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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPL4
Full Name:
Nuclear protein localization protein 4 homolog
Alias:
FLJ20657; KIAA1499; nuclear protein localization 4; Q9P229
Type:
Mass (Da):
68120
Number AA:
608
UniProt ID:
Q8TAT6
International Prot ID:
IPI00001676
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005783
GO:0042175
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030433
GO:0007030
GO:0006944
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
P
D
G
V
K
R
I
T
A
T
K
R
E
T
A
Site 2
T25
I
T
A
T
K
R
E
T
A
A
T
F
L
K
K
Site 3
T28
T
K
R
E
T
A
A
T
F
L
K
K
V
A
K
Site 4
Y47
Q
N
N
G
F
S
V
Y
I
N
R
N
K
T
G
Site 5
T53
V
Y
I
N
R
N
K
T
G
E
I
T
A
S
S
Site 6
T57
R
N
K
T
G
E
I
T
A
S
S
N
K
S
L
Site 7
S59
K
T
G
E
I
T
A
S
S
N
K
S
L
N
L
Site 8
S63
I
T
A
S
S
N
K
S
L
N
L
L
K
I
K
Site 9
S86
P
S
S
L
A
G
P
S
S
E
M
E
T
S
V
Site 10
S87
S
S
L
A
G
P
S
S
E
M
E
T
S
V
P
Site 11
T91
G
P
S
S
E
M
E
T
S
V
P
P
G
F
K
Site 12
S92
P
S
S
E
M
E
T
S
V
P
P
G
F
K
V
Site 13
Y113
V
E
D
E
I
D
Q
Y
L
S
K
Q
D
G
K
Site 14
Y122
S
K
Q
D
G
K
I
Y
R
S
R
D
P
Q
L
Site 15
S124
Q
D
G
K
I
Y
R
S
R
D
P
Q
L
C
R
Site 16
Y151
L
E
P
F
D
E
D
Y
L
N
H
L
E
P
P
Site 17
Y167
K
H
M
S
F
H
A
Y
I
R
K
L
T
G
G
Site 18
T172
H
A
Y
I
R
K
L
T
G
G
A
D
K
G
K
Site 19
S192
N
I
S
C
K
I
K
S
G
C
E
G
H
L
P
Site 20
Y220
I
T
L
N
R
Q
K
Y
R
H
V
D
N
I
M
Site 21
T232
N
I
M
F
E
N
H
T
V
A
D
R
F
L
D
Site 22
Y251
T
G
N
Q
H
F
G
Y
L
Y
G
R
Y
T
E
Site 23
Y253
N
Q
H
F
G
Y
L
Y
G
R
Y
T
E
H
K
Site 24
Y256
F
G
Y
L
Y
G
R
Y
T
E
H
K
D
I
P
Site 25
T257
G
Y
L
Y
G
R
Y
T
E
H
K
D
I
P
L
Site 26
Y274
R
A
E
V
A
A
I
Y
E
P
P
Q
I
G
T
Site 27
S284
P
Q
I
G
T
Q
N
S
L
E
L
L
E
D
P
Site 28
T313
R
K
V
G
W
I
F
T
D
L
V
S
E
D
T
Site 29
T324
S
E
D
T
R
K
G
T
V
R
Y
S
R
N
K
Site 30
Y327
T
R
K
G
T
V
R
Y
S
R
N
K
D
T
Y
Site 31
S328
R
K
G
T
V
R
Y
S
R
N
K
D
T
Y
F
Site 32
T333
R
Y
S
R
N
K
D
T
Y
F
L
S
S
E
E
Site 33
Y334
Y
S
R
N
K
D
T
Y
F
L
S
S
E
E
C
Site 34
S337
N
K
D
T
Y
F
L
S
S
E
E
C
I
T
A
Site 35
T343
L
S
S
E
E
C
I
T
A
G
D
F
Q
N
K
Site 36
S358
H
P
N
M
C
R
L
S
P
D
G
H
F
G
S
Site 37
Y411
K
D
A
P
E
L
G
Y
A
K
E
S
S
S
E
Site 38
S417
G
Y
A
K
E
S
S
S
E
Q
Y
V
P
D
V
Site 39
Y420
K
E
S
S
S
E
Q
Y
V
P
D
V
F
Y
K
Site 40
Y426
Q
Y
V
P
D
V
F
Y
K
D
V
D
K
F
G
Site 41
T453
E
Y
L
I
I
D
I
T
T
T
F
P
K
D
P
Site 42
Y462
T
F
P
K
D
P
V
Y
T
F
S
I
S
Q
N
Site 43
T463
F
P
K
D
P
V
Y
T
F
S
I
S
Q
N
P
Site 44
S465
K
D
P
V
Y
T
F
S
I
S
Q
N
P
F
P
Site 45
S467
P
V
Y
T
F
S
I
S
Q
N
P
F
P
I
E
Site 46
S487
G
E
T
Q
D
F
H
S
L
A
T
Y
L
S
Q
Site 47
Y491
D
F
H
S
L
A
T
Y
L
S
Q
N
T
S
S
Site 48
S493
H
S
L
A
T
Y
L
S
Q
N
T
S
S
V
F
Site 49
S497
T
Y
L
S
Q
N
T
S
S
V
F
L
D
T
I
Site 50
T534
L
L
L
E
A
V
R
T
R
N
E
E
L
A
Q
Site 51
T542
R
N
E
E
L
A
Q
T
W
K
R
S
E
Q
W
Site 52
T551
K
R
S
E
Q
W
A
T
I
E
Q
L
C
S
T
Site 53
Y569
Q
L
P
G
L
H
E
Y
G
A
V
G
G
S
T
Site 54
S575
E
Y
G
A
V
G
G
S
T
H
T
A
T
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation