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Updated November 2019
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Protein Info
Short Name:
TNRC6A
Full Name:
Trinucleotide repeat-containing gene 6A protein
Alias:
CAG repeat protein 26; CAGH26; EDIE; EMSY interactor; Glycin-tryptophan protein of 182 kDa; GW1; GW182; GW182 autoantigen; TNR6A; TNRC6; Trinucleotide repeat containing 6A; Trinucleotide repeat-containing gene 6A
Type:
RNA binding protein
Mass (Da):
210272
Number AA:
1962
UniProt ID:
Q8NDV7
International Prot ID:
IPI00395878
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000932
GO:0035068
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0035278
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
R
E
L
E
A
K
A
T
K
D
V
E
R
N
L
Site 2
S17
K
D
V
E
R
N
L
S
R
D
L
V
Q
E
E
Site 3
S62
V
P
E
Q
I
K
P
S
V
S
Q
P
Q
P
A
Site 4
S64
E
Q
I
K
P
S
V
S
Q
P
Q
P
A
N
S
Site 5
S71
S
Q
P
Q
P
A
N
S
N
N
G
T
S
T
A
Site 6
T75
P
A
N
S
N
N
G
T
S
T
A
T
S
T
N
Site 7
S76
A
N
S
N
N
G
T
S
T
A
T
S
T
N
N
Site 8
S80
N
G
T
S
T
A
T
S
T
N
N
N
A
K
R
Site 9
T89
N
N
N
A
K
R
A
T
A
N
N
Q
Q
P
Q
Site 10
Y132
Q
P
Q
A
L
P
R
Y
P
R
E
V
P
P
R
Site 11
S171
S
A
V
K
V
L
N
S
Q
S
E
S
S
A
L
Site 12
S173
V
K
V
L
N
S
Q
S
E
S
S
A
L
T
N
Site 13
S175
V
L
N
S
Q
S
E
S
S
A
L
T
N
Q
Q
Site 14
T179
Q
S
E
S
S
A
L
T
N
Q
Q
P
Q
N
N
Site 15
S192
N
N
G
E
V
Q
N
S
K
N
Q
S
D
I
N
Site 16
S196
V
Q
N
S
K
N
Q
S
D
I
N
H
S
T
S
Site 17
S201
N
Q
S
D
I
N
H
S
T
S
G
S
H
Y
E
Site 18
S203
S
D
I
N
H
S
T
S
G
S
H
Y
E
N
S
Site 19
S205
I
N
H
S
T
S
G
S
H
Y
E
N
S
Q
R
Site 20
Y207
H
S
T
S
G
S
H
Y
E
N
S
Q
R
G
P
Site 21
S210
S
G
S
H
Y
E
N
S
Q
R
G
P
V
S
S
Site 22
S216
N
S
Q
R
G
P
V
S
S
T
S
D
S
S
T
Site 23
S217
S
Q
R
G
P
V
S
S
T
S
D
S
S
T
N
Site 24
T218
Q
R
G
P
V
S
S
T
S
D
S
S
T
N
C
Site 25
S219
R
G
P
V
S
S
T
S
D
S
S
T
N
C
K
Site 26
S221
P
V
S
S
T
S
D
S
S
T
N
C
K
N
A
Site 27
S222
V
S
S
T
S
D
S
S
T
N
C
K
N
A
V
Site 28
T223
S
S
T
S
D
S
S
T
N
C
K
N
A
V
V
Site 29
S241
S
E
K
E
A
W
P
S
A
P
G
S
D
P
E
Site 30
S245
A
W
P
S
A
P
G
S
D
P
E
L
A
S
E
Site 31
S251
G
S
D
P
E
L
A
S
E
C
M
D
A
D
S
Site 32
S258
S
E
C
M
D
A
D
S
A
S
S
S
E
S
E
Site 33
S260
C
M
D
A
D
S
A
S
S
S
E
S
E
R
N
Site 34
S262
D
A
D
S
A
S
S
S
E
S
E
R
N
I
T
Site 35
S264
D
S
A
S
S
S
E
S
E
R
N
I
T
I
M
Site 36
T269
S
E
S
E
R
N
I
T
I
M
A
S
G
N
T
Site 37
S273
R
N
I
T
I
M
A
S
G
N
T
G
G
E
K
Site 38
S286
E
K
D
G
L
R
N
S
T
G
L
G
S
Q
N
Site 39
T287
K
D
G
L
R
N
S
T
G
L
G
S
Q
N
K
Site 40
S291
R
N
S
T
G
L
G
S
Q
N
K
F
V
V
G
Site 41
S299
Q
N
K
F
V
V
G
S
S
S
N
N
V
G
H
Site 42
S300
N
K
F
V
V
G
S
S
S
N
N
V
G
H
G
Site 43
S301
K
F
V
V
G
S
S
S
N
N
V
G
H
G
S
Site 44
S308
S
N
N
V
G
H
G
S
S
T
G
P
W
G
F
Site 45
S309
N
N
V
G
H
G
S
S
T
G
P
W
G
F
S
Site 46
S316
S
T
G
P
W
G
F
S
H
G
A
I
I
S
T
Site 47
S333
V
S
V
D
A
P
E
S
K
S
E
S
S
N
N
Site 48
S335
V
D
A
P
E
S
K
S
E
S
S
N
N
R
M
Site 49
S337
A
P
E
S
K
S
E
S
S
N
N
R
M
N
A
Site 50
S338
P
E
S
K
S
E
S
S
N
N
R
M
N
A
W
Site 51
T347
N
R
M
N
A
W
G
T
V
S
S
S
S
N
G
Site 52
S349
M
N
A
W
G
T
V
S
S
S
S
N
G
G
L
Site 53
S350
N
A
W
G
T
V
S
S
S
S
N
G
G
L
N
Site 54
S351
A
W
G
T
V
S
S
S
S
N
G
G
L
N
P
Site 55
S352
W
G
T
V
S
S
S
S
N
G
G
L
N
P
S
Site 56
S359
S
N
G
G
L
N
P
S
T
L
N
S
A
S
N
Site 57
T360
N
G
G
L
N
P
S
T
L
N
S
A
S
N
H
Site 58
S363
L
N
P
S
T
L
N
S
A
S
N
H
G
A
W
Site 59
S365
P
S
T
L
N
S
A
S
N
H
G
A
W
P
V
Site 60
S388
K
G
P
V
G
S
G
S
S
G
I
N
I
Q
C
Site 61
S406
G
Q
M
P
N
N
Q
S
I
N
S
K
V
S
G
Site 62
S409
P
N
N
Q
S
I
N
S
K
V
S
G
G
S
T
Site 63
T416
S
K
V
S
G
G
S
T
H
G
T
W
G
S
L
Site 64
T419
S
G
G
S
T
H
G
T
W
G
S
L
Q
E
T
Site 65
S422
S
T
H
G
T
W
G
S
L
Q
E
T
C
E
S
Site 66
T426
T
W
G
S
L
Q
E
T
C
E
S
E
V
S
G
Site 67
S429
S
L
Q
E
T
C
E
S
E
V
S
G
T
Q
K
Site 68
S432
E
T
C
E
S
E
V
S
G
T
Q
K
V
S
F
Site 69
T434
C
E
S
E
V
S
G
T
Q
K
V
S
F
S
G
Site 70
S438
V
S
G
T
Q
K
V
S
F
S
G
Q
P
Q
N
Site 71
T447
S
G
Q
P
Q
N
I
T
T
E
M
T
G
P
N
Site 72
S463
T
T
N
F
M
T
S
S
L
P
N
S
G
S
V
Site 73
S467
M
T
S
S
L
P
N
S
G
S
V
Q
N
N
E
Site 74
S469
S
S
L
P
N
S
G
S
V
Q
N
N
E
L
P
Site 75
S478
Q
N
N
E
L
P
S
S
N
T
G
A
W
R
V
Site 76
S503
P
S
G
M
N
G
T
S
L
S
H
L
S
N
G
Site 77
S505
G
M
N
G
T
S
L
S
H
L
S
N
G
E
S
Site 78
S508
G
T
S
L
S
H
L
S
N
G
E
S
K
S
G
Site 79
S512
S
H
L
S
N
G
E
S
K
S
G
G
S
Y
G
Site 80
S514
L
S
N
G
E
S
K
S
G
G
S
Y
G
T
T
Site 81
Y518
E
S
K
S
G
G
S
Y
G
T
T
W
G
A
Y
Site 82
T521
S
G
G
S
Y
G
T
T
W
G
A
Y
G
S
N
Site 83
Y525
Y
G
T
T
W
G
A
Y
G
S
N
Y
S
G
D
Site 84
Y529
W
G
A
Y
G
S
N
Y
S
G
D
K
C
S
G
Site 85
S530
G
A
Y
G
S
N
Y
S
G
D
K
C
S
G
P
Site 86
S535
N
Y
S
G
D
K
C
S
G
P
N
G
Q
A
N
Site 87
T545
N
G
Q
A
N
G
D
T
V
N
A
T
L
M
Q
Site 88
T549
N
G
D
T
V
N
A
T
L
M
Q
P
G
V
N
Site 89
S576
K
G
G
G
V
W
E
S
G
A
A
N
S
Q
S
Site 90
S581
W
E
S
G
A
A
N
S
Q
S
T
S
W
G
S
Site 91
S583
S
G
A
A
N
S
Q
S
T
S
W
G
S
G
N
Site 92
S585
A
A
N
S
Q
S
T
S
W
G
S
G
N
G
A
Site 93
S588
S
Q
S
T
S
W
G
S
G
N
G
A
N
S
G
Site 94
S594
G
S
G
N
G
A
N
S
G
G
S
R
R
G
W
Site 95
S597
N
G
A
N
S
G
G
S
R
R
G
W
G
T
P
Site 96
T603
G
S
R
R
G
W
G
T
P
A
Q
N
T
G
T
Site 97
T610
T
P
A
Q
N
T
G
T
N
L
P
S
V
E
W
Site 98
S622
V
E
W
N
K
L
P
S
N
Q
H
S
N
D
S
Site 99
S626
K
L
P
S
N
Q
H
S
N
D
S
A
N
G
N
Site 100
S629
S
N
Q
H
S
N
D
S
A
N
G
N
G
K
T
Site 101
T636
S
A
N
G
N
G
K
T
F
T
N
G
W
K
S
Site 102
T638
N
G
N
G
K
T
F
T
N
G
W
K
S
T
E
Site 103
S643
T
F
T
N
G
W
K
S
T
E
E
E
D
Q
G
Site 104
S651
T
E
E
E
D
Q
G
S
A
T
S
Q
T
N
E
Site 105
S654
E
D
Q
G
S
A
T
S
Q
T
N
E
Q
S
S
Site 106
T656
Q
G
S
A
T
S
Q
T
N
E
Q
S
S
V
W
Site 107
S661
S
Q
T
N
E
Q
S
S
V
W
A
K
T
G
G
Site 108
T669
V
W
A
K
T
G
G
T
V
E
S
D
G
S
T
Site 109
S672
K
T
G
G
T
V
E
S
D
G
S
T
E
S
T
Site 110
S675
G
T
V
E
S
D
G
S
T
E
S
T
G
R
L
Site 111
T676
T
V
E
S
D
G
S
T
E
S
T
G
R
L
E
Site 112
S678
E
S
D
G
S
T
E
S
T
G
R
L
E
E
K
Site 113
T679
S
D
G
S
T
E
S
T
G
R
L
E
E
K
G
Site 114
T687
G
R
L
E
E
K
G
T
G
E
S
Q
S
R
D
Site 115
S690
E
E
K
G
T
G
E
S
Q
S
R
D
R
R
K
Site 116
S692
K
G
T
G
E
S
Q
S
R
D
R
R
K
I
D
Site 117
T702
R
R
K
I
D
Q
H
T
L
L
Q
S
I
V
N
Site 118
S706
D
Q
H
T
L
L
Q
S
I
V
N
R
T
D
L
Site 119
S719
D
L
D
P
R
V
L
S
N
S
G
W
G
Q
T
Site 120
S721
D
P
R
V
L
S
N
S
G
W
G
Q
T
P
I
Site 121
T726
S
N
S
G
W
G
Q
T
P
I
K
Q
N
T
A
Site 122
T738
N
T
A
W
D
T
E
T
S
P
R
G
E
R
K
Site 123
S739
T
A
W
D
T
E
T
S
P
R
G
E
R
K
T
Site 124
T746
S
P
R
G
E
R
K
T
D
N
G
T
E
A
W
Site 125
T750
E
R
K
T
D
N
G
T
E
A
W
G
S
S
A
Site 126
S755
N
G
T
E
A
W
G
S
S
A
T
Q
T
F
N
Site 127
T760
W
G
S
S
A
T
Q
T
F
N
S
G
A
C
I
Site 128
T770
S
G
A
C
I
D
K
T
S
P
N
G
N
D
T
Site 129
S771
G
A
C
I
D
K
T
S
P
N
G
N
D
T
S
Site 130
T777
T
S
P
N
G
N
D
T
S
S
V
S
G
W
G
Site 131
S778
S
P
N
G
N
D
T
S
S
V
S
G
W
G
D
Site 132
S779
P
N
G
N
D
T
S
S
V
S
G
W
G
D
P
Site 133
S781
G
N
D
T
S
S
V
S
G
W
G
D
P
K
P
Site 134
S795
P
A
L
R
W
G
D
S
K
G
S
N
C
Q
G
Site 135
S808
Q
G
G
W
E
D
D
S
A
A
T
G
M
V
K
Site 136
S845
G
W
G
D
G
Q
K
S
S
Q
G
W
S
V
S
Site 137
S846
W
G
D
G
Q
K
S
S
Q
G
W
S
V
S
A
Site 138
S850
Q
K
S
S
Q
G
W
S
V
S
A
S
D
N
W
Site 139
S852
S
S
Q
G
W
S
V
S
A
S
D
N
W
G
E
Site 140
S854
Q
G
W
S
V
S
A
S
D
N
W
G
E
T
S
Site 141
S873
W
G
E
A
N
K
K
S
S
S
G
G
S
D
S
Site 142
S874
G
E
A
N
K
K
S
S
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W
G
E
S
S
S
G
R
I
T
N
W
Site 295
S1776
S
S
W
G
E
S
S
S
G
R
I
T
N
W
L
Site 296
T1780
E
S
S
S
G
R
I
T
N
W
L
V
L
K
N
Site 297
T1789
W
L
V
L
K
N
L
T
P
Q
I
D
G
S
T
Site 298
T1796
T
P
Q
I
D
G
S
T
L
R
T
L
C
M
Q
Site 299
T1799
I
D
G
S
T
L
R
T
L
C
M
Q
H
G
P
Site 300
T1809
M
Q
H
G
P
L
I
T
F
H
L
N
L
P
H
Site 301
Y1823
H
G
N
A
L
V
R
Y
S
S
K
E
E
V
V
Site 302
S1824
G
N
A
L
V
R
Y
S
S
K
E
E
V
V
K
Site 303
S1825
N
A
L
V
R
Y
S
S
K
E
E
V
V
K
A
Site 304
S1852
T
I
L
A
E
F
A
S
E
E
E
I
S
R
F
Site 305
S1863
I
S
R
F
F
A
Q
S
Q
S
L
T
P
S
P
Site 306
S1865
R
F
F
A
Q
S
Q
S
L
T
P
S
P
G
W
Site 307
T1867
F
A
Q
S
Q
S
L
T
P
S
P
G
W
Q
S
Site 308
S1869
Q
S
Q
S
L
T
P
S
P
G
W
Q
S
L
G
Site 309
S1874
T
P
S
P
G
W
Q
S
L
G
S
S
Q
S
R
Site 310
S1877
P
G
W
Q
S
L
G
S
S
Q
S
R
L
G
S
Site 311
S1878
G
W
Q
S
L
G
S
S
Q
S
R
L
G
S
L
Site 312
S1880
Q
S
L
G
S
S
Q
S
R
L
G
S
L
D
C
Site 313
S1884
S
S
Q
S
R
L
G
S
L
D
C
S
H
S
F
Site 314
S1888
R
L
G
S
L
D
C
S
H
S
F
S
S
R
T
Site 315
S1890
G
S
L
D
C
S
H
S
F
S
S
R
T
D
L
Site 316
S1892
L
D
C
S
H
S
F
S
S
R
T
D
L
N
H
Site 317
T1908
N
G
A
G
L
S
G
T
N
C
G
D
L
H
G
Site 318
T1921
H
G
T
S
L
W
G
T
P
H
Y
S
T
S
L
Site 319
Y1924
S
L
W
G
T
P
H
Y
S
T
S
L
W
G
P
Site 320
S1927
G
T
P
H
Y
S
T
S
L
W
G
P
P
S
S
Site 321
S1933
T
S
L
W
G
P
P
S
S
S
D
P
R
G
I
Site 322
S1934
S
L
W
G
P
P
S
S
S
D
P
R
G
I
S
Site 323
S1935
L
W
G
P
P
S
S
S
D
P
R
G
I
S
S
Site 324
S1941
S
S
D
P
R
G
I
S
S
P
S
P
I
N
A
Site 325
S1942
S
D
P
R
G
I
S
S
P
S
P
I
N
A
F
Site 326
S1944
P
R
G
I
S
S
P
S
P
I
N
A
F
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation