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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPPL2B
Full Name:
Signal peptide peptidase-like 2B
Alias:
Intramembrane protease 4;Presenilin-like protein 1
Type:
Mass (Da):
64644
Number AA:
592
UniProt ID:
Q8TCT7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
Y
G
M
V
H
V
V
S
Q
A
G
G
P
E
G
Site 2
Y44
G
G
P
E
G
K
D
Y
C
I
L
Y
N
P
Q
Site 3
S60
A
H
L
P
H
D
L
S
K
A
S
F
L
Q
L
Site 4
S63
P
H
D
L
S
K
A
S
F
L
Q
L
R
N
W
Site 5
S73
Q
L
R
N
W
T
A
S
L
L
C
S
A
A
D
Site 6
Y101
A
R
G
N
C
T
F
Y
E
K
V
R
L
A
Q
Site 7
T131
V
P
P
G
G
N
K
T
Q
Y
D
E
I
G
I
Site 8
Y133
P
G
G
N
K
T
Q
Y
D
E
I
G
I
P
V
Site 9
Y164
R
T
V
R
A
A
L
Y
A
P
K
E
P
V
L
Site 10
Y173
P
K
E
P
V
L
D
Y
N
M
V
I
I
F
I
Site 11
Y202
S
R
D
V
K
K
R
Y
M
K
H
K
R
D
D
Site 12
S285
K
C
R
I
P
N
N
S
L
P
Y
F
H
K
R
Site 13
Y288
I
P
N
N
S
L
P
Y
F
H
K
R
P
Q
A
Site 14
S387
V
A
T
G
P
S
D
S
A
T
R
E
K
L
P
Site 15
T389
T
G
P
S
D
S
A
T
R
E
K
L
P
M
V
Site 16
S405
K
V
P
R
L
N
S
S
P
L
A
L
C
D
R
Site 17
S441
R
F
D
I
Q
V
Q
S
S
R
V
Y
F
V
A
Site 18
S527
G
P
Q
P
P
K
D
S
A
T
P
L
S
P
Q
Site 19
T529
Q
P
P
K
D
S
A
T
P
L
S
P
Q
P
P
Site 20
S532
K
D
S
A
T
P
L
S
P
Q
P
P
S
E
E
Site 21
S537
P
L
S
P
Q
P
P
S
E
E
P
A
T
S
P
Site 22
T542
P
P
S
E
E
P
A
T
S
P
W
P
A
E
Q
Site 23
S543
P
S
E
E
P
A
T
S
P
W
P
A
E
Q
S
Site 24
S550
S
P
W
P
A
E
Q
S
P
K
S
R
T
S
E
Site 25
S553
P
A
E
Q
S
P
K
S
R
T
S
E
E
M
G
Site 26
S556
Q
S
P
K
S
R
T
S
E
E
M
G
A
G
A
Site 27
S570
A
P
M
R
E
P
G
S
P
A
E
S
E
G
R
Site 28
S574
E
P
G
S
P
A
E
S
E
G
R
D
Q
A
Q
Site 29
S583
G
R
D
Q
A
Q
P
S
P
V
T
Q
P
G
A
Site 30
T586
Q
A
Q
P
S
P
V
T
Q
P
G
A
S
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation