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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC8C
Full Name:
Leucine-rich repeat-containing protein 8C
Alias:
AD158; Leucine rich repeat containing 8 family, member C; Leucine-rich repeat-containing protein 8C: Protein AD158; LRC8C
Type:
Unknown function
Mass (Da):
92392
Number AA:
803
UniProt ID:
Q8TDW0
International Prot ID:
IPI00152642
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
V
T
E
F
R
Q
F
S
E
Q
Q
P
A
F
R
Site 2
S67
Q
P
A
Q
N
H
S
S
L
S
N
V
S
Q
A
Site 3
S69
A
Q
N
H
S
S
L
S
N
V
S
Q
A
V
A
Site 4
S72
H
S
S
L
S
N
V
S
Q
A
V
A
S
T
T
Site 5
S77
N
V
S
Q
A
V
A
S
T
T
P
L
P
P
P
Site 6
T79
S
Q
A
V
A
S
T
T
P
L
P
P
P
K
P
Site 7
S87
P
L
P
P
P
K
P
S
P
A
N
P
I
T
V
Site 8
T93
P
S
P
A
N
P
I
T
V
E
M
K
G
L
K
Site 9
T101
V
E
M
K
G
L
K
T
D
L
D
L
Q
Q
Y
Site 10
Y108
T
D
L
D
L
Q
Q
Y
S
F
I
N
Q
M
C
Site 11
Y123
Y
E
R
A
L
H
W
Y
A
K
Y
F
P
Y
L
Site 12
S153
F
K
F
P
G
S
S
S
K
I
E
H
F
I
S
Site 13
T171
K
C
F
D
S
P
W
T
T
R
A
L
S
E
V
Site 14
T172
C
F
D
S
P
W
T
T
R
A
L
S
E
V
S
Site 15
S176
P
W
T
T
R
A
L
S
E
V
S
G
E
D
S
Site 16
S179
T
R
A
L
S
E
V
S
G
E
D
S
E
E
K
Site 17
S183
S
E
V
S
G
E
D
S
E
E
K
D
N
R
K
Site 18
S196
R
K
N
N
M
N
R
S
N
T
I
Q
S
G
P
Site 19
T198
N
N
M
N
R
S
N
T
I
Q
S
G
P
E
G
Site 20
S201
N
R
S
N
T
I
Q
S
G
P
E
G
S
L
V
Site 21
S206
I
Q
S
G
P
E
G
S
L
V
N
S
Q
S
L
Site 22
S210
P
E
G
S
L
V
N
S
Q
S
L
K
S
I
P
Site 23
S212
G
S
L
V
N
S
Q
S
L
K
S
I
P
E
K
Site 24
S215
V
N
S
Q
S
L
K
S
I
P
E
K
F
V
V
Site 25
S225
E
K
F
V
V
D
K
S
T
A
G
A
L
D
K
Site 26
Y259
V
E
E
G
D
I
L
Y
A
M
Y
V
R
Q
T
Site 27
T301
N
V
D
I
Q
D
M
T
G
Y
K
N
F
S
C
Site 28
Y303
D
I
Q
D
M
T
G
Y
K
N
F
S
C
N
H
Site 29
Y343
Y
T
L
Y
W
L
F
Y
R
S
L
R
E
Y
S
Site 30
Y349
F
Y
R
S
L
R
E
Y
S
F
E
Y
V
R
Q
Site 31
S350
Y
R
S
L
R
E
Y
S
F
E
Y
V
R
Q
E
Site 32
Y353
L
R
E
Y
S
F
E
Y
V
R
Q
E
T
G
I
Site 33
T358
F
E
Y
V
R
Q
E
T
G
I
D
D
I
P
D
Site 34
Y380
M
L
H
M
I
D
Q
Y
D
P
L
Y
S
K
R
Site 35
Y384
I
D
Q
Y
D
P
L
Y
S
K
R
F
A
V
F
Site 36
S385
D
Q
Y
D
P
L
Y
S
K
R
F
A
V
F
L
Site 37
S393
K
R
F
A
V
F
L
S
E
V
S
E
N
K
L
Site 38
T410
L
N
L
N
N
E
W
T
P
D
K
L
R
Q
K
Site 39
T420
K
L
R
Q
K
L
Q
T
N
A
H
N
R
L
E
Site 40
T444
P
D
T
V
F
E
I
T
E
L
Q
S
L
K
L
Site 41
S473
L
D
N
L
Q
E
L
S
L
H
Q
C
S
V
K
Site 42
S478
E
L
S
L
H
Q
C
S
V
K
I
H
S
A
A
Site 43
S487
K
I
H
S
A
A
L
S
F
L
K
E
N
L
K
Site 44
S497
K
E
N
L
K
V
L
S
V
K
F
D
D
M
R
Site 45
Y511
R
E
L
P
P
W
M
Y
G
L
R
N
L
E
E
Site 46
Y520
L
R
N
L
E
E
L
Y
L
V
G
S
L
S
H
Site 47
S524
E
E
L
Y
L
V
G
S
L
S
H
D
I
S
R
Site 48
S530
G
S
L
S
H
D
I
S
R
N
V
T
L
E
S
Site 49
T534
H
D
I
S
R
N
V
T
L
E
S
L
R
D
L
Site 50
S537
S
R
N
V
T
L
E
S
L
R
D
L
K
S
L
Site 51
S543
E
S
L
R
D
L
K
S
L
K
I
L
S
I
K
Site 52
S548
L
K
S
L
K
I
L
S
I
K
S
N
V
S
K
Site 53
S551
L
K
I
L
S
I
K
S
N
V
S
K
I
P
Q
Site 54
S564
P
Q
A
V
V
D
V
S
S
H
L
Q
K
M
C
Site 55
S626
L
K
E
N
N
L
K
S
I
E
E
I
V
S
F
Site 56
S632
K
S
I
E
E
I
V
S
F
Q
H
L
R
K
L
Site 57
T640
F
Q
H
L
R
K
L
T
V
L
K
L
W
H
N
Site 58
S661
E
H
I
K
K
L
T
S
L
E
R
L
S
F
S
Site 59
S666
L
T
S
L
E
R
L
S
F
S
H
N
K
I
E
Site 60
Y687
F
L
C
N
K
I
R
Y
L
D
L
S
Y
N
D
Site 61
S691
K
I
R
Y
L
D
L
S
Y
N
D
I
R
F
I
Site 62
Y692
I
R
Y
L
D
L
S
Y
N
D
I
R
F
I
P
Site 63
S720
I
T
C
N
K
V
E
S
L
P
D
E
L
Y
F
Site 64
Y726
E
S
L
P
D
E
L
Y
F
C
K
K
L
K
T
Site 65
T733
Y
F
C
K
K
L
K
T
L
K
I
G
K
N
S
Site 66
S740
T
L
K
I
G
K
N
S
L
S
V
L
S
P
K
Site 67
S742
K
I
G
K
N
S
L
S
V
L
S
P
K
I
G
Site 68
S794
A
L
F
E
T
L
P
S
D
V
R
E
Q
M
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation