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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TCEB3C
Full Name:
RNA polymerase II transcription factor SIII subunit A3
Alias:
EloA3; Elongin-A3; TCEB3L2; Transcription elongation factor B polypeptide 3C
Type:
Nucleus, Integral membrane protein
Mass (Da):
59760
Number AA:
546
UniProt ID:
Q8NG57
International Prot ID:
IPI00168919
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0030528
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
K
L
Q
V
R
L
A
T
K
T
E
P
K
K
L
Site 2
T22
Q
V
R
L
A
T
K
T
E
P
K
K
L
E
K
Site 3
Y30
E
P
K
K
L
E
K
Y
L
Q
K
L
S
A
L
Site 4
S35
E
K
Y
L
Q
K
L
S
A
L
P
M
T
A
D
Site 5
T52
A
E
T
G
I
R
K
T
V
K
R
L
R
K
H
Site 6
T83
L
V
L
V
D
R
N
T
G
P
D
P
Q
D
P
Site 7
S93
D
P
Q
D
P
E
E
S
A
S
R
Q
R
F
G
Site 8
S95
Q
D
P
E
E
S
A
S
R
Q
R
F
G
E
A
Site 9
T117
W
G
F
P
E
N
A
T
A
P
R
S
P
S
H
Site 10
S121
E
N
A
T
A
P
R
S
P
S
H
S
P
E
H
Site 11
S123
A
T
A
P
R
S
P
S
H
S
P
E
H
R
R
Site 12
S125
A
P
R
S
P
S
H
S
P
E
H
R
R
T
A
Site 13
T131
H
S
P
E
H
R
R
T
A
R
R
T
P
P
G
Site 14
T135
H
R
R
T
A
R
R
T
P
P
G
Q
Q
R
P
Site 15
S146
Q
Q
R
P
H
P
R
S
P
S
R
E
P
R
A
Site 16
S148
R
P
H
P
R
S
P
S
R
E
P
R
A
E
R
Site 17
S165
P
R
M
A
P
A
D
S
G
P
H
R
D
P
P
Site 18
T173
G
P
H
R
D
P
P
T
R
T
A
P
L
P
M
Site 19
S222
P
Q
G
E
A
V
G
S
H
S
K
G
H
K
S
Site 20
S224
G
E
A
V
G
S
H
S
K
G
H
K
S
S
R
Site 21
S229
S
H
S
K
G
H
K
S
S
R
G
A
S
A
Q
Site 22
S230
H
S
K
G
H
K
S
S
R
G
A
S
A
Q
K
Site 23
S234
H
K
S
S
R
G
A
S
A
Q
K
S
P
P
V
Site 24
S238
R
G
A
S
A
Q
K
S
P
P
V
Q
E
S
Q
Site 25
S244
K
S
P
P
V
Q
E
S
Q
S
E
R
L
Q
A
Site 26
S246
P
P
V
Q
E
S
Q
S
E
R
L
Q
A
A
G
Site 27
S256
L
Q
A
A
G
A
D
S
A
G
P
K
T
V
P
Site 28
T261
A
D
S
A
G
P
K
T
V
P
S
H
V
F
S
Site 29
S264
A
G
P
K
T
V
P
S
H
V
F
S
E
L
W
Site 30
S268
T
V
P
S
H
V
F
S
E
L
W
D
P
S
E
Site 31
S286
Q
A
N
Y
D
L
L
S
A
F
E
A
M
T
S
Site 32
S293
S
A
F
E
A
M
T
S
Q
A
N
P
E
A
L
Site 33
Y323
V
N
A
K
M
P
V
Y
S
G
S
R
P
A
C
Site 34
S324
N
A
K
M
P
V
Y
S
G
S
R
P
A
C
Q
Site 35
S326
K
M
P
V
Y
S
G
S
R
P
A
C
Q
L
Q
Site 36
T371
E
P
V
L
E
G
W
T
P
D
Q
L
Y
R
T
Site 37
Y376
G
W
T
P
D
Q
L
Y
R
T
E
K
D
N
A
Site 38
T389
N
A
A
L
A
R
E
T
D
E
L
W
R
I
H
Site 39
S411
E
K
P
Q
E
H
E
S
W
R
E
L
Y
L
R
Site 40
Y416
H
E
S
W
R
E
L
Y
L
R
L
R
D
A
R
Site 41
T431
E
Q
R
L
R
V
V
T
T
K
I
R
S
A
R
Site 42
T432
Q
R
L
R
V
V
T
T
K
I
R
S
A
R
E
Site 43
S436
V
V
T
T
K
I
R
S
A
R
E
N
K
P
S
Site 44
S443
S
A
R
E
N
K
P
S
G
R
Q
T
K
M
I
Site 45
T447
N
K
P
S
G
R
Q
T
K
M
I
C
F
N
S
Site 46
T458
C
F
N
S
V
A
K
T
P
Y
D
A
S
R
R
Site 47
S463
A
K
T
P
Y
D
A
S
R
R
Q
E
K
S
A
Site 48
S469
A
S
R
R
Q
E
K
S
A
G
A
A
D
P
G
Site 49
S489
P
A
P
K
P
A
G
S
S
Q
A
P
S
G
L
Site 50
S490
A
P
K
P
A
G
S
S
Q
A
P
S
G
L
G
Site 51
S494
A
G
S
S
Q
A
P
S
G
L
G
D
G
D
G
Site 52
S503
L
G
D
G
D
G
G
S
V
S
G
G
G
S
S
Site 53
S505
D
G
D
G
G
S
V
S
G
G
G
S
S
N
R
Site 54
S509
G
S
V
S
G
G
G
S
S
N
R
H
A
A
P
Site 55
S510
S
V
S
G
G
G
S
S
N
R
H
A
A
P
A
Site 56
Y539
M
A
K
A
I
R
D
Y
K
G
R
F
S
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation