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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PNPT1
Full Name:
Polyribonucleotide nucleotidyltransferase 1, mitochondrial
Alias:
3'-5' RNA exonuclease OLD35; OLD35; Old-35; PNPASE; PNPase 1; PNPase old-35; Polynucleotide phosphorylase; Polynucleotide phosphorylase-like protein; Polyribonucleotide nucleotidyltransferase 1; Polyribonucleotide nucleotidyltransferase 1, mitochondrial
Type:
Nucleotide Metabolism - pyrimidine; Mitochondrial; Transferase; Nucleotide Metabolism - purine; RNA binding protein; EC 2.7.7.8
Mass (Da):
85951
Number AA:
783
UniProt ID:
Q8TCS8
International Prot ID:
IPI00744711
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0000175
GO:0003676
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006396
GO:0006401
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
P
R
R
D
R
A
L
T
Q
L
Q
V
R
A
L
Site 2
S59
G
N
R
K
L
E
I
S
S
G
K
L
A
R
F
Site 3
S60
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
Site 4
T88
M
V
T
A
V
S
K
T
K
P
S
P
S
Q
F
Site 5
S91
A
V
S
K
T
K
P
S
P
S
Q
F
M
P
L
Site 6
S93
S
K
T
K
P
S
P
S
Q
F
M
P
L
V
V
Site 7
Y102
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
Site 8
T114
A
A
A
G
R
I
P
T
N
Y
L
R
R
E
I
Site 9
Y116
A
G
R
I
P
T
N
Y
L
R
R
E
I
G
T
Site 10
S124
L
R
R
E
I
G
T
S
D
K
E
I
L
T
S
Site 11
S137
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
Site 12
Y200
I
G
I
I
D
G
E
Y
V
V
N
P
T
R
K
Site 13
S210
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
Site 14
S211
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
Site 15
S212
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
Site 16
T269
L
V
K
E
T
G
V
T
K
R
T
P
Q
K
L
Site 17
T272
E
T
G
V
T
K
R
T
P
Q
K
L
F
T
P
Site 18
T278
R
T
P
Q
K
L
F
T
P
S
P
E
I
V
K
Site 19
S280
P
Q
K
L
F
T
P
S
P
E
I
V
K
Y
T
Site 20
Y286
P
S
P
E
I
V
K
Y
T
H
K
L
A
M
E
Site 21
Y296
K
L
A
M
E
R
L
Y
A
V
F
T
D
Y
E
Site 22
Y302
L
Y
A
V
F
T
D
Y
E
H
D
K
V
S
R
Site 23
T320
V
N
K
I
R
L
D
T
E
E
Q
L
K
E
K
Site 24
Y334
K
F
P
E
A
D
P
Y
E
I
I
E
S
F
N
Site 25
S339
D
P
Y
E
I
I
E
S
F
N
V
V
A
K
E
Site 26
S350
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
Site 27
Y356
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
Site 28
T365
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
Site 29
S366
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
Site 30
S371
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
Site 31
Y427
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
Site 32
Y432
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
Site 33
Y459
A
L
A
E
K
A
L
Y
P
V
I
P
R
D
F
Site 34
S474
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
Site 35
S479
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
Site 36
S482
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
Site 37
S483
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
Site 38
S484
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
Site 39
T517
A
I
G
L
V
T
K
T
D
P
E
K
G
E
I
Site 40
Y527
E
K
G
E
I
E
D
Y
R
L
L
T
D
I
L
Site 41
T531
I
E
D
Y
R
L
L
T
D
I
L
G
I
E
D
Site 42
Y539
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
Site 43
T592
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
Site 44
S594
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
Site 45
S599
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
Site 46
T609
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
Site 47
S615
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
Site 48
Y626
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
Site 49
T638
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
Site 50
S640
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
Site 51
T646
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
Site 52
S648
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
Site 53
T665
H
E
A
R
D
F
I
T
E
I
C
K
D
D
Q
Site 54
T683
L
E
F
G
A
V
Y
T
A
T
I
T
E
I
R
Site 55
T687
A
V
Y
T
A
T
I
T
E
I
R
D
T
G
V
Site 56
T721
Q
R
K
I
K
H
P
T
A
L
G
L
E
V
G
Site 57
Y735
G
Q
E
I
Q
V
K
Y
F
G
R
D
P
A
D
Site 58
S748
A
D
G
R
M
R
L
S
R
K
V
L
Q
S
P
Site 59
S754
L
S
R
K
V
L
Q
S
P
A
T
T
V
V
R
Site 60
T758
V
L
Q
S
P
A
T
T
V
V
R
T
L
N
D
Site 61
T762
P
A
T
T
V
V
R
T
L
N
D
R
S
S
I
Site 62
S768
R
T
L
N
D
R
S
S
I
V
M
G
E
P
I
Site 63
S776
I
V
M
G
E
P
I
S
Q
S
S
S
N
S
Q
Site 64
S778
M
G
E
P
I
S
Q
S
S
S
N
S
Q
_
_
Site 65
S779
G
E
P
I
S
Q
S
S
S
N
S
Q
_
_
_
Site 66
S780
E
P
I
S
Q
S
S
S
N
S
Q
_
_
_
_
Site 67
S782
I
S
Q
S
S
S
N
S
Q
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation