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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EHBP1
Full Name:
EH domain-binding protein 1
Alias:
DKFZp566N1646; EH domain binding protein 1; EH domain-binding protein 1: EH domain-binding protein 1: EH domain-binding protein 1; KIAA0903; NACSIN; NPF/calponin-like protein
Type:
Vesicle protein
Mass (Da):
140017
Number AA:
1231
UniProt ID:
Q8NDI1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
Q
R
V
G
K
H
A
S
K
F
Q
F
V
A
S
Site 2
S23
S
K
F
Q
F
V
A
S
Y
Q
E
L
M
V
E
Site 3
T45
D
K
L
V
V
V
W
T
R
R
S
R
R
K
S
Site 4
S48
V
V
V
W
T
R
R
S
R
R
K
S
S
K
A
Site 5
S52
T
R
R
S
R
R
K
S
S
K
A
H
S
W
Q
Site 6
S53
R
R
S
R
R
K
S
S
K
A
H
S
W
Q
P
Site 7
S57
R
K
S
S
K
A
H
S
W
Q
P
G
I
K
N
Site 8
T83
E
N
I
E
I
T
V
T
L
F
K
D
P
H
A
Site 9
T99
E
F
E
D
K
E
W
T
F
V
I
E
N
E
S
Site 10
S106
T
F
V
I
E
N
E
S
P
S
G
R
R
K
A
Site 11
S108
V
I
E
N
E
S
P
S
G
R
R
K
A
L
A
Site 12
T116
G
R
R
K
A
L
A
T
S
S
I
N
M
K
Q
Site 13
S117
R
R
K
A
L
A
T
S
S
I
N
M
K
Q
Y
Site 14
S118
R
K
A
L
A
T
S
S
I
N
M
K
Q
Y
A
Site 15
Y124
S
S
I
N
M
K
Q
Y
A
S
P
M
P
T
Q
Site 16
S126
I
N
M
K
Q
Y
A
S
P
M
P
T
Q
T
D
Site 17
T130
Q
Y
A
S
P
M
P
T
Q
T
D
V
K
L
K
Site 18
S142
K
L
K
F
K
P
L
S
K
K
V
V
S
A
A
Site 19
S147
P
L
S
K
K
V
V
S
A
A
L
Q
F
S
L
Site 20
T165
F
L
R
E
G
K
A
T
D
E
D
M
Q
S
L
Site 21
S171
A
T
D
E
D
M
Q
S
L
A
S
L
M
S
M
Site 22
S174
E
D
M
Q
S
L
A
S
L
M
S
M
K
Q
A
Site 23
S177
Q
S
L
A
S
L
M
S
M
K
Q
A
D
I
G
Site 24
S222
N
Q
L
N
A
L
S
S
L
D
E
D
Q
D
D
Site 25
S238
I
K
Q
A
N
M
R
S
A
K
S
A
S
S
S
Site 26
S241
A
N
M
R
S
A
K
S
A
S
S
S
E
E
L
Site 27
S243
M
R
S
A
K
S
A
S
S
S
E
E
L
I
N
Site 28
S245
S
A
K
S
A
S
S
S
E
E
L
I
N
K
L
Site 29
T264
E
A
E
K
D
L
A
T
V
N
S
N
P
F
D
Site 30
S267
S
P
R
K
T
E
D
S
F
Y
N
N
S
Y
N
Site 31
S286
N
P
F
G
D
P
D
S
E
E
P
I
T
E
T
Site 32
T291
P
D
S
E
E
P
I
T
E
T
A
S
P
R
K
Site 33
T293
S
E
E
P
I
T
E
T
A
S
P
R
K
T
E
Site 34
S295
E
P
I
T
E
T
A
S
P
R
K
T
E
D
S
Site 35
T299
E
T
A
S
P
R
K
T
E
D
S
F
Y
N
N
Site 36
S302
S
P
R
K
T
E
D
S
F
Y
N
N
S
Y
N
Site 37
Y304
R
K
T
E
D
S
F
Y
N
N
S
Y
N
P
F
Site 38
T316
N
P
F
K
E
V
Q
T
P
Q
Y
L
N
P
F
Site 39
Y319
K
E
V
Q
T
P
Q
Y
L
N
P
F
D
E
P
Site 40
T331
D
E
P
E
A
F
V
T
I
K
D
S
P
P
Q
Site 41
S335
A
F
V
T
I
K
D
S
P
P
Q
S
T
K
R
Site 42
S339
I
K
D
S
P
P
Q
S
T
K
R
K
N
I
R
Site 43
S351
N
I
R
P
V
D
M
S
K
Y
L
Y
A
D
S
Site 44
Y353
R
P
V
D
M
S
K
Y
L
Y
A
D
S
S
K
Site 45
Y355
V
D
M
S
K
Y
L
Y
A
D
S
S
K
T
E
Site 46
S358
S
K
Y
L
Y
A
D
S
S
K
T
E
E
E
E
Site 47
S359
K
Y
L
Y
A
D
S
S
K
T
E
E
E
E
L
Site 48
S369
E
E
E
E
L
D
E
S
N
P
F
Y
E
P
K
Site 49
Y373
L
D
E
S
N
P
F
Y
E
P
K
S
T
P
P
Site 50
S377
N
P
F
Y
E
P
K
S
T
P
P
P
N
N
L
Site 51
T378
P
F
Y
E
P
K
S
T
P
P
P
N
N
L
V
Site 52
T393
N
P
V
Q
E
L
E
T
E
R
R
V
K
R
K
Site 53
S408
A
P
A
P
P
V
L
S
P
K
T
G
V
L
N
Site 54
T411
P
P
V
L
S
P
K
T
G
V
L
N
E
N
T
Site 55
T418
T
G
V
L
N
E
N
T
V
S
A
G
K
D
L
Site 56
S420
V
L
N
E
N
T
V
S
A
G
K
D
L
S
T
Site 57
S426
V
S
A
G
K
D
L
S
T
S
P
K
P
S
P
Site 58
T427
S
A
G
K
D
L
S
T
S
P
K
P
S
P
I
Site 59
S428
A
G
K
D
L
S
T
S
P
K
P
S
P
I
P
Site 60
S432
L
S
T
S
P
K
P
S
P
I
P
S
P
V
L
Site 61
S436
P
K
P
S
P
I
P
S
P
V
L
G
R
K
P
Site 62
S446
L
G
R
K
P
N
A
S
Q
S
L
L
V
W
C
Site 63
S448
R
K
P
N
A
S
Q
S
L
L
V
W
C
K
E
Site 64
Y492
F
R
P
D
L
I
D
Y
K
S
L
N
P
Q
D
Site 65
S494
P
D
L
I
D
Y
K
S
L
N
P
Q
D
I
K
Site 66
Y539
D
K
L
T
V
M
T
Y
L
Y
Q
I
R
A
H
Site 67
S564
I
E
E
N
S
S
K
S
T
Y
K
V
G
N
Y
Site 68
T565
E
E
N
S
S
K
S
T
Y
K
V
G
N
Y
E
Site 69
Y566
E
N
S
S
K
S
T
Y
K
V
G
N
Y
E
T
Site 70
Y571
S
T
Y
K
V
G
N
Y
E
T
D
T
N
S
S
Site 71
T573
Y
K
V
G
N
Y
E
T
D
T
N
S
S
V
D
Site 72
T575
V
G
N
Y
E
T
D
T
N
S
S
V
D
Q
E
Site 73
S577
N
Y
E
T
D
T
N
S
S
V
D
Q
E
K
F
Site 74
S578
Y
E
T
D
T
N
S
S
V
D
Q
E
K
F
Y
Site 75
Y585
S
V
D
Q
E
K
F
Y
A
E
L
S
D
L
K
Site 76
S589
E
K
F
Y
A
E
L
S
D
L
K
R
E
P
E
Site 77
S602
P
E
L
Q
Q
P
I
S
G
A
V
D
F
L
S
Site 78
S613
D
F
L
S
Q
D
D
S
V
F
V
N
D
S
G
Site 79
S619
D
S
V
F
V
N
D
S
G
V
G
E
S
E
S
Site 80
S626
S
G
V
G
E
S
E
S
E
H
Q
T
P
D
D
Site 81
T630
E
S
E
S
E
H
Q
T
P
D
D
H
L
S
P
Site 82
S636
Q
T
P
D
D
H
L
S
P
S
T
A
S
P
Y
Site 83
S638
P
D
D
H
L
S
P
S
T
A
S
P
Y
C
R
Site 84
T639
D
D
H
L
S
P
S
T
A
S
P
Y
C
R
R
Site 85
S641
H
L
S
P
S
T
A
S
P
Y
C
R
R
T
K
Site 86
Y643
S
P
S
T
A
S
P
Y
C
R
R
T
K
S
D
Site 87
T647
A
S
P
Y
C
R
R
T
K
S
D
T
E
P
Q
Site 88
S649
P
Y
C
R
R
T
K
S
D
T
E
P
Q
K
S
Site 89
T651
C
R
R
T
K
S
D
T
E
P
Q
K
S
Q
Q
Site 90
S656
S
D
T
E
P
Q
K
S
Q
Q
S
S
G
R
T
Site 91
S659
E
P
Q
K
S
Q
Q
S
S
G
R
T
S
G
S
Site 92
S660
P
Q
K
S
Q
Q
S
S
G
R
T
S
G
S
D
Site 93
T663
S
Q
Q
S
S
G
R
T
S
G
S
D
D
P
G
Site 94
S664
Q
Q
S
S
G
R
T
S
G
S
D
D
P
G
I
Site 95
S666
S
S
G
R
T
S
G
S
D
D
P
G
I
C
S
Site 96
S673
S
D
D
P
G
I
C
S
N
T
D
S
T
Q
A
Site 97
T694
K
R
L
L
K
A
E
T
L
E
L
S
D
L
Y
Site 98
S698
K
A
E
T
L
E
L
S
D
L
Y
V
S
D
K
Site 99
Y701
T
L
E
L
S
D
L
Y
V
S
D
K
K
K
D
Site 100
S703
E
L
S
D
L
Y
V
S
D
K
K
K
D
M
S
Site 101
S710
S
D
K
K
K
D
M
S
P
P
F
I
C
E
E
Site 102
T718
P
P
F
I
C
E
E
T
D
E
Q
K
L
Q
T
Site 103
T725
T
D
E
Q
K
L
Q
T
L
D
I
G
S
N
L
Site 104
S740
E
K
E
K
L
E
N
S
R
S
L
E
C
R
S
Site 105
S742
E
K
L
E
N
S
R
S
L
E
C
R
S
D
P
Site 106
S747
S
R
S
L
E
C
R
S
D
P
E
S
P
I
K
Site 107
S751
E
C
R
S
D
P
E
S
P
I
K
K
T
S
L
Site 108
T756
P
E
S
P
I
K
K
T
S
L
S
P
T
S
K
Site 109
S757
E
S
P
I
K
K
T
S
L
S
P
T
S
K
L
Site 110
S759
P
I
K
K
T
S
L
S
P
T
S
K
L
G
Y
Site 111
T761
K
K
T
S
L
S
P
T
S
K
L
G
Y
S
Y
Site 112
S762
K
T
S
L
S
P
T
S
K
L
G
Y
S
Y
S
Site 113
Y766
S
P
T
S
K
L
G
Y
S
Y
S
R
D
L
D
Site 114
S767
P
T
S
K
L
G
Y
S
Y
S
R
D
L
D
L
Site 115
Y768
T
S
K
L
G
Y
S
Y
S
R
D
L
D
L
A
Site 116
S769
S
K
L
G
Y
S
Y
S
R
D
L
D
L
A
K
Site 117
S781
L
A
K
K
K
H
A
S
L
R
Q
T
E
S
D
Site 118
T785
K
H
A
S
L
R
Q
T
E
S
D
P
D
A
D
Site 119
S787
A
S
L
R
Q
T
E
S
D
P
D
A
D
R
T
Site 120
T795
D
P
D
A
D
R
T
T
L
N
H
A
D
H
S
Site 121
S803
L
N
H
A
D
H
S
S
K
I
V
Q
H
R
L
Site 122
S812
I
V
Q
H
R
L
L
S
R
Q
E
E
L
K
E
Site 123
T846
K
H
N
T
N
T
A
T
P
F
C
N
R
Q
L
Site 124
S854
P
F
C
N
R
Q
L
S
D
Q
Q
D
E
E
R
Site 125
S883
A
R
S
G
V
K
M
S
E
L
P
S
Y
G
E
Site 126
S887
V
K
M
S
E
L
P
S
Y
G
E
M
A
A
E
Site 127
Y888
K
M
S
E
L
P
S
Y
G
E
M
A
A
E
K
Site 128
T914
N
D
N
I
E
I
D
T
N
E
E
I
P
E
G
Site 129
T931
V
G
G
G
D
E
L
T
N
L
E
N
D
L
D
Site 130
T939
N
L
E
N
D
L
D
T
P
E
Q
N
S
K
L
Site 131
S964
V
Q
P
Q
V
A
N
S
P
S
S
A
A
Q
K
Site 132
T974
S
A
A
Q
K
A
V
T
E
S
S
E
Q
D
M
Site 133
S976
A
Q
K
A
V
T
E
S
S
E
Q
D
M
K
S
Site 134
S977
Q
K
A
V
T
E
S
S
E
Q
D
M
K
S
G
Site 135
S983
S
S
E
Q
D
M
K
S
G
T
E
D
L
R
T
Site 136
T990
S
G
T
E
D
L
R
T
E
R
L
Q
K
T
T
Site 137
T996
R
T
E
R
L
Q
K
T
T
E
R
F
R
N
P
Site 138
T997
T
E
R
L
Q
K
T
T
E
R
F
R
N
P
V
Site 139
S1010
P
V
V
F
S
K
D
S
T
V
R
K
T
Q
L
Site 140
T1011
V
V
F
S
K
D
S
T
V
R
K
T
Q
L
Q
Site 141
T1015
K
D
S
T
V
R
K
T
Q
L
Q
S
F
S
Q
Site 142
S1019
V
R
K
T
Q
L
Q
S
F
S
Q
Y
I
E
N
Site 143
S1021
K
T
Q
L
Q
S
F
S
Q
Y
I
E
N
R
P
Site 144
Y1023
Q
L
Q
S
F
S
Q
Y
I
E
N
R
P
E
M
Site 145
S1035
P
E
M
K
R
Q
R
S
I
Q
E
D
T
K
K
Site 146
T1040
Q
R
S
I
Q
E
D
T
K
K
G
N
E
E
K
Site 147
T1053
E
K
A
A
I
T
E
T
Q
R
K
P
S
E
D
Site 148
S1058
T
E
T
Q
R
K
P
S
E
D
E
V
L
N
K
Site 149
T1070
L
N
K
G
F
K
D
T
S
Q
Y
V
V
G
E
Site 150
S1071
N
K
G
F
K
D
T
S
Q
Y
V
V
G
E
L
Site 151
Y1073
G
F
K
D
T
S
Q
Y
V
V
G
E
L
A
A
Site 152
Y1101
L
V
E
K
R
L
R
Y
L
M
D
T
G
R
N
Site 153
T1105
R
L
R
Y
L
M
D
T
G
R
N
T
E
E
E
Site 154
T1109
L
M
D
T
G
R
N
T
E
E
E
E
A
M
M
Site 155
S1137
I
R
R
M
N
Q
L
S
L
L
E
K
E
H
D
Site 156
Y1149
E
H
D
L
E
R
R
Y
E
L
L
N
R
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation