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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTL
Full Name:
Tubulin--tyrosine ligase
Alias:
EC 6.3.2.25; Tubulin tyrosine ligase
Type:
Mass (Da):
43212
Number AA:
377
UniProt ID:
Q8NG68
International Prot ID:
IPI00166611
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0030955
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
V
V
R
D
E
N
S
S
V
Y
A
E
V
S
R
Site 2
Y14
R
D
E
N
S
S
V
Y
A
E
V
S
R
L
L
Site 3
S18
S
S
V
Y
A
E
V
S
R
L
L
L
A
T
G
Site 4
T24
V
S
R
L
L
L
A
T
G
H
W
K
R
L
R
Site 5
Y64
G
L
V
Q
L
V
N
Y
Y
R
G
A
D
K
L
Site 6
S76
D
K
L
C
R
K
A
S
L
V
K
L
I
K
T
Site 7
S90
T
S
P
E
L
A
E
S
C
T
W
F
P
E
S
Site 8
T92
P
E
L
A
E
S
C
T
W
F
P
E
S
Y
V
Site 9
Y101
F
P
E
S
Y
V
I
Y
P
T
N
L
K
T
P
Site 10
T107
I
Y
P
T
N
L
K
T
P
V
A
P
A
Q
N
Site 11
S121
N
G
I
Q
P
P
I
S
N
S
R
T
D
E
R
Site 12
T125
P
P
I
S
N
S
R
T
D
E
R
E
F
F
L
Site 13
S134
E
R
E
F
F
L
A
S
Y
N
R
K
K
E
D
Site 14
Y135
R
E
F
F
L
A
S
Y
N
R
K
K
E
D
G
Site 15
S151
G
N
V
W
I
A
K
S
S
A
G
A
K
G
E
Site 16
Y211
W
V
L
V
D
H
Q
Y
N
I
Y
L
Y
R
E
Site 17
Y214
V
D
H
Q
Y
N
I
Y
L
Y
R
E
G
V
L
Site 18
Y216
H
Q
Y
N
I
Y
L
Y
R
E
G
V
L
R
T
Site 19
S225
E
G
V
L
R
T
A
S
E
P
Y
H
V
D
N
Site 20
Y256
Y
S
K
N
Y
G
K
Y
E
E
G
N
E
M
F
Site 21
S303
L
S
V
E
P
A
I
S
T
K
H
L
P
Y
Q
Site 22
Y309
I
S
T
K
H
L
P
Y
Q
S
F
Q
L
F
G
Site 23
T369
P
D
V
E
Q
P
Q
T
Q
P
A
A
F
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation