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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LNX1
Full Name:
E3 ubiquitin-protein ligase LNX
Alias:
Ligand of Numb-protein X 1;Numb-binding protein 1
Type:
Mass (Da):
80629
Number AA:
728
UniProt ID:
Q8TBB1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
N
Q
P
E
S
A
N
D
P
E
P
L
Site 2
Y29
S
L
E
E
N
H
F
Y
S
Y
P
E
E
V
D
Site 3
S30
L
E
E
N
H
F
Y
S
Y
P
E
E
V
D
D
Site 4
Y31
E
E
N
H
F
Y
S
Y
P
E
E
V
D
D
D
Site 5
S144
T
K
D
R
K
R
R
S
Q
D
G
C
P
D
G
Site 6
T156
P
D
G
C
A
S
L
T
A
T
A
P
S
P
E
Site 7
T174
A
A
T
I
S
L
M
T
D
E
P
G
L
D
N
Site 8
Y184
P
G
L
D
N
P
A
Y
V
S
S
A
E
D
G
Site 9
S196
E
D
G
Q
P
A
I
S
P
V
D
S
G
R
S
Site 10
S200
P
A
I
S
P
V
D
S
G
R
S
N
R
T
R
Site 11
S203
S
P
V
D
S
G
R
S
N
R
T
R
A
R
P
Site 12
S214
R
A
R
P
F
E
R
S
T
I
R
S
R
S
F
Site 13
T215
A
R
P
F
E
R
S
T
I
R
S
R
S
F
K
Site 14
S218
F
E
R
S
T
I
R
S
R
S
F
K
K
I
N
Site 15
S220
R
S
T
I
R
S
R
S
F
K
K
I
N
R
A
Site 16
S229
K
K
I
N
R
A
L
S
V
L
R
R
T
K
S
Site 17
S236
S
V
L
R
R
T
K
S
G
S
A
V
A
N
H
Site 18
S238
L
R
R
T
K
S
G
S
A
V
A
N
H
A
D
Site 19
S251
A
D
Q
G
R
E
N
S
E
N
T
T
A
P
E
Site 20
T255
R
E
N
S
E
N
T
T
A
P
E
V
F
P
R
Site 21
Y264
P
E
V
F
P
R
L
Y
H
L
I
P
D
G
E
Site 22
S283
K
I
N
R
V
D
P
S
E
S
L
S
I
R
L
Site 23
S285
N
R
V
D
P
S
E
S
L
S
I
R
L
V
G
Site 24
S287
V
D
P
S
E
S
L
S
I
R
L
V
G
G
S
Site 25
Y339
I
S
N
V
P
H
N
Y
A
V
R
L
L
R
Q
Site 26
T354
P
C
Q
V
L
W
L
T
V
M
R
E
Q
K
F
Site 27
Y373
N
G
Q
A
P
D
A
Y
R
P
R
D
D
S
F
Site 28
S379
A
Y
R
P
R
D
D
S
F
H
V
I
L
N
K
Site 29
S387
F
H
V
I
L
N
K
S
S
P
E
E
Q
L
G
Site 30
S388
H
V
I
L
N
K
S
S
P
E
E
Q
L
G
I
Site 31
Y439
I
N
G
H
D
L
R
Y
G
S
P
E
S
A
A
Site 32
S441
G
H
D
L
R
Y
G
S
P
E
S
A
A
H
L
Site 33
S444
L
R
Y
G
S
P
E
S
A
A
H
L
I
Q
A
Site 34
S468
S
R
Q
V
R
Q
R
S
P
D
I
F
Q
E
A
Site 35
S482
A
G
W
N
S
N
G
S
W
S
P
G
P
G
E
Site 36
S484
W
N
S
N
G
S
W
S
P
G
P
G
E
R
S
Site 37
S491
S
P
G
P
G
E
R
S
N
T
P
K
P
L
H
Site 38
T493
G
P
G
E
R
S
N
T
P
K
P
L
H
P
T
Site 39
T521
P
G
E
S
L
G
M
T
V
A
G
G
A
S
H
Site 40
S527
M
T
V
A
G
G
A
S
H
R
E
W
D
L
P
Site 41
Y536
R
E
W
D
L
P
I
Y
V
I
S
V
E
P
G
Site 42
T554
S
R
D
G
R
I
K
T
G
D
I
L
L
N
V
Site 43
T567
N
V
D
G
V
E
L
T
E
V
S
R
S
E
A
Site 44
S570
G
V
E
L
T
E
V
S
R
S
E
A
V
A
L
Site 45
S572
E
L
T
E
V
S
R
S
E
A
V
A
L
L
K
Site 46
Y595
K
A
L
E
V
K
E
Y
E
P
Q
E
D
C
S
Site 47
S603
E
P
Q
E
D
C
S
S
P
A
A
L
D
S
N
Site 48
S609
S
S
P
A
A
L
D
S
N
H
N
M
A
P
P
Site 49
Y657
G
F
C
I
V
G
G
Y
E
E
Y
N
G
N
K
Site 50
Y660
I
V
G
G
Y
E
E
Y
N
G
N
K
P
F
F
Site 51
S670
N
K
P
F
F
I
K
S
I
V
E
G
T
P
A
Site 52
T675
I
K
S
I
V
E
G
T
P
A
Y
N
D
G
R
Site 53
Y678
I
V
E
G
T
P
A
Y
N
D
G
R
I
R
C
Site 54
T717
K
E
L
K
G
R
I
T
L
T
I
V
S
W
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation