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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHQ1
Full Name:
Pleckstrin homology domain-containing family O member 2
Alias:
PH domain-containing protein; PKHQ1; Pleckstrin homology domain containing, family Q member 1; PP1628; Pp9099
Type:
Mass (Da):
53350
Number AA:
490
UniProt ID:
Q8TD55
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
K
A
G
W
I
K
K
S
S
G
G
L
L
G
F
Site 2
S29
A
G
W
I
K
K
S
S
G
G
L
L
G
F
W
Site 3
T62
D
D
Q
K
C
V
E
T
V
E
L
G
S
Y
E
Site 4
Y68
E
T
V
E
L
G
S
Y
E
K
C
Q
D
L
R
Site 5
S89
H
R
F
I
L
L
R
S
P
G
N
K
V
S
D
Site 6
S95
R
S
P
G
N
K
V
S
D
I
K
F
Q
A
P
Site 7
S109
P
T
G
E
E
K
E
S
W
I
K
A
L
N
E
Site 8
S134
D
E
V
K
V
D
K
S
C
A
L
E
H
V
T
Site 9
T155
G
Q
R
R
R
P
P
T
R
V
H
L
K
E
V
Site 10
S188
G
P
P
V
F
A
P
S
N
H
V
S
E
A
Q
Site 11
S192
F
A
P
S
N
H
V
S
E
A
Q
P
R
E
T
Site 12
T199
S
E
A
Q
P
R
E
T
P
R
P
L
M
P
P
Site 13
T207
P
R
P
L
M
P
P
T
K
P
F
L
A
P
E
Site 14
T215
K
P
F
L
A
P
E
T
T
S
P
G
D
R
V
Site 15
S217
F
L
A
P
E
T
T
S
P
G
D
R
V
E
T
Site 16
T224
S
P
G
D
R
V
E
T
P
V
G
E
R
A
P
Site 17
T232
P
V
G
E
R
A
P
T
P
V
S
A
S
S
E
Site 18
S235
E
R
A
P
T
P
V
S
A
S
S
E
V
S
P
Site 19
S237
A
P
T
P
V
S
A
S
S
E
V
S
P
E
S
Site 20
S238
P
T
P
V
S
A
S
S
E
V
S
P
E
S
Q
Site 21
S241
V
S
A
S
S
E
V
S
P
E
S
Q
E
D
S
Site 22
S244
S
S
E
V
S
P
E
S
Q
E
D
S
E
T
P
Site 23
S248
S
P
E
S
Q
E
D
S
E
T
P
A
E
E
D
Site 24
T250
E
S
Q
E
D
S
E
T
P
A
E
E
D
S
G
Site 25
S256
E
T
P
A
E
E
D
S
G
S
E
Q
P
P
N
Site 26
S258
P
A
E
E
D
S
G
S
E
Q
P
P
N
S
V
Site 27
S264
G
S
E
Q
P
P
N
S
V
L
P
D
K
L
K
Site 28
S273
L
P
D
K
L
K
V
S
W
E
N
P
S
P
Q
Site 29
S278
K
V
S
W
E
N
P
S
P
Q
E
A
P
A
A
Site 30
S287
Q
E
A
P
A
A
E
S
A
E
P
S
Q
A
P
Site 31
S291
A
A
E
S
A
E
P
S
Q
A
P
C
S
E
T
Site 32
S296
E
P
S
Q
A
P
C
S
E
T
S
E
A
A
P
Site 33
T311
R
E
G
G
K
P
P
T
P
P
P
K
I
L
S
Site 34
S318
T
P
P
P
K
I
L
S
E
K
L
K
A
S
M
Site 35
S331
S
M
G
E
M
Q
A
S
G
P
P
A
P
G
T
Site 36
T338
S
G
P
P
A
P
G
T
V
Q
V
S
V
N
G
Site 37
S342
A
P
G
T
V
Q
V
S
V
N
G
M
D
D
S
Site 38
S349
S
V
N
G
M
D
D
S
P
E
P
A
K
P
S
Site 39
S356
S
P
E
P
A
K
P
S
Q
A
E
G
T
P
G
Site 40
T361
K
P
S
Q
A
E
G
T
P
G
T
P
P
K
D
Site 41
T364
Q
A
E
G
T
P
G
T
P
P
K
D
A
T
T
Site 42
T370
G
T
P
P
K
D
A
T
T
S
T
A
L
P
P
Site 43
T371
T
P
P
K
D
A
T
T
S
T
A
L
P
P
W
Site 44
S389
P
Q
F
H
P
R
C
S
S
L
G
D
L
L
G
Site 45
S390
Q
F
H
P
R
C
S
S
L
G
D
L
L
G
E
Site 46
Y410
L
Q
P
R
E
R
L
Y
R
A
Q
L
E
V
K
Site 47
S420
Q
L
E
V
K
V
A
S
E
Q
T
E
K
L
L
Site 48
S439
G
S
E
P
A
P
V
S
A
E
T
L
L
S
Q
Site 49
T455
V
E
Q
L
R
Q
A
T
Q
V
L
Q
E
M
R
Site 50
S468
M
R
D
L
G
E
L
S
Q
E
A
P
G
L
R
Site 51
T483
E
K
R
K
E
L
V
T
L
Y
R
R
S
A
P
Site 52
Y485
R
K
E
L
V
T
L
Y
R
R
S
A
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation