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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LINS1
Full Name:
Protein Lines homolog 1
Alias:
Wnt-signaling molecule Lines homolog 1
Type:
Mass (Da):
85889
Number AA:
757
UniProt ID:
Q8NG48
International Prot ID:
IPI00168910
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
K
K
V
L
L
G
A
T
L
E
N
D
S
H
D
Site 2
Y28
L
E
N
D
S
H
D
Y
I
F
Y
L
N
P
A
Site 3
Y31
D
S
H
D
Y
I
F
Y
L
N
P
A
V
S
D
Site 4
S37
F
Y
L
N
P
A
V
S
D
Q
D
C
S
T
A
Site 5
S42
A
V
S
D
Q
D
C
S
T
A
T
S
L
E
W
Site 6
T43
V
S
D
Q
D
C
S
T
A
T
S
L
E
W
A
Site 7
T78
V
A
P
V
C
L
K
T
N
S
Q
M
S
G
S
Site 8
S80
P
V
C
L
K
T
N
S
Q
M
S
G
S
R
E
Site 9
S83
L
K
T
N
S
Q
M
S
G
S
R
E
V
M
L
Site 10
T165
F
Q
L
R
E
K
I
T
L
S
N
S
W
I
A
Site 11
S179
A
F
C
Q
K
N
L
S
E
Y
S
E
S
N
K
Site 12
Y189
S
E
S
N
K
A
I
Y
C
L
W
T
L
T
A
Site 13
S205
I
K
E
I
F
K
D
S
C
S
Q
K
T
E
I
Site 14
S207
E
I
F
K
D
S
C
S
Q
K
T
E
I
L
K
Site 15
Y228
D
T
I
F
E
V
F
Y
N
S
L
F
S
Q
H
Site 16
S319
G
E
D
L
C
R
G
S
V
P
A
L
M
P
P
Site 17
T352
V
N
S
G
L
L
K
T
L
S
V
Y
E
K
H
Site 18
S354
S
G
L
L
K
T
L
S
V
Y
E
K
H
S
F
Site 19
S360
L
S
V
Y
E
K
H
S
F
F
G
G
D
E
V
Site 20
S376
P
E
C
E
L
I
T
S
P
D
H
V
I
L
R
Site 21
Y400
L
E
I
K
F
Q
N
Y
S
S
A
S
E
M
K
Site 22
S402
I
K
F
Q
N
Y
S
S
A
S
E
M
K
V
D
Site 23
T419
R
F
M
S
E
L
L
T
F
L
K
P
H
L
Q
Site 24
S428
L
K
P
H
L
Q
P
S
L
Q
L
H
N
P
C
Site 25
T470
L
T
R
G
C
E
A
T
E
S
L
T
Q
G
K
Site 26
S472
R
G
C
E
A
T
E
S
L
T
Q
G
K
E
M
Site 27
T548
I
C
N
N
F
D
A
T
E
S
K
Y
D
I
S
Site 28
Y552
F
D
A
T
E
S
K
Y
D
I
S
I
C
G
C
Site 29
S555
T
E
S
K
Y
D
I
S
I
C
G
C
V
P
S
Site 30
S568
P
S
L
V
Q
D
Q
S
S
N
Q
T
I
P
H
Site 31
S569
S
L
V
Q
D
Q
S
S
N
Q
T
I
P
H
R
Site 32
T572
Q
D
Q
S
S
N
Q
T
I
P
H
R
L
T
A
Site 33
T578
Q
T
I
P
H
R
L
T
A
P
H
S
H
R
D
Site 34
S582
H
R
L
T
A
P
H
S
H
R
D
V
C
A
R
Site 35
S591
R
D
V
C
A
R
H
S
W
A
S
D
A
P
S
Site 36
S594
C
A
R
H
S
W
A
S
D
A
P
S
E
P
L
Site 37
S598
S
W
A
S
D
A
P
S
E
P
L
K
A
V
M
Site 38
S606
E
P
L
K
A
V
M
S
K
G
A
H
T
M
C
Site 39
T611
V
M
S
K
G
A
H
T
M
C
A
S
S
L
S
Site 40
S615
G
A
H
T
M
C
A
S
S
L
S
S
P
R
A
Site 41
S616
A
H
T
M
C
A
S
S
L
S
S
P
R
A
S
Site 42
S618
T
M
C
A
S
S
L
S
S
P
R
A
S
Q
S
Site 43
S619
M
C
A
S
S
L
S
S
P
R
A
S
Q
S
L
Site 44
S623
S
L
S
S
P
R
A
S
Q
S
L
V
D
Y
D
Site 45
S625
S
S
P
R
A
S
Q
S
L
V
D
Y
D
S
S
Site 46
Y629
A
S
Q
S
L
V
D
Y
D
S
S
D
D
S
D
Site 47
S631
Q
S
L
V
D
Y
D
S
S
D
D
S
D
V
E
Site 48
S632
S
L
V
D
Y
D
S
S
D
D
S
D
V
E
S
Site 49
S635
D
Y
D
S
S
D
D
S
D
V
E
S
T
E
Q
Site 50
S639
S
D
D
S
D
V
E
S
T
E
Q
C
L
A
N
Site 51
S647
T
E
Q
C
L
A
N
S
K
Q
T
S
L
H
Q
Site 52
S651
L
A
N
S
K
Q
T
S
L
H
Q
Q
A
T
K
Site 53
S674
S
R
D
K
K
E
F
S
L
E
P
P
S
R
P
Site 54
S679
E
F
S
L
E
P
P
S
R
P
L
V
L
K
E
Site 55
S692
K
E
F
D
T
A
F
S
F
D
C
E
V
A
P
Site 56
Y734
Q
K
K
N
L
F
P
Y
N
P
T
A
L
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation