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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX54
Full Name:
ATP-dependent RNA helicase DDX54
Alias:
APR-5; ATP-dependent RNA helicase DP97; DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; DEAD box protein 54; DP97; MGC2835
Type:
Helicase, Nuclear receptor co-regulator, Transcription, coactivator/corepressor
Mass (Da):
98595
Number AA:
881
UniProt ID:
Q8TDD1
International Prot ID:
IPI00152510
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005730
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004004
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0006396
GO:0030520
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
G
P
A
A
G
P
R
S
R
A
A
M
A
Q
W
Site 2
S34
R
K
R
R
G
A
A
S
Q
A
R
G
S
D
S
Site 3
S39
A
A
S
Q
A
R
G
S
D
S
E
D
G
E
F
Site 4
S41
S
Q
A
R
G
S
D
S
E
D
G
E
F
E
I
Site 5
T67
G
P
G
R
P
L
P
T
F
P
T
S
E
C
T
Site 6
T70
R
P
L
P
T
F
P
T
S
E
C
T
S
D
V
Site 7
S71
P
L
P
T
F
P
T
S
E
C
T
S
D
V
E
Site 8
T74
T
F
P
T
S
E
C
T
S
D
V
E
P
D
T
Site 9
S75
F
P
T
S
E
C
T
S
D
V
E
P
D
T
R
Site 10
T81
T
S
D
V
E
P
D
T
R
E
M
V
R
A
Q
Site 11
S95
Q
N
K
K
K
K
K
S
G
G
F
Q
S
M
G
Site 12
S100
K
K
S
G
G
F
Q
S
M
G
L
S
Y
P
V
Site 13
Y105
F
Q
S
M
G
L
S
Y
P
V
F
K
G
I
M
Site 14
Y116
K
G
I
M
K
K
G
Y
K
V
P
T
P
I
Q
Site 15
T120
K
K
G
Y
K
V
P
T
P
I
Q
R
K
T
I
Site 16
T126
P
T
P
I
Q
R
K
T
I
P
V
I
L
D
G
Site 17
T142
D
V
V
A
M
A
R
T
G
S
G
K
T
A
C
Site 18
T147
A
R
T
G
S
G
K
T
A
C
F
L
L
P
M
Site 19
T160
P
M
F
E
R
L
K
T
H
S
A
Q
T
G
A
Site 20
S162
F
E
R
L
K
T
H
S
A
Q
T
G
A
R
A
Site 21
T182
T
R
E
L
A
L
Q
T
L
K
F
T
K
E
L
Site 22
Y243
L
K
L
Q
S
V
E
Y
V
V
F
D
E
A
D
Site 23
T305
L
I
R
L
D
V
D
T
K
L
N
E
Q
L
K
Site 24
T313
K
L
N
E
Q
L
K
T
S
F
F
L
V
R
E
Site 25
S314
L
N
E
Q
L
K
T
S
F
F
L
V
R
E
D
Site 26
T359
E
Y
L
T
E
L
L
T
T
Q
R
V
S
C
A
Site 27
T360
Y
L
T
E
L
L
T
T
Q
R
V
S
C
A
H
Site 28
T375
I
Y
S
A
L
D
P
T
A
R
K
I
N
L
A
Site 29
Y413
L
L
D
N
V
I
N
Y
S
F
P
A
K
G
K
Site 30
S414
L
D
N
V
I
N
Y
S
F
P
A
K
G
K
L
Site 31
S435
R
V
A
R
A
G
R
S
G
T
A
Y
S
L
V
Site 32
T437
A
R
A
G
R
S
G
T
A
Y
S
L
V
A
P
Site 33
Y439
A
G
R
S
G
T
A
Y
S
L
V
A
P
D
E
Site 34
S440
G
R
S
G
T
A
Y
S
L
V
A
P
D
E
I
Site 35
S460
L
H
L
F
L
G
R
S
L
T
L
A
R
P
L
Site 36
T462
L
F
L
G
R
S
L
T
L
A
R
P
L
K
E
Site 37
S471
A
R
P
L
K
E
P
S
G
V
A
G
V
D
G
Site 38
S486
M
L
G
R
V
P
Q
S
V
V
D
E
E
D
S
Site 39
S493
S
V
V
D
E
E
D
S
G
L
Q
S
T
L
E
Site 40
S497
E
E
D
S
G
L
Q
S
T
L
E
A
S
L
E
Site 41
T498
E
D
S
G
L
Q
S
T
L
E
A
S
L
E
L
Site 42
Y519
A
D
N
A
Q
Q
Q
Y
V
R
S
R
P
A
P
Site 43
S527
V
R
S
R
P
A
P
S
P
E
S
I
K
R
A
Site 44
S530
R
P
A
P
S
P
E
S
I
K
R
A
K
E
M
Site 45
S549
L
G
L
H
P
L
F
S
S
R
F
E
E
E
E
Site 46
S565
Q
R
L
R
L
V
D
S
I
K
N
Y
R
S
R
Site 47
Y569
L
V
D
S
I
K
N
Y
R
S
R
A
T
I
F
Site 48
T574
K
N
Y
R
S
R
A
T
I
F
E
I
N
A
S
Site 49
S581
T
I
F
E
I
N
A
S
S
R
D
L
C
S
Q
Site 50
S587
A
S
S
R
D
L
C
S
Q
V
M
R
A
K
R
Site 51
S644
E
E
E
E
A
G
E
S
V
E
D
I
F
S
E
Site 52
S650
E
S
V
E
D
I
F
S
E
V
V
G
R
K
R
Site 53
S660
V
G
R
K
R
Q
R
S
G
P
N
R
G
A
K
Site 54
Y681
R
Q
R
D
Q
E
F
Y
I
P
Y
R
P
K
D
Site 55
S691
Y
R
P
K
D
F
D
S
E
R
G
L
S
I
S
Site 56
S696
F
D
S
E
R
G
L
S
I
S
G
E
G
G
A
Site 57
S698
S
E
R
G
L
S
I
S
G
E
G
G
A
F
E
Site 58
S743
K
K
R
F
V
G
Q
S
G
Q
E
D
K
K
K
Site 59
T753
E
D
K
K
K
I
K
T
E
S
G
R
Y
I
S
Site 60
S755
K
K
K
I
K
T
E
S
G
R
Y
I
S
S
S
Site 61
Y758
I
K
T
E
S
G
R
Y
I
S
S
S
Y
K
R
Site 62
S760
T
E
S
G
R
Y
I
S
S
S
Y
K
R
D
L
Site 63
S761
E
S
G
R
Y
I
S
S
S
Y
K
R
D
L
Y
Site 64
S762
S
G
R
Y
I
S
S
S
Y
K
R
D
L
Y
Q
Site 65
Y763
G
R
Y
I
S
S
S
Y
K
R
D
L
Y
Q
K
Site 66
Y768
S
S
Y
K
R
D
L
Y
Q
K
W
K
Q
K
Q
Site 67
S782
Q
K
I
D
D
R
D
S
D
E
E
G
A
S
D
Site 68
S788
D
S
D
E
E
G
A
S
D
R
R
G
P
E
R
Site 69
S807
R
D
R
G
Q
G
A
S
R
P
H
A
P
G
T
Site 70
T814
S
R
P
H
A
P
G
T
P
A
G
R
V
R
P
Site 71
T825
R
V
R
P
E
L
K
T
K
Q
Q
I
L
K
Q
Site 72
S851
R
G
G
L
K
Q
L
S
A
R
N
R
R
R
V
Site 73
S872
A
F
G
R
G
A
R
S
K
K
G
K
M
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation