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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIPK4
Full Name:
Homeodomain-interacting protein kinase 4
Alias:
Type:
Mass (Da):
69425
Number AA:
616
UniProt ID:
Q8NE63
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
DYRKtide KinSub - DYR peptide substrate - Powder PE-01ACQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACQ95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
V
A
K
G
W
R
R
S
T
G
E
M
V
A
I
Site 2
T33
A
K
G
W
R
R
S
T
G
E
M
V
A
I
K
Site 3
Y47
K
I
L
K
N
D
A
Y
R
N
R
I
I
K
N
Site 4
S166
F
G
S
A
S
I
F
S
E
V
R
Y
V
K
E
Site 5
Y170
S
I
F
S
E
V
R
Y
V
K
E
P
Y
I
Q
Site 6
Y175
V
R
Y
V
K
E
P
Y
I
Q
S
R
F
Y
R
Site 7
Y181
P
Y
I
Q
S
R
F
Y
R
A
P
E
I
L
L
Site 8
Y215
L
H
L
G
W
P
L
Y
P
G
N
N
E
Y
D
Site 9
Y221
L
Y
P
G
N
N
E
Y
D
Q
V
R
Y
I
C
Site 10
Y226
N
E
Y
D
Q
V
R
Y
I
C
E
T
Q
G
L
Site 11
T230
Q
V
R
Y
I
C
E
T
Q
G
L
P
K
P
H
Site 12
S265
A
N
P
W
Q
L
K
S
S
A
D
Y
L
A
E
Site 13
Y269
Q
L
K
S
S
A
D
Y
L
A
E
T
K
V
R
Site 14
T273
S
A
D
Y
L
A
E
T
K
V
R
P
L
E
R
Site 15
Y283
R
P
L
E
R
R
K
Y
M
L
K
S
L
D
Q
Site 16
S287
R
R
K
Y
M
L
K
S
L
D
Q
I
E
T
V
Site 17
T293
K
S
L
D
Q
I
E
T
V
N
G
G
S
V
A
Site 18
T304
G
S
V
A
S
R
L
T
F
P
D
R
E
A
L
Site 19
S319
A
E
H
A
D
L
K
S
M
V
E
L
I
K
R
Site 20
T329
E
L
I
K
R
M
L
T
W
E
S
H
E
R
I
Site 21
S332
K
R
M
L
T
W
E
S
H
E
R
I
S
P
S
Site 22
S337
W
E
S
H
E
R
I
S
P
S
A
A
L
R
H
Site 23
S339
S
H
E
R
I
S
P
S
A
A
L
R
H
P
F
Site 24
S348
A
L
R
H
P
F
V
S
M
Q
Q
L
R
S
A
Site 25
S354
V
S
M
Q
Q
L
R
S
A
H
E
T
T
H
Y
Site 26
T358
Q
L
R
S
A
H
E
T
T
H
Y
Y
Q
L
S
Site 27
Y361
S
A
H
E
T
T
H
Y
Y
Q
L
S
L
R
S
Site 28
Y362
A
H
E
T
T
H
Y
Y
Q
L
S
L
R
S
Y
Site 29
S365
T
T
H
Y
Y
Q
L
S
L
R
S
Y
R
L
S
Site 30
S368
Y
Y
Q
L
S
L
R
S
Y
R
L
S
L
Q
V
Site 31
Y369
Y
Q
L
S
L
R
S
Y
R
L
S
L
Q
V
E
Site 32
S372
S
L
R
S
Y
R
L
S
L
Q
V
E
G
K
P
Site 33
T381
Q
V
E
G
K
P
P
T
P
V
V
A
A
E
D
Site 34
T390
V
V
A
A
E
D
G
T
P
Y
Y
C
L
A
E
Site 35
Y392
A
A
E
D
G
T
P
Y
Y
C
L
A
E
E
K
Site 36
Y393
A
E
D
G
T
P
Y
Y
C
L
A
E
E
K
E
Site 37
S406
K
E
A
A
G
M
G
S
V
A
G
S
S
P
F
Site 38
S410
G
M
G
S
V
A
G
S
S
P
F
F
R
E
E
Site 39
S411
M
G
S
V
A
G
S
S
P
F
F
R
E
E
K
Site 40
S433
I
D
Q
L
D
D
L
S
L
Q
E
A
G
H
G
Site 41
S469
T
G
H
H
V
P
D
S
G
P
E
P
I
L
A
Site 42
Y478
P
E
P
I
L
A
F
Y
S
S
R
L
A
G
R
Site 43
S479
E
P
I
L
A
F
Y
S
S
R
L
A
G
R
H
Site 44
S480
P
I
L
A
F
Y
S
S
R
L
A
G
R
H
K
Site 45
S495
A
R
K
P
P
A
G
S
K
S
D
S
N
F
S
Site 46
S497
K
P
P
A
G
S
K
S
D
S
N
F
S
N
L
Site 47
S499
P
A
G
S
K
S
D
S
N
F
S
N
L
I
R
Site 48
S502
S
K
S
D
S
N
F
S
N
L
I
R
L
S
Q
Site 49
S508
F
S
N
L
I
R
L
S
Q
V
S
P
E
D
D
Site 50
S511
L
I
R
L
S
Q
V
S
P
E
D
D
R
P
C
Site 51
S521
D
D
R
P
C
R
G
S
S
W
E
E
G
E
H
Site 52
S522
D
R
P
C
R
G
S
S
W
E
E
G
E
H
L
Site 53
T552
G
P
N
I
D
N
M
T
M
E
A
E
R
P
D
Site 54
S566
D
P
E
L
F
D
P
S
S
C
P
G
E
W
L
Site 55
S567
P
E
L
F
D
P
S
S
C
P
G
E
W
L
S
Site 56
S574
S
C
P
G
E
W
L
S
E
P
D
C
T
L
E
Site 57
T579
W
L
S
E
P
D
C
T
L
E
S
V
R
G
P
Site 58
S582
E
P
D
C
T
L
E
S
V
R
G
P
R
A
Q
Site 59
S596
Q
G
L
P
P
R
R
S
H
Q
H
G
P
P
R
Site 60
T606
H
G
P
P
R
G
A
T
S
F
L
Q
H
V
T
Site 61
S607
G
P
P
R
G
A
T
S
F
L
Q
H
V
T
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation