W
L
S
S
D
T
K
Q
P
F
Site 154
T2283
K
P
W
L
S
S
D
T
K
Q
P
F
I
L
V
Site 155
Y2303
G
K
G
M
L
L
R
Y
A
F
S
Q
L
R
S
Site 156
S2310
Y
A
F
S
Q
L
R
S
T
Q
I
A
T
V
H
Site 157
T2323
V
H
C
S
A
Q
T
T
S
R
H
L
L
Q
K
Site 158
Y2346
S
T
N
T
G
R
V
Y
R
P
K
D
C
E
R
Site 159
T2383
A
F
L
Q
Q
V
L
T
Y
Q
G
F
Y
D
E
Site 160
T2418
R
L
G
R
H
K
L
T
T
R
F
T
S
I
V
Site 161
T2419
L
G
R
H
K
L
T
T
R
F
T
S
I
V
R
Site 162
T2422
H
K
L
T
T
R
F
T
S
I
V
R
L
C
S
Site 163
S2429
T
S
I
V
R
L
C
S
I
D
Y
P
E
R
E
Site 164
Y2432
V
R
L
C
S
I
D
Y
P
E
R
E
Q
L
Q
Site 165
T2440
P
E
R
E
Q
L
Q
T
I
Y
G
A
Y
L
E
Site 166
Y2442
R
E
Q
L
Q
T
I
Y
G
A
Y
L
E
P
V
Site 167
S2458
H
K
N
L
K
N
H
S
I
W
G
S
S
S
K
Site 168
S2462
K
N
H
S
I
W
G
S
S
S
K
I
Y
L
L
Site 169
Y2477
A
G
S
M
V
Q
V
Y
E
Q
V
R
A
K
F
Site 170
T2485
E
Q
V
R
A
K
F
T
V
D
D
Y
S
H
Y
Site 171
Y2489
A
K
F
T
V
D
D
Y
S
H
Y
F
F
T
P
Site 172
Y2509
W
V
L
G
L
F
R
Y
D
L
E
G
G
S
S
Site 173
S2516
Y
D
L
E
G
G
S
S
N
H
P
L
D
Y
V
Site 174
Y2573
D
N
M
S
D
S
F
Y
V
T
W
G
A
R
H
Site 175
S2582
T
W
G
A
R
H
N
S
G
A
R
A
A
P
G
Site 176
S2604
K
P
L
G
K
L
N
S
T
D
L
K
D
V
I
Site 177
Y2618
I
K
K
G
L
I
H
Y
G
R
D
N
Q
N
L
Site 178
Y2636
L
F
H
E
V
L
E
Y
M
S
R
I
D
R
V
Site 179
T2663
R
S
G
V
G
R
R
T
I
T
S
L
V
S
H
Site 180
T2665
G
V
G
R
R
T
I
T
S
L
V
S
H
M
H
Site 181
S2666
V
G
R
R
T
I
T
S
L
V
S
H
M
H
G
Site 182
S2678
M
H
G
A
V
L
F
S
P
K
I
S
R
G
Y
Site 183
S2682
V
L
F
S
P
K
I
S
R
G
Y
E
L
K
Q
Site 184
Y2685
S
P
K
I
S
R
G
Y
E
L
K
Q
F
K
N
Site 185
Y2739
S
G
E
V
P
G
L
Y
T
L
E
E
L
E
P
Site 186
S2756
L
P
L
K
D
Q
A
S
Q
D
G
F
F
G
P
Site 187
Y2767
F
F
G
P
V
F
N
Y
F
T
Y
R
I
Q
Q
Site 188
S2825
K
I
P
E
M
L
F
S
E
T
G
G
G
E
K
Site 189
Y2833
E
T
G
G
G
E
K
Y
N
D
K
K
R
K
E
Site 190
S2846
K
E
E
K
K
K
N
S
V
D
P
D
F
L
K
Site 191
T2868
S
C
K
A
Y
G
A
T
P
S
Q
Y
M
T
F
Site 192
Y2872
Y
G
A
T
P
S
Q
Y
M
T
F
L
H
V
Y
Site 193
T2874
A
T
P
S
Q
Y
M
T
F
L
H
V
Y
S
A
Site 194
S2880
M
T
F
L
H
V
Y
S
A
I
S
S
S
K
K
Site 195
S2884
H
V
Y
S
A
I
S
S
S
K
K
K
E
L
L
Site 196
S2885
V
Y
S
A
I
S
S
S
K
K
K
E
L
L
K
Site 197
S2895
K
E
L
L
K
R
Q
S
H
L
Q
A
G
V
S
Site 198
S2942
A
L
Q
M
I
T
V
S
M
Q
D
A
S
E
Q
Site 199
T2951
Q
D
A
S
E
Q
K
T
E
L
E
R
L
K
H
Site 200
S2999
V
G
N
I
K
P
E
S
L
S
E
I
R
S
L
Site 201
S3001
N
I
K
P
E
S
L
S
E
I
R
S
L
R
M
Site 202
S3005
E
S
L
S
E
I
R
S
L
R
M
P
P
D
V
Site 203
T3029
R
L
M
G
I
F
D
T
S
W
V
S
M
K
S
Site 204
S3036
T
S
W
V
S
M
K
S
F
L
A
K
R
G
V
Site 205
T3049
G
V
R
E
D
I
A
T
F
D
A
R
N
I
S
Site 206
S3056
T
F
D
A
R
N
I
S
K
E
I
R
E
S
V
Site 207
S3062
I
S
K
E
I
R
E
S
V
E
E
L
L
F
K
Site 208
S3073
L
L
F
K
N
K
G
S
F
D
P
K
N
A
K
Site 209
S3083
P
K
N
A
K
R
A
S
T
A
A
A
P
L
A
Site 210
T3084
K
N
A
K
R
A
S
T
A
A
A
P
L
A
A
Site 211
T3123
L
E
S
N
L
K
K
T
E
D
R
K
R
K
L
Site 212
S3136
K
L
E
E
L
L
N
S
V
G
Q
K
V
S
E
Site 213
S3150
E
L
K
E
K
F
Q
S
R
T
S
E
A
A
K
Site 214
S3153
E
K
F
Q
S
R
T
S
E
A
A
K
L
E
A
Site 215
S3163
A
K
L
E
A
E
V
S
K
A
Q
E
T
I
K
Site 216
T3199
E
I
T
E
E
L
A
T
L
P
K
R
A
Q
L
Site 217
S3220
Y
L
S
A
A
P
E
S
L
R
K
T
C
L
E
Site 218
T3224
A
P
E
S
L
R
K
T
C
L
E
E
W
T
K
Site 219
S3232
C
L
E
E
W
T
K
S
A
G
L
E
K
F
D
Site 220
T3246
D
L
R
R
F
L
C
T
E
S
E
Q
L
I
W
Site 221
S3255
S
E
Q
L
I
W
K
S
E
G
L
P
S
D
D
Site 222
S3260
W
K
S
E
G
L
P
S
D
D
L
S
I
E
N
Site 223
S3285
P
F
L
I
D
P
S
S
Q
A
T
E
W
L
K
Site 224
T3288
I
D
P
S
S
Q
A
T
E
W
L
K
T
H
L
Site 225
T3293
Q
A
T
E
W
L
K
T
H
L
K
D
S
R
L
Site 226
T3312
Q
Q
D
S
N
F
I
T
A
L
E
L
A
V
R
Site 227
Y3337
D
G
V
E
P
V
L
Y
P
L
L
R
R
D
L
Site 228
Y3351
L
V
A
Q
G
P
R
Y
V
V
Q
I
G
D
K
Site 229
Y3362
I
G
D
K
I
I
D
Y
N
E
E
F
R
L
F
Site 230
S3371
E
E
F
R
L
F
L
S
T
R
N
P
N
P
F
Site 231
T3372
E
F
R
L
F
L
S
T
R
N
P
N
P
F
I
Site 232
T3393
I
V
T
E
V
N
F
T
T
T
R
S
G
L
R
Site 233
T3394
V
T
E
V
N
F
T
T
T
R
S
G
L
R
G
Site 234
T3407
R
G
Q
L
L
A
L
T
I
Q
H
E
K
P
D
Site 235
T3420
P
D
L
E
E
Q
K
T
K
L
L
Q
Q
E
E
Site 236
T3443
L
E
E
S
L
L
E
T
L
A
T
S
Q
G
N
Site 237
S3460
E
N
K
D
L
I
E
S
L
N
Q
T
K
A
S
Site 238
S3474
S
S
A
L
I
Q
E
S
L
K
E
S
Y
K
L
Site 239
S3478
I
Q
E
S
L
K
E
S
Y
K
L
Q
I
S
L
Site 240
S3484
E
S
Y
K
L
Q
I
S
L
D
Q
E
R
D
A
Site 241
Y3492
L
D
Q
E
R
D
A
Y
L
P
L
A
E
S
A
Site 242
S3507
S
K
M
Y
F
I
I
S
D
L
S
K
I
N
N
Site 243
S3546
N
T
E
Q
R
I
Q
S
L
I
S
S
L
Q
H
Site 244
S3550
R
I
Q
S
L
I
S
S
L
Q
H
M
V
Y
E
Site 245
T3593
E
N
E
W
D
T
F
T
G
V
V
V
G
D
M
Site 246
S3606
D
M
L
R
K
A
D
S
Q
Q
K
I
R
D
Q
Site 247
S3616
K
I
R
D
Q
L
P
S
W
I
D
Q
E
R
S
Site 248
Y3651
D
A
A
L
W
R
T
Y
Y
N
N
S
M
C
E
Site 249
Y3714
P
L
N
L
K
R
L
Y
K
E
T
L
E
I
E
Site 250
T3717
L
K
R
L
Y
K
E
T
L
E
I
E
P
I
L
Site 251
S3734
I
S
P
G
A
D
P
S
Q
E
L
Q
E
L
A
Site 252
Y3750
A
E
R
S
G
E
C
Y
H
Q
V
A
M
G
Q
Site 253
T3804
N
T
L
Q
P
K
D
T
F
R
L
W
L
T
A
Site 254
T3810
D
T
F
R
L
W
L
T
A
E
V
H
P
N
F
Site 255
T3818
A
E
V
H
P
N
F
T
P
I
L
L
Q
S
S
Site 256
S3825
T
P
I
L
L
Q
S
S
L
K
I
T
Y
E
S
Site 257
T3829
L
Q
S
S
L
K
I
T
Y
E
S
P
P
G
L
Site 258
Y3830
Q
S
S
L
K
I
T
Y
E
S
P
P
G
L
K
Site 259
S3832
S
L
K
I
T
Y
E
S
P
P
G
L
K
K
N
Site 260
Y3844
K
K
N
L
M
R
T
Y
E
S
W
T
P
E
Q
Site 261
T3848
M
R
T
Y
E
S
W
T
P
E
Q
I
S
K
K
Site 262
T3858
Q
I
S
K
K
D
N
T
H
R
A
H
A
L
F
Site 263
Y3880
A
C
Q
E
R
R
N
Y
I
P
Q
G
W
T
K
Site 264
Y3889
P
Q
G
W
T
K
F
Y
E
F
S
L
S
D
L
Site 265
S3892
W
T
K
F
Y
E
F
S
L
S
D
L
R
A
G
Site 266
S3894
K
F
Y
E
F
S
L
S
D
L
R
A
G
Y
N
Site 267
Y3927
G
L
L
E
N
A
I
Y
G
G
R
I
D
N
Y
Site 268
Y3934
Y
G
G
R
I
D
N
Y
F
D
L
R
V
L
Q
Site 269
Y3943
D
L
R
V
L
Q
S
Y
L
K
Q
F
F
N
S
Site 270
S3951
L
K
Q
F
F
N
S
S
V
I
D
V
F
N
Q
Site 271
S3963
F
N
Q
R
N
K
K
S
I
F
P
Y
S
V
S
Site 272
Y3967
N
K
K
S
I
F
P
Y
S
V
S
L
P
Q
S
Site 273
S3968
K
K
S
I
F
P
Y
S
V
S
L
P
Q
S
C
Site 274
S3974
Y
S
V
S
L
P
Q
S
C
S
I
L
D
Y
R
Site 275
S3994
I
P
E
D
D
K
P
S
F
F
G
L
P
A
N
Site 276
S4006
P
A
N
I
A
R
S
S
Q
R
M
I
S
S
Q
Site 277
S4011
R
S
S
Q
R
M
I
S
S
Q
V
I
S
Q
L
Site 278
S4012
S
S
Q
R
M
I
S
S
Q
V
I
S
Q
L
R
Site 279
S4024
Q
L
R
I
L
G
R
S
I
T
A
G
S
K
F
Site 280
T4026
R
I
L
G
R
S
I
T
A
G
S
K
F
D
R
Site 281
S4037
K
F
D
R
E
I
W
S
N
E
L
S
P
V
L
Site 282
S4041
E
I
W
S
N
E
L
S
P
V
L
N
L
W
K
Site 283
S4070
P
P
N
D
R
Q
G
S
P
I
L
S
F
I
I
Site 284
T4105
S
K
V
I
R
G
T
T
L
L
S
S
E
V
Q
Site 285
S4109
R
G
T
T
L
L
S
S
E
V
Q
K
L
A
S
Site 286
Y4140
G
P
E
D
P
L
Q
Y
L
R
G
L
V
A
R
Site 287
S4165
A
E
K
Q
A
L
L
S
E
T
L
D
L
S
E
Site 288
S4171
L
S
E
T
L
D
L
S
E
L
F
H
P
D
T
Site 289
T4178
S
E
L
F
H
P
D
T
F
L
N
A
L
R
Q
Site 290
T4187
L
N
A
L
R
Q
E
T
A
R
A
V
G
R
S
Site 291
S4203
D
S
L
K
F
V
A
S
W
K
G
R
L
Q
E
Site 292
S4233
S
F
D
G
N
Q
L
S
E
N
Q
L
D
S
P
Site 293
S4239
L
S
E
N
Q
L
D
S
P
S
V
S
S
V
L
Site 294
S4241
E
N
Q
L
D
S
P
S
V
S
S
V
L
P
C
Site 295
S4262
Q
D
A
C
G
P
Y
S
P
D
E
C
I
S
L
Site 296
S4268
Y
S
P
D
E
C
I
S
L
P
V
Y
T
S
A
Site 297
Y4272
E
C
I
S
L
P
V
Y
T
S
A
E
R
D
R
Site 298
S4274
I
S
L
P
V
Y
T
S
A
E
R
D
R
V
V
Site 299
T4282
A
E
R
D
R
V
V
T
N
I
D
V
P
C
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation