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Updated November 2019
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Protein Info
Short Name:
CXXC6
Full Name:
Methylcytosine dioxygenase TET1
Alias:
BA119F7.1; CXXC finger 6; CXXC-type zinc finger protein 6; KIAA1676; LCX; Leukemia-associated protein with a CXXC domain; Ten-eleven translocation 1 gene protein; Ten-eleven translocation-1; Tet oncogene 1; TET1
Type:
DNA binding protein
Mass (Da):
235290
Number AA:
2136
UniProt ID:
Q8NFU7
International Prot ID:
IPI00303112
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0070579
GO:0016702
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
S
R
H
A
R
P
S
R
L
V
R
K
E
D
Site 2
S25
V
N
K
K
K
K
N
S
Q
L
R
K
T
T
K
Site 3
T30
K
N
S
Q
L
R
K
T
T
K
G
A
N
K
N
Site 4
T31
N
S
Q
L
R
K
T
T
K
G
A
N
K
N
V
Site 5
S40
G
A
N
K
N
V
A
S
V
K
T
L
S
P
G
Site 6
T43
K
N
V
A
S
V
K
T
L
S
P
G
K
L
K
Site 7
S45
V
A
S
V
K
T
L
S
P
G
K
L
K
Q
L
Site 8
T62
E
R
D
V
K
K
K
T
E
P
K
P
P
V
P
Site 9
T87
A
R
M
N
L
D
R
T
E
V
L
F
Q
N
P
Site 10
S108
G
F
T
M
A
L
R
S
T
S
L
S
R
R
L
Site 11
T109
F
T
M
A
L
R
S
T
S
L
S
R
R
L
S
Site 12
S110
T
M
A
L
R
S
T
S
L
S
R
R
L
S
Q
Site 13
S112
A
L
R
S
T
S
L
S
R
R
L
S
Q
P
P
Site 14
S116
T
S
L
S
R
R
L
S
Q
P
P
L
V
V
A
Site 15
S125
P
P
L
V
V
A
K
S
K
K
V
P
L
S
K
Site 16
S131
K
S
K
K
V
P
L
S
K
G
L
E
K
Q
H
Site 17
Y142
E
K
Q
H
D
C
D
Y
K
I
L
P
A
L
G
Site 18
S153
P
A
L
G
V
K
H
S
E
N
D
S
V
P
M
Site 19
S157
V
K
H
S
E
N
D
S
V
P
M
Q
D
T
Q
Site 20
S179
L
I
G
V
Q
N
P
S
L
L
K
G
K
S
Q
Site 21
S185
P
S
L
L
K
G
K
S
Q
E
T
T
Q
F
W
Site 22
T189
K
G
K
S
Q
E
T
T
Q
F
W
S
Q
R
V
Site 23
S193
Q
E
T
T
Q
F
W
S
Q
R
V
E
D
S
K
Site 24
S199
W
S
Q
R
V
E
D
S
K
I
N
I
P
T
H
Site 25
S229
R
C
G
E
G
L
F
S
E
E
T
L
N
D
T
Site 26
T232
E
G
L
F
S
E
E
T
L
N
D
T
S
G
S
Site 27
S237
E
E
T
L
N
D
T
S
G
S
P
K
M
F
A
Site 28
S239
T
L
N
D
T
S
G
S
P
K
M
F
A
Q
D
Site 29
T247
P
K
M
F
A
Q
D
T
V
C
A
P
F
P
Q
Site 30
T257
A
P
F
P
Q
R
A
T
P
K
V
T
S
Q
G
Site 31
S262
R
A
T
P
K
V
T
S
Q
G
N
P
S
I
Q
Site 32
S275
I
Q
L
E
E
L
G
S
R
V
E
S
L
K
L
Site 33
S279
E
L
G
S
R
V
E
S
L
K
L
S
D
S
Y
Site 34
S283
R
V
E
S
L
K
L
S
D
S
Y
L
D
P
I
Site 35
S285
E
S
L
K
L
S
D
S
Y
L
D
P
I
K
S
Site 36
Y286
S
L
K
L
S
D
S
Y
L
D
P
I
K
S
E
Site 37
S292
S
Y
L
D
P
I
K
S
E
H
D
C
Y
P
T
Site 38
Y297
I
K
S
E
H
D
C
Y
P
T
S
S
L
N
K
Site 39
S300
E
H
D
C
Y
P
T
S
S
L
N
K
V
I
P
Site 40
S301
H
D
C
Y
P
T
S
S
L
N
K
V
I
P
D
Site 41
T338
L
A
G
S
K
Q
A
T
L
G
A
K
P
D
H
Site 42
S359
T
A
N
Q
Q
E
V
S
D
T
T
S
F
L
G
Site 43
T361
N
Q
Q
E
V
S
D
T
T
S
F
L
G
Q
A
Site 44
S363
Q
E
V
S
D
T
T
S
F
L
G
Q
A
F
G
Site 45
T392
H
G
E
A
L
G
E
T
P
D
L
P
E
I
P
Site 46
T411
V
Q
G
E
V
F
G
T
I
L
D
Q
Q
E
T
Site 47
T418
T
I
L
D
Q
Q
E
T
L
G
M
S
G
S
V
Site 48
T442
V
P
P
N
P
I
A
T
F
N
A
P
S
K
W
Site 49
S447
I
A
T
F
N
A
P
S
K
W
P
E
P
Q
S
Site 50
S454
S
K
W
P
E
P
Q
S
T
V
S
Y
G
L
A
Site 51
T455
K
W
P
E
P
Q
S
T
V
S
Y
G
L
A
V
Site 52
Y458
E
P
Q
S
T
V
S
Y
G
L
A
V
Q
G
A
Site 53
T476
L
P
L
G
S
G
H
T
P
Q
S
S
S
N
S
Site 54
S479
G
S
G
H
T
P
Q
S
S
S
N
S
E
K
N
Site 55
S480
S
G
H
T
P
Q
S
S
S
N
S
E
K
N
S
Site 56
S481
G
H
T
P
Q
S
S
S
N
S
E
K
N
S
L
Site 57
S483
T
P
Q
S
S
S
N
S
E
K
N
S
L
P
P
Site 58
S487
S
S
N
S
E
K
N
S
L
P
P
V
M
A
I
Site 59
S495
L
P
P
V
M
A
I
S
N
V
E
N
E
K
Q
Site 60
S506
N
E
K
Q
V
H
I
S
F
L
P
A
N
T
Q
Site 61
S534
S
L
G
I
A
Q
L
S
Q
A
G
P
S
K
S
Site 62
S539
Q
L
S
Q
A
G
P
S
K
S
D
R
G
S
S
Site 63
S541
S
Q
A
G
P
S
K
S
D
R
G
S
S
Q
V
Site 64
S545
P
S
K
S
D
R
G
S
S
Q
V
S
V
T
S
Site 65
S546
S
K
S
D
R
G
S
S
Q
V
S
V
T
S
T
Site 66
S549
D
R
G
S
S
Q
V
S
V
T
S
T
V
H
V
Site 67
S570
T
M
P
V
P
M
V
S
T
S
S
S
S
Y
T
Site 68
T571
M
P
V
P
M
V
S
T
S
S
S
S
Y
T
T
Site 69
S572
P
V
P
M
V
S
T
S
S
S
S
Y
T
T
L
Site 70
S574
P
M
V
S
T
S
S
S
S
Y
T
T
L
L
P
Site 71
T577
S
T
S
S
S
S
Y
T
T
L
L
P
T
L
E
Site 72
T578
T
S
S
S
S
Y
T
T
L
L
P
T
L
E
K
Site 73
T582
S
Y
T
T
L
L
P
T
L
E
K
K
K
R
K
Site 74
S632
E
E
L
K
K
K
P
S
V
V
V
P
L
E
V
Site 75
S669
K
P
V
N
G
P
K
S
E
S
M
D
Y
S
R
Site 76
S671
V
N
G
P
K
S
E
S
M
D
Y
S
R
C
G
Site 77
Y674
P
K
S
E
S
M
D
Y
S
R
C
G
H
G
E
Site 78
S675
K
S
E
S
M
D
Y
S
R
C
G
H
G
E
E
Site 79
T691
K
L
E
L
N
P
H
T
V
E
N
V
T
K
N
Site 80
S701
N
V
T
K
N
E
D
S
M
T
G
I
E
V
E
Site 81
T703
T
K
N
E
D
S
M
T
G
I
E
V
E
K
W
Site 82
S716
K
W
T
Q
N
K
K
S
Q
L
T
D
H
V
K
Site 83
S727
D
H
V
K
G
D
F
S
A
N
V
P
E
A
E
Site 84
S736
N
V
P
E
A
E
K
S
K
N
S
E
V
D
K
Site 85
T746
S
E
V
D
K
K
R
T
K
S
P
K
L
F
V
Site 86
S748
V
D
K
K
R
T
K
S
P
K
L
F
V
Q
T
Site 87
T755
S
P
K
L
F
V
Q
T
V
R
N
G
I
K
H
Site 88
S773
L
P
A
E
T
N
V
S
F
K
K
F
N
I
E
Site 89
T785
N
I
E
E
F
G
K
T
L
E
N
N
S
Y
K
Site 90
Y791
K
T
L
E
N
N
S
Y
K
F
L
K
D
T
A
Site 91
S805
A
N
H
K
N
A
M
S
S
V
A
T
D
M
S
Site 92
S806
N
H
K
N
A
M
S
S
V
A
T
D
M
S
C
Site 93
T809
N
A
M
S
S
V
A
T
D
M
S
C
D
H
L
Site 94
S812
S
S
V
A
T
D
M
S
C
D
H
L
K
G
R
Site 95
S833
Q
Q
P
G
F
N
C
S
S
I
P
H
S
S
H
Site 96
S834
Q
P
G
F
N
C
S
S
I
P
H
S
S
H
S
Site 97
S838
N
C
S
S
I
P
H
S
S
H
S
I
I
N
H
Site 98
S841
S
I
P
H
S
S
H
S
I
I
N
H
H
A
S
Site 99
T858
N
E
G
D
Q
P
K
T
P
E
N
I
P
S
K
Site 100
S864
K
T
P
E
N
I
P
S
K
E
P
K
D
G
S
Site 101
S871
S
K
E
P
K
D
G
S
P
V
Q
P
S
L
L
Site 102
S876
D
G
S
P
V
Q
P
S
L
L
S
L
M
K
D
Site 103
S879
P
V
Q
P
S
L
L
S
L
M
K
D
R
R
L
Site 104
S901
I
E
A
L
T
Q
L
S
E
A
P
S
E
N
S
Site 105
S905
T
Q
L
S
E
A
P
S
E
N
S
S
P
S
K
Site 106
S908
S
E
A
P
S
E
N
S
S
P
S
K
S
E
K
Site 107
S909
E
A
P
S
E
N
S
S
P
S
K
S
E
K
D
Site 108
S911
P
S
E
N
S
S
P
S
K
S
E
K
D
E
E
Site 109
S913
E
N
S
S
P
S
K
S
E
K
D
E
E
S
E
Site 110
S919
K
S
E
K
D
E
E
S
E
Q
R
T
A
S
L
Site 111
T923
D
E
E
S
E
Q
R
T
A
S
L
L
N
S
C
Site 112
S925
E
S
E
Q
R
T
A
S
L
L
N
S
C
K
A
Site 113
Y935
N
S
C
K
A
I
L
Y
T
V
R
K
D
L
Q
Site 114
T936
S
C
K
A
I
L
Y
T
V
R
K
D
L
Q
D
Site 115
S958
P
K
L
N
H
C
P
S
L
E
K
Q
S
S
C
Site 116
S964
P
S
L
E
K
Q
S
S
C
N
T
V
V
F
N
Site 117
T967
E
K
Q
S
S
C
N
T
V
V
F
N
G
Q
T
Site 118
T976
V
F
N
G
Q
T
T
T
L
S
N
S
H
I
N
Site 119
S978
N
G
Q
T
T
T
L
S
N
S
H
I
N
S
A
Site 120
S984
L
S
N
S
H
I
N
S
A
T
N
Q
A
S
T
Site 121
T986
N
S
H
I
N
S
A
T
N
Q
A
S
T
K
S
Site 122
S990
N
S
A
T
N
Q
A
S
T
K
S
H
E
Y
S
Site 123
S993
T
N
Q
A
S
T
K
S
H
E
Y
S
K
V
T
Site 124
S997
S
T
K
S
H
E
Y
S
K
V
T
N
S
L
S
Site 125
T1000
S
H
E
Y
S
K
V
T
N
S
L
S
L
F
I
Site 126
S1002
E
Y
S
K
V
T
N
S
L
S
L
F
I
P
K
Site 127
S1004
S
K
V
T
N
S
L
S
L
F
I
P
K
S
N
Site 128
S1010
L
S
L
F
I
P
K
S
N
S
S
K
I
D
T
Site 129
S1012
L
F
I
P
K
S
N
S
S
K
I
D
T
N
K
Site 130
T1017
S
N
S
S
K
I
D
T
N
K
S
I
A
Q
G
Site 131
S1020
S
K
I
D
T
N
K
S
I
A
Q
G
I
I
T
Site 132
T1027
S
I
A
Q
G
I
I
T
L
D
N
C
S
N
D
Site 133
Y1047
P
R
N
N
E
V
E
Y
C
N
Q
L
L
D
S
Site 134
S1054
Y
C
N
Q
L
L
D
S
S
K
K
L
D
S
D
Site 135
S1060
D
S
S
K
K
L
D
S
D
D
L
S
C
Q
D
Site 136
S1064
K
L
D
S
D
D
L
S
C
Q
D
A
T
H
T
Site 137
T1079
Q
I
E
E
D
V
A
T
Q
L
T
Q
L
A
S
Site 138
Y1092
A
S
I
I
K
I
N
Y
I
K
P
E
D
K
K
Site 139
S1102
P
E
D
K
K
V
E
S
T
P
T
S
L
V
T
Site 140
T1103
E
D
K
K
V
E
S
T
P
T
S
L
V
T
C
Site 141
T1105
K
K
V
E
S
T
P
T
S
L
V
T
C
N
V
Site 142
S1106
K
V
E
S
T
P
T
S
L
V
T
C
N
V
Q
Site 143
Y1116
T
C
N
V
Q
Q
K
Y
N
Q
E
K
G
T
I
Site 144
S1129
T
I
Q
Q
K
P
P
S
S
V
H
N
N
H
G
Site 145
S1130
I
Q
Q
K
P
P
S
S
V
H
N
N
H
G
S
Site 146
T1150
K
N
P
T
Q
K
K
T
K
S
T
P
S
R
D
Site 147
S1152
P
T
Q
K
K
T
K
S
T
P
S
R
D
R
R
Site 148
T1153
T
Q
K
K
T
K
S
T
P
S
R
D
R
R
K
Site 149
S1155
K
K
T
K
S
T
P
S
R
D
R
R
K
K
K
Site 150
T1164
D
R
R
K
K
K
P
T
V
V
S
Y
Q
E
N
Site 151
Y1181
Q
K
W
E
K
L
S
Y
M
Y
G
T
I
C
D
Site 152
S1214
P
T
V
F
G
K
I
S
S
S
T
K
I
W
K
Site 153
S1216
V
F
G
K
I
S
S
S
T
K
I
W
K
P
L
Site 154
S1228
K
P
L
A
Q
T
R
S
I
M
Q
P
K
T
V
Site 155
T1234
R
S
I
M
Q
P
K
T
V
F
P
P
L
T
Q
Site 156
T1240
K
T
V
F
P
P
L
T
Q
I
K
L
Q
R
Y
Site 157
Y1247
T
Q
I
K
L
Q
R
Y
P
E
S
A
E
E
K
Site 158
S1250
K
L
Q
R
Y
P
E
S
A
E
E
K
V
K
V
Site 159
S1264
V
E
P
L
D
S
L
S
L
F
H
L
K
T
E
Site 160
T1270
L
S
L
F
H
L
K
T
E
S
N
G
K
A
F
Site 161
S1272
L
F
H
L
K
T
E
S
N
G
K
A
F
T
D
Site 162
Y1282
K
A
F
T
D
K
A
Y
N
S
Q
V
Q
L
T
Site 163
S1284
F
T
D
K
A
Y
N
S
Q
V
Q
L
T
V
N
Site 164
T1289
Y
N
S
Q
V
Q
L
T
V
N
A
N
Q
K
A
Site 165
T1300
N
Q
K
A
H
P
L
T
Q
P
S
S
P
P
N
Site 166
S1303
A
H
P
L
T
Q
P
S
S
P
P
N
Q
C
A
Site 167
S1304
H
P
L
T
Q
P
S
S
P
P
N
Q
C
A
N
Site 168
T1336
L
M
H
Q
R
L
P
T
L
P
G
I
S
H
E
Site 169
T1344
L
P
G
I
S
H
E
T
P
L
P
E
S
A
L
Site 170
S1368
S
G
G
I
T
V
V
S
T
K
S
E
E
E
V
Site 171
S1371
I
T
V
V
S
T
K
S
E
E
E
V
C
S
S
Site 172
S1377
K
S
E
E
E
V
C
S
S
S
F
G
T
S
E
Site 173
S1378
S
E
E
E
V
C
S
S
S
F
G
T
S
E
F
Site 174
S1379
E
E
E
V
C
S
S
S
F
G
T
S
E
F
S
Site 175
T1382
V
C
S
S
S
F
G
T
S
E
F
S
T
V
D
Site 176
S1383
C
S
S
S
F
G
T
S
E
F
S
T
V
D
S
Site 177
S1386
S
F
G
T
S
E
F
S
T
V
D
S
A
Q
K
Site 178
T1387
F
G
T
S
E
F
S
T
V
D
S
A
Q
K
N
Site 179
S1390
S
E
F
S
T
V
D
S
A
Q
K
N
F
N
D
Site 180
Y1398
A
Q
K
N
F
N
D
Y
A
M
N
F
F
T
N
Site 181
T1421
T
K
D
S
E
L
P
T
C
S
C
L
D
R
V
Site 182
Y1436
I
Q
K
D
K
G
P
Y
Y
T
H
L
G
A
G
Site 183
Y1437
Q
K
D
K
G
P
Y
Y
T
H
L
G
A
G
P
Site 184
Y1457
R
E
I
M
E
N
R
Y
G
Q
K
G
N
A
I
Site 185
Y1471
I
R
I
E
I
V
V
Y
T
G
K
E
G
K
S
Site 186
S1478
Y
T
G
K
E
G
K
S
S
H
G
C
P
I
A
Site 187
S1479
T
G
K
E
G
K
S
S
H
G
C
P
I
A
K
Site 188
S1492
A
K
W
V
L
R
R
S
S
D
E
E
K
V
L
Site 189
S1493
K
W
V
L
R
R
S
S
D
E
E
K
V
L
C
Site 190
T1506
L
C
L
V
R
Q
R
T
G
H
H
C
P
T
A
Site 191
Y1534
L
P
M
A
D
R
L
Y
T
E
L
T
E
N
L
Site 192
T1535
P
M
A
D
R
L
Y
T
E
L
T
E
N
L
K
Site 193
T1538
D
R
L
Y
T
E
L
T
E
N
L
K
S
Y
N
Site 194
S1543
E
L
T
E
N
L
K
S
Y
N
G
H
P
T
D
Site 195
T1549
K
S
Y
N
G
H
P
T
D
R
R
C
T
L
N
Site 196
T1554
H
P
T
D
R
R
C
T
L
N
E
N
R
T
C
Site 197
T1562
L
N
E
N
R
T
C
T
C
Q
G
I
D
P
E
Site 198
T1570
C
Q
G
I
D
P
E
T
C
G
A
S
F
S
F
Site 199
S1593
N
G
C
K
F
G
R
S
P
S
P
R
R
F
R
Site 200
S1595
C
K
F
G
R
S
P
S
P
R
R
F
R
I
D
Site 201
S1605
R
F
R
I
D
P
S
S
P
L
H
E
K
N
L
Site 202
S1618
N
L
E
D
N
L
Q
S
L
A
T
R
L
A
P
Site 203
Y1641
A
Y
Q
N
Q
V
E
Y
E
N
V
A
R
E
C
Site 204
S1652
A
R
E
C
R
L
G
S
K
E
G
R
P
F
S
Site 205
S1659
S
K
E
G
R
P
F
S
G
V
T
A
C
L
D
Site 206
T1689
S
T
V
V
C
T
L
T
R
E
D
N
R
S
L
Site 207
S1695
L
T
R
E
D
N
R
S
L
G
V
I
P
Q
D
Site 208
Y1711
Q
L
H
V
L
P
L
Y
K
L
S
D
T
D
E
Site 209
S1714
V
L
P
L
Y
K
L
S
D
T
D
E
F
G
S
Site 210
T1716
P
L
Y
K
L
S
D
T
D
E
F
G
S
K
E
Site 211
S1721
S
D
T
D
E
F
G
S
K
E
G
M
E
A
K
Site 212
T1745
A
P
R
R
K
K
R
T
C
F
T
Q
P
V
P
Site 213
T1748
R
K
K
R
T
C
F
T
Q
P
V
P
R
S
G
Site 214
S1754
F
T
Q
P
V
P
R
S
G
K
K
R
A
A
M
Site 215
T1763
K
K
R
A
A
M
M
T
E
V
L
A
H
K
I
Site 216
T1788
I
K
R
K
N
N
S
T
T
T
N
N
S
K
P
Site 217
T1789
K
R
K
N
N
S
T
T
T
N
N
S
K
P
S
Site 218
T1790
R
K
N
N
S
T
T
T
N
N
S
K
P
S
S
Site 219
S1793
N
S
T
T
T
N
N
S
K
P
S
S
L
P
T
Site 220
S1797
T
N
N
S
K
P
S
S
L
P
T
L
G
S
N
Site 221
T1800
S
K
P
S
S
L
P
T
L
G
S
N
T
E
T
Site 222
S1803
S
S
L
P
T
L
G
S
N
T
E
T
V
Q
P
Site 223
T1807
T
L
G
S
N
T
E
T
V
Q
P
E
V
K
S
Site 224
S1824
E
P
H
F
I
L
K
S
S
D
N
T
K
T
Y
Site 225
S1825
P
H
F
I
L
K
S
S
D
N
T
K
T
Y
S
Site 226
T1828
I
L
K
S
S
D
N
T
K
T
Y
S
L
M
P
Site 227
T1830
K
S
S
D
N
T
K
T
Y
S
L
M
P
S
A
Site 228
S1832
S
D
N
T
K
T
Y
S
L
M
P
S
A
P
H
Site 229
S1836
K
T
Y
S
L
M
P
S
A
P
H
P
V
K
E
Site 230
S1845
P
H
P
V
K
E
A
S
P
G
F
S
W
S
P
Site 231
S1849
K
E
A
S
P
G
F
S
W
S
P
K
T
A
S
Site 232
S1851
A
S
P
G
F
S
W
S
P
K
T
A
S
A
T
Site 233
T1854
G
F
S
W
S
P
K
T
A
S
A
T
P
A
P
Site 234
S1856
S
W
S
P
K
T
A
S
A
T
P
A
P
L
K
Site 235
T1858
S
P
K
T
A
S
A
T
P
A
P
L
K
N
D
Site 236
T1867
A
P
L
K
N
D
A
T
A
S
C
G
F
S
E
Site 237
S1869
L
K
N
D
A
T
A
S
C
G
F
S
E
R
S
Site 238
S1873
A
T
A
S
C
G
F
S
E
R
S
S
T
P
H
Site 239
S1877
C
G
F
S
E
R
S
S
T
P
H
C
T
M
P
Site 240
T1878
G
F
S
E
R
S
S
T
P
H
C
T
M
P
S
Site 241
T1882
R
S
S
T
P
H
C
T
M
P
S
G
R
L
S
Site 242
S1885
T
P
H
C
T
M
P
S
G
R
L
S
G
A
N
Site 243
S1889
T
M
P
S
G
R
L
S
G
A
N
A
A
A
A
Site 244
S1924
V
M
E
P
L
I
N
S
E
P
S
T
G
V
T
Site 245
T1928
L
I
N
S
E
P
S
T
G
V
T
E
P
L
T
Site 246
T1931
S
E
P
S
T
G
V
T
E
P
L
T
P
H
Q
Site 247
T1935
T
G
V
T
E
P
L
T
P
H
Q
P
N
H
Q
Site 248
S1944
H
Q
P
N
H
Q
P
S
F
L
T
S
P
Q
D
Site 249
S1948
H
Q
P
S
F
L
T
S
P
Q
D
L
A
S
S
Site 250
S1955
S
P
Q
D
L
A
S
S
P
M
E
E
D
E
Q
Site 251
S1971
S
E
A
D
E
P
P
S
D
E
P
L
S
D
D
Site 252
S1976
P
P
S
D
E
P
L
S
D
D
P
L
S
P
A
Site 253
S1981
P
L
S
D
D
P
L
S
P
A
E
E
K
L
P
Site 254
Y1993
K
L
P
H
I
D
E
Y
W
S
D
S
E
H
I
Site 255
T2030
A
R
R
E
L
H
A
T
T
P
V
E
H
P
N
Site 256
T2031
R
R
E
L
H
A
T
T
P
V
E
H
P
N
R
Site 257
S2045
R
N
H
P
T
R
L
S
L
V
F
Y
Q
H
K
Site 258
Y2049
T
R
L
S
L
V
F
Y
Q
H
K
N
L
N
K
Site 259
S2106
N
E
L
N
Q
I
P
S
H
K
A
L
T
L
T
Site 260
T2126
T
V
S
P
Y
A
L
T
H
V
A
G
P
Y
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation