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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RASGRP4
Full Name:
RAS guanyl-releasing protein 4
Alias:
Type:
Mass (Da):
74882
Number AA:
673
UniProt ID:
Q8TDF6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
N
R
K
D
S
K
R
K
S
H
Q
E
Site 2
S10
R
K
D
S
K
R
K
S
H
Q
E
C
T
G
K
Site 3
T32
R
Q
V
R
R
H
K
T
C
P
S
P
R
E
I
Site 4
S35
R
R
H
K
T
C
P
S
P
R
E
I
S
K
V
Site 5
S40
C
P
S
P
R
E
I
S
K
V
M
A
S
M
N
Site 6
S52
S
M
N
L
G
L
L
S
E
G
G
C
S
E
D
Site 7
S57
L
L
S
E
G
G
C
S
E
D
E
L
L
E
K
Site 8
S71
K
C
I
Q
S
F
D
S
A
G
S
L
C
H
E
Site 9
S74
Q
S
F
D
S
A
G
S
L
C
H
E
D
H
M
Site 10
T104
D
L
A
A
R
L
L
T
S
Y
Q
K
A
T
G
Site 11
Y106
A
A
R
L
L
T
S
Y
Q
K
A
T
G
D
T
Site 12
T152
V
I
G
R
F
W
A
T
V
A
R
E
G
N
S
Site 13
S167
A
Q
R
R
L
G
D
S
S
D
L
L
S
P
G
Site 14
S168
Q
R
R
L
G
D
S
S
D
L
L
S
P
G
G
Site 15
S172
G
D
S
S
D
L
L
S
P
G
G
P
G
P
P
Site 16
S183
P
G
P
P
L
P
M
S
S
P
G
L
G
K
K
Site 17
S184
G
P
P
L
P
M
S
S
P
G
L
G
K
K
R
Site 18
S194
L
G
K
K
R
K
V
S
L
L
F
D
H
L
E
Site 19
T210
G
E
L
A
Q
H
L
T
Y
L
E
F
R
S
F
Site 20
Y211
E
L
A
Q
H
L
T
Y
L
E
F
R
S
F
Q
Site 21
S216
L
T
Y
L
E
F
R
S
F
Q
A
I
T
P
Q
Site 22
T221
F
R
S
F
Q
A
I
T
P
Q
D
L
R
S
Y
Site 23
S227
I
T
P
Q
D
L
R
S
Y
V
L
Q
G
S
V
Site 24
Y228
T
P
Q
D
L
R
S
Y
V
L
Q
G
S
V
R
Site 25
S260
W
V
Q
V
M
V
L
S
R
P
G
P
L
Q
R
Site 26
T289
H
Q
L
Q
N
F
N
T
L
M
A
V
T
G
G
Site 27
S303
G
L
C
H
S
A
I
S
R
L
K
D
S
H
A
Site 28
S308
A
I
S
R
L
K
D
S
H
A
H
L
S
P
D
Site 29
S313
K
D
S
H
A
H
L
S
P
D
S
T
K
A
L
Site 30
S316
H
A
H
L
S
P
D
S
T
K
A
L
L
E
L
Site 31
T317
A
H
L
S
P
D
S
T
K
A
L
L
E
L
T
Site 32
S329
E
L
T
E
L
L
A
S
H
N
N
Y
A
R
Y
Site 33
Y333
L
L
A
S
H
N
N
Y
A
R
Y
R
R
T
W
Site 34
Y336
S
H
N
N
Y
A
R
Y
R
R
T
W
A
G
C
Site 35
S360
V
H
L
K
D
L
V
S
L
H
E
A
Q
P
D
Site 36
Y383
L
P
K
L
N
N
L
Y
L
R
L
Q
E
L
V
Site 37
S400
Q
G
Q
H
P
P
C
S
A
N
E
D
L
L
H
Site 38
Y417
T
L
S
L
D
L
F
Y
T
E
D
E
I
Y
E
Site 39
T418
L
S
L
D
L
F
Y
T
E
D
E
I
Y
E
L
Site 40
Y423
F
Y
T
E
D
E
I
Y
E
L
S
Y
A
R
E
Site 41
S426
E
D
E
I
Y
E
L
S
Y
A
R
E
P
R
C
Site 42
S436
R
E
P
R
C
P
K
S
L
P
P
S
P
F
N
Site 43
S440
C
P
K
S
L
P
P
S
P
F
N
A
P
L
V
Site 44
T455
V
E
W
A
P
G
V
T
P
K
P
D
R
V
T
Site 45
T462
T
P
K
P
D
R
V
T
L
G
R
H
V
E
Q
Site 46
S473
H
V
E
Q
L
V
E
S
V
F
K
N
Y
D
P
Site 47
Y478
V
E
S
V
F
K
N
Y
D
P
E
G
R
G
T
Site 48
T485
Y
D
P
E
G
R
G
T
I
S
Q
E
D
F
E
Site 49
S487
P
E
G
R
G
T
I
S
Q
E
D
F
E
R
L
Site 50
S495
Q
E
D
F
E
R
L
S
G
N
F
P
F
A
C
Site 51
S515
P
P
R
Q
G
R
G
S
F
S
R
E
E
L
T
Site 52
S517
R
Q
G
R
G
S
F
S
R
E
E
L
T
G
Y
Site 53
Y524
S
R
E
E
L
T
G
Y
L
L
R
A
S
A
I
Site 54
T547
L
H
T
F
H
E
V
T
F
R
K
P
T
F
C
Site 55
T552
E
V
T
F
R
K
P
T
F
C
D
S
C
S
G
Site 56
Y569
W
G
V
T
K
Q
G
Y
R
C
R
E
C
G
L
Site 57
S609
P
P
G
A
P
V
P
S
T
P
A
P
H
A
S
Site 58
T610
P
G
A
P
V
P
S
T
P
A
P
H
A
S
C
Site 59
S616
S
T
P
A
P
H
A
S
C
G
S
E
E
N
H
Site 60
S624
C
G
S
E
E
N
H
S
Y
T
L
S
L
E
P
Site 61
Y625
G
S
E
E
N
H
S
Y
T
L
S
L
E
P
E
Site 62
T626
S
E
E
N
H
S
Y
T
L
S
L
E
P
E
T
Site 63
S628
E
N
H
S
Y
T
L
S
L
E
P
E
T
G
C
Site 64
T642
C
Q
L
R
H
A
W
T
Q
T
E
S
P
H
P
Site 65
T644
L
R
H
A
W
T
Q
T
E
S
P
H
P
S
W
Site 66
S646
H
A
W
T
Q
T
E
S
P
H
P
S
W
E
T
Site 67
S650
Q
T
E
S
P
H
P
S
W
E
T
D
T
V
P
Site 68
S665
C
P
V
M
D
P
P
S
T
A
S
S
K
L
D
Site 69
T666
P
V
M
D
P
P
S
T
A
S
S
K
L
D
S
Site 70
S669
D
P
P
S
T
A
S
S
K
L
D
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation