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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF169
Full Name:
RING finger protein 169
Alias:
kiaa1991; RN169
Type:
Uncharacterized protein
Mass (Da):
77194
Number AA:
708
UniProt ID:
Q8NCN4
International Prot ID:
IPI00456899
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
A
A
G
P
S
T
R
A
S
S
A
A
Site 2
T8
M
A
A
A
G
P
S
T
R
A
S
S
A
A
A
Site 3
S11
A
G
P
S
T
R
A
S
S
A
A
A
A
A
A
Site 4
S20
A
A
A
A
A
A
L
S
R
R
G
R
R
G
R
Site 5
T31
R
R
G
R
C
D
E
T
A
A
A
K
T
G
A
Site 6
S126
R
D
D
G
Q
A
D
S
E
V
L
G
E
C
A
Site 7
S136
L
G
E
C
A
R
R
S
Q
P
E
R
C
R
P
Site 8
S178
F
R
A
P
I
K
L
S
K
P
G
E
L
R
E
Site 9
Y187
P
G
E
L
R
E
E
Y
E
S
L
R
K
L
R
Site 10
S189
E
L
R
E
E
Y
E
S
L
R
K
L
R
E
E
Site 11
S204
K
L
Q
E
E
K
P
S
E
D
Q
I
H
K
L
Site 12
T216
H
K
L
L
P
E
D
T
E
T
G
K
R
K
M
Site 13
T218
L
L
P
E
D
T
E
T
G
K
R
K
M
D
E
Site 14
S247
E
R
C
P
A
R
L
S
D
S
E
N
E
E
P
Site 15
S249
C
P
A
R
L
S
D
S
E
N
E
E
P
S
R
Site 16
T260
E
P
S
R
G
Q
M
T
Q
T
H
R
S
A
F
Site 17
T262
S
R
G
Q
M
T
Q
T
H
R
S
A
F
V
S
Site 18
S269
T
H
R
S
A
F
V
S
K
N
N
S
Y
S
L
Site 19
S275
V
S
K
N
N
S
Y
S
L
A
F
L
A
G
K
Site 20
S285
F
L
A
G
K
L
N
S
K
V
E
R
S
Q
S
Site 21
S290
L
N
S
K
V
E
R
S
Q
S
C
S
D
T
A
Site 22
S292
S
K
V
E
R
S
Q
S
C
S
D
T
A
Q
E
Site 23
S294
V
E
R
S
Q
S
C
S
D
T
A
Q
E
R
A
Site 24
T296
R
S
Q
S
C
S
D
T
A
Q
E
R
A
K
S
Site 25
S303
T
A
Q
E
R
A
K
S
R
V
R
A
V
P
G
Site 26
T319
K
A
K
V
T
T
M
T
P
A
S
N
P
I
I
Site 27
S322
V
T
T
M
T
P
A
S
N
P
I
I
G
V
L
Site 28
S339
T
Q
N
N
R
C
V
S
A
P
D
L
T
I
E
Site 29
S352
I
E
K
R
L
P
F
S
S
L
S
S
L
A
S
Site 30
S353
E
K
R
L
P
F
S
S
L
S
S
L
A
S
L
Site 31
S355
R
L
P
F
S
S
L
S
S
L
A
S
L
H
K
Site 32
S359
S
S
L
S
S
L
A
S
L
H
K
P
E
R
S
Site 33
S366
S
L
H
K
P
E
R
S
V
S
P
E
S
N
D
Site 34
S368
H
K
P
E
R
S
V
S
P
E
S
N
D
S
I
Site 35
S371
E
R
S
V
S
P
E
S
N
D
S
I
S
E
E
Site 36
S374
V
S
P
E
S
N
D
S
I
S
E
E
L
N
H
Site 37
S376
P
E
S
N
D
S
I
S
E
E
L
N
H
F
K
Site 38
S388
H
F
K
P
I
V
C
S
P
C
T
P
P
K
R
Site 39
T391
P
I
V
C
S
P
C
T
P
P
K
R
L
P
D
Site 40
S403
L
P
D
G
R
V
L
S
P
L
I
I
K
S
T
Site 41
S409
L
S
P
L
I
I
K
S
T
P
R
N
L
N
R
Site 42
T410
S
P
L
I
I
K
S
T
P
R
N
L
N
R
S
Site 43
S417
T
P
R
N
L
N
R
S
L
Q
K
Q
T
S
Y
Site 44
S423
R
S
L
Q
K
Q
T
S
Y
E
A
S
P
R
I
Site 45
S427
K
Q
T
S
Y
E
A
S
P
R
I
L
K
K
W
Site 46
T446
Q
E
R
Q
I
K
K
T
L
S
K
A
T
L
T
Site 47
S448
R
Q
I
K
K
T
L
S
K
A
T
L
T
S
L
Site 48
S454
L
S
K
A
T
L
T
S
L
A
P
E
M
G
E
Site 49
S466
M
G
E
E
L
L
G
S
E
G
I
H
S
S
K
Site 50
S471
L
G
S
E
G
I
H
S
S
K
E
K
P
L
V
Site 51
S472
G
S
E
G
I
H
S
S
K
E
K
P
L
V
A
Site 52
S485
V
A
V
N
T
R
L
S
G
G
Q
V
L
S
E
Site 53
S491
L
S
G
G
Q
V
L
S
E
Y
T
G
P
T
S
Site 54
Y493
G
G
Q
V
L
S
E
Y
T
G
P
T
S
A
D
Site 55
S498
S
E
Y
T
G
P
T
S
A
D
L
D
H
F
P
Site 56
S506
A
D
L
D
H
F
P
S
V
S
Q
T
K
A
E
Site 57
S508
L
D
H
F
P
S
V
S
Q
T
K
A
E
Q
D
Site 58
T510
H
F
P
S
V
S
Q
T
K
A
E
Q
D
S
D
Site 59
S516
Q
T
K
A
E
Q
D
S
D
N
K
S
S
T
E
Site 60
S520
E
Q
D
S
D
N
K
S
S
T
E
I
P
L
E
Site 61
T522
D
S
D
N
K
S
S
T
E
I
P
L
E
T
C
Site 62
T528
S
T
E
I
P
L
E
T
C
C
S
S
E
L
K
Site 63
S531
I
P
L
E
T
C
C
S
S
E
L
K
G
G
G
Site 64
S532
P
L
E
T
C
C
S
S
E
L
K
G
G
G
S
Site 65
S542
K
G
G
G
S
G
T
S
L
E
R
E
Q
F
E
Site 66
S553
E
Q
F
E
G
L
G
S
T
P
D
A
K
L
D
Site 67
T554
Q
F
E
G
L
G
S
T
P
D
A
K
L
D
K
Site 68
T562
P
D
A
K
L
D
K
T
C
I
S
R
A
M
K
Site 69
T572
S
R
A
M
K
I
T
T
V
N
S
V
L
P
Q
Site 70
T595
K
T
K
Q
Q
L
K
T
L
N
H
F
D
L
T
Site 71
S609
T
N
G
V
L
V
E
S
L
S
E
E
P
L
P
Site 72
S617
L
S
E
E
P
L
P
S
L
R
R
G
R
K
R
Site 73
T628
G
R
K
R
H
C
K
T
K
H
L
E
Q
N
G
Site 74
S636
K
H
L
E
Q
N
G
S
L
K
K
L
R
Q
T
Site 75
T643
S
L
K
K
L
R
Q
T
S
G
E
V
G
L
A
Site 76
S644
L
K
K
L
R
Q
T
S
G
E
V
G
L
A
P
Site 77
T686
M
F
D
N
E
R
R
T
V
S
R
R
K
G
S
Site 78
S688
D
N
E
R
R
T
V
S
R
R
K
G
S
V
D
Site 79
S693
T
V
S
R
R
K
G
S
V
D
Q
Y
L
L
R
Site 80
Y697
R
K
G
S
V
D
Q
Y
L
L
R
S
S
N
M
Site 81
S702
D
Q
Y
L
L
R
S
S
N
M
A
G
A
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation