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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEIL3
Full Name:
Endonuclease 8-like 3
Alias:
DNA glycosylase FPG2; FLJ10858; FPG2; HFPG2; HNEI3; Nei endonuclease VIII-like 3; Nei-like 3; Nei-like protein 3
Type:
DNA binding protein
Mass (Da):
67893
Number AA:
605
UniProt ID:
Q8TAT5
International Prot ID:
IPI00303135
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003906
GO:0003684
GO:0016799
PhosphoSite+
KinaseNET
Biological Process:
GO:0006284
GO:0006289
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
V
R
G
S
A
L
R
S
L
Q
G
R
A
L
R
Site 2
S60
A
A
A
L
N
N
D
S
S
Q
N
V
L
S
L
Site 3
S61
A
A
L
N
N
D
S
S
Q
N
V
L
S
L
F
Site 4
S66
D
S
S
Q
N
V
L
S
L
F
N
G
Y
V
Y
Site 5
Y111
I
N
P
L
E
Y
K
Y
K
N
G
A
S
P
V
Site 6
S116
Y
K
Y
K
N
G
A
S
P
V
L
E
V
Q
L
Site 7
S140
S
S
V
E
L
R
N
S
M
E
S
Q
Q
R
I
Site 8
S143
E
L
R
N
S
M
E
S
Q
Q
R
I
R
M
M
Site 9
S157
M
K
E
L
D
V
C
S
P
E
F
S
F
L
R
Site 10
S161
D
V
C
S
P
E
F
S
F
L
R
A
E
S
E
Site 11
S167
F
S
F
L
R
A
E
S
E
V
K
K
Q
K
G
Site 12
T214
A
V
K
V
C
Q
L
T
D
E
Q
I
H
H
L
Site 13
Y233
R
D
F
S
I
L
F
Y
R
C
R
K
A
G
L
Site 14
S243
R
K
A
G
L
A
L
S
K
H
Y
K
V
Y
K
Site 15
Y246
G
L
A
L
S
K
H
Y
K
V
Y
K
R
P
N
Site 16
Y249
L
S
K
H
Y
K
V
Y
K
R
P
N
C
G
Q
Site 17
T297
C
K
L
P
T
R
N
T
I
I
S
W
T
S
S
Site 18
S300
P
T
R
N
T
I
I
S
W
T
S
S
R
V
D
Site 19
T302
R
N
T
I
I
S
W
T
S
S
R
V
D
H
V
Site 20
S312
R
V
D
H
V
M
D
S
V
A
R
K
S
E
E
Site 21
S334
T
L
I
N
K
P
S
S
K
A
C
D
A
C
L
Site 22
T342
K
A
C
D
A
C
L
T
S
R
P
I
D
S
V
Site 23
S348
L
T
S
R
P
I
D
S
V
L
K
S
E
E
N
Site 24
S352
P
I
D
S
V
L
K
S
E
E
N
S
T
V
F
Site 25
S356
V
L
K
S
E
E
N
S
T
V
F
S
H
L
M
Site 26
T357
L
K
S
E
E
N
S
T
V
F
S
H
L
M
K
Site 27
Y365
V
F
S
H
L
M
K
Y
P
C
N
T
F
G
K
Site 28
T369
L
M
K
Y
P
C
N
T
F
G
K
P
H
T
E
Site 29
T375
N
T
F
G
K
P
H
T
E
V
K
I
N
R
K
Site 30
T383
E
V
K
I
N
R
K
T
A
F
G
T
T
T
L
Site 31
T388
R
K
T
A
F
G
T
T
T
L
V
L
T
D
F
Site 32
T393
G
T
T
T
L
V
L
T
D
F
S
N
K
S
S
Site 33
S396
T
L
V
L
T
D
F
S
N
K
S
S
T
L
E
Site 34
S399
L
T
D
F
S
N
K
S
S
T
L
E
R
K
T
Site 35
S400
T
D
F
S
N
K
S
S
T
L
E
R
K
T
K
Site 36
T401
D
F
S
N
K
S
S
T
L
E
R
K
T
K
Q
Site 37
T406
S
S
T
L
E
R
K
T
K
Q
N
Q
I
L
D
Site 38
S419
L
D
E
E
F
Q
N
S
P
P
A
S
V
C
L
Site 39
S423
F
Q
N
S
P
P
A
S
V
C
L
N
D
I
Q
Site 40
T437
Q
H
P
S
K
K
T
T
N
D
I
T
Q
L
S
Site 41
T441
K
K
T
T
N
D
I
T
Q
L
S
S
K
V
N
Site 42
S444
T
N
D
I
T
Q
L
S
S
K
V
N
I
S
P
Site 43
S450
L
S
S
K
V
N
I
S
P
T
I
S
S
E
S
Site 44
T452
S
K
V
N
I
S
P
T
I
S
S
E
S
K
L
Site 45
S454
V
N
I
S
P
T
I
S
S
E
S
K
L
F
S
Site 46
S455
N
I
S
P
T
I
S
S
E
S
K
L
F
S
P
Site 47
S457
S
P
T
I
S
S
E
S
K
L
F
S
P
A
H
Site 48
S461
S
S
E
S
K
L
F
S
P
A
H
K
K
P
K
Site 49
T469
P
A
H
K
K
P
K
T
A
H
Y
S
S
P
E
Site 50
Y472
K
K
P
K
T
A
H
Y
S
S
P
E
L
K
S
Site 51
S473
K
P
K
T
A
H
Y
S
S
P
E
L
K
S
C
Site 52
S474
P
K
T
A
H
Y
S
S
P
E
L
K
S
C
N
Site 53
S479
Y
S
S
P
E
L
K
S
C
N
P
G
Y
S
N
Site 54
Y484
L
K
S
C
N
P
G
Y
S
N
S
E
L
Q
I
Site 55
T494
S
E
L
Q
I
N
M
T
D
G
P
R
T
L
N
Site 56
T499
N
M
T
D
G
P
R
T
L
N
P
D
S
P
R
Site 57
S504
P
R
T
L
N
P
D
S
P
R
C
S
K
H
N
Site 58
Y531
E
N
K
G
R
Q
F
Y
A
C
P
L
P
R
E
Site 59
T561
C
N
H
G
K
R
S
T
M
K
T
V
L
K
I
Site 60
T564
G
K
R
S
T
M
K
T
V
L
K
I
G
P
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation