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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEK9
Full Name:
Serine/threonine-protein kinase Nek9
Alias:
DKFZp434D0935; EC 2.7.11.1; KIAA1995; MGC16714; Nek8; NERCC; Nercc1 kinase; Never in mitosis A-related kinase 9; NIMA (never in mitosis gene a)- related kinase 9; NimA-related kinase 8; NimA-related protein kinase 9
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; NEK family
Mass (Da):
107168
Number AA:
979
UniProt ID:
Q8TD19
International Prot ID:
IPI00301609
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
V
L
G
E
Y
E
R
Site 2
Y7
_
M
S
V
L
G
E
Y
E
R
H
C
D
S
I
Site 3
S13
E
Y
E
R
H
C
D
S
I
N
S
D
F
G
S
Site 4
S16
R
H
C
D
S
I
N
S
D
F
G
S
E
S
G
Site 5
S20
S
I
N
S
D
F
G
S
E
S
G
G
C
G
D
Site 6
S22
N
S
D
F
G
S
E
S
G
G
C
G
D
S
S
Site 7
S28
E
S
G
G
C
G
D
S
S
P
G
P
S
A
S
Site 8
S29
S
G
G
C
G
D
S
S
P
G
P
S
A
S
Q
Site 9
S33
G
D
S
S
P
G
P
S
A
S
Q
G
P
R
A
Site 10
S35
S
S
P
G
P
S
A
S
Q
G
P
R
A
G
G
Site 11
Y52
A
E
Q
E
E
L
H
Y
I
P
I
R
V
L
G
Site 12
T67
R
G
A
F
G
E
A
T
L
Y
R
R
T
E
D
Site 13
Y69
A
F
G
E
A
T
L
Y
R
R
T
E
D
D
S
Site 14
T72
E
A
T
L
Y
R
R
T
E
D
D
S
L
V
V
Site 15
S76
Y
R
R
T
E
D
D
S
L
V
V
W
K
E
V
Site 16
T86
V
W
K
E
V
D
L
T
R
L
S
E
K
E
R
Site 17
S89
E
V
D
L
T
R
L
S
E
K
E
R
R
D
A
Site 18
T123
N
H
F
M
D
N
T
T
L
L
I
E
L
E
Y
Site 19
Y137
Y
C
N
G
G
N
L
Y
D
K
I
L
R
Q
K
Site 20
Y195
N
L
I
K
L
G
D
Y
G
L
A
K
K
L
N
Site 21
S203
G
L
A
K
K
L
N
S
E
Y
S
M
A
E
T
Site 22
Y205
A
K
K
L
N
S
E
Y
S
M
A
E
T
L
V
Site 23
S206
K
K
L
N
S
E
Y
S
M
A
E
T
L
V
G
Site 24
T210
S
E
Y
S
M
A
E
T
L
V
G
T
P
Y
Y
Site 25
T214
M
A
E
T
L
V
G
T
P
Y
Y
M
S
P
E
Site 26
Y216
E
T
L
V
G
T
P
Y
Y
M
S
P
E
L
C
Site 27
Y217
T
L
V
G
T
P
Y
Y
M
S
P
E
L
C
Q
Site 28
Y228
E
L
C
Q
G
V
K
Y
N
F
K
S
D
I
W
Site 29
T250
E
L
L
T
L
K
R
T
F
D
A
T
N
P
L
Site 30
T254
L
K
R
T
F
D
A
T
N
P
L
N
L
C
V
Site 31
S274
I
R
A
M
E
V
D
S
S
Q
Y
S
L
E
L
Site 32
S275
R
A
M
E
V
D
S
S
Q
Y
S
L
E
L
I
Site 33
S278
E
V
D
S
S
Q
Y
S
L
E
L
I
Q
M
V
Site 34
T298
Q
D
P
E
Q
R
P
T
A
D
E
L
L
D
R
Site 35
T320
R
E
M
E
E
K
V
T
L
L
N
A
P
T
K
Site 36
T326
V
T
L
L
N
A
P
T
K
R
P
R
S
S
T
Site 37
S331
A
P
T
K
R
P
R
S
S
T
V
T
E
A
P
Site 38
S332
P
T
K
R
P
R
S
S
T
V
T
E
A
P
I
Site 39
T333
T
K
R
P
R
S
S
T
V
T
E
A
P
I
A
Site 40
T335
R
P
R
S
S
T
V
T
E
A
P
I
A
V
V
Site 41
Y350
T
S
R
T
S
E
V
Y
V
W
G
G
G
K
S
Site 42
S357
Y
V
W
G
G
G
K
S
T
P
Q
K
L
D
V
Site 43
T358
V
W
G
G
G
K
S
T
P
Q
K
L
D
V
I
Site 44
S367
Q
K
L
D
V
I
K
S
G
C
S
A
R
Q
V
Site 45
T385
N
T
H
F
A
V
V
T
V
E
K
E
L
Y
T
Site 46
Y391
V
T
V
E
K
E
L
Y
T
W
V
N
M
Q
G
Site 47
S413
L
G
H
G
D
K
A
S
Y
R
Q
P
K
H
V
Site 48
Y414
G
H
G
D
K
A
S
Y
R
Q
P
K
H
V
E
Site 49
S432
G
K
A
I
R
Q
V
S
C
G
D
D
F
T
V
Site 50
Y448
V
T
D
E
G
Q
L
Y
A
F
G
S
D
Y
Y
Site 51
Y455
Y
A
F
G
S
D
Y
Y
G
C
M
G
V
D
K
Site 52
Y502
L
T
R
N
K
E
V
Y
S
W
G
C
G
E
Y
Site 53
Y509
Y
S
W
G
C
G
E
Y
G
R
L
G
L
D
S
Site 54
S516
Y
G
R
L
G
L
D
S
E
E
D
Y
Y
T
P
Site 55
Y520
G
L
D
S
E
E
D
Y
Y
T
P
Q
K
V
D
Site 56
Y521
L
D
S
E
E
D
Y
Y
T
P
Q
K
V
D
V
Site 57
T522
D
S
E
E
D
Y
Y
T
P
Q
K
V
D
V
P
Site 58
Y579
G
I
I
N
H
E
A
Y
H
E
V
P
Y
T
T
Site 59
Y584
E
A
Y
H
E
V
P
Y
T
T
S
F
T
L
A
Site 60
T585
A
Y
H
E
V
P
Y
T
T
S
F
T
L
A
K
Site 61
S587
H
E
V
P
Y
T
T
S
F
T
L
A
K
Q
L
Site 62
T601
L
S
F
Y
K
I
R
T
I
A
P
G
K
T
H
Site 63
T620
D
E
R
G
R
L
L
T
F
G
C
N
K
C
G
Site 64
Y634
G
Q
L
G
V
G
N
Y
K
K
R
L
G
I
N
Site 65
T685
G
N
G
R
L
A
M
T
P
T
E
R
P
H
G
Site 66
T687
G
R
L
A
M
T
P
T
E
R
P
H
G
S
D
Site 67
S706
W
P
R
P
I
F
G
S
L
H
H
V
P
D
L
Site 68
S730
I
V
E
K
V
L
N
S
K
T
I
R
S
N
S
Site 69
T732
E
K
V
L
N
S
K
T
I
R
S
N
S
S
G
Site 70
S735
L
N
S
K
T
I
R
S
N
S
S
G
L
S
I
Site 71
S737
S
K
T
I
R
S
N
S
S
G
L
S
I
G
T
Site 72
S738
K
T
I
R
S
N
S
S
G
L
S
I
G
T
V
Site 73
S741
R
S
N
S
S
G
L
S
I
G
T
V
F
Q
S
Site 74
T744
S
S
G
L
S
I
G
T
V
F
Q
S
S
S
P
Site 75
S748
S
I
G
T
V
F
Q
S
S
S
P
G
G
G
G
Site 76
S749
I
G
T
V
F
Q
S
S
S
P
G
G
G
G
G
Site 77
S750
G
T
V
F
Q
S
S
S
P
G
G
G
G
G
G
Site 78
S765
G
G
G
E
E
E
D
S
Q
Q
E
S
E
T
P
Site 79
S769
E
E
D
S
Q
Q
E
S
E
T
P
D
P
S
G
Site 80
T771
D
S
Q
Q
E
S
E
T
P
D
P
S
G
G
F
Site 81
S775
E
S
E
T
P
D
P
S
G
G
F
R
G
T
M
Site 82
T781
P
S
G
G
F
R
G
T
M
E
A
D
R
G
M
Site 83
S793
R
G
M
E
G
L
I
S
P
T
E
A
M
G
N
Site 84
T795
M
E
G
L
I
S
P
T
E
A
M
G
N
S
N
Site 85
S801
P
T
E
A
M
G
N
S
N
G
A
S
S
S
C
Site 86
S805
M
G
N
S
N
G
A
S
S
S
C
P
G
W
L
Site 87
S806
G
N
S
N
G
A
S
S
S
C
P
G
W
L
R
Site 88
S807
N
S
N
G
A
S
S
S
C
P
G
W
L
R
K
Site 89
S827
E
F
I
P
M
P
D
S
P
S
P
L
S
A
A
Site 90
S829
I
P
M
P
D
S
P
S
P
L
S
A
A
F
S
Site 91
S832
P
D
S
P
S
P
L
S
A
A
F
S
E
S
E
Site 92
S836
S
P
L
S
A
A
F
S
E
S
E
K
D
T
L
Site 93
S838
L
S
A
A
F
S
E
S
E
K
D
T
L
P
Y
Site 94
T842
F
S
E
S
E
K
D
T
L
P
Y
E
E
L
Q
Site 95
Y845
S
E
K
D
T
L
P
Y
E
E
L
Q
G
L
K
Site 96
S868
H
K
P
Q
V
E
A
S
S
P
R
L
N
P
A
Site 97
S869
K
P
Q
V
E
A
S
S
P
R
L
N
P
A
V
Site 98
T877
P
R
L
N
P
A
V
T
C
A
G
K
G
T
P
Site 99
T883
V
T
C
A
G
K
G
T
P
L
T
P
P
A
C
Site 100
T886
A
G
K
G
T
P
L
T
P
P
A
C
A
C
S
Site 101
S944
G
Q
Q
V
G
M
H
S
K
G
T
Q
T
A
K
Site 102
S964
D
P
K
P
D
L
D
S
D
S
W
C
L
L
G
Site 103
S966
K
P
D
L
D
S
D
S
W
C
L
L
G
T
D
Site 104
T972
D
S
W
C
L
L
G
T
D
S
C
R
P
S
L
Site 105
S974
W
C
L
L
G
T
D
S
C
R
P
S
L
_
_
Site 106
S978
G
T
D
S
C
R
P
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation