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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APPL2
Full Name:
DCC-interacting protein 13-beta
Alias:
adapter protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13 beta; Dip13 betaRho GTPase activating protein 28; DIP13B; DP13B; FLJ10659
Type:
Adaptor/scaffold
Mass (Da):
74490
Number AA:
UniProt ID:
Q8NEU8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0010008
GO:0019898
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0008283
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
E
E
A
L
Q
D
S
P
Q
T
R
S
L
L
Site 2
S21
Q
D
S
P
Q
T
R
S
L
L
S
V
F
E
E
Site 3
S24
P
Q
T
R
S
L
L
S
V
F
E
E
D
A
G
Site 4
T32
V
F
E
E
D
A
G
T
L
T
D
Y
T
N
Q
Site 5
Y36
D
A
G
T
L
T
D
Y
T
N
Q
L
L
Q
A
Site 6
T37
A
G
T
L
T
D
Y
T
N
Q
L
L
Q
A
M
Site 7
Y48
L
Q
A
M
Q
R
V
Y
G
A
Q
N
E
M
C
Site 8
S84
K
G
D
E
E
V
I
S
T
L
H
Y
F
S
K
Site 9
T85
G
D
E
E
V
I
S
T
L
H
Y
F
S
K
V
Site 10
T124
Q
F
R
E
K
D
L
T
E
V
S
T
L
K
D
Site 11
T128
K
D
L
T
E
V
S
T
L
K
D
L
F
G
L
Site 12
S137
K
D
L
F
G
L
A
S
N
E
H
D
L
S
M
Site 13
S143
A
S
N
E
H
D
L
S
M
A
K
Y
S
R
L
Site 14
Y147
H
D
L
S
M
A
K
Y
S
R
L
P
K
K
K
Site 15
T161
K
E
N
E
K
V
K
T
E
V
G
K
E
V
A
Site 16
S177
A
R
R
K
Q
H
L
S
S
L
Q
Y
Y
C
A
Site 17
S178
R
R
K
Q
H
L
S
S
L
Q
Y
Y
C
A
L
Site 18
S219
K
K
G
A
E
M
F
S
K
R
M
D
S
F
L
Site 19
S224
M
F
S
K
R
M
D
S
F
L
S
S
V
A
D
Site 20
S228
R
M
D
S
F
L
S
S
V
A
D
M
V
Q
S
Site 21
S250
E
A
E
K
M
R
V
S
Q
Q
E
L
L
S
V
Site 22
S256
V
S
Q
Q
E
L
L
S
V
D
E
S
V
Y
T
Site 23
S260
E
L
L
S
V
D
E
S
V
Y
T
P
D
S
D
Site 24
Y262
L
S
V
D
E
S
V
Y
T
P
D
S
D
V
A
Site 25
T263
S
V
D
E
S
V
Y
T
P
D
S
D
V
A
A
Site 26
S266
E
S
V
Y
T
P
D
S
D
V
A
A
P
Q
I
Site 27
Y283
N
L
I
Q
K
A
G
Y
L
N
L
R
N
K
T
Site 28
T290
Y
L
N
L
R
N
K
T
G
L
V
T
T
T
W
Site 29
T296
K
T
G
L
V
T
T
T
W
E
R
L
Y
F
F
Site 30
Y301
T
T
T
W
E
R
L
Y
F
F
T
Q
G
G
N
Site 31
Y340
V
D
C
E
D
R
R
Y
C
F
Q
I
T
T
P
Site 32
T345
R
R
Y
C
F
Q
I
T
T
P
N
G
K
S
G
Site 33
T346
R
Y
C
F
Q
I
T
T
P
N
G
K
S
G
I
Site 34
Y378
N
N
I
S
R
Q
I
Y
L
T
D
N
P
E
A
Site 35
T380
I
S
R
Q
I
Y
L
T
D
N
P
E
A
V
A
Site 36
S403
Q
A
V
T
P
I
T
S
F
G
K
K
Q
E
S
Site 37
S410
S
F
G
K
K
Q
E
S
S
C
P
S
Q
N
L
Site 38
S414
K
Q
E
S
S
C
P
S
Q
N
L
K
N
S
E
Site 39
S420
P
S
Q
N
L
K
N
S
E
M
E
N
E
N
D
Site 40
S468
F
L
D
Q
N
R
G
S
R
R
T
N
P
F
G
Site 41
T471
Q
N
R
G
S
R
R
T
N
P
F
G
E
T
E
Site 42
S481
F
G
E
T
E
D
E
S
F
P
E
A
E
D
S
Site 43
S488
S
F
P
E
A
E
D
S
L
L
Q
Q
M
F
I
Site 44
S508
S
M
A
V
K
T
D
S
T
T
E
V
I
Y
E
Site 45
Y514
D
S
T
T
E
V
I
Y
E
A
M
R
Q
V
L
Site 46
S541
E
S
H
L
M
V
T
S
Q
S
L
R
L
I
D
Site 47
S543
H
L
M
V
T
S
Q
S
L
R
L
I
D
P
Q
Site 48
T551
L
R
L
I
D
P
Q
T
Q
V
S
R
A
N
F
Site 49
S562
R
A
N
F
E
L
T
S
V
T
Q
F
A
A
H
Site 50
S585
F
V
I
R
V
P
E
S
T
G
E
E
S
L
S
Site 51
T586
V
I
R
V
P
E
S
T
G
E
E
S
L
S
T
Site 52
S590
P
E
S
T
G
E
E
S
L
S
T
Y
I
F
E
Site 53
S592
S
T
G
E
E
S
L
S
T
Y
I
F
E
S
N
Site 54
T593
T
G
E
E
S
L
S
T
Y
I
F
E
S
N
S
Site 55
Y594
G
E
E
S
L
S
T
Y
I
F
E
S
N
S
E
Site 56
S598
L
S
T
Y
I
F
E
S
N
S
E
G
E
K
I
Site 57
Y607
S
E
G
E
K
I
C
Y
A
I
N
L
G
K
E
Site 58
Y640
P
L
T
N
D
G
K
Y
V
L
L
N
D
Q
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation