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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D16
Full Name:
TBC1 domain family member 16
Alias:
FLJ20748; MGC25062; TBC1 domain family, member 16; TBC16
Type:
GTPase activating protein, Rab
Mass (Da):
86372
Number AA:
767
UniProt ID:
Q8TBP0
International Prot ID:
IPI00290824
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
G
R
L
L
R
R
A
S
S
K
A
S
D
L
L
Site 2
S12
R
L
L
R
R
A
S
S
K
A
S
D
L
L
T
Site 3
S15
R
R
A
S
S
K
A
S
D
L
L
T
L
T
P
Site 4
T19
S
K
A
S
D
L
L
T
L
T
P
G
G
S
G
Site 5
T21
A
S
D
L
L
T
L
T
P
G
G
S
G
S
G
Site 6
S25
L
T
L
T
P
G
G
S
G
S
G
S
P
S
V
Site 7
S27
L
T
P
G
G
S
G
S
G
S
P
S
V
L
D
Site 8
S29
P
G
G
S
G
S
G
S
P
S
V
L
D
G
E
Site 9
S31
G
S
G
S
G
S
P
S
V
L
D
G
E
I
I
Site 10
Y62
L
G
E
H
H
P
G
Y
L
C
L
Y
M
E
K
Site 11
Y66
H
P
G
Y
L
C
L
Y
M
E
K
D
E
M
L
Site 12
Y97
Q
D
E
E
A
L
R
Y
I
T
P
E
S
S
P
Site 13
T99
E
E
A
L
R
Y
I
T
P
E
S
S
P
V
R
Site 14
S102
L
R
Y
I
T
P
E
S
S
P
V
R
K
A
P
Site 15
S103
R
Y
I
T
P
E
S
S
P
V
R
K
A
P
R
Site 16
T116
P
R
P
R
G
R
R
T
R
S
S
G
A
S
H
Site 17
S118
P
R
G
R
R
T
R
S
S
G
A
S
H
Q
P
Site 18
S119
R
G
R
R
T
R
S
S
G
A
S
H
Q
P
S
Site 19
S122
R
T
R
S
S
G
A
S
H
Q
P
S
P
T
E
Site 20
S126
S
G
A
S
H
Q
P
S
P
T
E
L
R
P
T
Site 21
T133
S
P
T
E
L
R
P
T
L
T
P
K
D
E
D
Site 22
T135
T
E
L
R
P
T
L
T
P
K
D
E
D
I
L
Site 23
S155
V
P
D
R
M
L
A
S
P
A
P
E
D
E
E
Site 24
S177
V
D
G
A
Q
P
A
S
Q
P
A
C
S
P
S
Site 25
S182
P
A
S
Q
P
A
C
S
P
S
G
I
L
S
T
Site 26
T189
S
P
S
G
I
L
S
T
V
S
P
Q
D
V
T
Site 27
S191
S
G
I
L
S
T
V
S
P
Q
D
V
T
E
E
Site 28
T196
T
V
S
P
Q
D
V
T
E
E
G
R
E
P
R
Site 29
S212
E
A
G
E
E
D
G
S
L
E
L
S
A
E
G
Site 30
S216
E
D
G
S
L
E
L
S
A
E
G
V
S
R
D
Site 31
S221
E
L
S
A
E
G
V
S
R
D
S
S
F
D
S
Site 32
S224
A
E
G
V
S
R
D
S
S
F
D
S
D
S
D
Site 33
S225
E
G
V
S
R
D
S
S
F
D
S
D
S
D
T
Site 34
S228
S
R
D
S
S
F
D
S
D
S
D
T
F
S
S
Site 35
S230
D
S
S
F
D
S
D
S
D
T
F
S
S
P
F
Site 36
T232
S
F
D
S
D
S
D
T
F
S
S
P
F
C
L
Site 37
S234
D
S
D
S
D
T
F
S
S
P
F
C
L
S
P
Site 38
S235
S
D
S
D
T
F
S
S
P
F
C
L
S
P
I
Site 39
S252
A
L
A
E
S
R
G
S
V
F
L
E
S
D
S
Site 40
S257
R
G
S
V
F
L
E
S
D
S
S
P
P
S
S
Site 41
S259
S
V
F
L
E
S
D
S
S
P
P
S
S
S
D
Site 42
S260
V
F
L
E
S
D
S
S
P
P
S
S
S
D
A
Site 43
S263
E
S
D
S
S
P
P
S
S
S
D
A
G
L
R
Site 44
S264
S
D
S
S
P
P
S
S
S
D
A
G
L
R
F
Site 45
S265
D
S
S
P
P
S
S
S
D
A
G
L
R
F
P
Site 46
S274
A
G
L
R
F
P
D
S
N
G
L
L
Q
T
P
Site 47
T280
D
S
N
G
L
L
Q
T
P
R
W
D
E
P
Q
Site 48
S308
V
D
L
G
H
M
R
S
L
R
L
F
F
S
D
Site 49
S314
R
S
L
R
L
F
F
S
D
E
A
C
T
S
G
Site 50
Y332
V
A
S
R
E
S
Q
Y
K
V
F
H
F
H
H
Site 51
S346
H
G
G
L
D
K
L
S
D
V
F
Q
Q
W
K
Site 52
S375
D
K
T
C
M
Q
F
S
I
R
R
P
K
L
P
Site 53
S383
I
R
R
P
K
L
P
S
S
E
T
H
P
E
E
Site 54
S384
R
R
P
K
L
P
S
S
E
T
H
P
E
E
S
Site 55
T386
P
K
L
P
S
S
E
T
H
P
E
E
S
M
Y
Site 56
Y393
T
H
P
E
E
S
M
Y
K
R
L
G
V
S
A
Site 57
Y415
L
G
Q
V
E
E
E
Y
K
L
R
K
A
I
F
Site 58
Y441
V
W
P
F
L
L
R
Y
Y
S
H
E
S
T
S
Site 59
Y442
W
P
F
L
L
R
Y
Y
S
H
E
S
T
S
E
Site 60
S443
P
F
L
L
R
Y
Y
S
H
E
S
T
S
E
E
Site 61
T447
R
Y
Y
S
H
E
S
T
S
E
E
R
E
A
L
Site 62
S448
Y
Y
S
H
E
S
T
S
E
E
R
E
A
L
R
Site 63
Y462
R
L
Q
K
R
K
E
Y
S
E
I
Q
Q
K
R
Site 64
S471
E
I
Q
Q
K
R
L
S
M
T
P
E
E
H
R
Site 65
T473
Q
Q
K
R
L
S
M
T
P
E
E
H
R
A
F
Site 66
S512
E
D
N
P
N
V
E
S
M
R
R
I
L
L
N
Site 67
S530
Y
N
P
A
V
G
Y
S
Q
G
M
S
D
L
V
Site 68
S566
Q
N
T
I
F
V
S
S
P
R
D
E
D
M
E
Site 69
Y578
D
M
E
K
Q
L
L
Y
L
R
E
L
L
R
L
Site 70
T586
L
R
E
L
L
R
L
T
H
V
R
F
Y
Q
H
Site 71
Y591
R
L
T
H
V
R
F
Y
Q
H
L
V
S
L
G
Site 72
S596
R
F
Y
Q
H
L
V
S
L
G
E
D
G
L
Q
Site 73
Y691
R
K
A
R
S
L
L
Y
Q
F
R
L
L
P
R
Site 74
S717
C
G
S
G
M
W
D
S
G
S
M
P
A
V
E
Site 75
S719
S
G
M
W
D
S
G
S
M
P
A
V
E
C
T
Site 76
S732
C
T
G
H
H
P
G
S
E
S
C
P
Y
G
G
Site 77
S734
G
H
H
P
G
S
E
S
C
P
Y
G
G
T
V
Site 78
Y737
P
G
S
E
S
C
P
Y
G
G
T
V
E
M
P
Site 79
S745
G
G
T
V
E
M
P
S
P
K
S
L
R
E
G
Site 80
S748
V
E
M
P
S
P
K
S
L
R
E
G
K
K
G
Site 81
T758
E
G
K
K
G
P
K
T
P
Q
D
G
F
G
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation