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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIP5K2C
Full Name:
Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma
Alias:
EC 2.7.1.149; FLJ22055; Phosphatidylinositol-5-phosphate 4-kinase type II gamma; Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma; PI(5)P 4-kinase type II gamma; PI42C; PIP4K2C; PIP4KII-gamma
Type:
EC 2.7.1.149; Endoplasmic reticulum; Kinase, lipid; Carbohydrate Metabolism - inositol phosphate
Mass (Da):
47286
Number AA:
421
UniProt ID:
Q8TBX8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0016309
GO:0005524
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0046488
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
G
P
G
F
G
F
A
S
K
T
K
K
K
H
F
Site 2
T28
G
F
G
F
A
S
K
T
K
K
K
H
F
V
Q
Site 3
S63
A
H
S
I
N
E
L
S
Q
V
P
P
P
V
M
Site 4
Y103
S
H
F
K
F
K
E
Y
C
P
Q
V
F
R
N
Site 5
Y122
F
G
I
D
D
Q
D
Y
L
V
S
L
T
R
N
Site 6
S125
D
D
Q
D
Y
L
V
S
L
T
R
N
P
P
S
Site 7
T127
Q
D
Y
L
V
S
L
T
R
N
P
P
S
E
S
Site 8
S132
S
L
T
R
N
P
P
S
E
S
E
G
S
D
G
Site 9
S134
T
R
N
P
P
S
E
S
E
G
S
D
G
R
F
Site 10
S137
P
P
S
E
S
E
G
S
D
G
R
F
L
I
S
Site 11
Y145
D
G
R
F
L
I
S
Y
D
R
T
L
V
I
K
Site 12
Y169
M
H
S
N
L
S
N
Y
H
Q
Y
I
V
K
C
Site 13
Y172
N
L
S
N
Y
H
Q
Y
I
V
K
C
H
G
N
Site 14
Y189
L
P
Q
F
L
G
M
Y
R
V
S
V
D
N
E
Site 15
S192
F
L
G
M
Y
R
V
S
V
D
N
E
D
S
Y
Site 16
Y199
S
V
D
N
E
D
S
Y
M
L
V
M
R
N
M
Site 17
S208
L
V
M
R
N
M
F
S
H
R
L
P
V
H
R
Site 18
Y217
R
L
P
V
H
R
K
Y
D
L
K
G
S
L
V
Site 19
S222
R
K
Y
D
L
K
G
S
L
V
S
R
E
A
S
Site 20
S229
S
L
V
S
R
E
A
S
D
K
E
K
V
K
E
Site 21
Y253
L
N
K
N
Q
K
V
Y
I
G
E
E
E
K
K
Site 22
Y281
V
Q
L
K
I
M
D
Y
S
L
L
L
G
I
H
Site 23
S294
I
H
D
I
I
R
G
S
E
P
E
E
E
G
P
Site 24
S307
G
P
V
R
E
D
E
S
E
V
D
G
D
C
S
Site 25
S314
S
E
V
D
G
D
C
S
L
T
G
P
P
A
L
Site 26
S324
G
P
P
A
L
V
G
S
Y
G
T
S
P
E
G
Site 27
Y325
P
P
A
L
V
G
S
Y
G
T
S
P
E
G
I
Site 28
T327
A
L
V
G
S
Y
G
T
S
P
E
G
I
G
G
Site 29
S328
L
V
G
S
Y
G
T
S
P
E
G
I
G
G
Y
Site 30
S338
G
I
G
G
Y
I
H
S
H
R
P
L
G
P
G
Site 31
S349
L
G
P
G
E
F
E
S
F
I
D
V
Y
A
I
Site 32
Y354
F
E
S
F
I
D
V
Y
A
I
R
S
A
E
G
Site 33
S358
I
D
V
Y
A
I
R
S
A
E
G
A
P
Q
K
Site 34
Y368
G
A
P
Q
K
E
V
Y
F
M
G
L
I
D
I
Site 35
T377
M
G
L
I
D
I
L
T
Q
Y
D
A
K
K
K
Site 36
Y379
L
I
D
I
L
T
Q
Y
D
A
K
K
K
A
A
Site 37
T391
K
A
A
H
A
A
K
T
V
K
H
G
A
G
A
Site 38
S401
H
G
A
G
A
E
I
S
T
V
H
P
E
Q
Y
Site 39
T402
G
A
G
A
E
I
S
T
V
H
P
E
Q
Y
A
Site 40
Y408
S
T
V
H
P
E
Q
Y
A
K
R
F
L
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation