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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PREX1
Full Name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Alias:
P-Rex1
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
186203
Number AA:
1659
UniProt ID:
Q8TCU6
International Prot ID:
IPI00218429
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005100
GO:0005089
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0030041
GO:0006915
GO:0008624
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
A
P
S
G
S
E
P
G
G
D
Site 2
S43
P
C
A
A
A
R
E
S
E
R
Q
L
R
L
R
Site 3
T60
V
L
N
E
I
L
G
T
E
R
D
Y
V
G
T
Site 4
T67
T
E
R
D
Y
V
G
T
L
R
F
L
Q
S
A
Site 5
S73
G
T
L
R
F
L
Q
S
A
F
L
H
R
I
R
Site 6
S86
I
R
Q
N
V
A
D
S
V
E
K
G
L
T
E
Site 7
T92
D
S
V
E
K
G
L
T
E
E
N
V
K
V
L
Site 8
S127
C
L
H
P
E
P
Q
S
Q
H
E
L
G
N
V
Site 9
Y145
F
K
D
K
F
C
V
Y
E
E
Y
C
S
N
H
Site 10
Y148
K
F
C
V
Y
E
E
Y
C
S
N
H
E
K
A
Site 11
T183
M
L
L
G
G
R
K
T
T
D
I
P
L
E
G
Site 12
T184
L
L
G
G
R
K
T
T
D
I
P
L
E
G
Y
Site 13
T213
L
K
E
L
A
K
R
T
P
G
K
H
P
D
H
Site 14
T232
S
A
L
Q
A
M
K
T
V
C
S
N
I
N
E
Site 15
S255
E
A
L
E
Q
L
Q
S
H
I
E
G
W
E
G
Site 16
Y300
L
F
D
N
L
L
V
Y
C
K
R
K
S
R
V
Site 17
S305
L
V
Y
C
K
R
K
S
R
V
T
G
S
K
K
Site 18
T308
C
K
R
K
S
R
V
T
G
S
K
K
S
T
K
Site 19
S310
R
K
S
R
V
T
G
S
K
K
S
T
K
R
T
Site 20
S313
R
V
T
G
S
K
K
S
T
K
R
T
K
S
I
Site 21
T314
V
T
G
S
K
K
S
T
K
R
T
K
S
I
N
Site 22
T317
S
K
K
S
T
K
R
T
K
S
I
N
G
S
L
Site 23
S319
K
S
T
K
R
T
K
S
I
N
G
S
L
Y
I
Site 24
S323
R
T
K
S
I
N
G
S
L
Y
I
F
R
G
R
Site 25
Y325
K
S
I
N
G
S
L
Y
I
F
R
G
R
I
N
Site 26
T333
I
F
R
G
R
I
N
T
E
V
M
E
V
E
N
Site 27
T345
V
E
N
V
E
D
G
T
A
D
Y
H
S
N
G
Site 28
Y348
V
E
D
G
T
A
D
Y
H
S
N
G
Y
T
V
Site 29
Y353
A
D
Y
H
S
N
G
Y
T
V
T
N
G
W
K
Site 30
S396
R
E
R
E
Q
R
E
S
L
K
L
G
M
E
R
Site 31
Y406
L
G
M
E
R
D
A
Y
V
M
I
A
E
K
G
Site 32
Y417
A
E
K
G
E
K
L
Y
H
M
M
M
N
K
K
Site 33
S436
K
D
R
R
R
K
L
S
T
V
P
K
C
F
L
Site 34
T437
D
R
R
R
K
L
S
T
V
P
K
C
F
L
G
Site 35
T460
E
I
G
E
I
S
K
T
E
E
G
V
N
L
G
Site 36
Y492
F
K
N
E
Q
V
M
Y
R
F
R
Y
D
D
G
Site 37
Y496
Q
V
M
Y
R
F
R
Y
D
D
G
T
Y
K
A
Site 38
T500
R
F
R
Y
D
D
G
T
Y
K
A
R
S
E
L
Site 39
Y501
F
R
Y
D
D
G
T
Y
K
A
R
S
E
L
E
Site 40
S512
S
E
L
E
D
I
M
S
K
G
V
R
L
Y
C
Site 41
Y518
M
S
K
G
V
R
L
Y
C
R
L
H
S
L
Y
Site 42
S523
R
L
Y
C
R
L
H
S
L
Y
T
P
V
I
K
Site 43
Y525
Y
C
R
L
H
S
L
Y
T
P
V
I
K
D
R
Site 44
T526
C
R
L
H
S
L
Y
T
P
V
I
K
D
R
D
Site 45
Y534
P
V
I
K
D
R
D
Y
H
L
K
T
Y
K
S
Site 46
T538
D
R
D
Y
H
L
K
T
Y
K
S
V
L
P
G
Site 47
Y539
R
D
Y
H
L
K
T
Y
K
S
V
L
P
G
S
Site 48
S541
Y
H
L
K
T
Y
K
S
V
L
P
G
S
K
L
Site 49
S584
M
H
H
V
L
E
K
S
E
F
R
D
E
S
Q
Site 50
S590
K
S
E
F
R
D
E
S
Q
Y
F
R
F
H
A
Site 51
Y592
E
F
R
D
E
S
Q
Y
F
R
F
H
A
D
E
Site 52
T604
A
D
E
E
M
E
G
T
S
S
K
N
K
Q
L
Site 53
S605
D
E
E
M
E
G
T
S
S
K
N
K
Q
L
R
Site 54
S606
E
E
M
E
G
T
S
S
K
N
K
Q
L
R
N
Site 55
Y635
I
L
P
Q
E
E
D
Y
G
F
D
I
E
E
K
Site 56
Y669
L
Q
V
G
R
K
I
Y
S
I
N
E
D
L
V
Site 57
S686
R
P
F
S
E
V
E
S
I
L
N
Q
S
F
C
Site 58
S691
V
E
S
I
L
N
Q
S
F
C
S
R
R
P
L
Site 59
T704
P
L
R
L
L
V
A
T
K
A
K
E
I
I
K
Site 60
T718
K
I
P
D
Q
P
D
T
L
C
F
Q
I
R
G
Site 61
Y732
G
A
A
P
P
Y
V
Y
A
V
G
R
G
S
E
Site 62
S776
E
H
F
Q
A
F
R
S
R
R
E
E
A
L
G
Site 63
Y785
R
E
E
A
L
G
L
Y
Q
W
I
Y
H
T
H
Site 64
Y789
L
G
L
Y
Q
W
I
Y
H
T
H
E
D
A
Q
Site 65
S801
D
A
Q
E
A
R
A
S
Q
E
A
S
T
E
D
Site 66
S805
A
R
A
S
Q
E
A
S
T
E
D
P
S
G
E
Site 67
T806
R
A
S
Q
E
A
S
T
E
D
P
S
G
E
Q
Site 68
S810
E
A
S
T
E
D
P
S
G
E
Q
A
Q
E
E
Site 69
S822
Q
E
E
D
Q
A
D
S
A
F
P
L
L
S
L
Site 70
S834
L
S
L
G
P
R
L
S
L
C
E
D
S
P
M
Site 71
T843
C
E
D
S
P
M
V
T
L
T
V
D
N
V
H
Site 72
T845
D
S
P
M
V
T
L
T
V
D
N
V
H
L
E
Site 73
Y857
H
L
E
H
G
V
V
Y
E
Y
V
S
T
A
G
Site 74
Y859
E
H
G
V
V
Y
E
Y
V
S
T
A
G
V
R
Site 75
S895
E
A
F
A
A
N
D
S
V
F
V
E
N
C
R
Site 76
T925
E
F
R
N
I
C
D
T
K
L
E
S
I
G
Q
Site 77
S946
E
F
A
A
Q
L
K
S
R
V
S
P
P
F
K
Site 78
S949
A
Q
L
K
S
R
V
S
P
P
F
K
Q
A
P
Site 79
Y981
I
N
L
M
E
V
S
Y
P
K
T
T
P
S
V
Site 80
T984
M
E
V
S
Y
P
K
T
T
P
S
V
G
R
S
Site 81
T985
E
V
S
Y
P
K
T
T
P
S
V
G
R
S
F
Site 82
S987
S
Y
P
K
T
T
P
S
V
G
R
S
F
S
I
Site 83
S991
T
T
P
S
V
G
R
S
F
S
I
R
F
G
R
Site 84
S993
P
S
V
G
R
S
F
S
I
R
F
G
R
K
P
Site 85
S1001
I
R
F
G
R
K
P
S
L
I
G
L
D
P
E
Site 86
S1049
G
Q
G
L
H
D
G
S
F
G
P
A
S
G
T
Site 87
S1054
D
G
S
F
G
P
A
S
G
T
L
G
Q
E
D
Site 88
S1065
G
Q
E
D
R
G
L
S
F
L
L
K
Q
E
D
Site 89
Y1079
D
R
E
I
Q
D
A
Y
L
Q
L
F
T
K
L
Site 90
Y1096
A
L
K
E
M
K
Q
Y
V
T
Q
I
N
R
L
Site 91
S1105
T
Q
I
N
R
L
L
S
T
I
T
E
P
T
S
Site 92
T1108
N
R
L
L
S
T
I
T
E
P
T
S
G
G
S
Site 93
S1112
S
T
I
T
E
P
T
S
G
G
S
C
D
A
S
Site 94
S1115
T
E
P
T
S
G
G
S
C
D
A
S
L
A
E
Site 95
S1119
S
G
G
S
C
D
A
S
L
A
E
E
A
S
S
Site 96
S1125
A
S
L
A
E
E
A
S
S
L
P
L
V
S
E
Site 97
S1126
S
L
A
E
E
A
S
S
L
P
L
V
S
E
E
Site 98
S1131
A
S
S
L
P
L
V
S
E
E
S
E
M
D
R
Site 99
S1134
L
P
L
V
S
E
E
S
E
M
D
R
S
D
H
Site 100
S1139
E
E
S
E
M
D
R
S
D
H
G
G
I
K
K
Site 101
S1159
A
E
E
D
Q
E
D
S
G
H
D
T
M
S
Y
Site 102
T1163
Q
E
D
S
G
H
D
T
M
S
Y
R
D
S
Y
Site 103
S1165
D
S
G
H
D
T
M
S
Y
R
D
S
Y
S
E
Site 104
Y1166
S
G
H
D
T
M
S
Y
R
D
S
Y
S
E
C
Site 105
S1169
D
T
M
S
Y
R
D
S
Y
S
E
C
N
S
N
Site 106
Y1170
T
M
S
Y
R
D
S
Y
S
E
C
N
S
N
R
Site 107
S1171
M
S
Y
R
D
S
Y
S
E
C
N
S
N
R
D
Site 108
S1175
D
S
Y
S
E
C
N
S
N
R
D
S
V
L
S
Site 109
S1179
E
C
N
S
N
R
D
S
V
L
S
Y
T
S
V
Site 110
S1182
S
N
R
D
S
V
L
S
Y
T
S
V
R
S
N
Site 111
Y1183
N
R
D
S
V
L
S
Y
T
S
V
R
S
N
S
Site 112
T1184
R
D
S
V
L
S
Y
T
S
V
R
S
N
S
S
Site 113
S1185
D
S
V
L
S
Y
T
S
V
R
S
N
S
S
Y
Site 114
S1188
L
S
Y
T
S
V
R
S
N
S
S
Y
L
G
S
Site 115
S1190
Y
T
S
V
R
S
N
S
S
Y
L
G
S
D
E
Site 116
S1191
T
S
V
R
S
N
S
S
Y
L
G
S
D
E
M
Site 117
Y1192
S
V
R
S
N
S
S
Y
L
G
S
D
E
M
G
Site 118
S1195
S
N
S
S
Y
L
G
S
D
E
M
G
S
G
D
Site 119
S1200
L
G
S
D
E
M
G
S
G
D
E
L
P
C
D
Site 120
S1212
P
C
D
M
R
I
P
S
D
K
Q
D
K
L
H
Site 121
T1267
F
K
Q
K
E
E
C
T
I
R
G
R
S
L
I
Site 122
S1272
E
C
T
I
R
G
R
S
L
I
Q
I
S
I
Q
Site 123
S1277
G
R
S
L
I
Q
I
S
I
Q
E
D
P
W
N
Site 124
S1288
D
P
W
N
L
P
N
S
I
K
T
L
V
D
N
Site 125
Y1299
L
V
D
N
I
Q
R
Y
V
E
D
G
K
N
Q
Site 126
T1317
A
L
L
K
C
T
D
T
E
L
Q
L
R
R
D
Site 127
Y1350
L
A
A
L
G
Y
R
Y
N
N
N
G
E
Y
E
Site 128
Y1356
R
Y
N
N
N
G
E
Y
E
E
S
S
R
D
A
Site 129
S1359
N
N
G
E
Y
E
E
S
S
R
D
A
S
R
K
Site 130
S1360
N
G
E
Y
E
E
S
S
R
D
A
S
R
K
W
Site 131
S1364
E
E
S
S
R
D
A
S
R
K
W
L
E
Q
V
Site 132
S1385
L
H
C
Q
S
L
L
S
P
A
T
V
K
E
E
Site 133
T1388
Q
S
L
L
S
P
A
T
V
K
E
E
R
T
M
Site 134
T1410
L
S
E
L
D
N
V
T
F
S
F
K
Q
L
D
Site 135
S1412
E
L
D
N
V
T
F
S
F
K
Q
L
D
E
N
Site 136
Y1420
F
K
Q
L
D
E
N
Y
V
A
N
T
N
V
F
Site 137
Y1428
V
A
N
T
N
V
F
Y
H
I
E
G
S
R
Q
Site 138
Y1442
Q
A
L
K
V
I
F
Y
L
D
S
Y
H
F
S
Site 139
S1445
K
V
I
F
Y
L
D
S
Y
H
F
S
K
L
P
Site 140
S1449
Y
L
D
S
Y
H
F
S
K
L
P
S
R
L
E
Site 141
S1453
Y
H
F
S
K
L
P
S
R
L
E
G
G
A
S
Site 142
S1460
S
R
L
E
G
G
A
S
L
R
L
H
T
A
L
Site 143
S1480
E
N
V
E
G
L
P
S
P
G
S
Q
A
A
E
Site 144
S1483
E
G
L
P
S
P
G
S
Q
A
A
E
D
L
Q
Site 145
S1497
Q
Q
D
I
N
A
Q
S
L
E
K
V
Q
Q
Y
Site 146
Y1504
S
L
E
K
V
Q
Q
Y
Y
R
K
L
R
A
F
Site 147
Y1512
Y
R
K
L
R
A
F
Y
L
E
R
S
N
L
P
Site 148
S1516
R
A
F
Y
L
E
R
S
N
L
P
T
D
A
S
Site 149
T1520
L
E
R
S
N
L
P
T
D
A
S
T
T
A
V
Site 150
S1523
S
N
L
P
T
D
A
S
T
T
A
V
K
I
D
Site 151
T1525
L
P
T
D
A
S
T
T
A
V
K
I
D
Q
L
Site 152
S1548
E
L
C
R
L
M
K
S
F
V
H
P
K
P
G
Site 153
S1590
C
G
T
G
M
Q
R
S
T
L
S
V
S
L
E
Site 154
T1591
G
T
G
M
Q
R
S
T
L
S
V
S
L
E
Q
Site 155
S1593
G
M
Q
R
S
T
L
S
V
S
L
E
Q
A
A
Site 156
Y1648
P
Q
G
A
P
R
L
Y
R
L
C
Q
P
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation