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Updated November 2019
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Protein Info
Short Name:
USP32
Full Name:
Ubiquitin carboxyl-terminal hydrolase 32
Alias:
Deubiquitinating enzyme 32; NY-REN-60; NY-REN-60 antigen; UB32; ubiquitin specific peptidase 32; Ubiquitin thiolesterase 32; Ubiquitin-specific processing protease 32; UBP32; USP10
Type:
Protease; Ubiquitin conjugating system; EC 3.1.2.15
Mass (Da):
181656
Number AA:
1604
UniProt ID:
Q8NFA0
International Prot ID:
IPI00185661
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
E
S
R
I
G
F
L
S
Y
E
E
A
L
R
R
Site 2
Y13
S
R
I
G
F
L
S
Y
E
E
A
L
R
R
V
Site 3
T21
E
E
A
L
R
R
V
T
D
V
E
L
K
R
L
Site 4
T35
L
K
D
A
F
K
R
T
C
G
L
S
Y
Y
M
Site 5
Y98
K
D
E
E
K
A
K
Y
I
F
S
L
F
S
S
Site 6
S101
E
K
A
K
Y
I
F
S
L
F
S
S
E
S
G
Site 7
S104
K
Y
I
F
S
L
F
S
S
E
S
G
N
Y
V
Site 8
S105
Y
I
F
S
L
F
S
S
E
S
G
N
Y
V
I
Site 9
S107
F
S
L
F
S
S
E
S
G
N
Y
V
I
R
E
Site 10
Y110
F
S
S
E
S
G
N
Y
V
I
R
E
E
M
E
Site 11
T130
V
D
G
K
V
P
D
T
L
R
K
C
F
S
E
Site 12
S136
D
T
L
R
K
C
F
S
E
G
E
K
V
N
Y
Site 13
Y143
S
E
G
E
K
V
N
Y
E
K
F
R
N
W
L
Site 14
S160
N
K
D
A
F
T
F
S
R
W
L
L
S
G
G
Site 15
T173
G
G
V
Y
V
T
L
T
D
D
S
D
T
P
T
Site 16
S176
Y
V
T
L
T
D
D
S
D
T
P
T
F
Y
Q
Site 17
T178
T
L
T
D
D
S
D
T
P
T
F
Y
Q
T
L
Site 18
T180
T
D
D
S
D
T
P
T
F
Y
Q
T
L
A
G
Site 19
Y182
D
S
D
T
P
T
F
Y
Q
T
L
A
G
V
T
Site 20
T184
D
T
P
T
F
Y
Q
T
L
A
G
V
T
H
L
Site 21
S194
G
V
T
H
L
E
E
S
D
I
I
D
L
E
K
Site 22
S210
Y
W
L
L
K
A
Q
S
R
T
G
R
F
D
L
Site 23
T219
T
G
R
F
D
L
E
T
F
G
P
L
V
S
P
Site 24
S225
E
T
F
G
P
L
V
S
P
P
I
R
P
S
L
Site 25
S231
V
S
P
P
I
R
P
S
L
S
E
G
L
F
N
Site 26
S233
P
P
I
R
P
S
L
S
E
G
L
F
N
A
F
Site 27
S285
V
D
R
D
G
V
L
S
R
V
E
L
R
D
M
Site 28
T305
E
V
W
K
D
N
R
T
D
D
I
P
E
L
H
Site 29
T328
G
I
L
N
A
H
D
T
T
K
M
G
H
L
T
Site 30
T335
T
T
K
M
G
H
L
T
L
E
D
Y
Q
I
W
Site 31
Y339
G
H
L
T
L
E
D
Y
Q
I
W
S
V
K
N
Site 32
T370
V
L
G
L
R
P
A
T
P
E
E
E
G
Q
I
Site 33
S386
R
G
W
L
E
R
E
S
R
Y
G
L
Q
A
G
Site 34
Y413
Q
W
K
E
Y
V
K
Y
D
A
N
P
V
V
I
Site 35
S423
N
P
V
V
I
E
P
S
S
V
L
N
G
G
K
Site 36
Y431
S
V
L
N
G
G
K
Y
S
F
G
T
A
A
H
Site 37
S432
V
L
N
G
G
K
Y
S
F
G
T
A
A
H
P
Site 38
S449
Q
V
E
D
R
I
G
S
S
L
S
Y
V
N
T
Site 39
S450
V
E
D
R
I
G
S
S
L
S
Y
V
N
T
T
Site 40
S452
D
R
I
G
S
S
L
S
Y
V
N
T
T
E
E
Site 41
Y453
R
I
G
S
S
L
S
Y
V
N
T
T
E
E
K
Site 42
T456
S
S
L
S
Y
V
N
T
T
E
E
K
F
S
D
Site 43
S462
N
T
T
E
E
K
F
S
D
N
I
S
T
A
S
Site 44
S466
E
K
F
S
D
N
I
S
T
A
S
E
A
S
E
Site 45
S469
S
D
N
I
S
T
A
S
E
A
S
E
T
A
G
Site 46
T474
T
A
S
E
A
S
E
T
A
G
S
G
F
L
Y
Site 47
Y481
T
A
G
S
G
F
L
Y
S
A
T
P
G
A
D
Site 48
S539
Q
E
P
V
K
A
T
S
L
T
L
E
G
G
R
Site 49
T541
P
V
K
A
T
S
L
T
L
E
G
G
R
L
K
Site 50
T550
E
G
G
R
L
K
R
T
P
Q
L
I
H
G
R
Site 51
Y559
Q
L
I
H
G
R
D
Y
E
M
V
P
E
P
V
Site 52
Y571
E
P
V
W
R
A
L
Y
H
W
Y
G
A
N
L
Site 53
S588
P
R
P
V
I
K
N
S
K
T
D
I
P
E
L
Site 54
T590
P
V
I
K
N
S
K
T
D
I
P
E
L
E
L
Site 55
Y601
E
L
E
L
F
P
R
Y
L
L
F
L
R
Q
Q
Site 56
T611
F
L
R
Q
Q
P
A
T
R
T
Q
Q
S
N
I
Site 57
S627
V
N
M
G
N
V
P
S
P
N
A
P
L
K
R
Site 58
T639
L
K
R
V
L
A
Y
T
G
C
F
S
R
M
Q
Site 59
T647
G
C
F
S
R
M
Q
T
I
K
E
I
H
E
Y
Site 60
Y654
T
I
K
E
I
H
E
Y
L
S
Q
R
L
R
I
Site 61
S656
K
E
I
H
E
Y
L
S
Q
R
L
R
I
K
E
Site 62
Y671
E
D
M
R
L
W
L
Y
N
S
E
N
Y
L
T
Site 63
T678
Y
N
S
E
N
Y
L
T
L
L
D
D
E
D
H
Site 64
Y689
D
E
D
H
K
L
E
Y
L
K
I
Q
D
E
Q
Site 65
S708
E
V
R
N
K
D
M
S
W
P
E
E
M
S
F
Site 66
S714
M
S
W
P
E
E
M
S
F
I
A
N
S
S
K
Site 67
T729
I
D
R
H
K
V
P
T
E
K
G
A
T
G
L
Site 68
S737
E
K
G
A
T
G
L
S
N
L
G
N
T
C
F
Site 69
S753
N
S
S
I
Q
C
V
S
N
T
Q
P
L
T
Q
Site 70
T755
S
I
Q
C
V
S
N
T
Q
P
L
T
Q
Y
F
Site 71
T759
V
S
N
T
Q
P
L
T
Q
Y
F
I
S
G
R
Site 72
Y761
N
T
Q
P
L
T
Q
Y
F
I
S
G
R
H
L
Site 73
S764
P
L
T
Q
Y
F
I
S
G
R
H
L
Y
E
L
Site 74
Y769
F
I
S
G
R
H
L
Y
E
L
N
R
T
N
P
Site 75
T774
H
L
Y
E
L
N
R
T
N
P
I
G
M
K
G
Site 76
Y787
K
G
H
M
A
K
C
Y
G
D
L
V
Q
E
L
Site 77
T810
A
P
L
K
L
R
W
T
I
A
K
Y
A
P
R
Site 78
Y814
L
R
W
T
I
A
K
Y
A
P
R
F
N
G
F
Site 79
S826
N
G
F
Q
Q
Q
D
S
Q
E
L
L
A
F
L
Site 80
Y849
N
R
V
H
E
K
P
Y
V
E
L
K
D
S
D
Site 81
S855
P
Y
V
E
L
K
D
S
D
G
R
P
D
W
E
Site 82
S877
N
H
L
R
R
N
R
S
I
V
V
D
L
F
H
Site 83
T895
R
S
Q
V
K
C
K
T
C
G
H
I
S
V
R
Site 84
T932
V
I
K
L
D
G
T
T
P
V
R
Y
G
L
R
Site 85
Y936
D
G
T
T
P
V
R
Y
G
L
R
L
N
M
D
Site 86
Y946
R
L
N
M
D
E
K
Y
T
G
L
K
K
Q
L
Site 87
S954
T
G
L
K
K
Q
L
S
D
L
C
G
L
N
S
Site 88
S972
L
L
A
E
V
H
G
S
N
I
K
N
F
P
Q
Site 89
S1005
P
V
P
V
S
P
I
S
A
S
S
P
T
Q
T
Site 90
S1007
P
V
S
P
I
S
A
S
S
P
T
Q
T
D
F
Site 91
S1008
V
S
P
I
S
A
S
S
P
T
Q
T
D
F
S
Site 92
T1010
P
I
S
A
S
S
P
T
Q
T
D
F
S
S
S
Site 93
T1012
S
A
S
S
P
T
Q
T
D
F
S
S
S
P
S
Site 94
S1015
S
P
T
Q
T
D
F
S
S
S
P
S
T
N
E
Site 95
S1016
P
T
Q
T
D
F
S
S
S
P
S
T
N
E
M
Site 96
S1017
T
Q
T
D
F
S
S
S
P
S
T
N
E
M
F
Site 97
S1019
T
D
F
S
S
S
P
S
T
N
E
M
F
T
L
Site 98
T1020
D
F
S
S
S
P
S
T
N
E
M
F
T
L
T
Site 99
T1027
T
N
E
M
F
T
L
T
T
N
G
D
L
P
R
Site 100
T1045
I
P
N
G
M
P
N
T
V
V
P
C
G
T
E
Site 101
S1066
M
V
N
G
H
M
P
S
L
P
D
S
P
F
T
Site 102
S1070
H
M
P
S
L
P
D
S
P
F
T
G
Y
I
I
Site 103
T1086
V
H
R
K
M
M
R
T
E
L
Y
F
L
S
S
Site 104
Y1089
K
M
M
R
T
E
L
Y
F
L
S
S
Q
K
N
Site 105
S1092
R
T
E
L
Y
F
L
S
S
Q
K
N
R
P
S
Site 106
S1093
T
E
L
Y
F
L
S
S
Q
K
N
R
P
S
L
Site 107
S1099
S
S
Q
K
N
R
P
S
L
F
G
M
P
L
I
Site 108
T1110
M
P
L
I
V
P
C
T
V
H
T
R
K
K
D
Site 109
Y1119
H
T
R
K
K
D
L
Y
D
A
V
W
I
Q
V
Site 110
S1127
D
A
V
W
I
Q
V
S
R
L
A
S
P
L
P
Site 111
S1131
I
Q
V
S
R
L
A
S
P
L
P
P
Q
E
A
Site 112
Y1151
D
C
D
D
S
M
G
Y
Q
Y
P
F
T
L
R
Site 113
Y1153
D
D
S
M
G
Y
Q
Y
P
F
T
L
R
V
V
Site 114
T1156
M
G
Y
Q
Y
P
F
T
L
R
V
V
Q
K
D
Site 115
Y1173
S
C
A
W
C
P
W
Y
R
F
C
R
G
C
K
Site 116
T1210
A
L
H
L
R
Y
Q
T
S
Q
E
R
V
V
D
Site 117
S1211
L
H
L
R
Y
Q
T
S
Q
E
R
V
V
D
E
Site 118
S1221
R
V
V
D
E
H
E
S
V
E
Q
S
R
R
A
Site 119
S1225
E
H
E
S
V
E
Q
S
R
R
A
Q
A
E
P
Site 120
S1237
A
E
P
I
N
L
D
S
C
L
R
A
F
T
S
Site 121
T1243
D
S
C
L
R
A
F
T
S
E
E
E
L
G
E
Site 122
S1244
S
C
L
R
A
F
T
S
E
E
E
L
G
E
N
Site 123
Y1254
E
L
G
E
N
E
M
Y
Y
C
S
K
C
K
T
Site 124
Y1255
L
G
E
N
E
M
Y
Y
C
S
K
C
K
T
H
Site 125
S1309
P
R
E
S
F
D
P
S
A
F
L
V
P
R
D
Site 126
T1326
L
C
Q
H
K
P
L
T
P
Q
G
D
E
L
S
Site 127
S1333
T
P
Q
G
D
E
L
S
E
P
R
I
L
A
R
Site 128
S1349
V
K
K
V
D
A
Q
S
S
A
G
E
E
D
V
Site 129
S1359
G
E
E
D
V
L
L
S
K
S
P
S
S
L
S
Site 130
S1361
E
D
V
L
L
S
K
S
P
S
S
L
S
A
N
Site 131
S1363
V
L
L
S
K
S
P
S
S
L
S
A
N
I
I
Site 132
S1366
S
K
S
P
S
S
L
S
A
N
I
I
S
S
P
Site 133
S1371
S
L
S
A
N
I
I
S
S
P
K
G
S
P
S
Site 134
S1372
L
S
A
N
I
I
S
S
P
K
G
S
P
S
S
Site 135
S1376
I
I
S
S
P
K
G
S
P
S
S
S
R
K
S
Site 136
S1378
S
S
P
K
G
S
P
S
S
S
R
K
S
G
T
Site 137
S1379
S
P
K
G
S
P
S
S
S
R
K
S
G
T
S
Site 138
S1380
P
K
G
S
P
S
S
S
R
K
S
G
T
S
C
Site 139
S1383
S
P
S
S
S
R
K
S
G
T
S
C
P
S
S
Site 140
T1385
S
S
S
R
K
S
G
T
S
C
P
S
S
K
N
Site 141
S1386
S
S
R
K
S
G
T
S
C
P
S
S
K
N
S
Site 142
S1389
K
S
G
T
S
C
P
S
S
K
N
S
S
P
N
Site 143
S1390
S
G
T
S
C
P
S
S
K
N
S
S
P
N
S
Site 144
S1393
S
C
P
S
S
K
N
S
S
P
N
S
S
P
R
Site 145
S1394
C
P
S
S
K
N
S
S
P
N
S
S
P
R
T
Site 146
S1397
S
K
N
S
S
P
N
S
S
P
R
T
L
G
R
Site 147
S1398
K
N
S
S
P
N
S
S
P
R
T
L
G
R
S
Site 148
T1401
S
P
N
S
S
P
R
T
L
G
R
S
K
G
R
Site 149
S1405
S
P
R
T
L
G
R
S
K
G
R
L
R
L
P
Site 150
S1416
L
R
L
P
Q
I
G
S
K
N
K
L
S
S
S
Site 151
S1421
I
G
S
K
N
K
L
S
S
S
K
E
N
L
D
Site 152
S1423
S
K
N
K
L
S
S
S
K
E
N
L
D
A
S
Site 153
S1430
S
K
E
N
L
D
A
S
K
E
N
G
A
G
Q
Site 154
S1454
R
G
H
V
L
G
G
S
Q
P
E
L
V
T
P
Site 155
T1460
G
S
Q
P
E
L
V
T
P
Q
D
H
E
V
A
Site 156
Y1474
A
L
A
N
G
F
L
Y
E
H
E
A
C
G
N
Site 157
S1492
N
G
Q
L
G
N
H
S
E
E
D
S
T
D
D
Site 158
S1496
G
N
H
S
E
E
D
S
T
D
D
Q
R
E
D
Site 159
T1497
N
H
S
E
E
D
S
T
D
D
Q
R
E
D
T
Site 160
T1504
T
D
D
Q
R
E
D
T
R
I
K
P
I
Y
N
Site 161
Y1510
D
T
R
I
K
P
I
Y
N
L
Y
A
I
S
C
Site 162
Y1527
G
I
L
G
G
G
H
Y
V
T
Y
A
K
N
P
Site 163
T1529
L
G
G
G
H
Y
V
T
Y
A
K
N
P
N
C
Site 164
Y1530
G
G
G
H
Y
V
T
Y
A
K
N
P
N
C
K
Site 165
Y1539
K
N
P
N
C
K
W
Y
C
Y
N
D
S
S
C
Site 166
Y1541
P
N
C
K
W
Y
C
Y
N
D
S
S
C
K
E
Site 167
S1544
K
W
Y
C
Y
N
D
S
S
C
K
E
L
H
P
Site 168
S1545
W
Y
C
Y
N
D
S
S
C
K
E
L
H
P
D
Site 169
T1556
L
H
P
D
E
I
D
T
D
S
A
Y
I
L
F
Site 170
S1558
P
D
E
I
D
T
D
S
A
Y
I
L
F
Y
E
Site 171
Y1560
E
I
D
T
D
S
A
Y
I
L
F
Y
E
Q
Q
Site 172
Y1564
D
S
A
Y
I
L
F
Y
E
Q
Q
G
I
D
Y
Site 173
Y1571
Y
E
Q
Q
G
I
D
Y
A
Q
F
L
P
K
T
Site 174
T1578
Y
A
Q
F
L
P
K
T
D
G
K
K
M
A
D
Site 175
T1586
D
G
K
K
M
A
D
T
S
S
M
D
E
D
F
Site 176
S1587
G
K
K
M
A
D
T
S
S
M
D
E
D
F
E
Site 177
S1588
K
K
M
A
D
T
S
S
M
D
E
D
F
E
S
Site 178
Y1597
D
E
D
F
E
S
D
Y
K
K
Y
C
V
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation