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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDEFL1
Full Name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Alias:
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Centaurin, beta 6; CENTB6; DDFL1; Development and differentiation enhancing factor-like 1; FLJ20199; UPLC1; Up-regulated in liver cancer 1; Up-regulated in liver cancer 1 (UPLC1)
Type:
Unknown function
Mass (Da):
99160
Number AA:
UniProt ID:
Q8TDY4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0032312
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S65
A
V
R
A
I
H
S
S
G
L
G
H
V
E
N
Site 2
S82
Q
Y
R
E
A
V
E
S
L
G
N
S
H
L
S
Site 3
S86
A
V
E
S
L
G
N
S
H
L
S
Q
N
S
H
Site 4
S89
S
L
G
N
S
H
L
S
Q
N
S
H
E
L
S
Site 5
S92
N
S
H
L
S
Q
N
S
H
E
L
S
T
G
F
Site 6
S96
S
Q
N
S
H
E
L
S
T
G
F
L
N
L
A
Site 7
S143
L
R
D
G
R
Q
D
S
K
K
Q
L
E
K
A
Site 8
Y154
L
E
K
A
W
K
D
Y
E
A
K
M
A
K
L
Site 9
T171
E
R
D
R
A
R
V
T
G
G
I
P
G
E
V
Site 10
Y196
F
Q
L
H
M
C
E
Y
L
L
K
A
G
E
S
Site 11
S203
Y
L
L
K
A
G
E
S
Q
M
K
Q
G
P
D
Site 12
S235
D
G
W
K
A
A
Q
S
L
F
P
F
I
E
K
Site 13
T262
E
D
E
L
Q
K
L
T
Q
L
R
D
S
L
R
Site 14
S267
K
L
T
Q
L
R
D
S
L
R
G
T
L
Q
L
Site 15
T271
L
R
D
S
L
R
G
T
L
Q
L
E
S
R
E
Site 16
S276
R
G
T
L
Q
L
E
S
R
E
E
H
L
S
R
Site 17
S282
E
S
R
E
E
H
L
S
R
K
N
S
G
C
G
Site 18
S286
E
H
L
S
R
K
N
S
G
C
G
Y
S
I
H
Site 19
Y290
R
K
N
S
G
C
G
Y
S
I
H
Q
H
Q
G
Site 20
T303
Q
G
N
K
Q
F
G
T
E
K
V
G
F
L
Y
Site 21
Y310
T
E
K
V
G
F
L
Y
K
K
S
D
G
I
R
Site 22
S313
V
G
F
L
Y
K
K
S
D
G
I
R
R
V
W
Site 23
Y329
K
R
K
C
G
V
K
Y
G
C
L
T
I
S
H
Site 24
S335
K
Y
G
C
L
T
I
S
H
S
T
I
N
R
P
Site 25
S337
G
C
L
T
I
S
H
S
T
I
N
R
P
P
V
Site 26
Y372
L
V
T
H
N
R
T
Y
H
F
Q
A
E
D
E
Site 27
S399
S
K
D
E
A
L
S
S
A
F
L
G
E
P
S
Site 28
S406
S
A
F
L
G
E
P
S
A
G
P
G
S
W
G
Site 29
S411
E
P
S
A
G
P
G
S
W
G
S
A
G
H
D
Site 30
S414
A
G
P
G
S
W
G
S
A
G
H
D
G
E
P
Site 31
T425
D
G
E
P
H
D
L
T
K
L
L
I
A
E
V
Site 32
S434
L
L
I
A
E
V
K
S
R
P
G
N
S
Q
C
Site 33
S439
V
K
S
R
P
G
N
S
Q
C
C
D
C
G
A
Site 34
S476
R
E
L
G
V
R
F
S
R
M
Q
S
L
T
L
Site 35
S501
A
L
N
M
G
N
T
S
F
N
E
V
M
E
A
Site 36
S519
S
H
G
G
P
K
P
S
A
E
S
D
M
G
T
Site 37
T526
S
A
E
S
D
M
G
T
R
R
D
Y
I
M
A
Site 38
Y530
D
M
G
T
R
R
D
Y
I
M
A
K
Y
V
E
Site 39
Y535
R
D
Y
I
M
A
K
Y
V
E
H
R
F
A
R
Site 40
T545
H
R
F
A
R
R
C
T
P
E
P
Q
R
L
W
Site 41
T553
P
E
P
Q
R
L
W
T
A
I
C
N
R
D
L
Site 42
Y628
D
G
N
T
A
L
H
Y
A
A
L
Y
N
Q
P
Site 43
Y632
A
L
H
Y
A
A
L
Y
N
Q
P
D
C
L
K
Site 44
T650
K
G
R
A
L
V
G
T
V
N
E
A
G
E
T
Site 45
S691
F
P
L
H
V
D
Y
S
W
V
I
S
T
E
P
Site 46
S695
V
D
Y
S
W
V
I
S
T
E
P
G
S
D
S
Site 47
T696
D
Y
S
W
V
I
S
T
E
P
G
S
D
S
E
Site 48
S700
V
I
S
T
E
P
G
S
D
S
E
E
D
E
E
Site 49
S702
S
T
E
P
G
S
D
S
E
E
D
E
E
E
K
Site 50
S723
P
A
Q
A
H
W
A
S
G
R
L
D
I
S
N
Site 51
S729
A
S
G
R
L
D
I
S
N
K
T
Y
E
T
V
Site 52
Y733
L
D
I
S
N
K
T
Y
E
T
V
A
S
L
G
Site 53
S738
K
T
Y
E
T
V
A
S
L
G
A
A
T
P
Q
Site 54
T743
V
A
S
L
G
A
A
T
P
Q
G
E
S
E
D
Site 55
S760
P
P
L
P
V
K
N
S
S
R
T
L
V
Q
G
Site 56
S773
Q
G
C
A
R
H
A
S
G
D
R
S
E
V
S
Site 57
S777
R
H
A
S
G
D
R
S
E
V
S
S
L
S
S
Site 58
S780
S
G
D
R
S
E
V
S
S
L
S
S
E
A
P
Site 59
S781
G
D
R
S
E
V
S
S
L
S
S
E
A
P
E
Site 60
S783
R
S
E
V
S
S
L
S
S
E
A
P
E
T
P
Site 61
S784
S
E
V
S
S
L
S
S
E
A
P
E
T
P
E
Site 62
T789
L
S
S
E
A
P
E
T
P
E
S
L
G
S
P
Site 63
S792
E
A
P
E
T
P
E
S
L
G
S
P
A
S
S
Site 64
S795
E
T
P
E
S
L
G
S
P
A
S
S
S
S
L
Site 65
S798
E
S
L
G
S
P
A
S
S
S
S
L
M
S
P
Site 66
S799
S
L
G
S
P
A
S
S
S
S
L
M
S
P
L
Site 67
S800
L
G
S
P
A
S
S
S
S
L
M
S
P
L
E
Site 68
S801
G
S
P
A
S
S
S
S
L
M
S
P
L
E
P
Site 69
S804
A
S
S
S
S
L
M
S
P
L
E
P
G
D
P
Site 70
S812
P
L
E
P
G
D
P
S
Q
A
P
P
N
S
E
Site 71
S818
P
S
Q
A
P
P
N
S
E
E
G
L
R
E
P
Site 72
T828
G
L
R
E
P
P
G
T
S
R
P
S
L
T
S
Site 73
S829
L
R
E
P
P
G
T
S
R
P
S
L
T
S
G
Site 74
S832
P
P
G
T
S
R
P
S
L
T
S
G
T
T
P
Site 75
T834
G
T
S
R
P
S
L
T
S
G
T
T
P
S
E
Site 76
S835
T
S
R
P
S
L
T
S
G
T
T
P
S
E
M
Site 77
T838
P
S
L
T
S
G
T
T
P
S
E
M
Y
L
P
Site 78
S840
L
T
S
G
T
T
P
S
E
M
Y
L
P
V
R
Site 79
Y843
G
T
T
P
S
E
M
Y
L
P
V
R
F
S
S
Site 80
S849
M
Y
L
P
V
R
F
S
S
E
S
T
R
S
Y
Site 81
S850
Y
L
P
V
R
F
S
S
E
S
T
R
S
Y
R
Site 82
S852
P
V
R
F
S
S
E
S
T
R
S
Y
R
R
G
Site 83
T853
V
R
F
S
S
E
S
T
R
S
Y
R
R
G
A
Site 84
S855
F
S
S
E
S
T
R
S
Y
R
R
G
A
R
S
Site 85
Y856
S
S
E
S
T
R
S
Y
R
R
G
A
R
S
P
Site 86
S862
S
Y
R
R
G
A
R
S
P
E
D
G
P
S
A
Site 87
S868
R
S
P
E
D
G
P
S
A
R
Q
P
L
P
R
Site 88
S888
G
I
T
E
G
D
G
S
R
T
G
S
L
P
A
Site 89
S892
G
D
G
S
R
T
G
S
L
P
A
S
S
V
Q
Site 90
S896
R
T
G
S
L
P
A
S
S
V
Q
L
L
Q
D
Site 91
S897
T
G
S
L
P
A
S
S
V
Q
L
L
Q
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation