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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DTX3L
Full Name:
E3 ubiquitin-protein ligase DTX3L
Alias:
BBAP; B-lymphoma- and BAL-associated protein; Deltex 3-like; Deltex 3-like protein; Protein deltex-3-like: B-lymphoma- and BAL-associated protein: Rhysin-2: Rhysin 2; Rhysin 2; Rhysin2; Rhysin-2
Type:
Ubiquitin conjugating system
Mass (Da):
83554
Number AA:
740
UniProt ID:
Q8TDB6
International Prot ID:
IPI00152503
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0042393
GO:0004842
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0010390
GO:0006974
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
H
L
R
P
P
S
P
Site 2
S9
A
S
H
L
R
P
P
S
P
L
L
V
R
V
Y
Site 3
Y16
S
P
L
L
V
R
V
Y
K
S
G
P
R
V
R
Site 4
S18
L
L
V
R
V
Y
K
S
G
P
R
V
R
R
K
Site 5
S28
R
V
R
R
K
L
E
S
Y
F
Q
S
S
K
S
Site 6
Y29
V
R
R
K
L
E
S
Y
F
Q
S
S
K
S
S
Site 7
S32
K
L
E
S
Y
F
Q
S
S
K
S
S
G
G
G
Site 8
S33
L
E
S
Y
F
Q
S
S
K
S
S
G
G
G
E
Site 9
S35
S
Y
F
Q
S
S
K
S
S
G
G
G
E
C
T
Site 10
S36
Y
F
Q
S
S
K
S
S
G
G
G
E
C
T
V
Site 11
T42
S
S
G
G
G
E
C
T
V
S
T
Q
E
H
E
Site 12
S44
G
G
G
E
C
T
V
S
T
Q
E
H
E
A
P
Site 13
T53
Q
E
H
E
A
P
G
T
F
R
V
E
F
S
E
Site 14
S59
G
T
F
R
V
E
F
S
E
R
A
A
K
E
R
Site 15
S102
K
N
T
R
P
Q
I
S
S
L
T
Q
S
Q
A
Site 16
S103
N
T
R
P
Q
I
S
S
L
T
Q
S
Q
A
E
Site 17
S107
Q
I
S
S
L
T
Q
S
Q
A
E
T
P
S
G
Site 18
T111
L
T
Q
S
Q
A
E
T
P
S
G
D
M
H
Q
Site 19
Y154
F
S
K
E
Q
R
A
Y
I
T
T
L
C
P
S
Site 20
T157
E
Q
R
A
Y
I
T
T
L
C
P
S
I
R
K
Site 21
S189
E
R
I
H
Q
F
L
S
E
Q
F
L
E
S
E
Site 22
S195
L
S
E
Q
F
L
E
S
E
Q
K
Q
Q
F
S
Site 23
S202
S
E
Q
K
Q
Q
F
S
P
S
M
T
E
R
K
Site 24
T206
Q
Q
F
S
P
S
M
T
E
R
K
P
L
S
Q
Site 25
S212
M
T
E
R
K
P
L
S
Q
Q
E
R
D
S
C
Site 26
S218
L
S
Q
Q
E
R
D
S
C
I
S
P
S
E
P
Site 27
S221
Q
E
R
D
S
C
I
S
P
S
E
P
E
T
K
Site 28
S223
R
D
S
C
I
S
P
S
E
P
E
T
K
A
E
Site 29
T227
I
S
P
S
E
P
E
T
K
A
E
Q
K
S
N
Site 30
S233
E
T
K
A
E
Q
K
S
N
Y
F
E
V
P
L
Site 31
Y235
K
A
E
Q
K
S
N
Y
F
E
V
P
L
P
Y
Site 32
Y248
P
Y
F
E
Y
F
K
Y
I
C
P
D
K
I
N
Site 33
S271
N
I
E
I
Q
E
S
S
P
N
M
V
C
L
D
Site 34
T280
N
M
V
C
L
D
F
T
S
S
R
S
G
D
L
Site 35
S281
M
V
C
L
D
F
T
S
S
R
S
G
D
L
E
Site 36
S282
V
C
L
D
F
T
S
S
R
S
G
D
L
E
A
Site 37
S293
D
L
E
A
A
R
E
S
F
A
S
E
F
Q
K
Site 38
S296
A
A
R
E
S
F
A
S
E
F
Q
K
N
T
E
Site 39
S311
P
L
K
Q
E
C
V
S
L
A
D
S
K
Q
A
Site 40
S315
E
C
V
S
L
A
D
S
K
Q
A
N
K
F
K
Site 41
S351
L
G
T
Q
D
D
I
S
A
A
K
Q
K
I
S
Site 42
Y373
V
K
L
F
A
A
N
Y
M
M
N
V
I
E
V
Site 43
Y385
I
E
V
D
S
A
H
Y
K
L
L
E
T
E
L
Site 44
S397
T
E
L
L
Q
E
I
S
E
I
E
K
R
Y
D
Site 45
S407
E
K
R
Y
D
I
C
S
K
V
S
E
K
G
Q
Site 46
T416
V
S
E
K
G
Q
K
T
C
I
L
F
E
S
K
Site 47
S430
K
D
R
Q
V
D
L
S
V
H
A
Y
A
S
F
Site 48
S457
R
E
V
L
L
L
K
S
L
G
K
E
R
K
H
Site 49
T491
V
L
N
Q
E
S
M
T
L
T
G
L
P
N
H
Site 50
T493
N
Q
E
S
M
T
L
T
G
L
P
N
H
L
A
Site 51
Y505
H
L
A
K
A
K
Q
Y
V
L
K
G
G
G
M
Site 52
S513
V
L
K
G
G
G
M
S
S
L
A
G
K
K
L
Site 53
S514
L
K
G
G
G
M
S
S
L
A
G
K
K
L
K
Site 54
T526
K
L
K
E
G
H
E
T
P
M
D
I
D
S
D
Site 55
S532
E
T
P
M
D
I
D
S
D
D
S
K
A
A
S
Site 56
S535
M
D
I
D
S
D
D
S
K
A
A
S
P
P
L
Site 57
S539
S
D
D
S
K
A
A
S
P
P
L
K
G
S
V
Site 58
S545
A
S
P
P
L
K
G
S
V
S
S
E
A
S
E
Site 59
S547
P
P
L
K
G
S
V
S
S
E
A
S
E
L
D
Site 60
S548
P
L
K
G
S
V
S
S
E
A
S
E
L
D
K
Site 61
S551
G
S
V
S
S
E
A
S
E
L
D
K
K
E
K
Site 62
Y592
C
I
N
K
A
M
S
Y
K
P
I
C
P
T
C
Site 63
T598
S
Y
K
P
I
C
P
T
C
Q
T
S
Y
G
I
Site 64
Y603
C
P
T
C
Q
T
S
Y
G
I
Q
K
G
N
Q
Site 65
S614
K
G
N
Q
P
E
G
S
M
V
F
T
V
S
R
Site 66
T618
P
E
G
S
M
V
F
T
V
S
R
D
S
L
P
Site 67
S620
G
S
M
V
F
T
V
S
R
D
S
L
P
G
Y
Site 68
S623
V
F
T
V
S
R
D
S
L
P
G
Y
E
S
F
Site 69
Y627
S
R
D
S
L
P
G
Y
E
S
F
G
T
I
V
Site 70
Y663
P
G
I
Q
R
T
A
Y
L
P
D
N
K
E
G
Site 71
Y678
R
K
V
L
K
L
L
Y
R
A
F
D
Q
K
L
Site 72
S698
Y
S
R
V
L
G
V
S
D
V
I
T
W
N
D
Site 73
Y719
R
F
G
G
P
E
M
Y
G
Y
P
D
P
S
Y
Site 74
Y721
G
G
P
E
M
Y
G
Y
P
D
P
S
Y
L
K
Site 75
S725
M
Y
G
Y
P
D
P
S
Y
L
K
R
V
K
E
Site 76
Y726
Y
G
Y
P
D
P
S
Y
L
K
R
V
K
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation