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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEK11
Full Name:
Serine/threonine-protein kinase Nek11
Alias:
FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NIMA-related kinase 11L
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; NEK family
Mass (Da):
74160
Number AA:
UniProt ID:
Q8NG66
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042802
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0031573
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
A
I
S
T
Y
P
K
T
L
I
A
R
R
Y
V
Site 2
Y29
K
T
L
I
A
R
R
Y
V
L
Q
Q
K
L
G
Site 3
Y44
S
G
S
F
G
T
V
Y
L
V
S
D
K
K
A
Site 4
S47
F
G
T
V
Y
L
V
S
D
K
K
A
K
R
G
Site 5
S84
N
L
E
A
Q
L
L
S
K
L
D
H
P
A
I
Site 6
Y110
N
F
C
I
I
T
E
Y
C
E
G
R
D
L
D
Site 7
Y123
L
D
D
K
I
Q
E
Y
K
Q
A
G
K
I
F
Site 8
S161
I
L
H
R
D
L
K
S
K
N
V
F
L
K
N
Site 9
T190
M
G
S
C
D
L
A
T
T
L
T
G
T
P
H
Site 10
T191
G
S
C
D
L
A
T
T
L
T
G
T
P
H
Y
Site 11
T193
C
D
L
A
T
T
L
T
G
T
P
H
Y
M
S
Site 12
T195
L
A
T
T
L
T
G
T
P
H
Y
M
S
P
E
Site 13
Y198
T
L
T
G
T
P
H
Y
M
S
P
E
A
L
K
Site 14
S200
T
G
T
P
H
Y
M
S
P
E
A
L
K
H
Q
Site 15
Y209
E
A
L
K
H
Q
G
Y
D
T
K
S
D
I
W
Site 16
T211
L
K
H
Q
G
Y
D
T
K
S
D
I
W
S
L
Site 17
T249
L
K
I
V
E
G
D
T
P
S
L
P
E
R
Y
Site 18
S251
I
V
E
G
D
T
P
S
L
P
E
R
Y
P
K
Site 19
S273
S
M
L
N
K
N
P
S
L
R
P
S
A
I
E
Site 20
S277
K
N
P
S
L
R
P
S
A
I
E
I
L
K
I
Site 21
T302
M
C
R
Y
S
E
M
T
L
E
D
K
N
L
D
Site 22
T329
Q
K
R
I
H
L
Q
T
L
R
A
L
S
E
V
Site 23
S334
L
Q
T
L
R
A
L
S
E
V
Q
K
M
T
P
Site 24
T340
L
S
E
V
Q
K
M
T
P
R
E
R
M
R
L
Site 25
Y368
K
K
I
V
E
E
K
Y
E
E
N
S
K
R
M
Site 26
S372
E
E
K
Y
E
E
N
S
K
R
M
Q
E
L
R
Site 27
S387
S
R
N
F
Q
Q
L
S
V
D
V
L
H
E
K
Site 28
S412
E
Q
P
E
G
R
L
S
C
S
P
Q
D
E
D
Site 29
S414
P
E
G
R
L
S
C
S
P
Q
D
E
D
E
E
Site 30
S430
W
Q
G
R
E
E
E
S
D
E
P
T
L
E
N
Site 31
T434
E
E
E
S
D
E
P
T
L
E
N
L
P
E
S
Site 32
S441
T
L
E
N
L
P
E
S
Q
P
I
P
S
M
D
Site 33
S454
M
D
L
H
E
L
E
S
I
V
E
D
A
T
S
Site 34
T460
E
S
I
V
E
D
A
T
S
D
L
G
Y
H
E
Site 35
S461
S
I
V
E
D
A
T
S
D
L
G
Y
H
E
I
Site 36
Y465
D
A
T
S
D
L
G
Y
H
E
I
P
E
D
P
Site 37
Y478
D
P
L
V
A
E
E
Y
Y
A
D
A
F
D
S
Site 38
Y479
P
L
V
A
E
E
Y
Y
A
D
A
F
D
S
Y
Site 39
Y486
Y
A
D
A
F
D
S
Y
C
V
E
S
D
E
E
Site 40
S511
K
E
I
R
N
E
G
S
Q
P
A
Y
R
T
N
Site 41
Y515
N
E
G
S
Q
P
A
Y
R
T
N
Q
Q
D
S
Site 42
S522
Y
R
T
N
Q
Q
D
S
D
I
E
A
L
A
R
Site 43
S539
E
N
V
L
G
C
T
S
L
D
T
K
T
I
T
Site 44
T544
C
T
S
L
D
T
K
T
I
T
T
M
A
E
D
Site 45
S553
T
T
M
A
E
D
M
S
P
G
P
P
I
F
N
Site 46
S561
P
G
P
P
I
F
N
S
V
M
A
R
T
K
M
Site 47
S574
K
M
K
R
M
R
E
S
A
M
Q
K
L
G
T
Site 48
Y590
V
F
E
E
V
Y
N
Y
L
K
R
A
R
H
Q
Site 49
S600
R
A
R
H
Q
N
A
S
E
A
E
I
R
E
C
Site 50
S616
E
K
V
V
P
Q
A
S
D
C
F
E
V
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation