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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Nkx2-3
Full Name:
Homeobox protein Nkx-2.3
Alias:
Csx3; Homeobox protein NK-2 homolog C; Nk2 transcription factor related, locus 3; Nk2 transcription factor related, locus 3 (drosophila); Nk2.3; Nkx2.3; Nkx2c; Nkx4-3
Type:
Nucleus protein
Mass (Da):
38406
Number AA:
364
UniProt ID:
Q8TAU0
International Prot ID:
IPI00152116
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
M
L
P
S
P
V
T
S
T
P
F
S
V
K
D
Site 2
S71
E
D
E
G
E
K
L
S
Y
L
N
S
L
A
A
Site 3
Y72
D
E
G
E
K
L
S
Y
L
N
S
L
A
A
A
Site 4
S75
E
K
L
S
Y
L
N
S
L
A
A
A
D
G
H
Site 5
S85
A
A
D
G
H
G
D
S
G
L
C
P
Q
G
Y
Site 6
Y92
S
G
L
C
P
Q
G
Y
V
H
T
V
L
R
D
Site 7
T95
C
P
Q
G
Y
V
H
T
V
L
R
D
S
C
S
Site 8
S100
V
H
T
V
L
R
D
S
C
S
E
P
K
E
H
Site 9
S102
T
V
L
R
D
S
C
S
E
P
K
E
H
E
E
Site 10
S118
P
E
V
V
R
D
R
S
Q
K
S
C
Q
L
K
Site 11
S121
V
R
D
R
S
Q
K
S
C
Q
L
K
K
S
L
Site 12
S127
K
S
C
Q
L
K
K
S
L
E
T
A
G
D
C
Site 13
S140
D
C
K
A
A
E
E
S
E
R
P
K
P
R
S
Site 14
S147
S
E
R
P
K
P
R
S
R
R
K
P
R
V
L
Site 15
S156
R
K
P
R
V
L
F
S
Q
A
Q
V
F
E
L
Site 16
Y172
R
R
F
K
Q
Q
R
Y
L
S
A
P
E
R
E
Site 17
S174
F
K
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
Site 18
S183
P
E
R
E
H
L
A
S
S
L
K
L
T
S
T
Site 19
S184
E
R
E
H
L
A
S
S
L
K
L
T
S
T
Q
Site 20
T190
S
S
L
K
L
T
S
T
Q
V
K
I
W
F
Q
Site 21
S211
K
R
Q
R
Q
D
K
S
L
E
L
G
A
H
A
Site 22
T240
R
D
G
K
P
C
V
T
P
S
A
Q
A
Y
G
Site 23
S242
G
K
P
C
V
T
P
S
A
Q
A
Y
G
A
P
Site 24
Y246
V
T
P
S
A
Q
A
Y
G
A
P
Y
S
V
G
Site 25
S251
Q
A
Y
G
A
P
Y
S
V
G
A
S
A
Y
S
Site 26
S255
A
P
Y
S
V
G
A
S
A
Y
S
Y
N
S
F
Site 27
S258
S
V
G
A
S
A
Y
S
Y
N
S
F
P
A
Y
Site 28
Y259
V
G
A
S
A
Y
S
Y
N
S
F
P
A
Y
G
Site 29
S261
A
S
A
Y
S
Y
N
S
F
P
A
Y
G
Y
G
Site 30
Y265
S
Y
N
S
F
P
A
Y
G
Y
G
N
S
A
A
Site 31
Y295
S
S
S
Y
G
C
A
Y
P
A
G
G
G
G
G
Site 32
S307
G
G
G
G
G
G
T
S
A
A
T
T
A
M
Q
Site 33
T311
G
G
T
S
A
A
T
T
A
M
Q
P
A
C
S
Site 34
S336
S
N
L
G
G
F
G
S
G
G
S
A
Q
P
L
Site 35
S339
G
G
F
G
S
G
G
S
A
Q
P
L
H
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation