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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Helicase B
Full Name:
DNA helicase B
Alias:
helicase (DNA) B
Type:
DNA replication; EC 3.6.1.-; Helicase
Mass (Da):
123252
Number AA:
1087
UniProt ID:
Q8NG08
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0043141
GO:0017116
PhosphoSite+
KinaseNET
Biological Process:
GO:0006269
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
A
R
S
S
P
Y
L
R
Q
L
Q
G
P
Site 2
Y28
L
V
E
E
D
D
D
Y
L
N
D
D
V
E
E
Site 3
S39
D
V
E
E
D
E
E
S
V
F
I
D
A
E
E
Site 4
S49
I
D
A
E
E
L
C
S
G
G
V
K
A
G
S
Site 5
S64
L
P
G
C
L
R
V
S
I
C
D
E
N
T
Q
Site 6
T70
V
S
I
C
D
E
N
T
Q
E
T
C
K
V
F
Site 7
Y102
P
V
V
G
S
R
S
Y
Q
Y
Q
V
Q
G
F
Site 8
Y104
V
G
S
R
S
Y
Q
Y
Q
V
Q
G
F
P
S
Site 9
Y112
Q
V
Q
G
F
P
S
Y
F
L
Q
S
D
M
S
Site 10
S116
F
P
S
Y
F
L
Q
S
D
M
S
P
P
N
Q
Site 11
S119
Y
F
L
Q
S
D
M
S
P
P
N
Q
K
H
I
Site 12
S138
L
K
E
C
E
V
S
S
D
D
V
N
K
F
L
Site 13
T146
D
D
V
N
K
F
L
T
W
V
K
E
V
S
N
Site 14
S152
L
T
W
V
K
E
V
S
N
Y
K
N
L
N
F
Site 15
Y154
W
V
K
E
V
S
N
Y
K
N
L
N
F
E
N
Site 16
T165
N
F
E
N
L
R
E
T
L
R
T
F
H
K
E
Site 17
T168
N
L
R
E
T
L
R
T
F
H
K
E
T
G
R
Site 18
S235
H
F
K
W
I
I
G
S
G
S
K
E
M
L
K
Site 19
T250
E
I
E
E
I
L
G
T
H
P
W
K
L
G
F
Site 20
Y262
L
G
F
S
K
I
T
Y
R
E
W
K
L
L
R
Site 21
Y298
E
K
N
A
L
I
M
Y
S
R
L
K
Q
I
C
Site 22
T311
I
C
R
E
D
G
H
T
Y
V
E
V
N
D
L
Site 23
Y312
C
R
E
D
G
H
T
Y
V
E
V
N
D
L
T
Site 24
T319
Y
V
E
V
N
D
L
T
L
T
L
S
N
H
M
Site 25
T321
E
V
N
D
L
T
L
T
L
S
N
H
M
S
F
Site 26
S323
N
D
L
T
L
T
L
S
N
H
M
S
F
H
A
Site 27
S327
L
T
L
S
N
H
M
S
F
H
A
A
S
E
S
Site 28
S334
S
F
H
A
A
S
E
S
L
K
F
L
K
D
I
Site 29
T392
V
L
A
S
I
H
T
T
K
P
E
N
S
S
D
Site 30
S405
S
D
D
A
L
N
E
S
K
P
D
E
V
R
L
Site 31
T421
N
P
V
D
V
V
D
T
Q
D
N
G
D
H
I
Site 32
S441
N
E
I
N
A
E
I
S
E
V
Q
L
D
Q
D
Site 33
S467
A
A
L
E
M
I
C
S
N
P
V
T
V
I
S
Site 34
S474
S
N
P
V
T
V
I
S
G
K
G
G
C
G
K
Site 35
T483
K
G
G
C
G
K
T
T
I
V
S
R
L
F
K
Site 36
S486
C
G
K
T
T
I
V
S
R
L
F
K
H
I
E
Site 37
T519
N
A
S
E
E
W
I
T
F
T
E
Q
S
Q
L
Site 38
T551
A
G
L
L
R
Q
K
T
G
L
H
A
Y
T
L
Site 39
T557
K
T
G
L
H
A
Y
T
L
C
Q
V
N
Y
S
Site 40
S583
N
K
P
W
K
F
S
S
V
R
V
L
V
V
D
Site 41
S643
D
L
F
E
T
L
K
S
R
N
C
A
I
E
L
Site 42
T652
N
C
A
I
E
L
K
T
N
H
R
A
E
S
Q
Site 43
S658
K
T
N
H
R
A
E
S
Q
L
I
V
D
N
A
Site 44
S669
V
D
N
A
T
R
I
S
R
R
Q
F
P
K
F
Site 45
S683
F
D
A
E
L
N
I
S
D
N
P
T
L
P
I
Site 46
T687
L
N
I
S
D
N
P
T
L
P
I
S
I
Q
D
Site 47
S691
D
N
P
T
L
P
I
S
I
Q
D
K
T
F
I
Site 48
S708
R
L
P
E
E
D
A
S
S
Q
S
S
K
T
N
Site 49
S709
L
P
E
E
D
A
S
S
Q
S
S
K
T
N
H
Site 50
S712
E
D
A
S
S
Q
S
S
K
T
N
H
H
S
C
Site 51
T714
A
S
S
Q
S
S
K
T
N
H
H
S
C
L
Y
Site 52
S718
S
S
K
T
N
H
H
S
C
L
Y
S
A
V
K
Site 53
Y721
T
N
H
H
S
C
L
Y
S
A
V
K
T
L
L
Site 54
S722
N
H
H
S
C
L
Y
S
A
V
K
T
L
L
Q
Site 55
T738
N
N
L
Q
N
A
K
T
S
Q
F
I
A
F
R
Site 56
T765
K
H
Y
T
G
H
L
T
K
D
H
Q
S
R
L
Site 57
S770
H
L
T
K
D
H
Q
S
R
L
V
F
G
I
G
Site 58
S789
C
T
R
N
A
Y
L
S
D
L
L
P
E
N
I
Site 59
S797
D
L
L
P
E
N
I
S
G
S
Q
Q
N
N
D
Site 60
S799
L
P
E
N
I
S
G
S
Q
Q
N
N
D
L
D
Site 61
S808
Q
N
N
D
L
D
A
S
S
E
D
F
S
G
T
Site 62
S809
N
N
D
L
D
A
S
S
E
D
F
S
G
T
L
Site 63
S813
D
A
S
S
E
D
F
S
G
T
L
P
D
F
A
Site 64
T815
S
S
E
D
F
S
G
T
L
P
D
F
A
K
N
Site 65
S828
K
N
K
R
D
F
E
S
N
V
R
L
C
N
G
Site 66
T845
F
F
I
T
N
D
V
T
D
V
T
F
G
K
R
Site 67
T848
T
N
D
V
T
D
V
T
F
G
K
R
R
S
L
Site 68
S854
V
T
F
G
K
R
R
S
L
T
I
N
N
M
A
Site 69
T856
F
G
K
R
R
S
L
T
I
N
N
M
A
G
L
Site 70
Y875
D
F
K
K
L
M
K
Y
C
R
I
K
H
A
W
Site 71
T888
A
W
A
R
T
I
H
T
F
Q
G
S
E
E
Q
Site 72
T896
F
Q
G
S
E
E
Q
T
V
V
Y
V
V
G
K
Site 73
Y899
S
E
E
Q
T
V
V
Y
V
V
G
K
A
G
R
Site 74
Y913
R
Q
H
W
Q
H
V
Y
T
A
V
T
R
G
R
Site 75
Y924
T
R
G
R
C
R
V
Y
V
I
A
E
E
S
Q
Site 76
S940
R
N
A
I
M
K
N
S
F
P
R
K
T
R
L
Site 77
T945
K
N
S
F
P
R
K
T
R
L
K
H
F
L
Q
Site 78
S953
R
L
K
H
F
L
Q
S
K
L
S
S
S
G
A
Site 79
S956
H
F
L
Q
S
K
L
S
S
S
G
A
P
P
A
Site 80
S957
F
L
Q
S
K
L
S
S
S
G
A
P
P
A
D
Site 81
S967
A
P
P
A
D
F
P
S
P
R
K
S
S
G
D
Site 82
S971
D
F
P
S
P
R
K
S
S
G
D
S
G
G
P
Site 83
S972
F
P
S
P
R
K
S
S
G
D
S
G
G
P
S
Site 84
S975
P
R
K
S
S
G
D
S
G
G
P
S
T
P
S
Site 85
S979
S
G
D
S
G
G
P
S
T
P
S
A
S
P
L
Site 86
T980
G
D
S
G
G
P
S
T
P
S
A
S
P
L
P
Site 87
S982
S
G
G
P
S
T
P
S
A
S
P
L
P
V
V
Site 88
S984
G
P
S
T
P
S
A
S
P
L
P
V
V
T
D
Site 89
T999
H
A
M
T
N
D
V
T
W
S
E
A
S
S
P
Site 90
S1001
M
T
N
D
V
T
W
S
E
A
S
S
P
D
E
Site 91
S1005
V
T
W
S
E
A
S
S
P
D
E
R
T
L
T
Site 92
T1010
A
S
S
P
D
E
R
T
L
T
F
A
E
R
W
Site 93
T1012
S
P
D
E
R
T
L
T
F
A
E
R
W
Q
L
Site 94
S1020
F
A
E
R
W
Q
L
S
S
P
D
G
V
D
T
Site 95
S1021
A
E
R
W
Q
L
S
S
P
D
G
V
D
T
D
Site 96
T1027
S
S
P
D
G
V
D
T
D
D
D
L
P
K
S
Site 97
S1034
T
D
D
D
L
P
K
S
R
A
S
K
R
T
C
Site 98
S1037
D
L
P
K
S
R
A
S
K
R
T
C
G
V
N
Site 99
S1048
C
G
V
N
D
D
E
S
P
S
K
I
F
M
V
Site 100
S1058
K
I
F
M
V
G
E
S
P
Q
V
S
S
R
L
Site 101
S1062
V
G
E
S
P
Q
V
S
S
R
L
Q
N
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation