PhosphoNET

           
Protein Info 
   
Short Name:  SPPL3
Full Name:  Signal peptide peptidase-like 3
Alias:  Intramembrane protease 2;Presenilin-like protein 4
Type: 
Mass (Da):  42563
Number AA:  385
UniProt ID:  Q8TCT6
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S11QTYSWAYSLVDSSQV
Site 2S49NQDKEKDSNSSSGSF
Site 3S51DKEKDSNSSSGSFNG
Site 4S53EKDSNSSSGSFNGEQ
Site 5S55DSNSSSGSFNGEQEP
Site 6S71IGFQPMDSTRARFLP
Site 7T72GFQPMDSTRARFLPM
Site 8S127QYLTRPCSPQNKISF
Site 9S233DNPLDVLSRKLHLGP
Site 10S259PGKLVFPSSTGSHFS
Site 11S260GKLVFPSSTGSHFSM
Site 12Y289FVLRYDNYKKQASGD
Site 13S297KKQASGDSCGAPGPA
Site 14S307APGPANISGRMQKVS
Site 15Y315GRMQKVSYFHCTLIG
Site 16S370GDLRRMWSEPFHSKS
Site 17S375MWSEPFHSKSSSSRF
Site 18S377SEPFHSKSSSSRFLE
Site 19S378EPFHSKSSSSRFLEV
Site 20S379PFHSKSSSSRFLEV_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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