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Updated November 2019
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Protein Info
Short Name:
FAM44A
Full Name:
Biorientation of chromosomes in cell division protein 1-like
Alias:
Protein FAM44A
Type:
Mass (Da):
330466
Number AA:
3051
UniProt ID:
Q8NFC6
International Prot ID:
IPI00797574
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T80
D
C
L
A
D
V
D
T
K
P
A
Y
Q
N
L
Site 2
Y84
D
V
D
T
K
P
A
Y
Q
N
L
R
Q
R
V
Site 3
T101
F
V
A
N
H
L
A
T
H
T
W
S
P
H
L
Site 4
T103
A
N
H
L
A
T
H
T
W
S
P
H
L
N
K
Site 5
S124
I
R
Q
Q
V
L
K
S
G
M
L
E
S
G
I
Site 6
T146
V
D
P
K
I
N
H
T
F
R
P
Q
V
E
K
Site 7
T161
A
V
H
E
F
L
A
T
L
N
H
K
E
E
G
Site 8
T181
P
D
D
E
K
P
D
T
S
L
I
T
Q
G
V
Site 9
S182
D
D
E
K
P
D
T
S
L
I
T
Q
G
V
P
Site 10
T207
D
A
M
S
I
L
E
T
I
T
S
L
N
Q
E
Site 11
S210
S
I
L
E
T
I
T
S
L
N
Q
E
A
S
A
Site 12
S216
T
S
L
N
Q
E
A
S
A
A
R
A
S
T
E
Site 13
S221
E
A
S
A
A
R
A
S
T
E
T
S
N
A
K
Site 14
T222
A
S
A
A
R
A
S
T
E
T
S
N
A
K
T
Site 15
S225
A
R
A
S
T
E
T
S
N
A
K
T
S
E
R
Site 16
T229
T
E
T
S
N
A
K
T
S
E
R
A
S
K
K
Site 17
S230
E
T
S
N
A
K
T
S
E
R
A
S
K
K
L
Site 18
S234
A
K
T
S
E
R
A
S
K
K
L
P
S
Q
P
Site 19
S239
R
A
S
K
K
L
P
S
Q
P
T
T
D
T
S
Site 20
T243
K
L
P
S
Q
P
T
T
D
T
S
T
D
K
E
Site 21
S246
S
Q
P
T
T
D
T
S
T
D
K
E
R
T
S
Site 22
S253
S
T
D
K
E
R
T
S
E
D
M
A
D
K
E
Site 23
S262
D
M
A
D
K
E
K
S
T
A
D
S
G
G
E
Site 24
S266
K
E
K
S
T
A
D
S
G
G
E
G
L
E
T
Site 25
T273
S
G
G
E
G
L
E
T
A
P
K
S
E
E
F
Site 26
S277
G
L
E
T
A
P
K
S
E
E
F
S
D
L
P
Site 27
S281
A
P
K
S
E
E
F
S
D
L
P
C
P
V
E
Site 28
Y293
P
V
E
E
I
K
N
Y
T
K
E
H
N
N
L
Site 29
S318
S
S
E
Q
K
N
K
S
T
D
K
G
E
K
K
Site 30
S328
K
G
E
K
K
P
D
S
N
E
K
G
E
R
K
Site 31
T342
K
K
E
K
K
E
K
T
E
K
K
F
D
H
S
Site 32
S352
K
F
D
H
S
K
K
S
E
D
T
Q
K
V
K
Site 33
S371
A
K
E
K
E
V
E
S
L
K
L
P
S
E
K
Site 34
S376
V
E
S
L
K
L
P
S
E
K
N
S
N
K
A
Site 35
S380
K
L
P
S
E
K
N
S
N
K
A
K
T
V
E
Site 36
T385
K
N
S
N
K
A
K
T
V
E
G
T
K
E
D
Site 37
S394
E
G
T
K
E
D
F
S
L
I
D
S
D
V
D
Site 38
S398
E
D
F
S
L
I
D
S
D
V
D
G
L
T
D
Site 39
T404
D
S
D
V
D
G
L
T
D
I
T
V
S
S
V
Site 40
T413
I
T
V
S
S
V
H
T
S
D
L
S
S
F
E
Site 41
S414
T
V
S
S
V
H
T
S
D
L
S
S
F
E
E
Site 42
S417
S
V
H
T
S
D
L
S
S
F
E
E
D
T
E
Site 43
S418
V
H
T
S
D
L
S
S
F
E
E
D
T
E
E
Site 44
T429
D
T
E
E
E
V
V
T
S
D
S
M
E
E
G
Site 45
S430
T
E
E
E
V
V
T
S
D
S
M
E
E
G
E
Site 46
S432
E
E
V
V
T
S
D
S
M
E
E
G
E
I
T
Site 47
T439
S
M
E
E
G
E
I
T
S
D
D
E
E
K
N
Site 48
T451
E
K
N
K
Q
N
K
T
K
T
Q
T
S
D
S
Site 49
T453
N
K
Q
N
K
T
K
T
Q
T
S
D
S
S
E
Site 50
S456
N
K
T
K
T
Q
T
S
D
S
S
E
G
K
T
Site 51
S458
T
K
T
Q
T
S
D
S
S
E
G
K
T
K
S
Site 52
T463
S
D
S
S
E
G
K
T
K
S
V
R
H
A
Y
Site 53
S465
S
S
E
G
K
T
K
S
V
R
H
A
Y
V
H
Site 54
Y470
T
K
S
V
R
H
A
Y
V
H
K
P
Y
L
Y
Site 55
Y475
H
A
Y
V
H
K
P
Y
L
Y
S
K
Y
Y
S
Site 56
S478
V
H
K
P
Y
L
Y
S
K
Y
Y
S
D
S
D
Site 57
Y480
K
P
Y
L
Y
S
K
Y
Y
S
D
S
D
D
E
Site 58
Y481
P
Y
L
Y
S
K
Y
Y
S
D
S
D
D
E
L
Site 59
S482
Y
L
Y
S
K
Y
Y
S
D
S
D
D
E
L
T
Site 60
S484
Y
S
K
Y
Y
S
D
S
D
D
E
L
T
V
E
Site 61
T489
S
D
S
D
D
E
L
T
V
E
Q
R
R
Q
S
Site 62
S496
T
V
E
Q
R
R
Q
S
I
A
K
E
K
E
E
Site 63
T526
R
K
Q
K
A
E
K
T
K
S
S
K
T
K
G
Site 64
S528
Q
K
A
E
K
T
K
S
S
K
T
K
G
Q
G
Site 65
S538
T
K
G
Q
G
R
S
S
V
D
L
E
E
S
S
Site 66
S544
S
S
V
D
L
E
E
S
S
T
K
S
L
E
P
Site 67
T546
V
D
L
E
E
S
S
T
K
S
L
E
P
K
A
Site 68
S548
L
E
E
S
S
T
K
S
L
E
P
K
A
A
R
Site 69
S573
L
E
K
K
V
A
L
S
K
K
R
K
K
D
S
Site 70
S580
S
K
K
R
K
K
D
S
R
N
V
E
E
N
S
Site 71
Y593
N
S
K
K
K
Q
Q
Y
E
E
D
S
K
E
T
Site 72
T603
D
S
K
E
T
L
K
T
S
E
H
C
E
K
E
Site 73
S604
S
K
E
T
L
K
T
S
E
H
C
E
K
E
K
Site 74
S614
C
E
K
E
K
I
S
S
S
K
E
L
K
H
V
Site 75
S615
E
K
E
K
I
S
S
S
K
E
L
K
H
V
H
Site 76
S625
L
K
H
V
H
A
K
S
E
P
S
K
P
A
R
Site 77
S635
S
K
P
A
R
R
L
S
E
S
L
H
V
V
D
Site 78
S637
P
A
R
R
L
S
E
S
L
H
V
V
D
E
N
Site 79
T658
E
R
E
H
K
R
R
T
S
T
P
V
I
M
E
Site 80
S659
R
E
H
K
R
R
T
S
T
P
V
I
M
E
G
Site 81
T660
E
H
K
R
R
T
S
T
P
V
I
M
E
G
V
Site 82
T673
G
V
Q
E
E
T
D
T
R
D
V
K
R
Q
V
Site 83
S683
V
K
R
Q
V
E
R
S
E
I
C
T
E
E
P
Site 84
T687
V
E
R
S
E
I
C
T
E
E
P
Q
K
Q
K
Site 85
S708
K
H
L
K
K
D
D
S
E
T
P
H
L
K
S
Site 86
T710
L
K
K
D
D
S
E
T
P
H
L
K
S
L
L
Site 87
S715
S
E
T
P
H
L
K
S
L
L
K
K
E
V
K
Site 88
S724
L
K
K
E
V
K
S
S
K
E
K
P
E
R
E
Site 89
T733
E
K
P
E
R
E
K
T
P
S
E
D
K
L
S
Site 90
S735
P
E
R
E
K
T
P
S
E
D
K
L
S
V
K
Site 91
S740
T
P
S
E
D
K
L
S
V
K
H
K
Y
K
G
Site 92
Y745
K
L
S
V
K
H
K
Y
K
G
D
C
M
H
K
Site 93
T753
K
G
D
C
M
H
K
T
G
D
E
T
E
L
H
Site 94
T757
M
H
K
T
G
D
E
T
E
L
H
S
S
E
K
Site 95
S762
D
E
T
E
L
H
S
S
E
K
G
L
K
V
E
Site 96
S776
E
E
N
I
Q
K
Q
S
Q
Q
T
K
L
S
S
Site 97
S783
S
Q
Q
T
K
L
S
S
D
D
K
T
E
R
K
Site 98
T787
K
L
S
S
D
D
K
T
E
R
K
S
K
H
R
Site 99
S791
D
D
K
T
E
R
K
S
K
H
R
N
E
R
K
Site 100
S800
H
R
N
E
R
K
L
S
V
L
G
K
D
G
K
Site 101
S810
G
K
D
G
K
P
V
S
E
Y
I
I
K
T
D
Site 102
Y812
D
G
K
P
V
S
E
Y
I
I
K
T
D
E
N
Site 103
S832
N
K
K
E
R
R
L
S
A
E
K
T
K
A
E
Site 104
T836
R
R
L
S
A
E
K
T
K
A
E
H
K
S
R
Site 105
S842
K
T
K
A
E
H
K
S
R
R
S
S
D
S
K
Site 106
S845
A
E
H
K
S
R
R
S
S
D
S
K
I
Q
K
Site 107
S846
E
H
K
S
R
R
S
S
D
S
K
I
Q
K
D
Site 108
S848
K
S
R
R
S
S
D
S
K
I
Q
K
D
S
L
Site 109
S854
D
S
K
I
Q
K
D
S
L
G
S
K
Q
H
G
Site 110
T863
G
S
K
Q
H
G
I
T
L
Q
R
R
S
E
S
Site 111
S868
G
I
T
L
Q
R
R
S
E
S
Y
S
E
D
K
Site 112
S870
T
L
Q
R
R
S
E
S
Y
S
E
D
K
C
D
Site 113
S872
Q
R
R
S
E
S
Y
S
E
D
K
C
D
M
D
Site 114
T900
V
H
K
E
K
R
R
T
K
S
L
L
E
E
K
Site 115
S902
K
E
K
R
R
T
K
S
L
L
E
E
K
L
V
Site 116
S912
E
E
K
L
V
L
K
S
K
S
K
T
Q
G
K
Site 117
S914
K
L
V
L
K
S
K
S
K
T
Q
G
K
Q
V
Site 118
T916
V
L
K
S
K
S
K
T
Q
G
K
Q
V
K
V
Site 119
T938
G
A
T
K
Q
A
T
T
P
K
P
D
K
E
K
Site 120
S952
K
N
T
E
E
N
D
S
E
K
Q
R
K
S
K
Site 121
S958
D
S
E
K
Q
R
K
S
K
V
E
D
K
P
F
Site 122
T976
G
V
E
P
V
L
E
T
A
S
S
S
A
H
S
Site 123
S978
E
P
V
L
E
T
A
S
S
S
A
H
S
T
Q
Site 124
S979
P
V
L
E
T
A
S
S
S
A
H
S
T
Q
K
Site 125
S983
T
A
S
S
S
A
H
S
T
Q
K
D
S
S
H
Site 126
T984
A
S
S
S
A
H
S
T
Q
K
D
S
S
H
R
Site 127
S989
H
S
T
Q
K
D
S
S
H
R
A
K
L
P
L
Site 128
Y1001
L
P
L
A
K
E
K
Y
K
S
D
K
D
S
T
Site 129
S1003
L
A
K
E
K
Y
K
S
D
K
D
S
T
S
T
Site 130
S1007
K
Y
K
S
D
K
D
S
T
S
T
R
L
E
R
Site 131
S1009
K
S
D
K
D
S
T
S
T
R
L
E
R
K
L
Site 132
S1017
T
R
L
E
R
K
L
S
D
G
H
K
S
R
S
Site 133
S1022
K
L
S
D
G
H
K
S
R
S
L
K
H
S
S
Site 134
S1024
S
D
G
H
K
S
R
S
L
K
H
S
S
K
D
Site 135
S1028
K
S
R
S
L
K
H
S
S
K
D
I
K
K
K
Site 136
S1040
K
K
K
D
E
N
K
S
D
D
K
D
G
K
E
Site 137
S1051
D
G
K
E
V
D
S
S
H
E
K
A
R
G
N
Site 138
S1059
H
E
K
A
R
G
N
S
S
L
M
E
K
K
L
Site 139
S1060
E
K
A
R
G
N
S
S
L
M
E
K
K
L
S
Site 140
S1067
S
L
M
E
K
K
L
S
R
R
L
C
E
N
R
Site 141
S1077
L
C
E
N
R
R
G
S
L
S
Q
E
M
A
K
Site 142
S1079
E
N
R
R
G
S
L
S
Q
E
M
A
K
G
E
Site 143
T1093
E
E
K
L
A
A
N
T
L
S
T
P
S
G
S
Site 144
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Site 249
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E
M
G
D
Site 296
T2290
P
A
E
E
M
G
D
T
A
M
I
S
T
S
T
Site 297
S2294
M
G
D
T
A
M
I
S
T
S
T
S
E
G
C
Site 298
S2296
D
T
A
M
I
S
T
S
T
S
E
G
C
E
A
Site 299
T2317
L
Q
D
E
D
R
L
T
I
T
R
V
E
D
L
Site 300
S2341
T
A
E
C
M
P
I
S
A
S
I
D
R
H
E
Site 301
S2343
E
C
M
P
I
S
A
S
I
D
R
H
E
E
N
Site 302
T2353
R
H
E
E
N
Q
L
T
A
D
N
P
E
G
N
Site 303
S2364
P
E
G
N
G
D
L
S
A
T
E
V
S
K
H
Site 304
S2403
P
G
P
V
L
A
V
S
T
E
E
G
H
N
G
Site 305
S2412
E
E
G
H
N
G
P
S
V
H
K
P
S
A
G
Site 306
S2417
G
P
S
V
H
K
P
S
A
G
Q
G
H
P
S
Site 307
S2452
A
G
R
G
Q
K
E
S
T
L
H
L
I
N
A
Site 308
S2468
E
K
N
V
L
L
N
S
L
Q
K
E
D
K
S
Site 309
S2475
S
L
Q
K
E
D
K
S
P
E
T
G
T
A
G
Site 310
T2478
K
E
D
K
S
P
E
T
G
T
A
G
G
S
S
Site 311
T2480
D
K
S
P
E
T
G
T
A
G
G
S
S
T
A
Site 312
S2484
E
T
G
T
A
G
G
S
S
T
A
S
Y
S
A
Site 313
S2485
T
G
T
A
G
G
S
S
T
A
S
Y
S
A
G
Site 314
T2486
G
T
A
G
G
S
S
T
A
S
Y
S
A
G
R
Site 315
S2488
A
G
G
S
S
T
A
S
Y
S
A
G
R
G
L
Site 316
Y2489
G
G
S
S
T
A
S
Y
S
A
G
R
G
L
E
Site 317
S2490
G
S
S
T
A
S
Y
S
A
G
R
G
L
E
G
Site 318
S2501
G
L
E
G
N
A
N
S
P
A
H
L
R
G
P
Site 319
S2520
G
Q
T
A
K
D
P
S
V
S
I
R
Y
L
A
Site 320
T2531
R
Y
L
A
A
V
N
T
G
A
I
K
A
D
D
Site 321
T2545
D
M
P
P
V
Q
G
T
V
A
E
H
S
F
L
Site 322
S2550
Q
G
T
V
A
E
H
S
F
L
P
A
E
Q
Q
Site 323
T2568
D
N
L
K
T
S
T
T
K
C
I
T
G
Q
E
Site 324
S2581
Q
E
S
K
I
A
P
S
H
T
M
I
P
P
A
Site 325
T2583
S
K
I
A
P
S
H
T
M
I
P
P
A
T
Y
Site 326
T2604
P
K
C
E
Q
D
L
T
I
K
N
D
Y
S
G
Site 327
Y2609
D
L
T
I
K
N
D
Y
S
G
K
W
T
D
Q
Site 328
T2614
N
D
Y
S
G
K
W
T
D
Q
A
S
A
E
K
Site 329
S2618
G
K
W
T
D
Q
A
S
A
E
K
T
G
D
D
Site 330
T2622
D
Q
A
S
A
E
K
T
G
D
D
N
S
T
R
Site 331
S2627
E
K
T
G
D
D
N
S
T
R
K
S
F
P
E
Site 332
T2628
K
T
G
D
D
N
S
T
R
K
S
F
P
E
E
Site 333
S2631
D
D
N
S
T
R
K
S
F
P
E
E
G
D
I
Site 334
T2641
E
E
G
D
I
M
V
T
V
S
S
E
E
N
V
Site 335
S2643
G
D
I
M
V
T
V
S
S
E
E
N
V
C
D
Site 336
S2656
C
D
I
G
N
E
E
S
P
L
N
V
L
G
G
Site 337
Y2675
A
N
L
K
M
E
A
Y
V
P
S
E
E
E
K
Site 338
S2692
E
I
L
A
P
P
E
S
L
C
G
G
K
P
S
Site 339
S2699
S
L
C
G
G
K
P
S
G
I
A
E
L
Q
R
Site 340
S2714
E
P
L
L
V
N
E
S
L
N
V
E
N
S
G
Site 341
S2720
E
S
L
N
V
E
N
S
G
F
R
T
N
E
E
Site 342
T2724
V
E
N
S
G
F
R
T
N
E
E
I
H
S
E
Site 343
S2730
R
T
N
E
E
I
H
S
E
S
Y
N
K
G
E
Site 344
S2732
N
E
E
I
H
S
E
S
Y
N
K
G
E
I
S
Site 345
S2739
S
Y
N
K
G
E
I
S
S
G
R
K
D
N
A
Site 346
S2740
Y
N
K
G
E
I
S
S
G
R
K
D
N
A
E
Site 347
Y2777
K
R
K
R
K
Q
H
Y
L
S
S
E
D
E
P
Site 348
S2779
K
R
K
Q
H
Y
L
S
S
E
D
E
P
D
D
Site 349
S2780
R
K
Q
H
Y
L
S
S
E
D
E
P
D
D
N
Site 350
S2793
D
N
P
D
V
L
D
S
R
I
E
T
A
Q
R
Site 351
T2797
V
L
D
S
R
I
E
T
A
Q
R
Q
C
P
E
Site 352
T2805
A
Q
R
Q
C
P
E
T
E
P
H
D
T
K
E
Site 353
T2810
P
E
T
E
P
H
D
T
K
E
E
N
S
R
D
Site 354
T2824
D
L
E
E
L
P
K
T
S
S
E
T
N
S
T
Site 355
S2826
E
E
L
P
K
T
S
S
E
T
N
S
T
T
S
Site 356
S2830
K
T
S
S
E
T
N
S
T
T
S
R
V
M
E
Site 357
T2831
T
S
S
E
T
N
S
T
T
S
R
V
M
E
E
Site 358
T2832
S
S
E
T
N
S
T
T
S
R
V
M
E
E
K
Site 359
Y2842
V
M
E
E
K
D
E
Y
S
S
S
E
T
T
G
Site 360
S2843
M
E
E
K
D
E
Y
S
S
S
E
T
T
G
E
Site 361
S2845
E
K
D
E
Y
S
S
S
E
T
T
G
E
K
P
Site 362
T2847
D
E
Y
S
S
S
E
T
T
G
E
K
P
E
Q
Site 363
T2859
P
E
Q
N
D
D
D
T
I
K
S
Q
E
E
D
Site 364
S2862
N
D
D
D
T
I
K
S
Q
E
E
D
Q
P
I
Site 365
Y2881
K
R
G
R
P
R
K
Y
P
V
E
T
T
L
K
Site 366
S2893
T
L
K
M
K
D
D
S
K
T
D
T
G
I
V
Site 367
T2895
K
M
K
D
D
S
K
T
D
T
G
I
V
T
V
Site 368
T2897
K
D
D
S
K
T
D
T
G
I
V
T
V
E
Q
Site 369
T2901
K
T
D
T
G
I
V
T
V
E
Q
S
P
S
S
Site 370
S2905
G
I
V
T
V
E
Q
S
P
S
S
S
K
L
K
Site 371
S2907
V
T
V
E
Q
S
P
S
S
S
K
L
K
V
M
Site 372
S2909
V
E
Q
S
P
S
S
S
K
L
K
V
M
Q
T
Site 373
T2916
S
K
L
K
V
M
Q
T
D
E
S
N
K
E
T
Site 374
S2932
N
L
Q
E
R
S
I
S
N
D
D
G
E
E
K
Site 375
T2942
D
G
E
E
K
I
V
T
S
V
R
R
R
G
R
Site 376
S2943
G
E
E
K
I
V
T
S
V
R
R
R
G
R
K
Site 377
S2954
R
G
R
K
P
K
R
S
L
T
V
S
D
D
A
Site 378
T2956
R
K
P
K
R
S
L
T
V
S
D
D
A
E
S
Site 379
S2958
P
K
R
S
L
T
V
S
D
D
A
E
S
S
E
Site 380
S2964
V
S
D
D
A
E
S
S
E
P
E
R
K
R
Q
Site 381
S2973
P
E
R
K
R
Q
K
S
V
S
D
P
V
E
D
Site 382
S2975
R
K
R
Q
K
S
V
S
D
P
V
E
D
K
K
Site 383
S2986
E
D
K
K
E
Q
E
S
D
E
E
E
E
E
E
Site 384
S2999
E
E
E
E
D
E
P
S
G
A
T
T
R
S
T
Site 385
T3003
D
E
P
S
G
A
T
T
R
S
T
T
R
S
E
Site 386
S3005
P
S
G
A
T
T
R
S
T
T
R
S
E
A
Q
Site 387
T3006
S
G
A
T
T
R
S
T
T
R
S
E
A
Q
R
Site 388
T3007
G
A
T
T
R
S
T
T
R
S
E
A
Q
R
S
Site 389
S3009
T
T
R
S
T
T
R
S
E
A
Q
R
S
K
T
Site 390
S3014
T
R
S
E
A
Q
R
S
K
T
Q
L
S
P
S
Site 391
T3016
S
E
A
Q
R
S
K
T
Q
L
S
P
S
I
K
Site 392
S3019
Q
R
S
K
T
Q
L
S
P
S
I
K
R
K
R
Site 393
S3021
S
K
T
Q
L
S
P
S
I
K
R
K
R
E
V
Site 394
S3029
I
K
R
K
R
E
V
S
P
P
G
A
R
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation