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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STEAP2
Full Name:
Metalloreductase STEAP2
Alias:
IPCA1; IPCA-1; PCANAP1; Prostate cancer-associated protein 1; Protein upregulated in metastatic prostate cancer; PUMPCn; Six transmembrane epithelial antigen of the prostate 2; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1; STAMP1; STMP
Type:
Vesicle protein; EC 1.16.1.-; Membrane protein, integral; Transporter; Oxidoreductase
Mass (Da):
55994
Number AA:
490
UniProt ID:
Q8NFT2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005769
GO:0030173
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0005507
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0006893
GO:0022900
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
E
S
I
S
M
M
G
S
P
Site 2
S5
_
_
_
M
E
S
I
S
M
M
G
S
P
K
S
Site 3
S9
E
S
I
S
M
M
G
S
P
K
S
L
S
E
T
Site 4
S12
S
M
M
G
S
P
K
S
L
S
E
T
C
L
P
Site 5
S14
M
G
S
P
K
S
L
S
E
T
C
L
P
N
G
Site 6
T16
S
P
K
S
L
S
E
T
C
L
P
N
G
I
N
Site 7
S44
G
S
G
D
F
A
K
S
L
T
I
R
L
I
R
Site 8
T84
T
H
H
E
D
A
L
T
K
T
N
I
I
F
V
Site 9
Y98
V
A
I
H
R
E
H
Y
T
S
L
W
D
L
R
Site 10
Y125
N
N
M
R
I
N
Q
Y
P
E
S
N
A
E
Y
Site 11
S128
R
I
N
Q
Y
P
E
S
N
A
E
Y
L
A
S
Site 12
Y132
Y
P
E
S
N
A
E
Y
L
A
S
L
F
P
D
Site 13
Y166
K
D
A
S
R
Q
V
Y
I
C
S
N
N
I
Q
Site 14
S196
P
I
D
L
G
S
L
S
S
A
R
E
I
E
N
Site 15
S197
I
D
L
G
S
L
S
S
A
R
E
I
E
N
L
Site 16
Y239
V
R
D
V
I
H
P
Y
A
R
N
Q
Q
S
D
Site 17
Y248
R
N
Q
Q
S
D
F
Y
K
I
P
I
E
I
V
Site 18
Y283
L
A
A
A
Y
Q
L
Y
Y
G
T
K
Y
R
R
Site 19
Y288
Q
L
Y
Y
G
T
K
Y
R
R
F
P
P
W
L
Site 20
S328
L
C
L
P
M
R
R
S
E
R
Y
L
F
L
N
Site 21
Y331
P
M
R
R
S
E
R
Y
L
F
L
N
M
A
Y
Site 22
S392
A
L
N
W
R
E
F
S
F
I
Q
S
T
L
G
Site 23
Y423
K
R
A
F
E
E
E
Y
Y
R
F
Y
T
P
P
Site 24
Y424
R
A
F
E
E
E
Y
Y
R
F
Y
T
P
P
N
Site 25
Y427
E
E
E
Y
Y
R
F
Y
T
P
P
N
F
V
L
Site 26
T428
E
E
Y
Y
R
F
Y
T
P
P
N
F
V
L
A
Site 27
S468
I
K
K
G
W
E
K
S
Q
F
L
E
E
G
I
Site 28
T478
L
E
E
G
I
G
G
T
I
P
H
V
S
P
E
Site 29
S483
G
G
T
I
P
H
V
S
P
E
R
V
T
V
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation