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Updated November 2019
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Protein Info
Short Name:
ARID1B
Full Name:
AT-rich interactive domain-containing protein 1B
Alias:
ARI1B; ARID domain- containing protein 1B; ARID domain-containing protein 1B; AT rich interactive domain 1B (SWI1-like); BRG1-associated factor 250b; BRG1-binding protein ELD/OSA1; BRG1-binding protein hELD/OSA1; DAN15; Eld (eyelid)/Osa protein; ELD/OSA1; HOsa2; Osa homologue 2; OSA2; P250R
Type:
DNA binding protein; Nuclear receptor co-regulator
Mass (Da):
236123
Number AA:
2236
UniProt ID:
Q8NFD5
International Prot ID:
IPI00643722
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003712
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006325
GO:0006338
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
A
A
A
A
G
T
H
S
A
K
S
G
G
S
E
Site 2
S18
A
G
T
H
S
A
K
S
G
G
S
E
A
A
L
Site 3
S35
G
G
S
A
A
A
L
S
S
S
S
S
S
S
A
Site 4
S36
G
S
A
A
A
L
S
S
S
S
S
S
S
A
A
Site 5
S48
S
A
A
A
A
A
A
S
S
S
S
S
S
G
P
Site 6
S49
A
A
A
A
A
A
S
S
S
S
S
S
G
P
G
Site 7
S50
A
A
A
A
A
S
S
S
S
S
S
G
P
G
S
Site 8
S51
A
A
A
A
S
S
S
S
S
S
G
P
G
S
A
Site 9
S52
A
A
A
S
S
S
S
S
S
G
P
G
S
A
M
Site 10
S53
A
A
S
S
S
S
S
S
G
P
G
S
A
M
E
Site 11
S57
S
S
S
S
G
P
G
S
A
M
E
T
G
L
L
Site 12
T61
G
P
G
S
A
M
E
T
G
L
L
P
N
H
K
Site 13
T71
L
P
N
H
K
L
K
T
V
G
E
A
P
A
A
Site 14
S135
Q
Q
Q
Q
H
P
I
S
N
N
N
S
L
G
G
Site 15
S139
H
P
I
S
N
N
N
S
L
G
G
A
G
G
G
Site 16
S165
Q
H
G
G
A
K
D
S
A
A
G
G
Q
A
D
Site 17
S180
P
P
G
P
P
L
L
S
K
P
G
D
E
D
D
Site 18
Y200
G
E
P
A
G
G
R
Y
E
H
P
G
L
G
A
Site 19
Y233
A
V
P
E
F
N
N
Y
Y
G
S
A
A
P
A
Site 20
Y234
V
P
E
F
N
N
Y
Y
G
S
A
A
P
A
S
Site 21
S236
E
F
N
N
Y
Y
G
S
A
A
P
A
S
G
G
Site 22
S241
Y
G
S
A
A
P
A
S
G
G
P
G
G
R
A
Site 23
S279
A
A
A
G
A
P
G
S
M
D
P
L
Q
N
S
Site 24
S286
S
M
D
P
L
Q
N
S
H
E
G
Y
P
N
S
Site 25
Y290
L
Q
N
S
H
E
G
Y
P
N
S
Q
C
N
H
Site 26
Y298
P
N
S
Q
C
N
H
Y
P
G
Y
S
R
P
G
Site 27
Y301
Q
C
N
H
Y
P
G
Y
S
R
P
G
A
G
G
Site 28
S302
C
N
H
Y
P
G
Y
S
R
P
G
A
G
G
G
Site 29
S320
G
G
G
G
G
G
G
S
G
G
G
G
G
G
G
Site 30
Y358
G
G
G
G
G
G
G
Y
G
G
S
S
A
G
Y
Site 31
S362
G
G
G
Y
G
G
S
S
A
G
Y
G
V
L
S
Site 32
Y365
Y
G
G
S
S
A
G
Y
G
V
L
S
S
P
R
Site 33
S369
S
A
G
Y
G
V
L
S
S
P
R
Q
Q
G
G
Site 34
S370
A
G
Y
G
V
L
S
S
P
R
Q
Q
G
G
G
Site 35
T416
N
Q
H
P
S
G
A
T
P
T
L
N
Q
L
L
Site 36
T424
P
T
L
N
Q
L
L
T
S
P
S
P
M
M
R
Site 37
S425
T
L
N
Q
L
L
T
S
P
S
P
M
M
R
S
Site 38
S427
N
Q
L
L
T
S
P
S
P
M
M
R
S
Y
G
Site 39
S432
S
P
S
P
M
M
R
S
Y
G
G
S
Y
P
E
Site 40
Y433
P
S
P
M
M
R
S
Y
G
G
S
Y
P
E
Y
Site 41
S436
M
M
R
S
Y
G
G
S
Y
P
E
Y
S
S
P
Site 42
Y437
M
R
S
Y
G
G
S
Y
P
E
Y
S
S
P
S
Site 43
Y440
Y
G
G
S
Y
P
E
Y
S
S
P
S
A
P
P
Site 44
S441
G
G
S
Y
P
E
Y
S
S
P
S
A
P
P
P
Site 45
S442
G
S
Y
P
E
Y
S
S
P
S
A
P
P
P
P
Site 46
S444
Y
P
E
Y
S
S
P
S
A
P
P
P
P
P
S
Site 47
S451
S
A
P
P
P
P
P
S
Q
P
Q
S
Q
A
A
Site 48
S455
P
P
P
S
Q
P
Q
S
Q
A
A
A
A
G
A
Site 49
Y483
G
K
D
M
G
A
Q
Y
A
A
A
S
P
A
W
Site 50
S487
G
A
Q
Y
A
A
A
S
P
A
W
A
A
A
Q
Site 51
S502
Q
R
S
H
P
A
M
S
P
G
T
P
G
P
T
Site 52
T505
H
P
A
M
S
P
G
T
P
G
P
T
M
G
R
Site 53
T509
S
P
G
T
P
G
P
T
M
G
R
S
Q
G
S
Site 54
S513
P
G
P
T
M
G
R
S
Q
G
S
P
M
D
P
Site 55
S516
T
M
G
R
S
Q
G
S
P
M
D
P
M
V
M
Site 56
Y529
V
M
K
R
P
Q
L
Y
G
M
G
S
N
P
H
Site 57
S533
P
Q
L
Y
G
M
G
S
N
P
H
S
Q
P
Q
Site 58
S537
G
M
G
S
N
P
H
S
Q
P
Q
Q
S
S
P
Site 59
S542
P
H
S
Q
P
Q
Q
S
S
P
Y
P
G
G
S
Site 60
S543
H
S
Q
P
Q
Q
S
S
P
Y
P
G
G
S
Y
Site 61
Y545
Q
P
Q
Q
S
S
P
Y
P
G
G
S
Y
G
P
Site 62
S549
S
S
P
Y
P
G
G
S
Y
G
P
P
G
P
Q
Site 63
Y550
S
P
Y
P
G
G
S
Y
G
P
P
G
P
Q
R
Site 64
Y558
G
P
P
G
P
Q
R
Y
P
I
G
I
Q
G
R
Site 65
Y575
G
A
M
A
G
M
Q
Y
P
Q
Q
Q
M
P
P
Site 66
Y584
Q
Q
Q
M
P
P
Q
Y
G
Q
Q
G
V
S
G
Site 67
S590
Q
Y
G
Q
Q
G
V
S
G
Y
C
Q
Q
G
Q
Site 68
Y600
C
Q
Q
G
Q
Q
P
Y
Y
S
Q
Q
P
Q
P
Site 69
Y601
Q
Q
G
Q
Q
P
Y
Y
S
Q
Q
P
Q
P
P
Site 70
S602
Q
G
Q
Q
P
Y
Y
S
Q
Q
P
Q
P
P
H
Site 71
Y616
H
L
P
P
Q
A
Q
Y
L
P
S
Q
S
Q
Q
Site 72
S619
P
Q
A
Q
Y
L
P
S
Q
S
Q
Q
R
Y
Q
Site 73
S621
A
Q
Y
L
P
S
Q
S
Q
Q
R
Y
Q
P
Q
Site 74
Y625
P
S
Q
S
Q
Q
R
Y
Q
P
Q
Q
D
M
S
Site 75
S632
Y
Q
P
Q
Q
D
M
S
Q
E
G
Y
G
T
R
Site 76
Y636
Q
D
M
S
Q
E
G
Y
G
T
R
S
Q
P
P
Site 77
T638
M
S
Q
E
G
Y
G
T
R
S
Q
P
P
L
A
Site 78
S640
Q
E
G
Y
G
T
R
S
Q
P
P
L
A
P
G
Site 79
S663
L
I
Q
Q
E
R
P
S
S
L
P
D
L
S
G
Site 80
S664
I
Q
Q
E
R
P
S
S
L
P
D
L
S
G
S
Site 81
S669
P
S
S
L
P
D
L
S
G
S
I
D
D
L
P
Site 82
S671
S
L
P
D
L
S
G
S
I
D
D
L
P
T
G
Site 83
S685
G
T
E
A
T
L
S
S
A
V
S
A
S
G
S
Site 84
S688
A
T
L
S
S
A
V
S
A
S
G
S
T
S
S
Site 85
S690
L
S
S
A
V
S
A
S
G
S
T
S
S
Q
G
Site 86
S692
S
A
V
S
A
S
G
S
T
S
S
Q
G
D
Q
Site 87
S694
V
S
A
S
G
S
T
S
S
Q
G
D
Q
S
N
Site 88
S695
S
A
S
G
S
T
S
S
Q
G
D
Q
S
N
P
Site 89
S700
T
S
S
Q
G
D
Q
S
N
P
A
Q
S
P
F
Site 90
S705
D
Q
S
N
P
A
Q
S
P
F
S
P
H
A
S
Site 91
S708
N
P
A
Q
S
P
F
S
P
H
A
S
P
H
L
Site 92
S712
S
P
F
S
P
H
A
S
P
H
L
S
S
I
P
Site 93
S716
P
H
A
S
P
H
L
S
S
I
P
G
G
P
S
Site 94
S717
H
A
S
P
H
L
S
S
I
P
G
G
P
S
P
Site 95
S723
S
S
I
P
G
G
P
S
P
S
P
V
G
S
P
Site 96
S725
I
P
G
G
P
S
P
S
P
V
G
S
P
V
G
Site 97
S729
P
S
P
S
P
V
G
S
P
V
G
S
N
Q
S
Site 98
S733
P
V
G
S
P
V
G
S
N
Q
S
R
S
G
P
Site 99
S736
S
P
V
G
S
N
Q
S
R
S
G
P
I
S
P
Site 100
S738
V
G
S
N
Q
S
R
S
G
P
I
S
P
A
S
Site 101
S742
Q
S
R
S
G
P
I
S
P
A
S
I
P
G
S
Site 102
S745
S
G
P
I
S
P
A
S
I
P
G
S
Q
M
P
Site 103
S749
S
P
A
S
I
P
G
S
Q
M
P
P
Q
P
P
Site 104
S758
M
P
P
Q
P
P
G
S
Q
S
E
S
S
S
H
Site 105
S760
P
Q
P
P
G
S
Q
S
E
S
S
S
H
P
A
Site 106
S762
P
P
G
S
Q
S
E
S
S
S
H
P
A
L
S
Site 107
S763
P
G
S
Q
S
E
S
S
S
H
P
A
L
S
Q
Site 108
S764
G
S
Q
S
E
S
S
S
H
P
A
L
S
Q
S
Site 109
S769
S
S
S
H
P
A
L
S
Q
S
P
M
P
Q
E
Site 110
S771
S
H
P
A
L
S
Q
S
P
M
P
Q
E
R
G
Site 111
T783
E
R
G
F
M
A
G
T
Q
R
N
P
Q
M
A
Site 112
Y792
R
N
P
Q
M
A
Q
Y
G
P
Q
Q
T
G
P
Site 113
S800
G
P
Q
Q
T
G
P
S
M
S
P
H
P
S
P
Site 114
S802
Q
Q
T
G
P
S
M
S
P
H
P
S
P
G
G
Site 115
S806
P
S
M
S
P
H
P
S
P
G
G
Q
M
H
A
Site 116
S816
G
Q
M
H
A
G
I
S
S
F
Q
Q
S
N
S
Site 117
S817
Q
M
H
A
G
I
S
S
F
Q
Q
S
N
S
S
Site 118
S821
G
I
S
S
F
Q
Q
S
N
S
S
G
T
Y
G
Site 119
S823
S
S
F
Q
Q
S
N
S
S
G
T
Y
G
P
Q
Site 120
Y827
Q
S
N
S
S
G
T
Y
G
P
Q
M
S
Q
Y
Site 121
S832
G
T
Y
G
P
Q
M
S
Q
Y
G
P
Q
G
N
Site 122
Y834
Y
G
P
Q
M
S
Q
Y
G
P
Q
G
N
Y
S
Site 123
Y840
Q
Y
G
P
Q
G
N
Y
S
R
P
P
A
Y
S
Site 124
S841
Y
G
P
Q
G
N
Y
S
R
P
P
A
Y
S
G
Site 125
S847
Y
S
R
P
P
A
Y
S
G
V
P
S
A
S
Y
Site 126
S851
P
A
Y
S
G
V
P
S
A
S
Y
S
G
P
G
Site 127
S853
Y
S
G
V
P
S
A
S
Y
S
G
P
G
P
G
Site 128
Y854
S
G
V
P
S
A
S
Y
S
G
P
G
P
G
M
Site 129
S855
G
V
P
S
A
S
Y
S
G
P
G
P
G
M
G
Site 130
S888
V
P
L
G
R
M
P
S
A
G
M
Q
N
R
P
Site 131
S901
R
P
F
P
G
N
M
S
S
M
T
P
S
S
P
Site 132
S902
P
F
P
G
N
M
S
S
M
T
P
S
S
P
G
Site 133
T904
P
G
N
M
S
S
M
T
P
S
S
P
G
M
S
Site 134
S906
N
M
S
S
M
T
P
S
S
P
G
M
S
Q
Q
Site 135
S907
M
S
S
M
T
P
S
S
P
G
M
S
Q
Q
G
Site 136
S911
T
P
S
S
P
G
M
S
Q
Q
G
G
P
G
M
Site 137
T924
G
M
G
P
P
M
P
T
V
N
R
K
A
Q
E
Site 138
S950
S
A
Q
S
R
Q
G
S
F
P
G
M
N
Q
S
Site 139
S957
S
F
P
G
M
N
Q
S
G
L
M
A
S
S
S
Site 140
S962
N
Q
S
G
L
M
A
S
S
S
P
Y
S
Q
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P
P
F
S
R
Q
E
Site 293
S2093
I
L
A
T
P
P
F
S
R
Q
E
K
F
Y
A
Site 294
Y2099
F
S
R
Q
E
K
F
Y
A
T
L
V
R
Y
V
Site 295
T2101
R
Q
E
K
F
Y
A
T
L
V
R
Y
V
G
D
Site 296
Y2105
F
Y
A
T
L
V
R
Y
V
G
D
R
K
N
P
Site 297
T2155
S
F
L
E
D
G
V
T
M
A
Q
Y
Q
Q
S
Site 298
Y2159
D
G
V
T
M
A
Q
Y
Q
Q
S
Q
H
N
L
Site 299
S2178
P
P
P
L
E
P
P
S
V
D
M
M
C
R
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation