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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADCY4
Full Name:
Adenylate cyclase type 4
Alias:
Adenylate cyclase, type IV; Adenylyl cyclase 4; ATP pyrophosphate-lyase 4; EC 4.6.1.1
Type:
Intracellular, Membrane, Dendrite, Integral membrane protein
Mass (Da):
119794
Number AA:
1077
UniProt ID:
Q8NFM4
International Prot ID:
IPI00465156
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004016
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007189
GO:0034199
GO:0006171
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
R
L
F
S
P
R
P
P
P
S
E
Site 2
S12
F
S
P
R
P
P
P
S
E
D
L
F
Y
E
T
Site 3
Y17
P
P
S
E
D
L
F
Y
E
T
Y
Y
S
L
S
Site 4
T19
S
E
D
L
F
Y
E
T
Y
Y
S
L
S
Q
Q
Site 5
Y20
E
D
L
F
Y
E
T
Y
Y
S
L
S
Q
Q
Y
Site 6
S22
L
F
Y
E
T
Y
Y
S
L
S
Q
Q
Y
P
L
Site 7
S24
Y
E
T
Y
Y
S
L
S
Q
Q
Y
P
L
L
L
Site 8
T56
W
A
S
G
R
E
L
T
S
D
P
S
F
L
T
Site 9
S57
A
S
G
R
E
L
T
S
D
P
S
F
L
T
T
Site 10
S80
S
L
L
L
G
L
A
S
R
E
Q
R
L
Q
R
Site 11
T89
E
Q
R
L
Q
R
W
T
R
P
L
S
G
L
V
Site 12
S166
Y
L
G
P
Q
P
D
S
R
P
A
L
L
P
Q
Site 13
Y190
C
G
N
V
A
G
V
Y
H
K
A
L
M
E
R
Site 14
T202
M
E
R
A
L
R
A
T
F
R
E
A
L
S
S
Site 15
S209
T
F
R
E
A
L
S
S
L
H
S
R
R
R
L
Site 16
S212
E
A
L
S
S
L
H
S
R
R
R
L
D
T
E
Site 17
T218
H
S
R
R
R
L
D
T
E
K
K
H
Q
E
H
Site 18
S253
R
L
Q
A
G
Q
G
S
R
P
E
S
T
N
N
Site 19
S257
G
Q
G
S
R
P
E
S
T
N
N
F
H
S
L
Site 20
T258
Q
G
S
R
P
E
S
T
N
N
F
H
S
L
Y
Site 21
S263
E
S
T
N
N
F
H
S
L
Y
V
K
R
H
Q
Site 22
Y265
T
N
N
F
H
S
L
Y
V
K
R
H
Q
G
V
Site 23
S287
V
G
F
T
R
L
A
S
E
C
S
P
K
E
L
Site 24
T359
I
R
K
L
R
A
A
T
G
V
D
I
N
M
R
Site 25
Y435
G
M
E
H
R
D
P
Y
L
R
E
L
G
E
P
Site 26
Y444
R
E
L
G
E
P
T
Y
L
V
I
D
P
R
A
Site 27
T459
E
E
E
D
E
K
G
T
A
G
G
L
L
S
S
Site 28
S475
E
G
L
K
M
R
P
S
L
L
M
T
R
Y
L
Site 29
T479
M
R
P
S
L
L
M
T
R
Y
L
E
S
W
G
Site 30
S495
A
K
P
F
A
H
L
S
H
G
D
S
P
V
S
Site 31
S499
A
H
L
S
H
G
D
S
P
V
S
T
S
T
P
Site 32
S502
S
H
G
D
S
P
V
S
T
S
T
P
L
P
E
Site 33
T503
H
G
D
S
P
V
S
T
S
T
P
L
P
E
K
Site 34
T505
D
S
P
V
S
T
S
T
P
L
P
E
K
T
L
Site 35
T511
S
T
P
L
P
E
K
T
L
A
S
F
S
T
Q
Site 36
S514
L
P
E
K
T
L
A
S
F
S
T
Q
W
S
L
Site 37
S516
E
K
T
L
A
S
F
S
T
Q
W
S
L
D
R
Site 38
S520
A
S
F
S
T
Q
W
S
L
D
R
S
R
T
P
Site 39
S524
T
Q
W
S
L
D
R
S
R
T
P
R
G
L
D
Site 40
T526
W
S
L
D
R
S
R
T
P
R
G
L
D
D
E
Site 41
T536
G
L
D
D
E
L
D
T
G
D
A
K
F
F
Q
Site 42
S550
Q
V
I
E
Q
L
N
S
Q
K
Q
W
K
Q
S
Site 43
T564
S
K
D
F
N
P
L
T
L
Y
F
R
E
K
E
Site 44
Y566
D
F
N
P
L
T
L
Y
F
R
E
K
E
M
E
Site 45
S579
M
E
K
E
Y
R
L
S
A
I
P
A
F
K
Y
Site 46
S780
L
Y
L
G
P
L
D
S
R
P
G
V
L
K
E
Site 47
Y812
V
L
A
R
Q
N
E
Y
Y
C
R
L
D
F
L
Site 48
Y813
L
A
R
Q
N
E
Y
Y
C
R
L
D
F
L
W
Site 49
T831
L
R
Q
E
R
E
E
T
E
T
M
E
N
L
T
Site 50
T833
Q
E
R
E
E
T
E
T
M
E
N
L
T
R
L
Site 51
Y865
N
R
R
N
E
D
L
Y
H
Q
S
Y
E
C
V
Site 52
S887
P
D
F
K
E
F
Y
S
E
S
N
I
N
H
E
Site 53
S914
A
D
F
D
E
L
L
S
K
P
K
F
S
G
V
Site 54
T926
S
G
V
E
K
I
K
T
I
G
S
T
Y
M
A
Site 55
S954
Q
D
A
E
R
S
C
S
H
L
G
T
M
V
E
Site 56
S977
L
D
V
I
N
K
H
S
F
N
N
F
R
L
R
Site 57
Y1004
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
Site 58
S1019
N
V
A
S
R
M
E
S
T
G
V
L
G
K
I
Site 59
Y1041
W
A
L
Q
S
L
G
Y
T
C
Y
S
R
G
V
Site 60
Y1044
Q
S
L
G
Y
T
C
Y
S
R
G
V
I
K
V
Site 61
Y1060
G
K
G
Q
L
C
T
Y
F
L
N
T
D
L
T
Site 62
T1067
Y
F
L
N
T
D
L
T
R
T
G
P
P
S
A
Site 63
T1069
L
N
T
D
L
T
R
T
G
P
P
S
A
T
L
Site 64
S1073
L
T
R
T
G
P
P
S
A
T
L
G
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation