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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC16B
Full Name:
Leucine-rich repeat-containing protein 16B
Alias:
Type:
Mass (Da):
150230
Number AA:
1372
UniProt ID:
Q8ND23
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
K
P
S
V
E
L
T
R
E
L
Q
D
S
I
Site 2
S15
L
T
R
E
L
Q
D
S
I
R
R
C
L
S
Q
Site 3
S21
D
S
I
R
R
C
L
S
Q
G
A
V
L
Q
Q
Site 4
T87
Q
N
Q
I
L
V
E
T
E
R
G
M
V
S
M
Site 5
S93
E
T
E
R
G
M
V
S
M
R
L
P
S
A
E
Site 6
S101
M
R
L
P
S
A
E
S
V
D
Q
V
T
R
H
Site 7
T106
A
E
S
V
D
Q
V
T
R
H
V
S
S
A
L
Site 8
S110
D
Q
V
T
R
H
V
S
S
A
L
S
K
V
C
Site 9
S114
R
H
V
S
S
A
L
S
K
V
C
P
G
P
G
Site 10
T131
I
R
R
G
N
A
D
T
P
E
G
P
R
D
T
Site 11
T138
T
P
E
G
P
R
D
T
S
P
N
S
E
T
S
Site 12
S139
P
E
G
P
R
D
T
S
P
N
S
E
T
S
T
Site 13
S142
P
R
D
T
S
P
N
S
E
T
S
T
S
T
T
Site 14
S145
T
S
P
N
S
E
T
S
T
S
T
T
H
S
V
Site 15
T146
S
P
N
S
E
T
S
T
S
T
T
H
S
V
C
Site 16
S147
P
N
S
E
T
S
T
S
T
T
H
S
V
C
G
Site 17
T149
S
E
T
S
T
S
T
T
H
S
V
C
G
G
F
Site 18
S151
T
S
T
S
T
T
H
S
V
C
G
G
F
S
E
Site 19
Y160
C
G
G
F
S
E
T
Y
A
A
L
C
D
Y
N
Site 20
Y166
T
Y
A
A
L
C
D
Y
N
G
L
H
C
R
E
Site 21
Y183
Q
W
D
V
D
T
I
Y
H
A
E
D
N
R
E
Site 22
S197
E
F
N
L
L
D
F
S
H
L
E
S
R
D
L
Site 23
Y221
N
Q
W
F
T
K
L
Y
C
K
D
L
R
L
G
Site 24
S240
E
Q
V
L
H
T
L
S
K
S
G
S
L
E
E
Site 25
S244
H
T
L
S
K
S
G
S
L
E
E
L
V
L
D
Site 26
S281
V
L
H
A
L
T
L
S
H
N
P
I
E
D
K
Site 27
T312
T
K
L
C
L
A
K
T
A
I
S
P
R
G
L
Site 28
S335
A
N
P
A
F
A
S
S
L
R
Y
L
D
L
S
Site 29
Y338
A
F
A
S
S
L
R
Y
L
D
L
S
K
N
P
Site 30
S342
S
L
R
Y
L
D
L
S
K
N
P
G
L
L
A
Site 31
S358
D
E
A
N
A
L
Y
S
F
L
A
Q
P
N
A
Site 32
Y395
G
C
C
S
H
L
T
Y
L
N
L
A
R
N
S
Site 33
S402
Y
L
N
L
A
R
N
S
C
S
H
R
K
G
R
Site 34
S404
N
L
A
R
N
S
C
S
H
R
K
G
R
E
A
Site 35
S420
P
A
F
K
Q
F
F
S
S
A
Y
T
L
S
H
Site 36
S426
F
S
S
A
Y
T
L
S
H
V
N
L
S
A
T
Site 37
S431
T
L
S
H
V
N
L
S
A
T
K
L
P
L
E
Site 38
T433
S
H
V
N
L
S
A
T
K
L
P
L
E
A
L
Site 39
S448
R
A
L
L
Q
G
L
S
L
N
S
H
L
S
D
Site 40
S454
L
S
L
N
S
H
L
S
D
L
H
L
D
L
S
Site 41
S461
S
D
L
H
L
D
L
S
S
C
E
L
R
S
A
Site 42
S462
D
L
H
L
D
L
S
S
C
E
L
R
S
A
G
Site 43
S489
C
V
G
S
L
D
L
S
D
N
G
F
D
S
D
Site 44
S509
P
A
L
G
K
N
K
S
L
K
H
L
F
L
G
Site 45
T525
N
F
N
V
K
A
K
T
L
E
E
I
L
H
K
Site 46
S546
E
E
D
C
S
L
Q
S
L
S
V
A
D
S
R
Site 47
S548
D
C
S
L
Q
S
L
S
V
A
D
S
R
L
K
Site 48
S552
Q
S
L
S
V
A
D
S
R
L
K
L
R
T
S
Site 49
S567
I
L
I
N
A
L
G
S
N
T
C
L
A
K
V
Site 50
S590
D
I
G
A
K
M
L
S
K
A
L
Q
I
N
S
Site 51
S597
S
K
A
L
Q
I
N
S
S
L
R
T
I
L
W
Site 52
S598
K
A
L
Q
I
N
S
S
L
R
T
I
L
W
D
Site 53
T609
I
L
W
D
R
N
N
T
S
A
L
G
F
L
D
Site 54
S610
L
W
D
R
N
N
T
S
A
L
G
F
L
D
I
Site 55
T626
R
A
L
E
S
N
H
T
L
R
F
M
S
F
P
Site 56
S631
N
H
T
L
R
F
M
S
F
P
V
S
D
I
S
Site 57
S635
R
F
M
S
F
P
V
S
D
I
S
Q
A
Y
R
Site 58
S638
S
F
P
V
S
D
I
S
Q
A
Y
R
S
A
P
Site 59
S684
Q
Q
G
L
V
T
S
S
A
E
Q
M
L
Q
R
Site 60
Y717
P
V
Q
D
E
L
L
Y
A
R
D
L
I
K
D
Site 61
S734
N
S
R
A
L
F
P
S
L
Y
E
L
G
H
V
Site 62
S754
P
V
R
Q
R
L
E
S
V
A
S
E
V
S
K
Site 63
S757
Q
R
L
E
S
V
A
S
E
V
S
K
A
V
D
Site 64
S797
E
G
H
N
K
M
L
S
N
V
A
E
R
V
T
Site 65
T804
S
N
V
A
E
R
V
T
V
P
R
N
F
I
R
Site 66
Y850
D
E
I
L
Q
E
L
Y
H
S
H
K
S
L
A
Site 67
S852
I
L
Q
E
L
Y
H
S
H
K
S
L
A
R
H
Site 68
S855
E
L
Y
H
S
H
K
S
L
A
R
H
L
T
Q
Site 69
T861
K
S
L
A
R
H
L
T
Q
L
R
T
L
S
D
Site 70
T865
R
H
L
T
Q
L
R
T
L
S
D
P
P
G
C
Site 71
S867
L
T
Q
L
R
T
L
S
D
P
P
G
C
P
G
Site 72
S880
P
G
Q
G
Q
D
L
S
S
R
G
R
G
R
N
Site 73
S881
G
Q
G
Q
D
L
S
S
R
G
R
G
R
N
H
Site 74
T904
E
L
G
T
N
I
D
T
M
A
I
K
K
Q
K
Site 75
S920
C
R
K
I
R
P
V
S
A
F
I
S
G
S
P
Site 76
S924
R
P
V
S
A
F
I
S
G
S
P
Q
D
M
E
Site 77
S926
V
S
A
F
I
S
G
S
P
Q
D
M
E
S
Q
Site 78
S932
G
S
P
Q
D
M
E
S
Q
L
G
N
L
G
I
Site 79
S945
G
I
P
P
G
W
F
S
G
L
G
G
S
Q
P
Site 80
S950
W
F
S
G
L
G
G
S
Q
P
T
A
S
G
S
Site 81
T953
G
L
G
G
S
Q
P
T
A
S
G
S
W
E
G
Site 82
S955
G
G
S
Q
P
T
A
S
G
S
W
E
G
L
S
Site 83
S957
S
Q
P
T
A
S
G
S
W
E
G
L
S
E
L
Site 84
S962
S
G
S
W
E
G
L
S
E
L
P
T
H
G
Y
Site 85
T966
E
G
L
S
E
L
P
T
H
G
Y
K
L
R
H
Site 86
Y969
S
E
L
P
T
H
G
Y
K
L
R
H
Q
T
Q
Site 87
T975
G
Y
K
L
R
H
Q
T
Q
G
R
P
R
P
P
Site 88
T984
G
R
P
R
P
P
R
T
T
P
P
G
P
G
R
Site 89
T985
R
P
R
P
P
R
T
T
P
P
G
P
G
R
P
Site 90
S993
P
P
G
P
G
R
P
S
M
P
A
P
G
T
R
Site 91
S1018
E
G
L
E
D
F
F
S
R
R
V
L
E
E
S
Site 92
S1025
S
R
R
V
L
E
E
S
S
S
Y
P
R
T
L
Site 93
S1026
R
R
V
L
E
E
S
S
S
Y
P
R
T
L
R
Site 94
S1027
R
V
L
E
E
S
S
S
Y
P
R
T
L
R
T
Site 95
Y1028
V
L
E
E
S
S
S
Y
P
R
T
L
R
T
V
Site 96
T1031
E
S
S
S
Y
P
R
T
L
R
T
V
R
P
G
Site 97
T1034
S
Y
P
R
T
L
R
T
V
R
P
G
L
S
E
Site 98
S1040
R
T
V
R
P
G
L
S
E
A
P
L
P
P
L
Site 99
S1063
F
H
F
R
R
P
R
S
F
K
G
D
R
G
P
Site 100
S1072
K
G
D
R
G
P
G
S
P
T
T
G
L
L
L
Site 101
T1075
R
G
P
G
S
P
T
T
G
L
L
L
P
P
P
Site 102
T1088
P
P
P
P
P
P
P
T
Q
E
S
P
P
S
P
Site 103
S1091
P
P
P
P
T
Q
E
S
P
P
S
P
D
P
P
Site 104
S1094
P
T
Q
E
S
P
P
S
P
D
P
P
S
L
G
Site 105
S1099
P
P
S
P
D
P
P
S
L
G
N
N
S
S
P
Site 106
S1104
P
P
S
L
G
N
N
S
S
P
C
W
S
P
E
Site 107
S1105
P
S
L
G
N
N
S
S
P
C
W
S
P
E
E
Site 108
S1109
N
N
S
S
P
C
W
S
P
E
E
E
S
S
L
Site 109
S1115
W
S
P
E
E
E
S
S
L
L
P
G
F
G
G
Site 110
S1127
F
G
G
G
R
G
P
S
F
R
R
K
M
G
T
Site 111
T1134
S
F
R
R
K
M
G
T
E
G
S
E
P
G
E
Site 112
S1137
R
K
M
G
T
E
G
S
E
P
G
E
G
G
P
Site 113
T1148
E
G
G
P
A
P
G
T
A
Q
Q
P
R
V
H
Site 114
S1169
L
E
R
A
K
G
W
S
F
D
G
K
R
E
G
Site 115
S1184
P
G
P
D
Q
E
G
S
T
Q
A
W
Q
K
R
Site 116
T1185
G
P
D
Q
E
G
S
T
Q
A
W
Q
K
R
R
Site 117
S1193
Q
A
W
Q
K
R
R
S
S
D
D
A
G
P
G
Site 118
S1194
A
W
Q
K
R
R
S
S
D
D
A
G
P
G
S
Site 119
S1201
S
D
D
A
G
P
G
S
W
K
P
P
P
P
P
Site 120
S1210
K
P
P
P
P
P
Q
S
T
K
P
S
F
S
A
Site 121
T1211
P
P
P
P
P
Q
S
T
K
P
S
F
S
A
M
Site 122
S1214
P
P
Q
S
T
K
P
S
F
S
A
M
R
R
A
Site 123
S1216
Q
S
T
K
P
S
F
S
A
M
R
R
A
E
A
Site 124
T1224
A
M
R
R
A
E
A
T
W
H
I
A
E
E
S
Site 125
S1236
E
E
S
A
P
N
H
S
C
Q
S
P
S
P
A
Site 126
S1239
A
P
N
H
S
C
Q
S
P
S
P
A
S
Q
D
Site 127
S1241
N
H
S
C
Q
S
P
S
P
A
S
Q
D
G
E
Site 128
S1244
C
Q
S
P
S
P
A
S
Q
D
G
E
E
E
K
Site 129
T1254
G
E
E
E
K
E
G
T
L
F
P
E
R
T
L
Site 130
T1260
G
T
L
F
P
E
R
T
L
P
A
R
N
A
K
Site 131
S1316
N
K
P
R
L
R
L
S
S
Q
Q
D
Q
E
E
Site 132
S1317
K
P
R
L
R
L
S
S
Q
Q
D
Q
E
E
P
Site 133
T1336
P
P
D
P
G
R
R
T
A
P
L
K
P
K
R
Site 134
T1344
A
P
L
K
P
K
R
T
R
R
A
Q
S
C
D
Site 135
S1349
K
R
T
R
R
A
Q
S
C
D
K
L
E
P
D
Site 136
T1364
R
R
R
P
P
D
P
T
G
T
S
E
P
G
T
Site 137
T1366
R
P
P
D
P
T
G
T
S
E
P
G
T
D
_
Site 138
S1367
P
P
D
P
T
G
T
S
E
P
G
T
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation