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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP6V1C2
Full Name:
V-type proton ATPase subunit C 2
Alias:
ATP6C2; ATPase, H+ transporting, lysosomal 42kD, V1 subunit C; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2; Vacuolar ATP synthase C 2; Vacuolar proton pump C 2; Vacuolar proton pump subunit C 2; VATC2; V-ATPase C 2; VMA5
Type:
EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Transporter; Hydrolase
Mass (Da):
48740
Number AA:
427
UniProt ID:
Q8NEY4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0033180
Uniprot
OncoNet
Molecular Function:
GO:0016820
PhosphoSite+
KinaseNET
Biological Process:
GO:0015986
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
Q
A
L
E
R
M
N
T
V
T
S
K
S
N
L
Site 2
T26
L
E
R
M
N
T
V
T
S
K
S
N
L
S
Y
Site 3
S27
E
R
M
N
T
V
T
S
K
S
N
L
S
Y
N
Site 4
S29
M
N
T
V
T
S
K
S
N
L
S
Y
N
T
K
Site 5
S32
V
T
S
K
S
N
L
S
Y
N
T
K
F
A
I
Site 6
Y33
T
S
K
S
N
L
S
Y
N
T
K
F
A
I
P
Site 7
T62
D
E
L
G
K
L
D
T
F
A
E
S
L
I
R
Site 8
S66
K
L
D
T
F
A
E
S
L
I
R
R
M
A
Q
Site 9
S74
L
I
R
R
M
A
Q
S
V
V
E
V
M
E
D
Site 10
Y111
F
E
W
D
M
A
K
Y
P
V
K
Q
P
L
V
Site 11
S137
Q
I
E
M
D
L
K
S
R
T
A
A
Y
N
T
Site 12
S166
N
L
F
T
R
T
L
S
D
I
V
S
K
E
D
Site 13
S170
R
T
L
S
D
I
V
S
K
E
D
F
V
L
D
Site 14
T183
L
D
S
E
Y
L
V
T
L
L
V
I
V
P
K
Site 15
Y193
V
I
V
P
K
P
N
Y
S
Q
W
Q
K
T
Y
Site 16
T199
N
Y
S
Q
W
Q
K
T
Y
E
S
L
S
D
M
Site 17
Y200
Y
S
Q
W
Q
K
T
Y
E
S
L
S
D
M
V
Site 18
S202
Q
W
Q
K
T
Y
E
S
L
S
D
M
V
V
P
Site 19
S204
Q
K
T
Y
E
S
L
S
D
M
V
V
P
R
S
Site 20
S211
S
D
M
V
V
P
R
S
T
K
L
I
T
E
D
Site 21
T212
D
M
V
V
P
R
S
T
K
L
I
T
E
D
K
Site 22
T225
D
K
E
G
G
L
F
T
V
T
L
F
R
K
V
Site 23
T238
K
V
I
E
D
F
K
T
K
A
K
E
N
K
F
Site 24
T246
K
A
K
E
N
K
F
T
V
R
E
F
Y
Y
D
Site 25
Y251
K
F
T
V
R
E
F
Y
Y
D
E
K
E
I
E
Site 26
Y252
F
T
V
R
E
F
Y
Y
D
E
K
E
I
E
R
Site 27
S269
E
E
M
A
R
L
L
S
D
K
K
Q
Q
Y
Q
Site 28
Y275
L
S
D
K
K
Q
Q
Y
Q
T
S
C
V
A
L
Site 29
S287
V
A
L
K
K
G
S
S
T
F
P
D
H
K
V
Site 30
T288
A
L
K
K
G
S
S
T
F
P
D
H
K
V
K
Site 31
T297
P
D
H
K
V
K
V
T
P
L
G
N
P
D
R
Site 32
S316
Q
T
D
R
E
R
E
S
E
G
E
G
E
G
P
Site 33
S372
L
L
Q
P
H
K
K
S
S
T
K
R
L
R
E
Site 34
S373
L
Q
P
H
K
K
S
S
T
K
R
L
R
E
V
Site 35
S383
R
L
R
E
V
L
N
S
V
F
R
H
L
D
E
Site 36
Y413
L
Q
L
N
N
Q
D
Y
F
P
Y
V
Y
F
H
Site 37
Y416
N
N
Q
D
Y
F
P
Y
V
Y
F
H
I
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation