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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLCN
Full Name:
Folliculin
Alias:
BHD; BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; Folliculin: Birt-Hogg-Dube syndrome protein: BHD skin lesion fibrofolliculoma protein: Folliculin: Birt-Hogg-Dube syndrome protein: BHD skin lesion fibrofolliculoma protein: Folliculin: Birt-Hogg-Dube syndrome protein: BHD skin lesion fibrofolliculoma protein; MGC17998; MGC23445
Type:
Mass (Da):
64473
Number AA:
579
UniProt ID:
Q8NFG4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
Q
G
D
G
N
E
D
S
P
G
Q
G
E
Q
A
Site 2
S56
E
G
G
I
Q
M
N
S
R
M
R
A
H
S
P
Site 3
S62
N
S
R
M
R
A
H
S
P
A
E
G
A
S
V
Site 4
S68
H
S
P
A
E
G
A
S
V
E
S
S
S
P
G
Site 5
S72
E
G
A
S
V
E
S
S
S
P
G
P
K
K
S
Site 6
S73
G
A
S
V
E
S
S
S
P
G
P
K
K
S
D
Site 7
S79
S
S
P
G
P
K
K
S
D
M
C
E
G
C
R
Site 8
S87
D
M
C
E
G
C
R
S
L
A
A
G
H
P
G
Site 9
Y95
L
A
A
G
H
P
G
Y
I
S
H
D
K
E
T
Site 10
S97
A
G
H
P
G
Y
I
S
H
D
K
E
T
S
I
Site 11
Y106
D
K
E
T
S
I
K
Y
V
S
H
Q
H
P
S
Site 12
S113
Y
V
S
H
Q
H
P
S
H
P
Q
L
F
S
I
Site 13
S130
Q
A
C
V
R
S
L
S
C
E
V
C
P
G
R
Site 14
S161
H
T
F
F
I
K
D
S
L
A
R
G
F
Q
R
Site 15
T224
Q
R
A
Q
R
M
N
T
A
F
T
P
F
L
H
Site 16
T227
Q
R
M
N
T
A
F
T
P
F
L
H
Q
R
N
Site 17
S240
R
N
G
N
A
A
R
S
L
T
S
L
T
S
D
Site 18
T242
G
N
A
A
R
S
L
T
S
L
T
S
D
D
N
Site 19
S246
R
S
L
T
S
L
T
S
D
D
N
L
W
A
C
Site 20
T270
K
A
C
G
S
R
L
T
E
K
L
L
E
G
A
Site 21
T279
K
L
L
E
G
A
P
T
E
D
T
L
V
Q
M
Site 22
T282
E
G
A
P
T
E
D
T
L
V
Q
M
E
K
L
Site 23
S298
D
L
E
E
E
S
E
S
W
D
N
S
E
A
E
Site 24
S302
E
S
E
S
W
D
N
S
E
A
E
E
E
E
K
Site 25
S316
K
A
P
V
L
P
E
S
T
E
G
R
E
L
T
Site 26
T323
S
T
E
G
R
E
L
T
Q
G
P
A
E
S
S
Site 27
S329
L
T
Q
G
P
A
E
S
S
S
L
S
G
C
G
Site 28
S331
Q
G
P
A
E
S
S
S
L
S
G
C
G
S
W
Site 29
S333
P
A
E
S
S
S
L
S
G
C
G
S
W
Q
P
Site 30
S337
S
S
L
S
G
C
G
S
W
Q
P
R
K
L
P
Site 31
S348
R
K
L
P
V
F
K
S
L
R
H
M
R
Q
V
Site 32
S360
R
Q
V
L
G
A
P
S
F
R
M
L
A
W
H
Site 33
T393
S
A
F
E
V
L
R
T
M
L
P
V
G
C
V
Site 34
S407
V
R
I
I
P
Y
S
S
Q
Y
E
E
A
Y
R
Site 35
Y409
I
I
P
Y
S
S
Q
Y
E
E
A
Y
R
C
N
Site 36
Y413
S
S
Q
Y
E
E
A
Y
R
C
N
F
L
G
L
Site 37
S421
R
C
N
F
L
G
L
S
P
H
V
Q
I
P
P
Site 38
S459
V
G
C
E
D
D
Q
S
L
S
K
Y
E
F
V
Site 39
S461
C
E
D
D
Q
S
L
S
K
Y
E
F
V
V
T
Site 40
Y463
D
D
Q
S
L
S
K
Y
E
F
V
V
T
S
G
Site 41
T491
N
K
I
E
A
A
L
T
N
Q
N
L
S
V
D
Site 42
S526
F
K
F
T
K
V
D
S
R
P
K
E
D
T
Q
Site 43
T532
D
S
R
P
K
E
D
T
Q
K
L
L
S
I
L
Site 44
S537
E
D
T
Q
K
L
L
S
I
L
G
A
S
E
E
Site 45
S542
L
L
S
I
L
G
A
S
E
E
D
N
V
K
L
Site 46
S558
K
F
W
M
T
G
L
S
K
T
Y
K
S
H
L
Site 47
T560
W
M
T
G
L
S
K
T
Y
K
S
H
L
M
S
Site 48
S563
G
L
S
K
T
Y
K
S
H
L
M
S
T
V
R
Site 49
S567
T
Y
K
S
H
L
M
S
T
V
R
S
P
T
A
Site 50
T568
Y
K
S
H
L
M
S
T
V
R
S
P
T
A
S
Site 51
S571
H
L
M
S
T
V
R
S
P
T
A
S
E
S
R
Site 52
T573
M
S
T
V
R
S
P
T
A
S
E
S
R
N
_
Site 53
S575
T
V
R
S
P
T
A
S
E
S
R
N
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation