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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BEST4
Full Name:
Bestrophin-4
Alias:
Vitelliform macular dystrophy 2-like protein 2
Type:
Mass (Da):
53497
Number AA:
473
UniProt ID:
Q8NFU0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
E
A
R
F
G
G
F
S
G
L
L
L
R
W
R
Site 2
T55
I
T
Y
R
L
L
L
T
Q
E
Q
R
Y
V
Y
Site 3
Y60
L
L
T
Q
E
Q
R
Y
V
Y
A
Q
V
A
R
Site 4
Y62
T
Q
E
Q
R
Y
V
Y
A
Q
V
A
R
Y
C
Site 5
Y68
V
Y
A
Q
V
A
R
Y
C
N
R
S
A
D
L
Site 6
S72
V
A
R
Y
C
N
R
S
A
D
L
I
P
L
S
Site 7
Y97
V
N
R
W
W
S
Q
Y
T
S
I
P
L
P
D
Site 8
T127
R
G
R
L
L
R
R
T
L
I
R
Y
A
N
L
Site 9
T153
R
V
L
K
R
F
P
T
M
E
H
V
V
D
A
Site 10
S164
V
V
D
A
G
F
M
S
Q
E
E
R
K
K
F
Site 11
S173
E
E
R
K
K
F
E
S
L
K
S
D
F
N
K
Site 12
S176
K
K
F
E
S
L
K
S
D
F
N
K
Y
W
V
Site 13
Y217
L
L
E
E
L
N
K
Y
R
A
K
C
S
M
L
Site 14
T322
E
D
D
D
D
F
E
T
N
Q
L
I
D
R
N
Site 15
S336
N
L
Q
V
S
L
L
S
V
D
E
M
Y
Q
N
Site 16
Y341
L
L
S
V
D
E
M
Y
Q
N
L
P
P
A
E
Site 17
Y352
P
P
A
E
K
D
Q
Y
W
D
E
D
Q
P
Q
Site 18
Y362
E
D
Q
P
Q
P
P
Y
T
V
A
T
A
A
E
Site 19
T363
D
Q
P
Q
P
P
Y
T
V
A
T
A
A
E
S
Site 20
T366
Q
P
P
Y
T
V
A
T
A
A
E
S
L
R
P
Site 21
S374
A
A
E
S
L
R
P
S
F
L
G
S
T
F
N
Site 22
S378
L
R
P
S
F
L
G
S
T
F
N
L
R
M
S
Site 23
T379
R
P
S
F
L
G
S
T
F
N
L
R
M
S
D
Site 24
S385
S
T
F
N
L
R
M
S
D
D
P
E
Q
S
L
Site 25
S391
M
S
D
D
P
E
Q
S
L
Q
V
E
A
S
P
Site 26
S397
Q
S
L
Q
V
E
A
S
P
G
S
G
R
P
A
Site 27
S400
Q
V
E
A
S
P
G
S
G
R
P
A
P
A
A
Site 28
S426
G
A
P
S
P
A
I
S
L
R
N
F
G
R
V
Site 29
T436
N
F
G
R
V
R
G
T
P
R
P
P
H
L
L
Site 30
S463
A
A
R
I
E
E
E
S
A
E
S
G
D
E
A
Site 31
S466
I
E
E
E
S
A
E
S
G
D
E
A
L
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation