PhosphoNET

           
Protein Info 
   
Short Name:  CASC5
Full Name:  Protein CASC5
Alias:  AF15q14; ALL1-fused gene from chromosome 15q14; Blinkin, bub-linking kinetochore protein; Cancer susceptibility candidate 5; Cancer/testis antigen 29; CT29; D40; Kinetochore null 1; KNL1
Type:  Uncharacterized protein
Mass (Da):  265391
Number AA:  2342
UniProt ID:  Q8NG31
International Prot ID:  IPI00220694
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0001669  GO:0000777  GO:0005634 Uniprot OncoNet
Molecular Function:  GO:0005515     PhosphoSite+ KinaseNET
Biological Process:  GO:0001675     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S6__MDGVSSEANEEND
Site 2S24RPVRRRHSSILKPPR
Site 3S25PVRRRHSSILKPPRS
Site 4S32SILKPPRSPLQDLRG
Site 5S56ALRNKKNSRRVSFAD
Site 6S60KKNSRRVSFADTIKV
Site 7T64RRVSFADTIKVFQTE
Site 8S80HMKIVRKSEMEGCSA
Site 9S104PPGFKRFSCLSLPET
Site 10S107FKRFSCLSLPETETG
Site 11T111SCLSLPETETGENLL
Site 12Y129NKKLEDNYCEITGMN
Site 13T168RKHANDQTVIFSDEN
Site 14T180DENQMDLTSSHTVMI
Site 15S197GLLDNPISEKSTKID
Site 16T201NPISEKSTKIDTTSF
Site 17T205EKSTKIDTTSFLANL
Site 18S207STKIDTTSFLANLKL
Site 19S219LKLHTEDSRMKKEVN
Site 20S228MKKEVNFSVDQNTSS
Site 21S235SVDQNTSSENKIDFN
Site 22T250DFIKRLKTGKCSAFP
Site 23Y270ENFEIPIYSKEPNSA
Site 24S271NFEIPIYSKEPNSAS
Site 25S276IYSKEPNSASSTHQM
Site 26S278SKEPNSASSTHQMHV
Site 27T280EPNSASSTHQMHVSL
Site 28S286STHQMHVSLKEDENN
Site 29T319CHTANIQTLIPTSSE
Site 30S324IQTLIPTSSETNSRE
Site 31S325QTLIPTSSETNSRES
Site 32T327LIPTSSETNSRESKG
Site 33S329PTSSETNSRESKGND
Site 34S332SETNSRESKGNDITI
Site 35Y340KGNDITIYGNDFMDL
Site 36Y379AMDVTTGYGTKASGN
Site 37S384TGYGTKASGNKTVFK
Site 38T388TKASGNKTVFKSKQN
Site 39S392GNKTVFKSKQNTAFQ
Site 40T396VFKSKQNTAFQDLSI
Site 41S402NTAFQDLSINSADKI
Site 42T412SADKIHITRSHIMGA
Site 43T438DARILAMTPESIYSN
Site 44Y443AMTPESIYSNPSIQG
Site 45S444MTPESIYSNPSIQGC
Site 46S447ESIYSNPSIQGCKTV
Site 47T453PSIQGCKTVFYSSCN
Site 48Y456QGCKTVFYSSCNDAM
Site 49S458CKTVFYSSCNDAMEM
Site 50Y485LLKHDSNYAKMYCNP
Site 51Y489DSNYAKMYCNPDAMS
Site 52S497CNPDAMSSLTEKTIY
Site 53Y504SLTEKTIYSGEENMD
Site 54T513GEENMDITKSHTVAI
Site 55T517MDITKSHTVAIDNQI
Site 56T539VQIAAAPTPEKEMML
Site 57S553LQNLMTTSEDGKMNV
Site 58S569CNSVPHVSKERIQQS
Site 59S576SKERIQQSLSNPLSI
Site 60S578ERIQQSLSNPLSISL
Site 61S582QSLSNPLSISLTDRK
Site 62S584LSNPLSISLTDRKTE
Site 63T586NPLSISLTDRKTELL
Site 64T590ISLTDRKTELLSGEN
Site 65T601SGENMDLTESHTSNL
Site 66S603ENMDLTESHTSNLGS
Site 67S610SHTSNLGSQVPLAAY
Site 68S623AYNLAPESTSESHSQ
Site 69S625NLAPESTSESHSQSK
Site 70S627APESTSESHSQSKSS
Site 71S629ESTSESHSQSKSSSD
Site 72S631TSESHSQSKSSSDEC
Site 73S633ESHSQSKSSSDECEE
Site 74S634SHSQSKSSSDECEEI
Site 75S635HSQSKSSSDECEEIT
Site 76T642SDECEEITKSRNEPF
Site 77S644ECEEITKSRNEPFQR
Site 78S659SDIIAKNSLTDTWNK
Site 79T663AKNSLTDTWNKDKDW
Site 80Y677WVLKILPYLDKDSPQ
Site 81S682LPYLDKDSPQSADCN
Site 82S685LDKDSPQSADCNQEI
Site 83T710GVLDKQITNRNTVSW
Site 84T714KQITNRNTVSWEQSL
Site 85S716ITNRNTVSWEQSLFS
Site 86S720NTVSWEQSLFSTTKP
Site 87S723SWEQSLFSTTKPLFS
Site 88T724WEQSLFSTTKPLFSS
Site 89T725EQSLFSTTKPLFSSG
Site 90S730STTKPLFSSGQFSMK
Site 91S731TTKPLFSSGQFSMKN
Site 92S735LFSSGQFSMKNHDTA
Site 93T741FSMKNHDTAISSHTV
Site 94S745NHDTAISSHTVKSVL
Site 95T747DTAISSHTVKSVLGQ
Site 96S750ISSHTVKSVLGQNSK
Site 97S756KSVLGQNSKLAEPLR
Site 98S765LAEPLRKSLSNPTPD
Site 99S767EPLRKSLSNPTPDYC
Site 100T770RKSLSNPTPDYCHDK
Site 101Y773LSNPTPDYCHDKMII
Site 102T791EEQNMDLTKSHTVVI
Site 103T811ELQELGKTNLEHTTG
Site 104S837KVEKCGKSPIEKSGV
Site 105S842GKSPIEKSGVLKSNC
Site 106S847EKSGVLKSNCIMDVL
Site 107S858MDVLEDESVQKPKFP
Site 108S878VKIWGRKSVGGPKID
Site 109T887GGPKIDKTIVFSEDD
Site 110T901DKNDMDITKSYTIEI
Site 111Y933GTSETILYTCRQDDM
Site 112S945DDMEITRSHTTALEC
Site 113T947MEITRSHTTALECKT
Site 114T954TTALECKTVSPDEIT
Site 115S956ALECKTVSPDEITTR
Site 116T961TVSPDEITTRPMDKT
Site 117T968TTRPMDKTVVFVDNH
Site 118T981NHVELEMTESHTVFI
Site 119Y990SHTVFIDYQEKERTD
Site 120T996DYQEKERTDRPNFEL
Site 121S1004DRPNFELSQRKSLGT
Site 122S1008FELSQRKSLGTPTVI
Site 123T1011SQRKSLGTPTVICTP
Site 124T1013RKSLGTPTVICTPTE
Site 125T1017GTPTVICTPTEESVF
Site 126S1031FFPGNGESDRLVAND
Site 127S1039DRLVANDSQLTPLEE
Site 128T1042VANDSQLTPLEEWSN
Site 129S1063VADNMELSKSATCKN
Site 130S1065DNMELSKSATCKNIK
Site 131T1067MELSKSATCKNIKDV
Site 132S1076KNIKDVQSPGFLNEP
Site 133S1085GFLNEPLSSKSQRRK
Site 134S1086FLNEPLSSKSQRRKS
Site 135S1088NEPLSSKSQRRKSLK
Site 136S1093SKSQRRKSLKLKNDK
Site 137T1101LKLKNDKTIVFSENH
Site 138Y1145GASKTILYSCGQDDM
Site 139T1180AIRPMDKTVLFTDNY
Site 140Y1187TVLFTDNYSDLEVTD
Site 141S1188VLFTDNYSDLEVTDS
Site 142S1195SDLEVTDSHTVFIDC
Site 143S1226KGKNLGVSFPKDNSC
Site 144T1263KQQLFAATNRTTNEI
Site 145T1267FAATNRTTNEIIKFH
Site 146T1314DRRNVDFTSSHATAV
Site 147S1315RRNVDFTSSHATAVC
Site 148T1319DFTSSHATAVCGSSD
Site 149S1329CGSSDNYSCLPNVIS
Site 150Y1358KDEEKANYCPVQNDL
Site 151Y1367PVQNDLAYANDFASE
Site 152S1373AYANDFASEYYLESE
Site 153Y1375ANDFASEYYLESEGQ
Site 154Y1376NDFASEYYLESEGQP
Site 155S1379ASEYYLESEGQPLSA
Site 156S1385ESEGQPLSAPCPLLE
Site 157T1399EKEEVIQTSTKGQLD
Site 158T1429RNLLANQTLVYSQDL
Site 159Y1432LANQTLVYSQDLGEM
Site 160S1433ANQTLVYSQDLGEMT
Site 161T1440SQDLGEMTKLNSKRV
Site 162S1444GEMTKLNSKRVSFKL
Site 163S1448KLNSKRVSFKLPKDQ
Site 164Y1459PKDQMKVYVDDIYVI
Site 165Y1464KVYVDDIYVIPQPHF
Site 166S1472VIPQPHFSTDQPPLP
Site 167S1494NKEEVILSKAGNKSL
Site 168S1500LSKAGNKSLNIIENS
Site 169S1521NKPKILNSEEWFAAA
Site 170T1539ELKENIQTTNYNTAL
Site 171Y1542ENIQTTNYNTALDFH
Site 172S1550NTALDFHSNSDVTKQ
Site 173S1552ALDFHSNSDVTKQVI
Site 174S1644ISSNAKDSRDEENKK
Site 175S1652RDEENKKSHNGAETT
Site 176S1660HNGAETTSLPPKTVF
Site 177T1665TTSLPPKTVFKDKVR
Site 178S1675KDKVRRCSLGIFLPR
Site 179S1690LPNKRNCSVTGIDDL
Site 180T1692NKRNCSVTGIDDLEQ
Site 181T1705EQIPADTTDINHLET
Site 182T1712TDINHLETQPVSSKD
Site 183S1716HLETQPVSSKDSGIG
Site 184S1720QPVSSKDSGIGSVAG
Site 185S1724SKDSGIGSVAGKLNL
Site 186S1732VAGKLNLSPSQYINE
Site 187S1734GKLNLSPSQYINEEN
Site 188Y1736LNLSPSQYINEENLP
Site 189Y1745NEENLPVYPDEINSS
Site 190S1752YPDEINSSDSINIET
Site 191S1754DEINSSDSINIETEE
Site 192Y1768EKALIETYQKEISPY
Site 193S1773ETYQKEISPYENKMG
Site 194Y1775YQKEISPYENKMGKT
Site 195T1789TCNSQKRTWVQEEED
Site 196S1811RKNEIKFSDTTQDRE
Site 197T1814EIKFSDTTQDREIFD
Site 198T1824REIFDHHTEEDIDKS
Site 199S1831TEEDIDKSANSVLIK
Site 200S1841SVLIKNLSRTPSSCS
Site 201T1843LIKNLSRTPSSCSSS
Site 202S1845KNLSRTPSSCSSSLD
Site 203S1846NLSRTPSSCSSSLDS
Site 204S1848SRTPSSCSSSLDSIK
Site 205S1849RTPSSCSSSLDSIKA
Site 206S1850TPSSCSSSLDSIKAD
Site 207S1853SCSSSLDSIKADGTS
Site 208T1859DSIKADGTSLDFSTY
Site 209S1860SIKADGTSLDFSTYR
Site 210S1864DGTSLDFSTYRSSQM
Site 211T1865GTSLDFSTYRSSQME
Site 212Y1866TSLDFSTYRSSQMES
Site 213S1868LDFSTYRSSQMESQF
Site 214S1869DFSTYRSSQMESQFL
Site 215S1873YRSSQMESQFLRDTI
Site 216T1879ESQFLRDTICEESLR
Site 217S1884RDTICEESLREKLQD
Site 218S1915LIQKPRQSNLPGNFT
Site 219T1922SNLPGNFTVNTPPTP
Site 220T1925PGNFTVNTPPTPEDL
Site 221T1928FTVNTPPTPEDLMLS
Site 222S1935TPEDLMLSQYVYRPK
Site 223Y1937EDLMLSQYVYRPKIQ
Site 224Y1939LMLSQYVYRPKIQIY
Site 225S1963KIEELKLSASNQDKL
Site 226S1965EELKLSASNQDKLLV
Site 227S1986WEKMRHCSDKELKAF
Site 228Y1996ELKAFGIYLNKIKSC
Site 229S2076NPVEEWDSEMRAAEK
Site 230T2090KELEQLKTEEEELQR
Site 231T2123MQKQRNRTEELLDQL
Site 232S2131EELLDQLSLSEWDVV
Site 233T2148SDDQAVFTFVYDTIQ
Site 234Y2174FPFLDKRYRKIVDVN
Site 235S2184IVDVNFQSLLDEDQA
Site 236S2194DEDQAPPSSLLVHKL
Site 237S2195EDQAPPSSLLVHKLI
Site 238Y2205VHKLIFQYVEEKESW
Site 239T2215EKESWKKTCTTQHQL
Site 240Y2245LLGEEIEYLKRWGPN
Site 241Y2253LKRWGPNYNLMNIDI
Site 242T2296PSVPLPSTIQNHVGN
Site 243S2305QNHVGNTSQDDIATI
Site 244Y2331KNVVKQIYQDLFQDC
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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