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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALK7
Full Name:
Activin receptor type-1C
Alias:
Activin A receptor type IC; Activin receptor-like kinase 7; ACV1C; ACVR1C; ACVRLK7; EC 2.7.11.30
Type:
Membrane, Activin receptor complex, Integral membrane protein
Mass (Da):
54871
Number AA:
493
UniProt ID:
Q8NER5
International Prot ID:
IPI00302552
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0048179
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016361
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0030154
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S142
A
C
Q
G
R
Q
C
S
Y
R
K
K
K
R
P
Site 2
S156
P
N
V
E
E
P
L
S
E
C
N
L
V
N
A
Site 3
T166
N
L
V
N
A
G
K
T
L
K
D
L
I
Y
D
Site 4
Y172
K
T
L
K
D
L
I
Y
D
V
T
A
S
G
S
Site 5
T175
K
D
L
I
Y
D
V
T
A
S
G
S
G
S
G
Site 6
S177
L
I
Y
D
V
T
A
S
G
S
G
S
G
L
P
Site 7
S179
Y
D
V
T
A
S
G
S
G
S
G
L
P
L
L
Site 8
S181
V
T
A
S
G
S
G
S
G
L
P
L
L
V
Q
Site 9
T190
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Site 10
T194
V
Q
R
T
I
A
R
T
I
V
L
Q
E
I
V
Site 11
S225
D
V
A
V
K
I
F
S
S
R
D
E
R
S
W
Site 12
S226
V
A
V
K
I
F
S
S
R
D
E
R
S
W
F
Site 13
S231
F
S
S
R
D
E
R
S
W
F
R
E
A
E
I
Site 14
Y239
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
Site 15
T241
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
Site 16
Y272
Q
L
W
L
V
S
E
Y
H
E
Q
G
S
L
Y
Site 17
S277
S
E
Y
H
E
Q
G
S
L
Y
D
Y
L
N
R
Site 18
Y279
Y
H
E
Q
G
S
L
Y
D
Y
L
N
R
N
I
Site 19
Y281
E
Q
G
S
L
Y
D
Y
L
N
R
N
I
V
T
Site 20
S326
I
A
H
R
D
I
K
S
K
N
I
L
V
K
K
Site 21
T354
K
H
D
S
I
L
N
T
I
D
I
P
Q
N
P
Site 22
Y368
P
K
V
G
T
K
R
Y
M
A
P
E
M
L
D
Site 23
S406
W
E
I
A
R
R
C
S
V
G
G
I
V
E
E
Site 24
Y414
V
G
G
I
V
E
E
Y
Q
L
P
Y
Y
D
M
Site 25
Y418
V
E
E
Y
Q
L
P
Y
Y
D
M
V
P
S
D
Site 26
Y419
E
E
Y
Q
L
P
Y
Y
D
M
V
P
S
D
P
Site 27
S424
P
Y
Y
D
M
V
P
S
D
P
S
I
E
E
M
Site 28
S427
D
M
V
P
S
D
P
S
I
E
E
M
R
K
V
Site 29
Y466
R
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
Site 30
T474
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
Site 31
S483
L
R
I
K
K
T
I
S
Q
L
C
V
K
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation