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Updated November 2019
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Protein Info
Short Name:
PKD1L1
Full Name:
Polycystic kidney disease protein 1-like 1
Alias:
PC1-like 1 protein;Polycystin-1L1
Type:
Mass (Da):
315435
Number AA:
2849
UniProt ID:
Q8TDX9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
L
S
F
G
G
E
L
S
V
S
T
D
K
S
W
Site 2
S32
F
G
G
E
L
S
V
S
T
D
K
S
W
G
L
Site 3
S36
L
S
V
S
T
D
K
S
W
G
L
H
L
C
S
Site 4
S43
S
W
G
L
H
L
C
S
C
S
P
P
G
G
G
Site 5
S84
G
K
A
E
D
R
E
S
Q
S
P
S
S
S
A
Site 6
S86
A
E
D
R
E
S
Q
S
P
S
S
S
A
S
R
Site 7
S88
D
R
E
S
Q
S
P
S
S
S
A
S
R
Q
K
Site 8
S89
R
E
S
Q
S
P
S
S
S
A
S
R
Q
K
N
Site 9
S90
E
S
Q
S
P
S
S
S
A
S
R
Q
K
N
I
Site 10
S92
Q
S
P
S
S
S
A
S
R
Q
K
N
I
W
K
Site 11
S102
K
N
I
W
K
T
T
S
E
A
A
L
S
V
V
Site 12
S107
T
T
S
E
A
A
L
S
V
V
N
E
K
T
Q
Site 13
T113
L
S
V
V
N
E
K
T
Q
A
V
V
N
E
K
Site 14
T121
Q
A
V
V
N
E
K
T
Q
A
P
L
D
C
D
Site 15
S130
A
P
L
D
C
D
N
S
A
D
R
I
P
H
K
Site 16
T161
H
H
R
R
L
C
A
T
G
T
A
D
S
T
F
Site 17
T217
P
G
T
V
T
M
E
T
P
T
K
V
A
R
P
Site 18
T225
P
T
K
V
A
R
P
T
Q
T
S
S
Q
R
V
Site 19
S228
V
A
R
P
T
Q
T
S
S
Q
R
V
P
L
W
Site 20
S229
A
R
P
T
Q
T
S
S
Q
R
V
P
L
W
P
Site 21
S238
R
V
P
L
W
P
I
S
H
F
P
T
S
P
R
Site 22
T242
W
P
I
S
H
F
P
T
S
P
R
S
S
H
G
Site 23
S243
P
I
S
H
F
P
T
S
P
R
S
S
H
G
L
Site 24
S246
H
F
P
T
S
P
R
S
S
H
G
L
P
P
G
Site 25
S247
F
P
T
S
P
R
S
S
H
G
L
P
P
G
I
Site 26
T257
L
P
P
G
I
P
R
T
P
S
F
T
A
S
Q
Site 27
S259
P
G
I
P
R
T
P
S
F
T
A
S
Q
S
G
Site 28
T261
I
P
R
T
P
S
F
T
A
S
Q
S
G
S
E
Site 29
S263
R
T
P
S
F
T
A
S
Q
S
G
S
E
I
L
Site 30
S265
P
S
F
T
A
S
Q
S
G
S
E
I
L
Y
P
Site 31
S267
F
T
A
S
Q
S
G
S
E
I
L
Y
P
P
T
Site 32
Y271
Q
S
G
S
E
I
L
Y
P
P
T
Q
H
P
P
Site 33
T274
S
E
I
L
Y
P
P
T
Q
H
P
P
V
A
I
Site 34
S330
M
M
D
F
G
D
S
S
G
V
E
M
R
L
H
Site 35
S340
E
M
R
L
H
N
M
S
E
A
M
A
V
T
A
Site 36
Y348
E
A
M
A
V
T
A
Y
H
Q
Y
S
K
G
I
Site 37
T377
K
E
A
E
T
Q
N
T
T
L
N
V
Y
L
C
Site 38
Y382
Q
N
T
T
L
N
V
Y
L
C
Q
S
E
N
S
Site 39
S394
E
N
S
C
L
E
D
S
D
P
S
N
L
G
Y
Site 40
Y420
Y
M
L
K
A
V
I
Y
N
E
F
H
G
T
E
Site 41
T426
I
Y
N
E
F
H
G
T
E
V
E
L
G
P
Y
Site 42
Y433
T
E
V
E
L
G
P
Y
Y
V
E
I
G
H
E
Site 43
Y434
E
V
E
L
G
P
Y
Y
V
E
I
G
H
E
A
Site 44
S443
E
I
G
H
E
A
V
S
A
F
M
N
S
S
S
Site 45
S450
S
A
F
M
N
S
S
S
V
H
E
D
E
V
L
Site 46
S462
E
V
L
V
F
A
D
S
Q
V
N
Q
K
S
T
Site 47
S480
H
H
F
P
S
I
P
S
Y
N
V
S
F
I
S
Site 48
Y481
H
F
P
S
I
P
S
Y
N
V
S
F
I
S
Q
Site 49
S484
S
I
P
S
Y
N
V
S
F
I
S
Q
T
Q
V
Site 50
S487
S
Y
N
V
S
F
I
S
Q
T
Q
V
G
D
S
Site 51
S494
S
Q
T
Q
V
G
D
S
Q
A
W
H
S
M
T
Site 52
T525
F
A
T
D
T
D
I
T
F
T
A
V
T
K
E
Site 53
Y541
I
P
L
E
F
E
W
Y
F
G
E
D
P
P
V
Site 54
T550
G
E
D
P
P
V
R
T
T
S
R
S
I
K
K
Site 55
T551
E
D
P
P
V
R
T
T
S
R
S
I
K
K
R
Site 56
S552
D
P
P
V
R
T
T
S
R
S
I
K
K
R
L
Site 57
S554
P
V
R
T
T
S
R
S
I
K
K
R
L
S
I
Site 58
S560
R
S
I
K
K
R
L
S
I
P
Q
W
Y
R
V
Site 59
S572
Y
R
V
M
V
K
A
S
N
R
M
S
S
V
V
Site 60
S576
V
K
A
S
N
R
M
S
S
V
V
S
E
P
H
Site 61
S577
K
A
S
N
R
M
S
S
V
V
S
E
P
H
V
Site 62
S580
N
R
M
S
S
V
V
S
E
P
H
V
I
R
V
Site 63
S600
A
N
R
L
T
S
P
S
S
A
L
V
N
A
S
Site 64
S601
N
R
L
T
S
P
S
S
A
L
V
N
A
S
V
Site 65
Y622
N
F
G
T
D
V
A
Y
L
W
D
F
G
D
G
Site 66
T630
L
W
D
F
G
D
G
T
V
S
L
G
S
S
S
Site 67
S632
D
F
G
D
G
T
V
S
L
G
S
S
S
S
S
Site 68
S635
D
G
T
V
S
L
G
S
S
S
S
S
H
V
Y
Site 69
S636
G
T
V
S
L
G
S
S
S
S
S
H
V
Y
S
Site 70
S637
T
V
S
L
G
S
S
S
S
S
H
V
Y
S
R
Site 71
S638
V
S
L
G
S
S
S
S
S
H
V
Y
S
R
E
Site 72
S639
S
L
G
S
S
S
S
S
H
V
Y
S
R
E
G
Site 73
Y642
S
S
S
S
S
H
V
Y
S
R
E
G
E
F
T
Site 74
S643
S
S
S
S
H
V
Y
S
R
E
G
E
F
T
V
Site 75
T649
Y
S
R
E
G
E
F
T
V
E
V
L
A
F
N
Site 76
S661
A
F
N
N
V
S
A
S
T
L
R
Q
Q
L
F
Site 77
S692
G
K
V
Q
I
W
R
S
Q
P
V
R
L
G
V
Site 78
T739
A
V
D
T
H
R
Q
T
L
I
L
P
S
H
T
Site 79
Y752
H
T
L
E
Y
G
N
Y
T
A
L
A
K
V
Q
Site 80
S782
V
R
A
Q
A
P
V
S
V
I
S
E
G
T
H
Site 81
S793
E
G
T
H
L
F
F
S
R
T
T
S
S
P
I
Site 82
S797
L
F
F
S
R
T
T
S
S
P
I
V
L
R
G
Site 83
S798
F
F
S
R
T
T
S
S
P
I
V
L
R
G
T
Site 84
T805
S
P
I
V
L
R
G
T
Q
S
F
D
P
D
D
Site 85
S807
I
V
L
R
G
T
Q
S
F
D
P
D
D
P
G
Site 86
T816
D
P
D
D
P
G
A
T
L
R
Y
H
W
E
C
Site 87
S836
P
A
H
P
C
F
D
S
S
T
A
H
Q
L
D
Site 88
S837
A
H
P
C
F
D
S
S
T
A
H
Q
L
D
A
Site 89
T848
Q
L
D
A
A
A
P
T
V
S
F
E
A
Q
W
Site 90
S857
S
F
E
A
Q
W
L
S
D
S
Y
D
Q
F
L
Site 91
S871
L
V
M
L
R
V
S
S
G
G
R
N
S
S
E
Site 92
S876
V
S
S
G
G
R
N
S
S
E
T
R
V
F
L
Site 93
S877
S
S
G
G
R
N
S
S
E
T
R
V
F
L
S
Site 94
T879
G
G
R
N
S
S
E
T
R
V
F
L
S
P
Y
Site 95
S884
S
E
T
R
V
F
L
S
P
Y
P
D
S
A
F
Site 96
Y886
T
R
V
F
L
S
P
Y
P
D
S
A
F
R
F
Site 97
T974
S
Q
L
N
L
L
P
T
E
P
G
T
A
D
P
Site 98
T978
L
L
P
T
E
P
G
T
A
D
P
D
A
T
T
Site 99
T984
G
T
A
D
P
D
A
T
T
T
P
F
S
R
E
Site 100
T985
T
A
D
P
D
A
T
T
T
P
F
S
R
E
P
Site 101
T986
A
D
P
D
A
T
T
T
P
F
S
R
E
P
S
Site 102
S989
D
A
T
T
T
P
F
S
R
E
P
S
P
V
T
Site 103
S993
T
P
F
S
R
E
P
S
P
V
T
L
G
Q
P
Site 104
T996
S
R
E
P
S
P
V
T
L
G
Q
P
A
T
S
Site 105
T1002
V
T
L
G
Q
P
A
T
S
A
P
R
G
T
P
Site 106
S1003
T
L
G
Q
P
A
T
S
A
P
R
G
T
P
T
Site 107
T1008
A
T
S
A
P
R
G
T
P
T
E
P
M
T
G
Site 108
T1010
S
A
P
R
G
T
P
T
E
P
M
T
G
V
Y
Site 109
T1014
G
T
P
T
E
P
M
T
G
V
Y
W
I
P
P
Site 110
Y1017
T
E
P
M
T
G
V
Y
W
I
P
P
A
G
D
Site 111
S1036
G
E
A
P
E
E
G
S
L
D
L
E
P
G
P
Site 112
S1045
D
L
E
P
G
P
Q
S
K
G
S
L
M
T
G
Site 113
S1048
P
G
P
Q
S
K
G
S
L
M
T
G
R
S
E
Site 114
T1051
Q
S
K
G
S
L
M
T
G
R
S
E
R
S
Q
Site 115
S1054
G
S
L
M
T
G
R
S
E
R
S
Q
P
T
H
Site 116
S1057
M
T
G
R
S
E
R
S
Q
P
T
H
S
P
D
Site 117
T1060
R
S
E
R
S
Q
P
T
H
S
P
D
P
H
L
Site 118
S1062
E
R
S
Q
P
T
H
S
P
D
P
H
L
S
D
Site 119
S1068
H
S
P
D
P
H
L
S
D
F
E
A
Y
Y
S
Site 120
Y1074
L
S
D
F
E
A
Y
Y
S
D
I
Q
E
A
I
Site 121
S1075
S
D
F
E
A
Y
Y
S
D
I
Q
E
A
I
P
Site 122
S1083
D
I
Q
E
A
I
P
S
G
G
R
Q
P
A
K
Site 123
T1092
G
R
Q
P
A
K
D
T
S
F
P
G
S
G
P
Site 124
S1093
R
Q
P
A
K
D
T
S
F
P
G
S
G
P
S
Site 125
S1097
K
D
T
S
F
P
G
S
G
P
S
L
S
A
E
Site 126
S1100
S
F
P
G
S
G
P
S
L
S
A
E
E
S
P
Site 127
S1102
P
G
S
G
P
S
L
S
A
E
E
S
P
G
D
Site 128
S1106
P
S
L
S
A
E
E
S
P
G
D
G
D
N
L
Site 129
S1117
G
D
N
L
V
D
P
S
L
S
A
G
R
A
E
Site 130
S1145
R
A
V
F
Q
G
Y
S
S
S
G
I
T
E
Q
Site 131
S1147
V
F
Q
G
Y
S
S
S
G
I
T
E
Q
T
V
Site 132
T1150
G
Y
S
S
S
G
I
T
E
Q
T
V
T
I
K
Site 133
T1153
S
S
G
I
T
E
Q
T
V
T
I
K
P
Y
S
Site 134
T1155
G
I
T
E
Q
T
V
T
I
K
P
Y
S
L
S
Site 135
S1160
T
V
T
I
K
P
Y
S
L
S
S
G
E
T
Y
Site 136
T1188
G
K
A
Q
L
Y
L
T
V
N
P
A
P
R
D
Site 137
Y1225
S
G
K
P
D
F
H
Y
E
F
S
Y
Q
I
G
Site 138
Y1229
D
F
H
Y
E
F
S
Y
Q
I
G
N
T
S
K
Site 139
Y1240
N
T
S
K
H
T
L
Y
H
G
R
D
T
Q
Y
Site 140
Y1247
Y
H
G
R
D
T
Q
Y
Y
F
V
L
P
A
G
Site 141
Y1248
H
G
R
D
T
Q
Y
Y
F
V
L
P
A
G
E
Site 142
Y1260
A
G
E
H
L
D
N
Y
K
V
M
V
S
T
E
Site 143
T1269
V
M
V
S
T
E
I
T
D
G
K
G
S
K
V
Site 144
Y1300
D
C
L
G
E
D
L
Y
N
S
S
L
K
N
L
Site 145
S1302
L
G
E
D
L
Y
N
S
S
L
K
N
L
S
T
Site 146
S1303
G
E
D
L
Y
N
S
S
L
K
N
L
S
T
L
Site 147
S1308
N
S
S
L
K
N
L
S
T
L
Q
L
M
G
S
Site 148
T1309
S
S
L
K
N
L
S
T
L
Q
L
M
G
S
Y
Site 149
S1315
S
T
L
Q
L
M
G
S
Y
T
E
I
R
N
Y
Site 150
Y1316
T
L
Q
L
M
G
S
Y
T
E
I
R
N
Y
I
Site 151
T1317
L
Q
L
M
G
S
Y
T
E
I
R
N
Y
I
T
Site 152
Y1322
S
Y
T
E
I
R
N
Y
I
T
V
I
T
R
I
Site 153
S1331
T
V
I
T
R
I
L
S
R
L
S
K
E
D
K
Site 154
S1334
T
R
I
L
S
R
L
S
K
E
D
K
T
A
S
Site 155
T1339
R
L
S
K
E
D
K
T
A
S
C
N
Q
W
S
Site 156
S1341
S
K
E
D
K
T
A
S
C
N
Q
W
S
R
I
Site 157
S1370
D
Q
E
E
M
I
G
S
V
L
M
L
R
D
L
Site 158
S1430
I
S
R
V
W
E
V
S
E
Q
E
N
S
K
E
Site 159
S1435
E
V
S
E
Q
E
N
S
K
E
E
V
Y
R
H
Site 160
Y1475
E
F
R
T
L
L
H
Y
N
L
Q
S
S
V
Q
Site 161
S1479
L
L
H
Y
N
L
Q
S
S
V
Q
S
L
G
S
Site 162
S1480
L
H
Y
N
L
Q
S
S
V
Q
S
L
G
S
V
Site 163
S1483
N
L
Q
S
S
V
Q
S
L
G
S
V
Q
V
H
Site 164
S1499
P
G
D
L
A
G
H
S
P
A
G
A
E
T
Q
Site 165
T1505
H
S
P
A
G
A
E
T
Q
S
P
C
Y
I
S
Site 166
S1507
P
A
G
A
E
T
Q
S
P
C
Y
I
S
Q
L
Site 167
S1512
T
Q
S
P
C
Y
I
S
Q
L
I
L
F
K
K
Site 168
Y1522
I
L
F
K
K
N
P
Y
P
G
S
Q
A
P
G
Site 169
S1525
K
K
N
P
Y
P
G
S
Q
A
P
G
Q
I
G
Site 170
Y1540
G
V
V
G
L
N
L
Y
T
C
S
S
R
R
P
Site 171
S1543
G
L
N
L
Y
T
C
S
S
R
R
P
I
N
R
Site 172
S1544
L
N
L
Y
T
C
S
S
R
R
P
I
N
R
Q
Site 173
T1574
L
D
N
R
R
N
K
T
T
F
V
L
L
R
D
Site 174
T1575
D
N
R
R
N
K
T
T
F
V
L
L
R
D
K
Site 175
S1592
L
H
Q
F
T
E
L
S
E
N
P
Q
E
S
L
Site 176
S1598
L
S
E
N
P
Q
E
S
L
Q
I
E
I
E
F
Site 177
S1622
V
M
L
L
V
R
F
S
E
K
P
T
P
S
D
Site 178
T1626
V
R
F
S
E
K
P
T
P
S
D
F
L
V
K
Site 179
S1651
Q
I
Y
I
P
A
A
S
Q
K
D
A
S
V
G
Site 180
S1661
D
A
S
V
G
Y
L
S
L
L
D
A
D
Y
D
Site 181
Y1667
L
S
L
L
D
A
D
Y
D
R
K
P
P
N
R
Site 182
Y1675
D
R
K
P
P
N
R
Y
L
A
K
A
V
N
Y
Site 183
S1701
W
D
K
R
E
W
K
S
E
R
F
S
P
Q
P
Site 184
S1705
E
W
K
S
E
R
F
S
P
Q
P
G
T
S
P
Site 185
S1711
F
S
P
Q
P
G
T
S
P
E
K
V
N
C
S
Site 186
S1718
S
P
E
K
V
N
C
S
Y
H
R
L
A
A
F
Site 187
Y1719
P
E
K
V
N
C
S
Y
H
R
L
A
A
F
A
Site 188
S1735
L
R
R
K
L
K
A
S
F
E
V
S
D
I
S
Site 189
S1739
L
K
A
S
F
E
V
S
D
I
S
K
L
Q
S
Site 190
S1742
S
F
E
V
S
D
I
S
K
L
Q
S
H
P
E
Site 191
S1746
S
D
I
S
K
L
Q
S
H
P
E
N
L
L
P
Site 192
S1771
Y
G
F
L
V
A
K
S
R
Q
V
D
H
H
E
Site 193
S1827
L
C
G
D
N
G
L
S
E
T
K
E
L
S
C
Site 194
S1833
L
S
E
T
K
E
L
S
C
P
E
K
P
L
F
Site 195
S1844
K
P
L
F
E
R
N
S
R
H
T
F
I
L
S
Site 196
T1847
F
E
R
N
S
R
H
T
F
I
L
S
A
P
A
Site 197
S1868
K
I
R
L
W
H
D
S
R
G
P
S
P
G
W
Site 198
S1872
W
H
D
S
R
G
P
S
P
G
W
F
I
S
H
Site 199
T1913
G
R
V
E
R
E
L
T
C
L
Q
G
G
L
G
Site 200
S1941
E
D
F
H
V
W
L
S
V
Y
S
R
P
S
S
Site 201
Y1943
F
H
V
W
L
S
V
Y
S
R
P
S
S
S
R
Site 202
S1944
H
V
W
L
S
V
Y
S
R
P
S
S
S
R
Y
Site 203
S1947
L
S
V
Y
S
R
P
S
S
S
R
Y
L
H
T
Site 204
S1948
S
V
Y
S
R
P
S
S
S
R
Y
L
H
T
P
Site 205
S1949
V
Y
S
R
P
S
S
S
R
Y
L
H
T
P
R
Site 206
T1954
S
S
S
R
Y
L
H
T
P
R
L
T
V
S
F
Site 207
S1987
E
Q
P
H
L
D
V
S
P
T
L
G
S
F
R
Site 208
T1989
P
H
L
D
V
S
P
T
L
G
S
F
R
V
G
Site 209
S2023
L
S
K
E
A
P
G
S
A
R
V
E
P
H
S
Site 210
S2030
S
A
R
V
E
P
H
S
P
L
R
G
G
A
Q
Site 211
T2038
P
L
R
G
G
A
Q
T
E
A
P
H
G
P
N
Site 212
S2046
E
A
P
H
G
P
N
S
W
G
R
I
P
D
A
Site 213
S2062
E
P
R
K
Q
P
A
S
A
I
L
S
G
S
G
Site 214
S2066
Q
P
A
S
A
I
L
S
G
S
G
R
A
Q
R
Site 215
S2068
A
S
A
I
L
S
G
S
G
R
A
Q
R
K
A
Site 216
T2081
K
A
A
S
D
N
G
T
A
C
P
A
P
K
L
Site 217
S2096
Q
V
H
G
A
D
H
S
R
T
S
L
M
G
K
Site 218
S2099
G
A
D
H
S
R
T
S
L
M
G
K
S
H
C
Site 219
T2111
S
H
C
C
P
P
H
T
Q
A
P
S
S
G
L
Site 220
S2115
P
P
H
T
Q
A
P
S
S
G
L
E
G
L
M
Site 221
S2116
P
H
T
Q
A
P
S
S
G
L
E
G
L
M
P
Site 222
Y2157
L
G
T
G
F
L
A
Y
R
F
G
Q
E
Q
C
Site 223
S2208
D
N
H
F
F
T
E
S
L
C
E
A
T
R
D
Site 224
S2218
E
A
T
R
D
L
D
S
E
L
A
E
R
S
W
Site 225
S2224
D
S
E
L
A
E
R
S
W
T
R
L
P
F
S
Site 226
T2226
E
L
A
E
R
S
W
T
R
L
P
F
S
S
S
Site 227
S2231
S
W
T
R
L
P
F
S
S
S
C
S
I
P
D
Site 228
S2232
W
T
R
L
P
F
S
S
S
C
S
I
P
D
C
Site 229
S2233
T
R
L
P
F
S
S
S
C
S
I
P
D
C
A
Site 230
S2263
L
R
W
A
H
P
P
S
K
A
Q
L
R
G
T
Site 231
T2270
S
K
A
Q
L
R
G
T
R
Q
R
M
R
R
E
Site 232
S2278
R
Q
R
M
R
R
E
S
R
T
R
A
A
L
R
Site 233
T2280
R
M
R
R
E
S
R
T
R
A
A
L
R
D
I
Site 234
S2306
C
V
I
Y
G
R
F
S
Q
D
E
Y
S
L
N
Site 235
Y2310
G
R
F
S
Q
D
E
Y
S
L
N
Q
A
I
R
Site 236
S2311
R
F
S
Q
D
E
Y
S
L
N
Q
A
I
R
K
Site 237
Y2350
T
T
L
L
D
G
L
Y
P
G
G
T
P
S
A
Site 238
T2354
D
G
L
Y
P
G
G
T
P
S
A
R
V
P
G
Site 239
S2356
L
Y
P
G
G
T
P
S
A
R
V
P
G
A
Q
Site 240
S2397
C
K
P
P
R
P
F
S
A
L
I
E
D
S
I
Site 241
S2408
E
D
S
I
P
T
C
S
P
E
V
G
G
P
E
Site 242
Y2418
V
G
G
P
E
N
P
Y
L
I
D
P
E
N
Q
Site 243
T2428
D
P
E
N
Q
N
V
T
L
N
G
P
G
G
C
Site 244
S2444
T
R
E
D
C
V
L
S
L
G
R
T
R
T
E
Site 245
T2450
L
S
L
G
R
T
R
T
E
A
H
T
A
L
S
Site 246
T2454
R
T
R
T
E
A
H
T
A
L
S
R
L
R
A
Site 247
S2457
T
E
A
H
T
A
L
S
R
L
R
A
S
M
W
Site 248
S2462
A
L
S
R
L
R
A
S
M
W
I
D
R
S
T
Site 249
S2468
A
S
M
W
I
D
R
S
T
R
A
V
S
V
H
Site 250
S2473
D
R
S
T
R
A
V
S
V
H
F
T
L
Y
N
Site 251
T2477
R
A
V
S
V
H
F
T
L
Y
N
P
P
T
Q
Site 252
S2511
S
S
L
V
E
S
F
S
I
F
R
S
D
S
A
Site 253
S2515
E
S
F
S
I
F
R
S
D
S
A
L
Q
Y
H
Site 254
Y2521
R
S
D
S
A
L
Q
Y
H
L
M
L
P
Q
L
Site 255
T2587
V
T
L
A
G
D
V
T
N
Q
F
H
R
G
L
Site 256
S2641
N
T
M
A
S
C
S
S
M
M
R
H
S
L
P
Site 257
S2697
L
F
H
F
P
R
R
S
Q
K
D
C
L
L
G
Site 258
S2706
K
D
C
L
L
G
L
S
K
S
D
Q
R
A
M
Site 259
T2738
M
L
R
G
F
L
M
T
L
P
Q
K
R
K
S
Site 260
S2745
T
L
P
Q
K
R
K
S
F
Q
S
K
S
F
V
Site 261
S2748
Q
K
R
K
S
F
Q
S
K
S
F
V
R
L
K
Site 262
S2750
R
K
S
F
Q
S
K
S
F
V
R
L
K
D
V
Site 263
T2767
Y
M
W
E
K
V
L
T
F
L
R
L
E
T
P
Site 264
T2773
L
T
F
L
R
L
E
T
P
K
L
E
E
A
E
Site 265
Y2787
E
M
V
E
N
H
N
Y
Y
L
D
E
F
A
N
Site 266
Y2788
M
V
E
N
H
N
Y
Y
L
D
E
F
A
N
L
Site 267
S2809
K
I
N
G
L
S
D
S
L
Q
L
P
L
L
E
Site 268
S2830
G
E
A
R
T
E
E
S
P
L
V
D
I
S
S
Site 269
S2837
S
P
L
V
D
I
S
S
Y
Q
A
A
E
P
A
Site 270
Y2838
P
L
V
D
I
S
S
Y
Q
A
A
E
P
A
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation