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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTC21A
Full Name:
Tetratricopeptide repeat protein 21A
Alias:
Stress-inducible protein 2
Type:
Mass (Da):
150944
Number AA:
1320
UniProt ID:
Q8NDW8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
I
Y
Y
S
Q
E
K
Y
F
H
H
V
Q
Q
A
Site 2
S60
E
H
I
Q
D
A
I
S
D
L
E
S
I
R
H
Site 3
S64
D
A
I
S
D
L
E
S
I
R
H
H
P
D
V
Site 4
S100
A
I
Q
E
L
E
Y
S
L
K
E
I
R
K
T
Site 5
T107
S
L
K
E
I
R
K
T
V
S
G
T
A
L
Y
Site 6
S109
K
E
I
R
K
T
V
S
G
T
A
L
Y
Y
A
Site 7
Y132
R
H
D
K
A
K
E
Y
I
D
R
M
L
K
I
Site 8
S140
I
D
R
M
L
K
I
S
R
G
F
R
E
A
Y
Site 9
Y147
S
R
G
F
R
E
A
Y
V
L
R
G
W
V
D
Site 10
T156
L
R
G
W
V
D
L
T
S
D
K
P
H
T
A
Site 11
S157
R
G
W
V
D
L
T
S
D
K
P
H
T
A
K
Site 12
Y169
T
A
K
K
A
I
E
Y
L
E
Q
G
I
Q
D
Site 13
T177
L
E
Q
G
I
Q
D
T
K
D
V
L
G
L
M
Site 14
S246
R
I
L
E
K
D
E
S
N
I
D
A
C
Q
I
Site 15
T266
L
A
R
E
G
N
M
T
T
V
S
S
L
K
T
Site 16
T267
A
R
E
G
N
M
T
T
V
S
S
L
K
T
Q
Site 17
S269
E
G
N
M
T
T
V
S
S
L
K
T
Q
K
A
Site 18
T273
T
T
V
S
S
L
K
T
Q
K
A
T
N
H
V
Site 19
S332
R
T
F
M
A
T
P
S
Y
V
H
V
A
T
E
Site 20
Y333
T
F
M
A
T
P
S
Y
V
H
V
A
T
E
L
Site 21
Y342
H
V
A
T
E
L
G
Y
L
F
I
L
K
N
Q
Site 22
Y389
G
H
L
E
E
A
E
Y
R
L
E
F
L
K
E
Site 23
S400
F
L
K
E
V
Q
K
S
L
G
K
S
E
V
L
Site 24
T426
H
K
G
E
E
E
T
T
A
L
L
K
E
A
V
Site 25
Y449
G
I
P
L
G
S
E
Y
F
E
K
L
D
P
Y
Site 26
Y514
L
M
A
Q
V
R
Y
Y
S
E
L
E
N
A
Q
Site 27
S515
M
A
Q
V
R
Y
Y
S
E
L
E
N
A
Q
S
Site 28
S522
S
E
L
E
N
A
Q
S
I
L
Q
R
C
L
E
Site 29
Y574
Q
V
R
D
H
P
L
Y
H
L
I
K
A
R
A
Site 30
Y588
A
L
N
K
A
G
D
Y
P
E
A
I
K
T
L
Site 31
S616
G
R
K
F
L
R
P
S
V
Q
P
S
Q
R
A
Site 32
S620
L
R
P
S
V
Q
P
S
Q
R
A
S
I
L
L
Site 33
T649
A
T
K
V
M
Q
D
T
I
N
E
F
G
G
T
Site 34
T656
T
I
N
E
F
G
G
T
P
E
E
N
R
I
T
Site 35
T663
T
P
E
E
N
R
I
T
I
A
N
V
D
L
V
Site 36
Y704
R
E
K
M
A
N
I
Y
L
Q
T
L
R
D
R
Site 37
T707
M
A
N
I
Y
L
Q
T
L
R
D
R
R
L
Y
Site 38
Y714
T
L
R
D
R
R
L
Y
I
R
C
Y
R
E
L
Site 39
Y718
R
R
L
Y
I
R
C
Y
R
E
L
C
E
H
L
Site 40
Y755
L
E
V
Y
D
E
A
Y
R
Q
N
P
H
D
A
Site 41
S763
R
Q
N
P
H
D
A
S
L
A
S
R
I
G
H
Site 42
Y772
A
S
R
I
G
H
A
Y
V
K
A
H
Q
Y
T
Site 43
Y778
A
Y
V
K
A
H
Q
Y
T
E
A
I
E
Y
Y
Site 44
Y784
Q
Y
T
E
A
I
E
Y
Y
E
A
A
Q
K
I
Site 45
Y847
L
L
L
L
A
K
V
Y
K
S
H
K
K
E
A
Site 46
S849
L
L
A
K
V
Y
K
S
H
K
K
E
A
V
I
Site 47
T858
K
K
E
A
V
I
E
T
L
N
K
A
L
D
L
Site 48
S883
E
Q
P
E
M
I
P
S
Q
K
Q
L
A
A
S
Site 49
Y899
C
I
Q
F
A
E
H
Y
L
A
E
K
E
Y
D
Site 50
Y905
H
Y
L
A
E
K
E
Y
D
K
A
V
Q
S
Y
Site 51
S911
E
Y
D
K
A
V
Q
S
Y
K
D
V
F
S
Y
Site 52
Y912
Y
D
K
A
V
Q
S
Y
K
D
V
F
S
Y
L
Site 53
S917
Q
S
Y
K
D
V
F
S
Y
L
P
T
D
N
K
Site 54
Y918
S
Y
K
D
V
F
S
Y
L
P
T
D
N
K
V
Site 55
T921
D
V
F
S
Y
L
P
T
D
N
K
V
M
L
E
Site 56
Y980
H
E
A
A
I
N
L
Y
H
Q
V
L
E
K
A
Site 57
S1004
L
I
D
L
L
R
R
S
G
K
L
E
D
I
P
Site 58
S1021
F
E
L
A
K
K
V
S
S
R
V
P
L
E
P
Site 59
S1058
L
N
K
A
R
K
D
S
T
W
G
Q
S
A
I
Site 60
T1059
N
K
A
R
K
D
S
T
W
G
Q
S
A
I
Y
Site 61
Y1116
E
K
L
L
R
E
F
Y
P
H
S
D
S
S
Q
Site 62
S1119
L
R
E
F
Y
P
H
S
D
S
S
Q
T
Q
L
Site 63
S1121
E
F
Y
P
H
S
D
S
S
Q
T
Q
L
R
L
Site 64
S1122
F
Y
P
H
S
D
S
S
Q
T
Q
L
R
L
L
Site 65
T1137
Q
G
L
C
R
L
A
T
R
E
K
A
N
M
E
Site 66
T1190
Q
L
K
R
L
A
K
T
P
W
V
L
S
E
A
Site 67
Y1230
L
L
R
R
C
V
Q
Y
N
K
S
C
Y
K
A
Site 68
Y1238
N
K
S
C
Y
K
A
Y
E
Y
M
G
F
I
M
Site 69
Y1240
S
C
Y
K
A
Y
E
Y
M
G
F
I
M
E
K
Site 70
T1256
Q
S
Y
K
D
A
V
T
N
Y
K
L
A
W
K
Site 71
Y1280
G
F
K
L
A
F
N
Y
L
K
D
K
K
F
V
Site 72
Y1303
V
L
R
E
H
P
D
Y
P
K
I
R
E
E
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation