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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYO3A
Full Name:
Myosin-IIIa
Alias:
Class III myosin; EC 2.7.11.1; MY3A; Myosin IIIA
Type:
Protein-serine kinase, STE group, STE20 family, NinaC subfamily; Actin binding
Mass (Da):
186208
Number AA:
1616
UniProt ID:
Q8NEV4
International Prot ID:
IPI00185036
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0031941
GO:0030175
Uniprot
OncoNet
Molecular Function:
GO:0043531
GO:0005524
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0046777
GO:0050896
GO:0007605
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
N
F
P
D
P
S
D
T
W
E
I
T
E
T
I
Site 2
T26
D
T
W
E
I
T
E
T
I
G
K
G
T
Y
G
Site 3
S73
Y
N
I
L
K
A
L
S
D
H
P
N
V
V
R
Site 4
Y82
H
P
N
V
V
R
F
Y
G
I
Y
F
K
K
D
Site 5
Y85
V
V
R
F
Y
G
I
Y
F
K
K
D
K
V
N
Site 6
S123
L
K
R
G
E
R
M
S
E
P
L
I
A
Y
I
Site 7
T159
K
G
N
N
I
L
L
T
T
E
G
G
V
K
L
Site 8
T176
F
G
V
S
A
Q
L
T
S
T
R
H
R
R
N
Site 9
S177
G
V
S
A
Q
L
T
S
T
R
H
R
R
N
T
Site 10
T178
V
S
A
Q
L
T
S
T
R
H
R
R
N
T
S
Site 11
T184
S
T
R
H
R
R
N
T
S
V
G
T
P
F
W
Site 12
T188
R
R
N
T
S
V
G
T
P
F
W
M
A
P
E
Site 13
Y207
E
Q
Q
L
D
T
T
Y
D
A
R
C
D
T
W
Site 14
T213
T
Y
D
A
R
C
D
T
W
S
L
G
I
T
A
Site 15
S215
D
A
R
C
D
T
W
S
L
G
I
T
A
I
E
Site 16
T269
D
F
I
S
K
C
L
T
K
D
Y
E
K
R
P
Site 17
Y272
S
K
C
L
T
K
D
Y
E
K
R
P
T
V
S
Site 18
T277
K
D
Y
E
K
R
P
T
V
S
E
L
L
Q
H
Site 19
T324
A
R
R
E
R
I
H
T
K
K
G
N
F
N
R
Site 20
T345
K
D
V
D
D
L
A
T
L
E
I
L
D
E
N
Site 21
T353
L
E
I
L
D
E
N
T
V
S
E
Q
L
E
K
Site 22
S355
I
L
D
E
N
T
V
S
E
Q
L
E
K
C
Y
Site 23
Y362
S
E
Q
L
E
K
C
Y
S
R
D
Q
I
Y
V
Site 24
Y387
P
F
Q
S
L
G
L
Y
S
T
K
H
S
K
L
Site 25
S388
F
Q
S
L
G
L
Y
S
T
K
H
S
K
L
Y
Site 26
T389
Q
S
L
G
L
Y
S
T
K
H
S
K
L
Y
I
Site 27
S392
G
L
Y
S
T
K
H
S
K
L
Y
I
G
S
K
Site 28
Y395
S
T
K
H
S
K
L
Y
I
G
S
K
R
T
A
Site 29
S398
H
S
K
L
Y
I
G
S
K
R
T
A
S
P
P
Site 30
S403
I
G
S
K
R
T
A
S
P
P
H
I
F
A
M
Site 31
Y421
G
Y
Q
S
M
I
T
Y
N
S
D
Q
C
I
V
Site 32
S430
S
D
Q
C
I
V
I
S
G
E
S
G
A
G
K
Site 33
S485
T
I
I
N
D
N
S
S
R
F
G
K
Y
L
E
Site 34
Y490
N
S
S
R
F
G
K
Y
L
E
M
K
F
T
S
Site 35
Y509
V
G
A
Q
I
S
E
Y
L
L
E
K
S
R
V
Site 36
S514
S
E
Y
L
L
E
K
S
R
V
I
H
Q
A
I
Site 37
Y545
E
K
K
K
L
A
H
Y
K
L
P
E
N
K
P
Site 38
Y555
P
E
N
K
P
P
R
Y
L
Q
N
D
H
L
R
Site 39
T563
L
Q
N
D
H
L
R
T
V
Q
D
I
M
N
N
Site 40
Y573
D
I
M
N
N
S
F
Y
K
S
Q
Y
E
L
I
Site 41
Y577
N
S
F
Y
K
S
Q
Y
E
L
I
E
Q
C
F
Site 42
S613
N
V
G
N
I
E
F
S
S
V
A
T
E
H
Q
Site 43
S614
V
G
N
I
E
F
S
S
V
A
T
E
H
Q
I
Site 44
S652
E
L
Q
E
A
L
T
S
H
C
V
V
T
R
G
Site 45
T667
E
T
I
I
R
P
N
T
V
E
K
A
T
D
V
Site 46
T681
V
R
D
A
M
A
K
T
L
Y
G
R
L
F
S
Site 47
S688
T
L
Y
G
R
L
F
S
W
I
V
N
C
I
N
Site 48
S702
N
S
L
L
K
H
D
S
S
P
S
G
N
G
D
Site 49
S703
S
L
L
K
H
D
S
S
P
S
G
N
G
D
E
Site 50
Y743
I
A
N
E
Q
I
Q
Y
Y
Y
N
Q
H
V
F
Site 51
Y744
A
N
E
Q
I
Q
Y
Y
Y
N
Q
H
V
F
A
Site 52
Y757
F
A
W
E
Q
N
E
Y
L
N
E
D
V
D
A
Site 53
Y769
V
D
A
R
V
I
E
Y
E
D
N
W
P
L
L
Site 54
S788
Q
K
P
M
G
L
L
S
L
L
D
E
E
S
R
Site 55
S794
L
S
L
L
D
E
E
S
R
F
P
K
A
T
D
Site 56
T800
E
S
R
F
P
K
A
T
D
Q
T
L
V
E
K
Site 57
T803
F
P
K
A
T
D
Q
T
L
V
E
K
F
E
G
Site 58
Y816
E
G
N
L
K
S
Q
Y
F
W
R
P
K
R
M
Site 59
S826
R
P
K
R
M
E
L
S
F
G
I
H
H
Y
A
Site 60
T853
K
N
R
D
T
L
P
T
D
I
V
L
L
L
R
Site 61
S865
L
L
R
S
S
D
N
S
V
I
R
Q
L
V
N
Site 62
T876
Q
L
V
N
H
P
L
T
K
T
G
N
L
P
H
Site 63
S884
K
T
G
N
L
P
H
S
K
T
K
N
V
I
N
Site 64
T886
G
N
L
P
H
S
K
T
K
N
V
I
N
Y
Q
Site 65
Y892
K
T
K
N
V
I
N
Y
Q
M
R
T
S
E
K
Site 66
S897
I
N
Y
Q
M
R
T
S
E
K
L
I
N
L
A
Site 67
T908
I
N
L
A
K
G
D
T
G
E
A
T
R
H
A
Site 68
T918
A
T
R
H
A
R
E
T
T
N
M
K
T
Q
T
Site 69
T919
T
R
H
A
R
E
T
T
N
M
K
T
Q
T
V
Site 70
T923
R
E
T
T
N
M
K
T
Q
T
V
A
S
Y
F
Site 71
T925
T
T
N
M
K
T
Q
T
V
A
S
Y
F
R
Y
Site 72
Y929
K
T
Q
T
V
A
S
Y
F
R
Y
S
L
M
D
Site 73
S956
V
R
C
I
K
P
N
S
E
R
Q
A
R
K
Y
Site 74
Y963
S
E
R
Q
A
R
K
Y
D
K
E
K
V
L
L
Site 75
S989
R
I
R
R
L
G
F
S
H
R
I
L
F
A
N
Site 76
Y1002
A
N
F
I
K
R
Y
Y
L
L
C
Y
K
S
S
Site 77
Y1006
K
R
Y
Y
L
L
C
Y
K
S
S
E
E
P
R
Site 78
S1008
Y
Y
L
L
C
Y
K
S
S
E
E
P
R
M
S
Site 79
S1009
Y
L
L
C
Y
K
S
S
E
E
P
R
M
S
P
Site 80
S1015
S
S
E
E
P
R
M
S
P
D
T
C
A
T
I
Site 81
T1018
E
P
R
M
S
P
D
T
C
A
T
I
L
E
K
Site 82
Y1042
K
T
K
V
F
L
K
Y
Y
H
V
E
Q
L
N
Site 83
Y1043
T
K
V
F
L
K
Y
Y
H
V
E
Q
L
N
L
Site 84
Y1075
A
F
L
C
S
R
R
Y
Q
K
I
Q
E
K
R
Site 85
S1085
I
Q
E
K
R
K
E
S
A
I
I
I
Q
S
A
Site 86
S1119
A
V
T
T
I
Q
T
S
D
Q
E
F
D
Y
K
Site 87
Y1125
T
S
D
Q
E
F
D
Y
K
K
N
F
E
N
T
Site 88
S1135
N
F
E
N
T
R
E
S
F
V
K
K
Q
A
E
Site 89
S1146
K
Q
A
E
N
A
I
S
A
N
E
R
F
I
S
Site 90
S1153
S
A
N
E
R
F
I
S
A
P
N
N
K
G
S
Site 91
S1160
S
A
P
N
N
K
G
S
V
S
V
V
K
T
S
Site 92
S1162
P
N
N
K
G
S
V
S
V
V
K
T
S
T
F
Site 93
T1166
G
S
V
S
V
V
K
T
S
T
F
K
P
E
E
Site 94
S1167
S
V
S
V
V
K
T
S
T
F
K
P
E
E
E
Site 95
T1168
V
S
V
V
K
T
S
T
F
K
P
E
E
E
T
Site 96
T1176
F
K
P
E
E
E
T
T
N
A
V
E
S
N
N
Site 97
Y1186
V
E
S
N
N
R
V
Y
Q
T
P
K
K
M
N
Site 98
T1188
S
N
N
R
V
Y
Q
T
P
K
K
M
N
N
V
Site 99
Y1205
E
E
V
K
Q
E
F
Y
L
V
G
P
E
V
S
Site 100
S1212
Y
L
V
G
P
E
V
S
P
K
Q
K
S
V
K
Site 101
S1217
E
V
S
P
K
Q
K
S
V
K
D
L
E
E
N
Site 102
S1225
V
K
D
L
E
E
N
S
N
L
R
K
V
E
K
Site 103
Y1241
E
A
M
I
Q
S
Y
Y
Q
R
Y
T
E
E
R
Site 104
T1245
Q
S
Y
Y
Q
R
Y
T
E
E
R
N
C
E
E
Site 105
S1253
E
E
R
N
C
E
E
S
K
A
A
Y
L
E
R
Site 106
Y1257
C
E
E
S
K
A
A
Y
L
E
R
K
A
I
S
Site 107
S1264
Y
L
E
R
K
A
I
S
E
R
P
S
Y
P
V
Site 108
S1268
K
A
I
S
E
R
P
S
Y
P
V
P
W
L
A
Site 109
Y1269
A
I
S
E
R
P
S
Y
P
V
P
W
L
A
E
Site 110
S1280
W
L
A
E
N
E
T
S
F
K
K
T
L
E
P
Site 111
T1284
N
E
T
S
F
K
K
T
L
E
P
T
L
S
Q
Site 112
T1288
F
K
K
T
L
E
P
T
L
S
Q
R
S
I
Y
Site 113
S1290
K
T
L
E
P
T
L
S
Q
R
S
I
Y
Q
N
Site 114
Y1295
T
L
S
Q
R
S
I
Y
Q
N
A
N
S
M
E
Site 115
S1300
S
I
Y
Q
N
A
N
S
M
E
K
E
K
K
T
Site 116
S1308
M
E
K
E
K
K
T
S
V
V
T
Q
R
A
P
Site 117
S1318
T
Q
R
A
P
I
C
S
Q
E
E
G
R
G
R
Site 118
T1330
R
G
R
L
R
H
E
T
V
K
E
R
Q
V
E
Site 119
S1355
K
A
A
V
F
I
Q
S
K
Y
R
G
Y
K
R
Site 120
Y1360
I
Q
S
K
Y
R
G
Y
K
R
R
Q
Q
L
R
Site 121
S1372
Q
L
R
K
D
K
M
S
S
F
K
H
Q
R
I
Site 122
S1373
L
R
K
D
K
M
S
S
F
K
H
Q
R
I
V
Site 123
T1381
F
K
H
Q
R
I
V
T
T
P
T
E
V
A
R
Site 124
T1382
K
H
Q
R
I
V
T
T
P
T
E
V
A
R
N
Site 125
T1390
P
T
E
V
A
R
N
T
H
N
L
Y
S
Y
P
Site 126
Y1394
A
R
N
T
H
N
L
Y
S
Y
P
T
K
H
E
Site 127
Y1396
N
T
H
N
L
Y
S
Y
P
T
K
H
E
E
I
Site 128
S1414
K
K
K
D
N
K
D
S
K
A
T
S
E
R
E
Site 129
S1418
N
K
D
S
K
A
T
S
E
R
E
A
C
G
L
Site 130
S1433
A
I
F
S
K
Q
I
S
K
L
S
E
E
Y
F
Site 131
S1436
S
K
Q
I
S
K
L
S
E
E
Y
F
I
L
Q
Site 132
S1452
K
L
N
E
M
I
L
S
Q
Q
L
K
S
L
Y
Site 133
Y1459
S
Q
Q
L
K
S
L
Y
L
G
V
S
H
H
K
Site 134
S1463
K
S
L
Y
L
G
V
S
H
H
K
P
I
N
R
Site 135
S1473
K
P
I
N
R
R
V
S
S
Q
Q
C
L
S
G
Site 136
S1474
P
I
N
R
R
V
S
S
Q
Q
C
L
S
G
V
Site 137
S1479
V
S
S
Q
Q
C
L
S
G
V
C
K
G
E
E
Site 138
T1501
R
R
P
R
K
P
K
T
L
N
N
P
E
D
S
Site 139
T1509
L
N
N
P
E
D
S
T
Y
Y
Y
L
L
H
K
Site 140
Y1510
N
N
P
E
D
S
T
Y
Y
Y
L
L
H
K
S
Site 141
Y1512
P
E
D
S
T
Y
Y
Y
L
L
H
K
S
I
Q
Site 142
S1517
Y
Y
Y
L
L
H
K
S
I
Q
E
E
K
R
R
Site 143
S1529
K
R
R
P
R
K
D
S
Q
G
K
L
L
D
L
Site 144
Y1540
L
L
D
L
E
D
F
Y
Y
K
E
F
L
P
S
Site 145
Y1541
L
D
L
E
D
F
Y
Y
K
E
F
L
P
S
R
Site 146
S1547
Y
Y
K
E
F
L
P
S
R
S
G
P
K
E
H
Site 147
S1549
K
E
F
L
P
S
R
S
G
P
K
E
H
S
P
Site 148
S1555
R
S
G
P
K
E
H
S
P
S
L
R
E
R
R
Site 149
S1557
G
P
K
E
H
S
P
S
L
R
E
R
R
P
Q
Site 150
S1583
E
R
C
W
A
A
E
S
P
E
K
E
E
E
R
Site 151
Y1597
R
E
P
A
A
N
P
Y
D
F
R
R
L
L
R
Site 152
T1606
F
R
R
L
L
R
K
T
S
Q
R
R
R
L
V
Site 153
S1607
R
R
L
L
R
K
T
S
Q
R
R
R
L
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation