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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMG8
Full Name:
Protein SMG8
Alias:
Chromosome 17 open reading frame 71; CQ071; FLJ10587; LOC55181; Protein smg-8 homolog
Type:
Unknown function
Mass (Da):
109684
Number AA:
991
UniProt ID:
Q8ND04
International Prot ID:
IPI00328183
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000184
GO:0045859
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
R
D
L
L
M
G
A
S
A
W
M
G
S
E
S
Site 2
S20
G
A
S
A
W
M
G
S
E
S
P
G
G
S
P
Site 3
S22
S
A
W
M
G
S
E
S
P
G
G
S
P
T
E
Site 4
S26
G
S
E
S
P
G
G
S
P
T
E
G
G
G
S
Site 5
T28
E
S
P
G
G
S
P
T
E
G
G
G
S
A
A
Site 6
S33
S
P
T
E
G
G
G
S
A
A
G
G
P
E
P
Site 7
S62
K
T
A
L
R
L
N
S
E
K
F
S
L
V
N
Site 8
S66
R
L
N
S
E
K
F
S
L
V
N
T
V
C
D
Site 9
T70
E
K
F
S
L
V
N
T
V
C
D
R
Q
V
F
Site 10
S119
A
G
G
S
V
R
G
S
G
A
V
A
E
G
N
Site 11
T128
A
V
A
E
G
N
R
T
E
A
G
S
Q
D
Y
Site 12
S132
G
N
R
T
E
A
G
S
Q
D
Y
S
L
L
Q
Site 13
Y135
T
E
A
G
S
Q
D
Y
S
L
L
Q
A
Y
Y
Site 14
S136
E
A
G
S
Q
D
Y
S
L
L
Q
A
Y
Y
S
Site 15
Y141
D
Y
S
L
L
Q
A
Y
Y
S
Q
E
S
K
V
Site 16
Y142
Y
S
L
L
Q
A
Y
Y
S
Q
E
S
K
V
L
Site 17
S143
S
L
L
Q
A
Y
Y
S
Q
E
S
K
V
L
Y
Site 18
S146
Q
A
Y
Y
S
Q
E
S
K
V
L
Y
L
L
L
Site 19
S160
L
T
S
I
C
D
N
S
Q
L
L
R
A
C
R
Site 20
S171
R
A
C
R
A
L
Q
S
G
E
A
G
G
G
L
Site 21
S179
G
E
A
G
G
G
L
S
L
P
H
A
E
A
H
Site 22
T222
P
T
C
S
F
D
I
T
Y
D
R
V
F
R
A
Site 23
S295
P
D
K
P
K
K
H
S
P
K
R
R
L
Q
H
Site 24
Y309
H
A
L
E
D
Q
I
Y
R
I
F
R
K
S
R
Site 25
S315
I
Y
R
I
F
R
K
S
R
V
L
T
N
Q
S
Site 26
T319
F
R
K
S
R
V
L
T
N
Q
S
I
N
C
L
Site 27
Y337
P
A
N
Q
A
F
V
Y
I
V
P
G
S
Q
E
Site 28
S342
F
V
Y
I
V
P
G
S
Q
E
E
D
P
V
G
Site 29
S357
M
L
L
D
Q
L
R
S
H
C
T
V
K
D
P
Site 30
T360
D
Q
L
R
S
H
C
T
V
K
D
P
E
S
L
Site 31
Y379
P
L
S
G
P
R
R
Y
Q
V
M
R
Q
H
S
Site 32
S391
Q
H
S
R
Q
Q
L
S
F
H
I
D
S
S
S
Site 33
S396
Q
L
S
F
H
I
D
S
S
S
S
S
S
S
G
Site 34
S397
L
S
F
H
I
D
S
S
S
S
S
S
S
G
Q
Site 35
S398
S
F
H
I
D
S
S
S
S
S
S
S
G
Q
L
Site 36
S399
F
H
I
D
S
S
S
S
S
S
S
G
Q
L
V
Site 37
S400
H
I
D
S
S
S
S
S
S
S
G
Q
L
V
D
Site 38
S401
I
D
S
S
S
S
S
S
S
G
Q
L
V
D
F
Site 39
S402
D
S
S
S
S
S
S
S
G
Q
L
V
D
F
T
Site 40
T409
S
G
Q
L
V
D
F
T
L
R
E
F
L
W
Q
Site 41
S423
Q
H
V
E
L
V
L
S
K
K
G
F
D
D
S
Site 42
S430
S
K
K
G
F
D
D
S
V
G
R
N
P
Q
P
Site 43
S438
V
G
R
N
P
Q
P
S
H
F
E
L
P
T
Y
Site 44
Y445
S
H
F
E
L
P
T
Y
Q
K
W
I
S
A
A
Site 45
S450
P
T
Y
Q
K
W
I
S
A
A
S
K
L
Y
E
Site 46
S469
G
K
E
E
D
L
G
S
P
T
G
E
L
T
S
Site 47
T475
G
S
P
T
G
E
L
T
S
K
I
L
S
S
I
Site 48
S476
S
P
T
G
E
L
T
S
K
I
L
S
S
I
K
Site 49
T493
E
G
F
L
D
I
D
T
K
F
S
E
N
R
C
Site 50
S509
K
A
L
P
M
A
H
S
A
Y
Q
S
N
L
P
Site 51
Y511
L
P
M
A
H
S
A
Y
Q
S
N
L
P
H
N
Site 52
T522
L
P
H
N
Y
T
M
T
V
H
K
N
Q
L
A
Site 53
Y535
L
A
Q
A
L
R
V
Y
S
Q
H
A
R
G
P
Site 54
S536
A
Q
A
L
R
V
Y
S
Q
H
A
R
G
P
A
Site 55
Y547
R
G
P
A
F
H
K
Y
A
M
Q
L
H
E
D
Site 56
T572
L
C
E
E
R
S
L
T
D
Q
H
C
V
H
K
Site 57
S582
H
C
V
H
K
F
H
S
L
P
K
S
G
E
K
Site 58
S586
K
F
H
S
L
P
K
S
G
E
K
P
E
A
D
Site 59
Y600
D
R
N
P
P
V
L
Y
H
N
S
R
A
R
S
Site 60
S603
P
P
V
L
Y
H
N
S
R
A
R
S
T
G
A
Site 61
T608
H
N
S
R
A
R
S
T
G
A
C
N
C
G
R
Site 62
Y634
K
A
A
N
Y
D
F
Y
Q
L
L
E
E
K
C
Site 63
S656
N
F
P
V
F
E
P
S
T
P
D
P
A
P
A
Site 64
T657
F
P
V
F
E
P
S
T
P
D
P
A
P
A
K
Site 65
S667
P
A
P
A
K
N
E
S
S
P
A
P
P
D
S
Site 66
S668
A
P
A
K
N
E
S
S
P
A
P
P
D
S
D
Site 67
S674
S
S
P
A
P
P
D
S
D
A
D
K
L
K
E
Site 68
T686
L
K
E
K
E
P
Q
T
Q
G
E
S
T
S
L
Site 69
S690
E
P
Q
T
Q
G
E
S
T
S
L
S
L
A
L
Site 70
S692
Q
T
Q
G
E
S
T
S
L
S
L
A
L
S
L
Site 71
S694
Q
G
E
S
T
S
L
S
L
A
L
S
L
G
Q
Site 72
S698
T
S
L
S
L
A
L
S
L
G
Q
S
T
D
S
Site 73
S705
S
L
G
Q
S
T
D
S
L
G
T
Y
P
A
D
Site 74
Y709
S
T
D
S
L
G
T
Y
P
A
D
P
Q
A
G
Site 75
T730
H
G
Q
V
E
V
K
T
E
K
R
P
N
F
V
Site 76
S742
N
F
V
D
R
Q
A
S
T
V
E
Y
L
P
G
Site 77
T743
F
V
D
R
Q
A
S
T
V
E
Y
L
P
G
M
Site 78
Y746
R
Q
A
S
T
V
E
Y
L
P
G
M
L
H
S
Site 79
S764
K
G
L
L
P
K
F
S
S
W
S
L
V
K
L
Site 80
S776
V
K
L
G
P
A
K
S
Y
N
F
H
T
G
L
Site 81
T814
E
D
E
G
D
L
D
T
N
S
W
P
A
P
N
Site 82
S816
E
G
D
L
D
T
N
S
W
P
A
P
N
K
A
Site 83
S829
K
A
I
P
G
K
R
S
A
V
V
M
G
R
G
Site 84
Y851
R
A
F
V
G
F
E
Y
E
D
S
R
G
R
R
Site 85
S862
R
G
R
R
F
M
C
S
G
P
D
K
V
M
K
Site 86
S873
K
V
M
K
V
M
G
S
G
P
K
E
S
A
L
Site 87
S878
M
G
S
G
P
K
E
S
A
L
K
A
L
N
S
Site 88
Y890
L
N
S
D
M
P
L
Y
I
L
S
S
S
Q
G
Site 89
S893
D
M
P
L
Y
I
L
S
S
S
Q
G
R
G
L
Site 90
S894
M
P
L
Y
I
L
S
S
S
Q
G
R
G
L
K
Site 91
S895
P
L
Y
I
L
S
S
S
Q
G
R
G
L
K
P
Site 92
Y904
G
R
G
L
K
P
H
Y
A
Q
L
M
R
L
F
Site 93
Y938
P
P
P
C
P
V
F
Y
P
E
K
Q
E
I
T
Site 94
T945
Y
P
E
K
Q
E
I
T
L
P
P
D
G
L
W
Site 95
Y960
V
L
R
F
P
Y
A
Y
V
T
E
R
G
P
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation