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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHD-5
Full Name:
Chromodomain-helicase-DNA-binding protein 5
Alias:
ATP-dependent helicase CHD5; CHD5; Chromodomain helicase-DNA-binding 5; EC 3.6.1.-
Type:
Chromatin, Nucleus protein
Mass (Da):
223050
Number AA:
1954
UniProt ID:
Q8TDI0
International Prot ID:
IPI00152535
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006333
GO:0016568
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
R
G
P
V
G
T
E
E
E
L
P
R
L
Site 2
S26
M
E
N
E
D
E
M
S
E
E
E
D
G
G
L
Site 3
S46
F
F
P
V
E
P
V
S
L
P
K
K
K
K
P
Site 4
S71
K
R
K
K
K
E
G
S
N
D
E
L
S
E
N
Site 5
S76
E
G
S
N
D
E
L
S
E
N
E
E
D
L
E
Site 6
S86
E
E
D
L
E
E
K
S
E
S
E
G
S
D
Y
Site 7
S88
D
L
E
E
K
S
E
S
E
G
S
D
Y
S
P
Site 8
S91
E
K
S
E
S
E
G
S
D
Y
S
P
N
K
K
Site 9
Y93
S
E
S
E
G
S
D
Y
S
P
N
K
K
K
K
Site 10
S94
E
S
E
G
S
D
Y
S
P
N
K
K
K
K
K
Site 11
S133
G
C
L
K
E
P
K
S
S
G
Q
L
M
A
E
Site 12
Y148
W
G
L
D
D
V
D
Y
L
F
S
E
E
D
Y
Site 13
Y155
Y
L
F
S
E
E
D
Y
H
T
L
T
N
Y
K
Site 14
T157
F
S
E
E
D
Y
H
T
L
T
N
Y
K
A
F
Site 15
T159
E
E
D
Y
H
T
L
T
N
Y
K
A
F
S
Q
Site 16
Y161
D
Y
H
T
L
T
N
Y
K
A
F
S
Q
F
L
Site 17
S182
K
N
P
K
I
P
M
S
K
M
M
T
V
L
G
Site 18
S196
G
A
K
W
R
E
F
S
A
N
N
P
F
K
G
Site 19
S229
I
S
P
P
L
A
V
S
P
P
Q
V
P
Q
P
Site 20
T244
V
P
I
R
K
A
K
T
K
E
G
K
G
P
G
Site 21
S259
V
R
K
K
I
K
G
S
K
D
G
K
K
K
G
Site 22
S282
K
F
R
F
G
G
I
S
N
K
R
K
K
G
S
Site 23
S289
S
N
K
R
K
K
G
S
S
S
E
E
D
E
R
Site 24
S290
N
K
R
K
K
G
S
S
S
E
E
D
E
R
E
Site 25
S291
K
R
K
K
G
S
S
S
E
E
D
E
R
E
E
Site 26
S299
E
E
D
E
R
E
E
S
D
F
D
S
A
S
I
Site 27
S303
R
E
E
S
D
F
D
S
A
S
I
H
S
A
S
Site 28
S305
E
S
D
F
D
S
A
S
I
H
S
A
S
V
R
Site 29
S308
F
D
S
A
S
I
H
S
A
S
V
R
S
E
C
Site 30
S310
S
A
S
I
H
S
A
S
V
R
S
E
C
S
A
Site 31
S323
S
A
A
L
G
K
K
S
K
R
R
R
K
K
K
Site 32
Y338
R
I
D
D
G
D
G
Y
E
T
D
H
Q
D
Y
Site 33
T340
D
D
G
D
G
Y
E
T
D
H
Q
D
Y
C
E
Site 34
Y345
Y
E
T
D
H
Q
D
Y
C
E
V
C
Q
Q
G
Site 35
S496
P
G
P
D
V
E
P
S
L
P
P
P
K
P
L
Site 36
Y534
K
E
L
Q
L
E
L
Y
H
T
V
M
Y
R
N
Site 37
Y542
H
T
V
M
Y
R
N
Y
Q
R
K
N
D
M
D
Site 38
Y556
D
E
P
P
P
F
D
Y
G
S
G
D
E
D
G
Site 39
S558
P
P
P
F
D
Y
G
S
G
D
E
D
G
K
S
Site 40
S565
S
G
D
E
D
G
K
S
E
K
R
K
N
K
D
Site 41
Y575
R
K
N
K
D
P
L
Y
A
K
M
E
E
R
F
Site 42
Y583
A
K
M
E
E
R
F
Y
R
Y
G
I
K
P
E
Site 43
S601
I
H
R
I
L
N
H
S
F
D
K
K
G
D
V
Site 44
Y610
D
K
K
G
D
V
H
Y
L
I
K
W
K
D
L
Site 45
Y633
I
D
D
I
D
I
P
Y
Y
D
N
L
K
Q
A
Site 46
Y634
D
D
I
D
I
P
Y
Y
D
N
L
K
Q
A
Y
Site 47
T653
E
L
M
L
G
E
D
T
R
L
P
K
R
L
L
Site 48
T677
K
Q
E
K
P
P
D
T
P
I
V
D
P
T
V
Site 49
T683
D
T
P
I
V
D
P
T
V
K
F
D
K
Q
P
Site 50
Y692
K
F
D
K
Q
P
W
Y
I
D
S
T
G
G
T
Site 51
S695
K
Q
P
W
Y
I
D
S
T
G
G
T
L
H
P
Site 52
T699
Y
I
D
S
T
G
G
T
L
H
P
Y
Q
L
E
Site 53
Y703
T
G
G
T
L
H
P
Y
Q
L
E
G
L
N
W
Site 54
T721
S
W
A
Q
G
T
D
T
I
L
A
D
E
M
G
Site 55
S741
Q
T
I
V
F
L
Y
S
L
Y
K
E
G
H
S
Site 56
Y743
I
V
F
L
Y
S
L
Y
K
E
G
H
S
K
G
Site 57
Y752
E
G
H
S
K
G
P
Y
L
V
S
A
P
L
S
Site 58
Y776
E
M
W
A
P
D
F
Y
V
V
T
Y
T
G
D
Site 59
S786
T
Y
T
G
D
K
E
S
R
S
V
I
R
E
N
Site 60
S788
T
G
D
K
E
S
R
S
V
I
R
E
N
E
F
Site 61
S796
V
I
R
E
N
E
F
S
F
E
D
N
A
I
R
Site 62
Y870
L
N
S
Y
K
I
D
Y
K
L
L
L
T
G
T
Site 63
T875
I
D
Y
K
L
L
L
T
G
T
P
L
Q
N
N
Site 64
T877
Y
K
L
L
L
T
G
T
P
L
Q
N
N
L
E
Site 65
T894
F
H
L
L
N
F
L
T
P
E
R
F
N
N
L
Site 66
S912
L
E
E
F
A
D
I
S
K
E
D
Q
I
K
K
Site 67
S953
L
I
V
R
V
E
L
S
Q
M
Q
K
K
Y
Y
Site 68
Y959
L
S
Q
M
Q
K
K
Y
Y
K
F
I
L
T
R
Site 69
Y960
S
Q
M
Q
K
K
Y
Y
K
F
I
L
T
R
N
Site 70
S973
R
N
F
E
A
L
N
S
K
G
G
G
N
Q
V
Site 71
S981
K
G
G
G
N
Q
V
S
L
L
N
I
M
M
D
Site 72
Y1014
P
V
L
P
N
G
S
Y
D
G
S
S
L
V
K
Site 73
S1017
P
N
G
S
Y
D
G
S
S
L
V
K
S
S
G
Site 74
S1018
N
G
S
Y
D
G
S
S
L
V
K
S
S
G
K
Site 75
Y1062
L
L
E
D
F
L
E
Y
E
G
Y
K
Y
E
R
Site 76
Y1065
D
F
L
E
Y
E
G
Y
K
Y
E
R
I
D
G
Site 77
Y1067
L
E
Y
E
G
Y
K
Y
E
R
I
D
G
G
I
Site 78
Y1118
T
A
D
T
V
I
I
Y
D
S
D
W
N
P
H
Site 79
T1150
V
M
I
Y
R
F
V
T
R
A
S
V
E
E
R
Site 80
S1153
Y
R
F
V
T
R
A
S
V
E
E
R
I
T
Q
Site 81
T1159
A
S
V
E
E
R
I
T
Q
V
A
K
R
K
M
Site 82
T1169
A
K
R
K
M
M
L
T
H
L
V
V
R
P
G
Site 83
S1179
V
V
R
P
G
L
G
S
K
S
G
S
M
T
K
Site 84
S1181
R
P
G
L
G
S
K
S
G
S
M
T
K
Q
E
Site 85
S1183
G
L
G
S
K
S
G
S
M
T
K
Q
E
L
D
Site 86
T1185
G
S
K
S
G
S
M
T
K
Q
E
L
D
D
I
Site 87
S1210
D
D
V
E
G
M
M
S
Q
G
Q
R
P
V
T
Site 88
T1217
S
Q
G
Q
R
P
V
T
P
I
P
D
V
Q
S
Site 89
S1224
T
P
I
P
D
V
Q
S
S
K
G
G
N
L
A
Site 90
S1233
K
G
G
N
L
A
A
S
A
K
K
K
H
G
S
Site 91
S1240
S
A
K
K
K
H
G
S
T
P
P
G
D
N
K
Site 92
T1241
A
K
K
K
H
G
S
T
P
P
G
D
N
K
D
Site 93
S1253
N
K
D
V
E
D
S
S
V
I
H
Y
D
D
A
Site 94
Y1257
E
D
S
S
V
I
H
Y
D
D
A
A
I
S
K
Site 95
T1273
L
D
R
N
Q
D
A
T
D
D
T
E
L
Q
N
Site 96
T1276
N
Q
D
A
T
D
D
T
E
L
Q
N
M
N
E
Site 97
Y1284
E
L
Q
N
M
N
E
Y
L
S
S
F
K
V
A
Site 98
Y1293
S
S
F
K
V
A
Q
Y
V
V
R
E
E
D
G
Site 99
Y1319
E
E
N
V
D
P
D
Y
W
E
K
L
L
R
H
Site 100
Y1328
E
K
L
L
R
H
H
Y
E
Q
Q
Q
E
D
L
Site 101
Y1351
R
I
R
K
Q
V
N
Y
N
D
A
S
Q
E
D
Site 102
S1355
Q
V
N
Y
N
D
A
S
Q
E
D
Q
E
W
Q
Site 103
S1366
Q
E
W
Q
D
E
L
S
D
N
Q
S
E
Y
S
Site 104
S1370
D
E
L
S
D
N
Q
S
E
Y
S
I
G
S
E
Site 105
S1373
S
D
N
Q
S
E
Y
S
I
G
S
E
D
E
D
Site 106
S1391
E
E
R
P
E
G
Q
S
G
R
R
Q
S
R
R
Site 107
S1396
G
Q
S
G
R
R
Q
S
R
R
Q
L
K
S
D
Site 108
S1402
Q
S
R
R
Q
L
K
S
D
R
D
K
P
L
P
Site 109
S1460
V
R
D
L
R
G
K
S
E
K
E
F
R
A
Y
Site 110
Y1467
S
E
K
E
F
R
A
Y
V
S
L
F
M
R
H
Site 111
T1485
P
G
A
D
G
A
E
T
F
A
D
G
V
P
R
Site 112
S1496
G
V
P
R
E
G
L
S
R
Q
H
V
L
T
R
Site 113
Y1524
F
E
H
V
N
G
K
Y
S
T
P
D
L
I
P
Site 114
S1525
E
H
V
N
G
K
Y
S
T
P
D
L
I
P
E
Site 115
T1526
H
V
N
G
K
Y
S
T
P
D
L
I
P
E
G
Site 116
S1539
E
G
P
E
G
K
K
S
G
E
V
I
S
S
D
Site 117
S1544
K
K
S
G
E
V
I
S
S
D
P
N
T
P
V
Site 118
S1545
K
S
G
E
V
I
S
S
D
P
N
T
P
V
P
Site 119
T1549
V
I
S
S
D
P
N
T
P
V
P
A
S
P
A
Site 120
S1554
P
N
T
P
V
P
A
S
P
A
H
L
L
P
A
Site 121
S1604
A
A
L
D
R
V
E
S
E
D
K
H
E
S
P
Site 122
S1610
E
S
E
D
K
H
E
S
P
A
S
K
E
R
A
Site 123
S1613
D
K
H
E
S
P
A
S
K
E
R
A
R
E
E
Site 124
S1631
E
T
E
K
A
P
P
S
P
E
Q
L
P
R
E
Site 125
S1654
I
L
D
K
L
E
L
S
L
I
H
S
R
G
D
Site 126
S1658
L
E
L
S
L
I
H
S
R
G
D
S
S
E
L
Site 127
S1662
L
I
H
S
R
G
D
S
S
E
L
R
P
D
D
Site 128
T1670
S
E
L
R
P
D
D
T
K
A
E
E
K
E
P
Site 129
T1680
E
E
K
E
P
I
E
T
Q
Q
N
G
D
K
E
Site 130
S1729
E
E
R
A
A
V
S
S
G
K
I
Y
D
I
W
Site 131
Y1733
A
V
S
S
G
K
I
Y
D
I
W
H
R
R
H
Site 132
Y1753
A
G
I
V
T
H
G
Y
A
R
W
Q
D
I
Q
Site 133
Y1765
D
I
Q
N
D
P
R
Y
M
I
L
N
E
P
F
Site 134
S1774
I
L
N
E
P
F
K
S
E
V
H
K
G
N
Y
Site 135
Y1781
S
E
V
H
K
G
N
Y
L
E
M
K
N
K
F
Site 136
Y1811
E
Q
L
R
R
A
A
Y
L
N
M
T
Q
D
P
Site 137
T1815
R
A
A
Y
L
N
M
T
Q
D
P
N
H
P
A
Site 138
S1843
A
E
S
H
Q
H
L
S
K
E
S
L
A
G
N
Site 139
S1869
N
Q
L
E
E
L
L
S
D
M
K
A
D
V
T
Site 140
T1876
S
D
M
K
A
D
V
T
R
L
P
S
M
L
S
Site 141
S1880
A
D
V
T
R
L
P
S
M
L
S
R
I
P
P
Site 142
S1895
V
A
A
R
L
Q
M
S
E
R
S
I
L
S
R
Site 143
S1898
R
L
Q
M
S
E
R
S
I
L
S
R
L
T
N
Site 144
T1904
R
S
I
L
S
R
L
T
N
R
A
G
D
P
T
Site 145
T1911
T
N
R
A
G
D
P
T
I
Q
Q
G
A
F
G
Site 146
Y1923
A
F
G
S
S
Q
M
Y
S
N
N
F
G
P
N
Site 147
Y1942
G
P
G
G
I
V
N
Y
N
Q
M
P
L
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation