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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D15
Full Name:
TBC1 domain family member 15
Alias:
4432405K22Rik; DKFZp761D0223; FLJ12085; TBC1 domain family, member 15; TBC15
Type:
GTPase-activating protein for Rab
Mass (Da):
79491
Number AA:
691
UniProt ID:
Q8TC07
International Prot ID:
IPI00154645
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
A
A
G
V
V
S
G
K
I
I
Y
E
Q
Site 2
Y19
I
Y
E
Q
E
G
V
Y
I
H
S
S
C
G
K
Site 3
S22
Q
E
G
V
Y
I
H
S
S
C
G
K
T
N
D
Site 4
S23
E
G
V
Y
I
H
S
S
C
G
K
T
N
D
Q
Site 5
T27
I
H
S
S
C
G
K
T
N
D
Q
D
G
L
I
Site 6
S60
P
L
D
D
A
L
D
S
S
S
I
L
Y
A
R
Site 7
S62
D
D
A
L
D
S
S
S
I
L
Y
A
R
K
D
Site 8
Y65
L
D
S
S
S
I
L
Y
A
R
K
D
S
S
S
Site 9
S70
I
L
Y
A
R
K
D
S
S
S
V
V
E
W
T
Site 10
S71
L
Y
A
R
K
D
S
S
S
V
V
E
W
T
Q
Site 11
S72
Y
A
R
K
D
S
S
S
V
V
E
W
T
Q
A
Site 12
T77
S
S
S
V
V
E
W
T
Q
A
P
K
E
R
G
Site 13
S88
K
E
R
G
H
R
G
S
E
H
L
N
S
Y
E
Site 14
S93
R
G
S
E
H
L
N
S
Y
E
A
E
W
D
M
Site 15
Y94
G
S
E
H
L
N
S
Y
E
A
E
W
D
M
V
Site 16
S105
W
D
M
V
N
T
V
S
F
K
R
K
P
H
T
Site 17
T112
S
F
K
R
K
P
H
T
N
G
D
A
P
S
H
Site 18
S118
H
T
N
G
D
A
P
S
H
R
N
G
K
S
K
Site 19
S124
P
S
H
R
N
G
K
S
K
W
S
F
L
F
S
Site 20
S127
R
N
G
K
S
K
W
S
F
L
F
S
L
T
D
Site 21
T133
W
S
F
L
F
S
L
T
D
L
K
S
I
K
Q
Site 22
S137
F
S
L
T
D
L
K
S
I
K
Q
N
K
E
G
Site 23
Y149
K
E
G
M
G
W
S
Y
L
V
F
C
L
K
D
Site 24
Y180
L
I
E
S
L
E
K
Y
V
V
L
C
E
S
P
Site 25
S186
K
Y
V
V
L
C
E
S
P
Q
D
K
R
T
L
Site 26
T192
E
S
P
Q
D
K
R
T
L
L
V
N
C
Q
N
Site 27
S201
L
V
N
C
Q
N
K
S
L
S
Q
S
F
E
N
Site 28
S203
N
C
Q
N
K
S
L
S
Q
S
F
E
N
L
L
Site 29
S205
Q
N
K
S
L
S
Q
S
F
E
N
L
L
D
E
Site 30
Y215
N
L
L
D
E
P
A
Y
G
L
I
Q
A
G
L
Site 31
Y243
K
K
I
K
K
D
P
Y
T
A
T
M
I
G
F
Site 32
T244
K
I
K
K
D
P
Y
T
A
T
M
I
G
F
S
Site 33
T246
K
K
D
P
Y
T
A
T
M
I
G
F
S
K
V
Site 34
Y256
G
F
S
K
V
T
N
Y
I
F
D
S
L
R
G
Site 35
S260
V
T
N
Y
I
F
D
S
L
R
G
S
D
P
S
Site 36
S264
I
F
D
S
L
R
G
S
D
P
S
T
H
Q
R
Site 37
S267
S
L
R
G
S
D
P
S
T
H
Q
R
P
P
S
Site 38
T268
L
R
G
S
D
P
S
T
H
Q
R
P
P
S
E
Site 39
S274
S
T
H
Q
R
P
P
S
E
M
A
D
F
L
S
Site 40
S318
V
Q
R
R
E
P
V
S
L
E
E
W
T
K
N
Site 41
S328
E
W
T
K
N
I
D
S
E
G
R
I
L
N
V
Site 42
S348
M
I
F
R
G
G
L
S
H
A
L
R
K
Q
A
Site 43
Y362
A
W
K
F
L
L
G
Y
F
P
W
D
S
T
K
Site 44
S367
L
G
Y
F
P
W
D
S
T
K
E
E
R
T
Q
Site 45
T368
G
Y
F
P
W
D
S
T
K
E
E
R
T
Q
L
Site 46
T380
T
Q
L
Q
K
Q
K
T
D
E
Y
F
R
M
K
Site 47
Y383
Q
K
Q
K
T
D
E
Y
F
R
M
K
L
Q
W
Site 48
S392
R
M
K
L
Q
W
K
S
I
S
Q
E
Q
E
K
Site 49
S394
K
L
Q
W
K
S
I
S
Q
E
Q
E
K
R
N
Site 50
S402
Q
E
Q
E
K
R
N
S
R
L
R
D
Y
R
S
Site 51
Y407
R
N
S
R
L
R
D
Y
R
S
L
I
E
K
D
Site 52
S409
S
R
L
R
D
Y
R
S
L
I
E
K
D
V
N
Site 53
T421
D
V
N
R
T
D
R
T
N
K
F
Y
E
G
Q
Site 54
Y425
T
D
R
T
N
K
F
Y
E
G
Q
D
N
P
G
Site 55
Y452
M
Y
D
F
D
L
G
Y
V
Q
G
M
S
D
L
Site 56
T497
E
Q
M
Q
G
M
K
T
Q
L
I
Q
L
S
T
Site 57
S515
L
L
D
S
G
F
C
S
Y
L
E
S
Q
D
S
Site 58
Y516
L
D
S
G
F
C
S
Y
L
E
S
Q
D
S
G
Site 59
S519
G
F
C
S
Y
L
E
S
Q
D
S
G
Y
L
Y
Site 60
Y524
L
E
S
Q
D
S
G
Y
L
Y
F
C
F
R
W
Site 61
S611
L
C
K
A
E
A
I
S
L
Q
M
V
K
C
K
Site 62
S633
E
I
L
G
L
Q
G
S
E
V
T
T
P
D
S
Site 63
T637
L
Q
G
S
E
V
T
T
P
D
S
D
V
G
E
Site 64
S640
S
E
V
T
T
P
D
S
D
V
G
E
D
E
N
Site 65
T651
E
D
E
N
V
V
M
T
P
C
P
T
S
A
F
Site 66
S660
C
P
T
S
A
F
Q
S
N
A
L
P
T
L
S
Site 67
T665
F
Q
S
N
A
L
P
T
L
S
A
S
G
A
R
Site 68
S667
S
N
A
L
P
T
L
S
A
S
G
A
R
N
D
Site 69
S669
A
L
P
T
L
S
A
S
G
A
R
N
D
S
P
Site 70
S675
A
S
G
A
R
N
D
S
P
T
Q
I
P
V
S
Site 71
T677
G
A
R
N
D
S
P
T
Q
I
P
V
S
S
D
Site 72
S682
S
P
T
Q
I
P
V
S
S
D
V
C
R
L
T
Site 73
S683
P
T
Q
I
P
V
S
S
D
V
C
R
L
T
P
Site 74
T689
S
S
D
V
C
R
L
T
P
A
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation