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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPPL2A
Full Name:
Signal peptide peptidase-like 2A
Alias:
Protein SPP-like 2A
Type:
Mass (Da):
58125
Number AA:
520
UniProt ID:
Q8TCT8
International Prot ID:
IPI00154588
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
GO:0016021
GO:0031224
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004175
GO:0004190
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T37
L
H
A
S
G
N
G
T
T
K
D
Y
C
M
L
Site 2
Y41
G
N
G
T
T
K
D
Y
C
M
L
Y
N
P
Y
Site 3
T50
M
L
Y
N
P
Y
W
T
A
L
P
S
T
L
E
Site 4
S54
P
Y
W
T
A
L
P
S
T
L
E
N
A
T
S
Site 5
T55
Y
W
T
A
L
P
S
T
L
E
N
A
T
S
I
Site 6
S94
A
V
V
V
P
W
G
S
C
H
F
L
E
K
A
Site 7
S124
N
S
V
L
F
P
P
S
G
N
R
S
E
F
P
Site 8
S128
F
P
P
S
G
N
R
S
E
F
P
D
V
K
I
Site 9
T151
D
F
R
D
M
N
Q
T
L
G
D
N
I
T
V
Site 10
T157
Q
T
L
G
D
N
I
T
V
K
M
Y
S
P
S
Site 11
Y161
D
N
I
T
V
K
M
Y
S
P
S
W
P
N
F
Site 12
T203
E
N
L
K
A
V
T
T
E
D
R
E
M
R
K
Site 13
Y215
M
R
K
K
K
E
E
Y
L
T
F
S
P
L
T
Site 14
T217
K
K
K
E
E
Y
L
T
F
S
P
L
T
V
V
Site 15
T430
C
R
R
F
D
V
Q
T
G
S
S
Y
I
Y
Y
Site 16
S432
R
F
D
V
Q
T
G
S
S
Y
I
Y
Y
V
S
Site 17
Y434
D
V
Q
T
G
S
S
Y
I
Y
Y
V
S
S
T
Site 18
Y436
Q
T
G
S
S
Y
I
Y
Y
V
S
S
T
V
A
Site 19
Y495
K
F
W
K
G
N
S
Y
Q
M
M
D
H
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation