KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PHC3
Full Name:
Polyhomeotic-like protein 3
Alias:
Polyhomeotic-like protein 3: Homolog of polyhomeotic 3: Early development regulatory protein 3: Polyhomeotic-like protein 3: Homolog of polyhomeotic 3: Early development regulatory protein 3
Type:
Transcription regulation protein
Mass (Da):
106162
Number AA:
983
UniProt ID:
Q8NDX5
International Prot ID:
IPI00302149
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
D
T
E
P
N
P
G
T
S
S
V
S
T
T
T
Site 2
S10
T
E
P
N
P
G
T
S
S
V
S
T
T
T
S
Site 3
S11
E
P
N
P
G
T
S
S
V
S
T
T
T
S
S
Site 4
S13
N
P
G
T
S
S
V
S
T
T
T
S
S
T
T
Site 5
T14
P
G
T
S
S
V
S
T
T
T
S
S
T
T
T
Site 6
T15
G
T
S
S
V
S
T
T
T
S
S
T
T
T
T
Site 7
S17
S
S
V
S
T
T
T
S
S
T
T
T
T
T
I
Site 8
S18
S
V
S
T
T
T
S
S
T
T
T
T
T
I
T
Site 9
T21
T
T
T
S
S
T
T
T
T
T
I
T
T
S
S
Site 10
T22
T
T
S
S
T
T
T
T
T
I
T
T
S
S
S
Site 11
T23
T
S
S
T
T
T
T
T
I
T
T
S
S
S
R
Site 12
T25
S
T
T
T
T
T
I
T
T
S
S
S
R
M
Q
Site 13
S28
T
T
T
I
T
T
S
S
S
R
M
Q
Q
P
Q
Site 14
S29
T
T
I
T
T
S
S
S
R
M
Q
Q
P
Q
I
Site 15
S37
R
M
Q
Q
P
Q
I
S
V
Y
S
G
S
D
R
Site 16
Y39
Q
Q
P
Q
I
S
V
Y
S
G
S
D
R
H
A
Site 17
S40
Q
P
Q
I
S
V
Y
S
G
S
D
R
H
A
V
Site 18
S42
Q
I
S
V
Y
S
G
S
D
R
H
A
V
Q
V
Site 19
S59
Q
A
L
H
R
P
P
S
S
A
A
Q
Y
L
Q
Site 20
S60
A
L
H
R
P
P
S
S
A
A
Q
Y
L
Q
Q
Site 21
Y64
P
P
S
S
A
A
Q
Y
L
Q
Q
M
Y
A
A
Site 22
Y69
A
Q
Y
L
Q
Q
M
Y
A
A
Q
Q
Q
H
L
Site 23
S89
A
L
Q
Q
Q
H
L
S
S
S
Q
L
Q
S
L
Site 24
S91
Q
Q
Q
H
L
S
S
S
Q
L
Q
S
L
A
A
Site 25
S102
S
L
A
A
V
Q
A
S
L
S
S
G
R
P
S
Site 26
S104
A
A
V
Q
A
S
L
S
S
G
R
P
S
T
S
Site 27
S105
A
V
Q
A
S
L
S
S
G
R
P
S
T
S
P
Site 28
S109
S
L
S
S
G
R
P
S
T
S
P
T
G
S
V
Site 29
T110
L
S
S
G
R
P
S
T
S
P
T
G
S
V
T
Site 30
S111
S
S
G
R
P
S
T
S
P
T
G
S
V
T
Q
Site 31
T113
G
R
P
S
T
S
P
T
G
S
V
T
Q
Q
S
Site 32
S115
P
S
T
S
P
T
G
S
V
T
Q
Q
S
S
M
Site 33
T117
T
S
P
T
G
S
V
T
Q
Q
S
S
M
S
Q
Site 34
S120
T
G
S
V
T
Q
Q
S
S
M
S
Q
T
S
I
Site 35
S121
G
S
V
T
Q
Q
S
S
M
S
Q
T
S
I
N
Site 36
S123
V
T
Q
Q
S
S
M
S
Q
T
S
I
N
L
S
Site 37
T125
Q
Q
S
S
M
S
Q
T
S
I
N
L
S
T
S
Site 38
S126
Q
S
S
M
S
Q
T
S
I
N
L
S
T
S
P
Site 39
S130
S
Q
T
S
I
N
L
S
T
S
P
T
P
A
Q
Site 40
T134
I
N
L
S
T
S
P
T
P
A
Q
L
I
S
R
Site 41
S140
P
T
P
A
Q
L
I
S
R
S
Q
A
S
S
S
Site 42
S142
P
A
Q
L
I
S
R
S
Q
A
S
S
S
T
S
Site 43
S145
L
I
S
R
S
Q
A
S
S
S
T
S
G
S
I
Site 44
S146
I
S
R
S
Q
A
S
S
S
T
S
G
S
I
T
Site 45
S147
S
R
S
Q
A
S
S
S
T
S
G
S
I
T
Q
Site 46
S149
S
Q
A
S
S
S
T
S
G
S
I
T
Q
Q
T
Site 47
S151
A
S
S
S
T
S
G
S
I
T
Q
Q
T
M
L
Site 48
T153
S
S
T
S
G
S
I
T
Q
Q
T
M
L
L
G
Site 49
T156
S
G
S
I
T
Q
Q
T
M
L
L
G
S
T
S
Site 50
S161
Q
Q
T
M
L
L
G
S
T
S
P
T
L
T
A
Site 51
T165
L
L
G
S
T
S
P
T
L
T
A
S
Q
A
Q
Site 52
T167
G
S
T
S
P
T
L
T
A
S
Q
A
Q
M
Y
Site 53
S169
T
S
P
T
L
T
A
S
Q
A
Q
M
Y
L
R
Site 54
S199
Q
S
D
I
P
V
V
S
S
S
S
S
S
S
C
Site 55
S200
S
D
I
P
V
V
S
S
S
S
S
S
S
C
Q
Site 56
S201
D
I
P
V
V
S
S
S
S
S
S
S
C
Q
S
Site 57
S202
I
P
V
V
S
S
S
S
S
S
S
C
Q
S
A
Site 58
S203
P
V
V
S
S
S
S
S
S
S
C
Q
S
A
A
Site 59
S204
V
V
S
S
S
S
S
S
S
C
Q
S
A
A
T
Site 60
S205
V
S
S
S
S
S
S
S
C
Q
S
A
A
T
Q
Site 61
S208
S
S
S
S
S
C
Q
S
A
A
T
Q
V
Q
N
Site 62
T217
A
T
Q
V
Q
N
L
T
L
R
S
Q
K
L
G
Site 63
S227
S
Q
K
L
G
V
L
S
S
S
Q
N
G
P
P
Site 64
S228
Q
K
L
G
V
L
S
S
S
Q
N
G
P
P
K
Site 65
S229
K
L
G
V
L
S
S
S
Q
N
G
P
P
K
S
Site 66
S236
S
Q
N
G
P
P
K
S
T
S
Q
T
Q
S
L
Site 67
S238
N
G
P
P
K
S
T
S
Q
T
Q
S
L
T
I
Site 68
T240
P
P
K
S
T
S
Q
T
Q
S
L
T
I
C
H
Site 69
S242
K
S
T
S
Q
T
Q
S
L
T
I
C
H
N
K
Site 70
T250
L
T
I
C
H
N
K
T
T
V
T
S
S
K
I
Site 71
T251
T
I
C
H
N
K
T
T
V
T
S
S
K
I
S
Site 72
S258
T
V
T
S
S
K
I
S
Q
R
D
P
S
P
E
Site 73
S263
K
I
S
Q
R
D
P
S
P
E
S
N
K
K
G
Site 74
S266
Q
R
D
P
S
P
E
S
N
K
K
G
E
S
P
Site 75
S272
E
S
N
K
K
G
E
S
P
S
L
E
S
R
S
Site 76
S274
N
K
K
G
E
S
P
S
L
E
S
R
S
T
A
Site 77
T280
P
S
L
E
S
R
S
T
A
V
T
R
T
S
S
Site 78
T283
E
S
R
S
T
A
V
T
R
T
S
S
I
H
Q
Site 79
S296
H
Q
L
I
A
P
A
S
Y
S
P
I
Q
P
H
Site 80
S298
L
I
A
P
A
S
Y
S
P
I
Q
P
H
S
L
Site 81
S304
Y
S
P
I
Q
P
H
S
L
I
K
H
Q
Q
I
Site 82
S315
H
Q
Q
I
P
L
H
S
P
P
S
K
V
S
H
Site 83
S318
I
P
L
H
S
P
P
S
K
V
S
H
H
Q
L
Site 84
T338
Q
Q
Q
I
Q
P
I
T
L
Q
N
S
T
Q
D
Site 85
S342
Q
P
I
T
L
Q
N
S
T
Q
D
P
P
P
S
Site 86
T343
P
I
T
L
Q
N
S
T
Q
D
P
P
P
S
Q
Site 87
S349
S
T
Q
D
P
P
P
S
Q
H
C
I
P
L
Q
Site 88
S365
H
G
L
P
P
A
P
S
N
A
Q
S
Q
H
C
Site 89
S369
P
A
P
S
N
A
Q
S
Q
H
C
S
P
I
Q
Site 90
S373
N
A
Q
S
Q
H
C
S
P
I
Q
S
H
P
S
Site 91
S377
Q
H
C
S
P
I
Q
S
H
P
S
P
L
T
V
Site 92
S380
S
P
I
Q
S
H
P
S
P
L
T
V
S
P
N
Site 93
T383
Q
S
H
P
S
P
L
T
V
S
P
N
Q
S
Q
Site 94
S385
H
P
S
P
L
T
V
S
P
N
Q
S
Q
S
A
Site 95
S389
L
T
V
S
P
N
Q
S
Q
S
A
Q
Q
S
V
Site 96
S391
V
S
P
N
Q
S
Q
S
A
Q
Q
S
V
V
V
Site 97
S395
Q
S
Q
S
A
Q
Q
S
V
V
V
S
P
P
P
Site 98
S399
A
Q
Q
S
V
V
V
S
P
P
P
P
H
S
P
Site 99
S405
V
S
P
P
P
P
H
S
P
S
Q
S
P
T
I
Site 100
S407
P
P
P
P
H
S
P
S
Q
S
P
T
I
I
I
Site 101
S409
P
P
H
S
P
S
Q
S
P
T
I
I
I
H
P
Site 102
T411
H
S
P
S
Q
S
P
T
I
I
I
H
P
Q
A
Site 103
S427
I
Q
P
H
P
L
V
S
S
A
L
Q
P
G
P
Site 104
S439
P
G
P
N
L
Q
Q
S
T
A
N
Q
V
Q
A
Site 105
T447
T
A
N
Q
V
Q
A
T
A
Q
L
N
L
P
S
Site 106
S454
T
A
Q
L
N
L
P
S
H
L
P
L
P
A
S
Site 107
S472
H
I
G
P
V
Q
Q
S
A
L
V
S
P
G
Q
Site 108
S483
S
P
G
Q
Q
I
V
S
P
S
H
Q
Q
Y
S
Site 109
S485
G
Q
Q
I
V
S
P
S
H
Q
Q
Y
S
S
L
Site 110
Y489
V
S
P
S
H
Q
Q
Y
S
S
L
Q
S
S
P
Site 111
S490
S
P
S
H
Q
Q
Y
S
S
L
Q
S
S
P
I
Site 112
S491
P
S
H
Q
Q
Y
S
S
L
Q
S
S
P
I
P
Site 113
S494
Q
Q
Y
S
S
L
Q
S
S
P
I
P
I
A
S
Site 114
S495
Q
Y
S
S
L
Q
S
S
P
I
P
I
A
S
P
Site 115
S501
S
S
P
I
P
I
A
S
P
P
Q
M
S
T
S
Site 116
S506
I
A
S
P
P
Q
M
S
T
S
P
P
A
Q
I
Site 117
S508
S
P
P
Q
M
S
T
S
P
P
A
Q
I
P
P
Site 118
S520
I
P
P
L
P
L
Q
S
M
Q
S
L
Q
V
Q
Site 119
S523
L
P
L
Q
S
M
Q
S
L
Q
V
Q
P
E
I
Site 120
S532
Q
V
Q
P
E
I
L
S
Q
G
Q
V
L
V
Q
Site 121
S600
E
E
E
M
P
E
E
S
D
E
C
V
R
M
D
Site 122
T609
E
C
V
R
M
D
R
T
P
P
P
P
T
L
S
Site 123
T614
D
R
T
P
P
P
P
T
L
S
P
A
A
I
T
Site 124
S616
T
P
P
P
P
T
L
S
P
A
A
I
T
V
G
Site 125
T621
T
L
S
P
A
A
I
T
V
G
R
G
E
D
L
Site 126
T629
V
G
R
G
E
D
L
T
S
E
H
P
L
L
E
Site 127
S630
G
R
G
E
D
L
T
S
E
H
P
L
L
E
Q
Site 128
S647
L
P
A
V
A
S
V
S
A
S
V
I
K
S
P
Site 129
S649
A
V
A
S
V
S
A
S
V
I
K
S
P
S
D
Site 130
S653
V
S
A
S
V
I
K
S
P
S
D
P
S
H
V
Site 131
S655
A
S
V
I
K
S
P
S
D
P
S
H
V
S
V
Site 132
S658
I
K
S
P
S
D
P
S
H
V
S
V
P
P
P
Site 133
S661
P
S
D
P
S
H
V
S
V
P
P
P
P
L
L
Site 134
T673
P
L
L
L
P
A
A
T
T
R
S
N
S
T
S
Site 135
T674
L
L
L
P
A
A
T
T
R
S
N
S
T
S
M
Site 136
S676
L
P
A
A
T
T
R
S
N
S
T
S
M
H
S
Site 137
S678
A
A
T
T
R
S
N
S
T
S
M
H
S
S
I
Site 138
S680
T
T
R
S
N
S
T
S
M
H
S
S
I
P
S
Site 139
S683
S
N
S
T
S
M
H
S
S
I
P
S
I
E
N
Site 140
S684
N
S
T
S
M
H
S
S
I
P
S
I
E
N
K
Site 141
S687
S
M
H
S
S
I
P
S
I
E
N
K
P
P
Q
Site 142
S723
E
P
F
P
V
S
R
S
S
L
L
I
E
Q
P
Site 143
S724
P
F
P
V
S
R
S
S
L
L
I
E
Q
P
V
Site 144
S761
N
T
K
H
A
D
N
S
S
D
T
E
M
E
D
Site 145
S762
T
K
H
A
D
N
S
S
D
T
E
M
E
D
M
Site 146
T764
H
A
D
N
S
S
D
T
E
M
E
D
M
I
A
Site 147
T774
E
D
M
I
A
E
E
T
L
E
E
M
D
S
E
Site 148
S780
E
T
L
E
E
M
D
S
E
L
L
K
C
E
F
Site 149
Y793
E
F
C
G
K
M
G
Y
A
N
E
F
L
R
S
Site 150
T805
L
R
S
K
R
F
C
T
M
S
C
A
K
R
Y
Site 151
Y812
T
M
S
C
A
K
R
Y
N
V
S
C
S
K
K
Site 152
S815
C
A
K
R
Y
N
V
S
C
S
K
K
F
A
L
Site 153
S817
K
R
Y
N
V
S
C
S
K
K
F
A
L
S
R
Site 154
S823
C
S
K
K
F
A
L
S
R
W
N
R
K
P
D
Site 155
S833
N
R
K
P
D
N
Q
S
L
G
H
R
G
R
R
Site 156
S842
G
H
R
G
R
R
P
S
G
P
D
G
A
A
R
Site 157
T859
I
L
R
Q
L
P
I
T
Y
P
S
A
E
E
D
Site 158
Y860
L
R
Q
L
P
I
T
Y
P
S
A
E
E
D
L
Site 159
S862
Q
L
P
I
T
Y
P
S
A
E
E
D
L
A
S
Site 160
S869
S
A
E
E
D
L
A
S
H
E
D
S
V
P
S
Site 161
S873
D
L
A
S
H
E
D
S
V
P
S
A
M
T
T
Site 162
T880
S
V
P
S
A
M
T
T
R
L
R
R
Q
S
E
Site 163
S886
T
T
R
L
R
R
Q
S
E
R
E
R
E
R
E
Site 164
S917
P
V
A
Q
T
E
P
S
I
W
T
V
D
D
V
Site 165
S979
K
I
C
A
R
I
N
S
L
K
E
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation