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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZSWIM2
Full Name:
E3 ubiquitin-protein ligase ZSWIM2
Alias:
MEKK1-related protein X;ZZ-type zinc finger-containing protein 2;Zinc finger SWIM domain-containing protein 2
Type:
Mass (Da):
72721
Number AA:
633
UniProt ID:
Q8NEG5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y6
_
_
M
L
R
R
G
Y
K
A
S
E
R
R
R
Site 2
S9
L
R
R
G
Y
K
A
S
E
R
R
R
H
L
S
Site 3
S16
S
E
R
R
R
H
L
S
E
R
L
S
W
H
Q
Site 4
S20
R
H
L
S
E
R
L
S
W
H
Q
D
Q
A
L
Site 5
S28
W
H
Q
D
Q
A
L
S
S
S
I
Y
L
L
R
Site 6
S29
H
Q
D
Q
A
L
S
S
S
I
Y
L
L
R
E
Site 7
S30
Q
D
Q
A
L
S
S
S
I
Y
L
L
R
E
M
Site 8
Y32
Q
A
L
S
S
S
I
Y
L
L
R
E
M
G
P
Site 9
T40
L
L
R
E
M
G
P
T
G
F
L
L
R
E
E
Site 10
Y51
L
R
E
E
E
P
E
Y
M
D
F
R
V
F
L
Site 11
T68
P
H
V
C
N
C
S
T
F
P
K
G
G
E
L
Site 12
S95
E
L
P
R
N
H
E
S
A
L
Q
L
G
L
G
Site 13
S107
G
L
G
E
R
E
I
S
D
L
L
R
G
I
H
Site 14
T118
R
G
I
H
R
V
Q
T
P
Q
P
G
T
N
D
Site 15
Y135
E
H
V
E
E
D
G
Y
I
K
Q
K
E
I
D
Site 16
Y183
C
M
K
I
L
A
N
Y
Q
S
T
S
N
T
S
Site 17
S185
K
I
L
A
N
Y
Q
S
T
S
N
T
S
M
L
Site 18
S187
L
A
N
Y
Q
S
T
S
N
T
S
M
L
K
C
Site 19
T189
N
Y
Q
S
T
S
N
T
S
M
L
K
C
P
L
Site 20
S190
Y
Q
S
T
S
N
T
S
M
L
K
C
P
L
C
Site 21
Y247
F
P
I
E
G
K
C
Y
K
C
T
E
C
I
E
Site 22
T271
S
Y
C
H
L
S
H
T
F
T
F
R
E
K
R
Site 23
T273
C
H
L
S
H
T
F
T
F
R
E
K
R
N
Q
Site 24
S284
K
R
N
Q
K
W
R
S
L
E
K
R
A
D
E
Site 25
Y295
R
A
D
E
V
V
K
Y
I
D
T
K
N
E
T
Site 26
T302
Y
I
D
T
K
N
E
T
E
E
K
M
S
H
F
Site 27
T318
E
K
Q
G
Q
V
Y
T
P
K
H
I
V
R
S
Site 28
T363
H
T
R
L
L
P
C
T
H
K
F
H
R
K
C
Site 29
Y390
P
I
G
G
Q
V
I
Y
N
P
L
T
W
K
N
Site 30
T394
Q
V
I
Y
N
P
L
T
W
K
N
S
A
V
N
Site 31
S407
V
N
G
Q
A
H
Q
S
V
S
N
R
D
I
I
Site 32
S409
G
Q
A
H
Q
S
V
S
N
R
D
I
I
H
L
Site 33
S417
N
R
D
I
I
H
L
S
K
Q
K
E
P
D
L
Site 34
S443
N
R
L
G
I
L
P
S
I
P
Q
C
N
F
D
Site 35
T454
C
N
F
D
E
L
N
T
P
Q
S
P
K
D
A
Site 36
S457
D
E
L
N
T
P
Q
S
P
K
D
A
Y
E
N
Site 37
Y462
P
Q
S
P
K
D
A
Y
E
N
T
T
I
D
N
Site 38
S478
C
S
I
K
L
D
N
S
N
S
K
K
L
T
Y
Site 39
S480
I
K
L
D
N
S
N
S
K
K
L
T
Y
E
Y
Site 40
T484
N
S
N
S
K
K
L
T
Y
E
Y
K
I
S
Q
Site 41
Y485
S
N
S
K
K
L
T
Y
E
Y
K
I
S
Q
H
Site 42
Y496
I
S
Q
H
F
P
R
Y
L
Q
D
L
P
T
V
Site 43
T502
R
Y
L
Q
D
L
P
T
V
S
F
G
K
I
P
Site 44
S504
L
Q
D
L
P
T
V
S
F
G
K
I
P
S
Q
Site 45
S534
A
M
E
S
P
C
I
S
G
K
Y
H
T
S
L
Site 46
Y537
S
P
C
I
S
G
K
Y
H
T
S
L
S
R
V
Site 47
S540
I
S
G
K
Y
H
T
S
L
S
R
V
T
K
G
Site 48
S542
G
K
Y
H
T
S
L
S
R
V
T
K
G
C
K
Site 49
T545
H
T
S
L
S
R
V
T
K
G
C
K
C
N
N
Site 50
T558
N
N
H
N
L
K
K
T
P
A
T
K
I
R
E
Site 51
T571
R
E
D
N
K
R
S
T
L
L
P
E
D
F
N
Site 52
S589
N
W
S
T
A
K
L
S
L
S
K
R
Y
S
N
Site 53
S591
S
T
A
K
L
S
L
S
K
R
Y
S
N
C
M
Site 54
Y594
K
L
S
L
S
K
R
Y
S
N
C
M
G
E
I
Site 55
S595
L
S
L
S
K
R
Y
S
N
C
M
G
E
I
T
Site 56
S606
G
E
I
T
R
K
C
S
H
L
S
R
Q
P
V
Site 57
S609
T
R
K
C
S
H
L
S
R
Q
P
V
S
H
S
Site 58
S614
H
L
S
R
Q
P
V
S
H
S
V
N
T
K
S
Site 59
S616
S
R
Q
P
V
S
H
S
V
N
T
K
S
T
E
Site 60
S621
S
H
S
V
N
T
K
S
T
E
L
S
L
I
I
Site 61
S625
N
T
K
S
T
E
L
S
L
I
I
E
G
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation